Abstract:
INTRODUCTION:Childhood abuse and neglect are risk factors for psychotic symptoms. Early adversities may contribute to alterations in neuro/social cognition, which in turn is associated with psychosis. This study explored the possible mediating/moderating role of neuro/social cognition between childhood abuse and neglect on the one hand, and psychotic symptoms on the other. METHOD:The sampling frame was 1.119 patients with a psychotic disorder. Childhood adversity was evaluated with the Dutch version of the Childhood Trauma Questionnaire. Psychotic symptoms were assessed with the Positive and Negative Syndrome Scale. Verbal learning-memory, attention-vigilance, working memory, information processing speed, reasoning-problem solving were evaluated as measures of neurocognition using the Word Learning Task, the Continuous Performance Test, the Wechsler Adult Intelligence Scale 3rd. Mentalization was evaluated as a measure of social cognition using the Hinting Task. Correlation, mediation, moderation, 95% Bias Corrected and accelerated (BCaCI) bootstrapped analyses were performed, considering possible sex differences. RESULTS:In male psychotic patients, attention and vigilance mediated the association between childhood neglect and negative symptoms (indirect effect: 0.18, BCaCI: 0.03-0.54), disorganization (indirect effect: 0.26, BCaCI: 0.05-0.61), excitement (indirect effect: 0.07, BCaCI: 0.004-0.23); mentalization mediated the association between childhood neglect and negative symptoms (indirect effect: 0.21, BCaCI: 0.02-0.51), excitement (indirect effect: 0.07, BCaCI: 0.01-0.20) disorganization (indirect effect: 0.29, BCaCI: 0.02-0.64); working memory mediated the association between childhood abuse and disorganization (indirect effect: 0.28, BCaCI: 0.05-0.57), excitement (indirect effect: 0.08, BCaCI: 0.01-0.20), emotional distress (indirect effect: 0.10, BCaCI: 0.01-0.27). DISCUSSION:In psychotic disorder, sex-specific mediation of neurocognition and mentalization may exist in the association between childhood adversity and psychotic symptoms.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Mansueto G,Schruers K,Cosci F,van Os J,GROUP Investigators.doi
10.1016/j.schres.2018.11.028subject
Has Abstractpub_date
2019-04-01 00:00:00pages
183-193eissn
0920-9964issn
1573-2509pii
S0920-9964(18)30680-7journal_volume
206pub_type
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.07.004
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doi:10.1016/j.schres.2018.04.043
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journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2009.04.007
更新日期:2009-07-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:10.1016/S0920-9964(03)00129-4
更新日期:2004-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.11.004
更新日期:2015-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.10.009
更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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pub_type: 传,历史文章,杂志文章
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更新日期:2014-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
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journal_title:Schizophrenia research
pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2017.06.013
更新日期:2018-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.12.010
更新日期:2012-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.07.016
更新日期:2014-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.schres.2009.03.004
更新日期:2009-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.03.022
更新日期:2014-06-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.06.019
更新日期:2013-09-01 00:00:00