Abstract：
BACKGROUND:The normal vasodilatory response to ingestion of nicotinic acid (NA) is impaired in some patients with schizophrenia. It is unclear whether the impairment is a feature of the disorder itself or to a confounding factor such as neuroleptics, caffeine or nicotine use. METHODS:To address this question in a controlled manner, we have developed an animal (rat) model of NA-induced vasodilation, in which response is monitored by measuring change in skin temperature. RESULTS:We observed that (i) acute administration of acetylsalicylic acid (100mg/kg), caffeine (2.5mg/kg) and haloperidol (0.1 or 0.5mg/kg) and (ii) chronic administration of haloperidol (0.2mg/kg/day) significantly inhibited NA (30 mg/kg) response, whereas neither acute (0.25mg/kg) or chronic (0.5mg/kg/day for 14 days) administration of nicotine, or chronic administration of caffeine (5mg/kg/day for 14 days) had any significant effect upon NA response. CONCLUSIONS:Our data suggest that at least one drug commonly used to treat schizophrenia (haloperidol) can interfere with the vasodilatory response to NA. Studies using non-medicated patients with schizophrenia are required to determine whether reduced vasodilatory response to NA in schizophrenia is a feature of the disorder or a consequence of treatment.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Turenne SD,Seeman M,Ross BMdoi
10.1016/s0920-9964(00)00082-7subject
Has Abstractpub_date
2001-07-01 00:00:00pages
191-7issue
3eissn
0920-9964issn
1573-2509pii
S0920996400000827journal_volume
50pub_type
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更新日期：1994-12-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2005-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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