Abstract：
OBJECTIVE:The comorbidity of schizophrenia and substance abuse is well documented and is remarkable for its prevalence and poor prognosis. While the etiology for this association is unknown, one possible mechanism relates to traumatic early life experiences, which have been shown to predispose individuals to both psychosis and substance abuse. METHODS:Participants (N=122) who were outpatients in an inner city public mental health clinic and who were diagnosed with schizophrenia, were administered a battery of structured clinical assessments including the Childhood Traumatic Events Scale (CTES), Davidson PTSD rating scale, Hamilton Depression Rating Scale (HDRS), Positive and Negative Symptom Scale (PANSS), and assessments of medication satisfaction and side effects. Patients with schizophrenia and a history of substance abuse (N=70) were compared to patients with schizophrenia who did not have a history of substance abuse (N=52). RESULTS:Patients with schizophrenia and a history of substance abuse had significantly higher frequency and severity of childhood traumatic events, greater PTSD symptomatology, significantly higher depression scores, and higher scores on the general subscale of the PANSS. DISCUSSION:Our findings lend support to the notion that sensitization to stress from early life experiences may be a factor contributing to the high rate of substance abuse comorbidity in patients with schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Scheller-Gilkey G,Moynes K,Cooper I,Kant C,Miller AHdoi
10.1016/s0920-9964(03)00188-9subject
Has Abstractpub_date
2004-08-01 00:00:00pages
167-74issue
2-3eissn
0920-9964issn
1573-2509pii
S0920-9964(03)00188-9journal_volume
69pub_type
杂志文章abstract：BACKGROUND:Deficient mirror neuron system (MNS)-activity is associated with social cognition deficits in schizophrenia. However, it is not known how socio-emotional contexts modulate the MNS-response. In a Transcranial Magnetic Stimulation (TMS)-experiment, we aimed to compare putative MNS-responses to action observati...
journal_title：Schizophrenia research
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doi：10.1016/j.schres.2018.07.043
更新日期：2019-02-01 00:00:00
abstract：:Neuropsychological performance in 20 chronic schizophrenic patients was contrasted to 25 Parkinson's disease, 12 Huntington's disease patients and 26 normal controls on measures shown to be sensitive to subcortical dysfunction. Some overlap was observed in the performance of the schizophrenic and basal ganglia groups ...
journal_title：Schizophrenia research
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更新日期：1996-05-01 00:00:00
abstract：OBJECTIVE:We examined the relationship between cerebral gray matter (GM) volume and severity of delusions and hallucinations in adults with schizophrenia. METHOD:MRI scans in 43 patients with schizophrenia were acquired. Correlations were computed between GM volume and clinician ratings of hallucinations and delusions...
journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
abstract：:Reduced glutamatergic activity and energy metabolism in the dorsolateral prefrontal cortex (DLPFC) have been described in schizophrenia. Glycogenolysis in astrocytes is responsible for providing neurons with lactate as a transient energy supply helping to couple glutamatergic neurotransmission and glucose utilization ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.024
更新日期：2016-11-01 00:00:00
abstract：:This paper examines trait arousability (TA), a temperament characteristic, in 47 stable outpatients with schizophrenia and 50 non-psychiatric controls. Self-reported levels of stress were obtained during a negative and positive memory speech task. Levels of TA, and the association of TA scores with reported stress dur...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.01.008
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVE:Neuregulin-1 (NRG1) has been put forward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype. METHODS:Participants were 64 patients with DSM-IV schizophrenia or schizoaffective disorder, 97 of their non psychotic re...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.03.025
更新日期：2008-08-01 00:00:00
abstract：:Recent trials support the hypothesis of the role of inflammation in the pathogenesis of schizophrenia. The overall therapeutic benefit of anti-inflammatory medication, in particular cyclo-oxygenase-2 (COX-2) inhibitors in schizophrenia, is still controversial. There are suggestions that therapy with COX-2 inhibitors m...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2010.04.015
更新日期：2010-08-01 00:00:00
abstract：:Schizophrenia and at-risk populations are suggested to exhibit referential cohesion deficits in language production (e.g., producing fewer pronouns or nouns that clearly link to concepts from previous sentences). Much of this work has focused on transcribed speech samples, while no work to our knowledge has examined r...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.04.025
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Little is known about the effects of antipsychotic medications on gray matter (GM) in schizophrenia. Although clozapine remains the most effective antipsychotic medication in treatment-refractory cases, it is unknown whether it has a differential effect on GM development. METHODS:In an exploratory analysis,...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.10.018
更新日期：2010-01-01 00:00:00
abstract：:Prenatal viral infection has been associated with development of schizophrenia and autism. Our laboratory has previously shown that viral infection causes deleterious effects on brain structure and function in mouse offspring following late first trimester (E9) administration of influenza virus. We hypothesized that l...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.11.018
更新日期：2008-02-01 00:00:00
abstract：:Impaired fiber bundle connectivity between brain regions is a key neuropathological finding in schizophrenia. Symptom dimensions in schizophrenia can be clustered into factor models. Single syndromes have been related to grey and white matter brain structure alterations. We associated all core syndromes of schizophren...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.11.045
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Neurocognitive deficits have been well documented in patients with schizophrenia. Research has shown that a significant proportion of patients with schizophrenia have co-morbid obsessive-compulsive symptoms/disorder (OCS/OCD). However, the impact of OCS/OCD on various neurocognitive domains in patients with ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.05.029
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Febrile seizure is a benign condition for most children, but experiments in animals and neuroimaging studies in humans suggest that some febrile seizures may damage the hippocampus, a brain area of possible importance in schizophrenia. METHODS:A population-based cohort of all children born in Denmark betwee...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.07.004
更新日期：2005-03-01 00:00:00
abstract：:A recent systematic review concluded that cannabis use increases risk of psychotic outcomes independently of confounding and transient intoxication effects. Furthermore, a model of the association between cannabis use and schizophrenia indicated that the incidence and prevalence of schizophrenia would increase from 19...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.05.031
更新日期：2009-09-01 00:00:00
abstract：:Previous research demonstrates that people with schizophrenia have abnormally 'restricted' visual scanpaths to face and facial expression stimuli, which appear to be diagnostically specific to schizophrenia [Schizophr. Res. 55 (2002) 159; Biol. Psychiatry 52 (2002) 338]. This study examined the familial transmission o...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(03)00094-x
更新日期：2004-03-01 00:00:00
abstract：:Aim Research regarding the effect of antipsychotic medications on the risk of upper respiratory infection (URI) progression to pneumonia in patients with schizophrenia is rare. This study investigated the effect of antipsychotic use on the risk of URI progression to pneumonia in patients with schizophrenia. METHODS:T...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.05.013
更新日期：2020-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.04.001
更新日期：2006-07-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.07.018
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Evidence indicating that symptoms of non-clinical psychosis (NCP) occur in 6-8% of the general population suggests that psychosis may occur across a continuum. Although a number of studies have examined environmental contributors, to date there have been few investigations of biological/genetic factors in th...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.06.018
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Cognitive remediation therapy (CRT) has proven to be effective in treating cognitive deficits in schizophrenia. The current study aimed to assess the efficacy of CRT on psychotic symptoms and cognitive complaints. METHODS:We contrasted the changes in symptoms and cognitive complaints in patients with schizo...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2009.03.029
更新日期：2009-06-01 00:00:00
abstract：:We found previously that a subgroup of schizophrenic patients who passed screening tests of attentional competence showed memory deficits on word memory tasks, but were comparable with controls on tone memory tasks. To better understand the nature of language-specific memory deficits in this subgroup of patients, the ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00194-3
更新日期：2002-01-15 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.01.046
更新日期：2019-06-01 00:00:00
abstract：INTRODUCTION:Progressive atrophy occurs in brain regions involved in the working memory network along the schizophrenia's course, but without parallel evolution of working memory impairment. We investigated the functional organization inside this network at different stages of the disease. METHODS:Twenty-eight patient...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.10.023
更新日期：2013-12-01 00:00:00
abstract：:Psychotic disorders are characterized by auditory verbal hallucinations (AVHs), and research has shown that AVHs are linked to deficits in working memory. Our understanding of AVHs across the psychosis continuum is limited. To date, little research has tested whether hallucination proneness (HP) is linked with abnorma...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.10.031
更新日期：2018-05-01 00:00:00
abstract：:Tardive dyskinesia is a severe debilitating movement disorder characterized by choreoathetotic movements developing in one-fifth of the patients with schizophrenia. In this study we have investigated the significance of CYP3A4*1B and CYP2D6*4 polymorphisms in TD susceptibility among chronic schizophrenia patients (n =...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.12.011
更新日期：2005-06-01 00:00:00
abstract：:Within 1 year of severe trauma to the left anterior temporal lobe and minor injury to the frontal lobes, a 35-year-old individual developed classic positive and negative symptoms of schizophrenia. His antipsychotic drug-induced parkinsonism was greater on the left side, suggesting increased left striatal dopaminergic ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00152-4
更新日期：2002-12-01 00:00:00
abstract：:Individuals with schizophrenia have very high rates of cigarette smoking, and much has been discovered about the influence of nicotine on brain functioning in schizophrenia. However, less is understood about the relationship between nicotine consumption and milder phenotypes related to schizophrenia, specifically schi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.08.024
更新日期：2007-12-01 00:00:00
abstract：:Despite the notion that increases in functioning should be associated with increases in life satisfaction in schizophrenia, research has often found no association between the two. Dual change models of global and domain-specific life satisfaction and functioning were examined in 145 individuals with schizophrenia rec...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.04.014
更新日期：2012-08-01 00:00:00
abstract：:There has been increasing interest in studying the impact of physical activity on the psychological and physical well-being and functioning in patients with first-episode psychosis. The exploration of factors which contribute to physical activity in psychosis may open up opportunities for improvement of functional out...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.08.034
更新日期：2013-11-01 00:00:00
abstract：:Nondeclarative memory (NDM) has subtypes associated with different brain regions; learning of a probabilistic classification task is impaired by striatal damage and learning of a gambling task is impaired by ventromedial prefrontocortical damage. Typical and atypical antipsychotic medications differentially affect imm...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00315-8
更新日期：2003-06-01 00:00:00
