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Neurocognitive performance in children aged 9-12 years who present putative antecedents of schizophrenia.

Abstract：

BACKGROUND:We previously developed a novel method of identifying children aged 9-12 years who may be at elevated risk of developing schizophrenia and the spectrum disorders because they present a triad of putative antecedents of schizophrenia (ASz). The present study aimed to determine whether ASz children also present neurocognitive deficits that are commonly observed in patients with schizophrenia. METHODS:Twenty-eight ASz children and 28 typically-developing (TD) children without the antecedents of schizophrenia completed a battery of neurocognitive tests assessing seven domains of function: General intelligence, scholastic achievement, verbal memory, visual memory, working memory, executive function (EF)-verbal fluency, and EF-inhibition. RESULTS:Relative to TD children, the ASz group showed poorer performance on all neurocognitive tests (mean Cohen's d effect size=0.52). In linear regression analyses, group status (ASz vs. TD) significantly predicted scores on the general intelligence, verbal memory, working memory, and EF-inhibition domains (p<0.05). The severity of problems on each of the individual antecedents comprising the antecedent triad did not relate strongly to performance on the neurocognitive domains. CONCLUSIONS:Children aged 9-12 years who present multiple antecedents of schizophrenia display poorer neurocognition than healthy peers on several domains showing pronounced deficits in schizophrenia, first-episode psychosis, and youth with prodromal symptoms. Longitudinal follow-up is necessary to determine the extent to which poorer neurocognitive performance is specific to those who develop schizophrenia.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Cullen AE,Dickson H,West SA,Morris RG,Mould GL,Hodgins S,Murray RM,Laurens KR

doi

10.1016/j.schres.2010.05.034

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

15-23

issue

1-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(10)01355-1

journal_volume

121

pub_type

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