Elevated IgG anti-histone antibodies in a subgroup of medicated schizophrenic patients.

abstract：:The positive and negative syndrome scale (PANSS) is widely used in psychiatric research. Reflecting this common use, considerable attention has been applied to the psychometric properties of this instrument. However, despite the publication of numerous studies and analyses, it remains uncertain how best data from the ...

journal_title：Schizophrenia research

authors： Fitzgerald PB,de Castella AR,Brewer K,Filia K,Collins J,Davey P,Rolfe T,Kulkarni J

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVE:The study was to examine the levels of adiponectin (APN) and other cytokines, and body metabolism in drug naïve, first episode schizophrenia patients with normal weight. METHODS:Ninety-six drug naïve, first episode schizophrenia patients with normal weight (SZ group), 60 healthy individuals with normal weigh...

journal_title：Schizophrenia research

authors： Song X,Fan X,Song X,Zhang J,Zhang W,Li X,Gao J,Harrington A,Ziedonis D,Lv L

更新日期：2013-10-01 00:00:00

abstract：:The etiologic factors underlying schizophrenia have been conceptualized as reflecting two largely genetic components - those unique to schizophrenia and those representing vulnerability to neurodevelopmental deviation in general. The Developmental Instability (DI) approach suggests that the latter can be indexed by mi...

journal_title：Schizophrenia research

authors： Euler M,Thoma RJ,Gangestad SW,Cañive JM,Yeo RA

更新日期：2009-11-01 00:00:00

abstract：:The majority of heat shock proteins (HSP) act as molecular chaperones protecting cells from deleterious stress. These proteins are able to inhibit the aggregation of partially denatured proteins and refold them into the correct conformation. They have also been shown to be involved in the pathogenesis of many neurodeg...

journal_title：Schizophrenia research

authors： Gabriele JP,Chong VZ,Pontoriero GF,Mishra RK

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:Patients with schizophrenia and comorbid drug use disorders (DUD) have a severe course of illness. Despite strong evidence that drug use can exacerbate psychotic symptoms, we have limited knowledge of how specific drugs may increase risk of schizophrenia readmission in this group. This study aimed to assess ...

journal_title：Schizophrenia research

authors： Rømer Thomsen K,Thylstrup B,Pedersen MM,Pedersen MU,Simonsen E,Hesse M

更新日期：2018-05-01 00:00:00

abstract：:Cognitive adaptation training (CAT) is a home-based, manualized treatment that utilizes environmental supports to improve target behaviors and functional outcomes in persons with schizophrenia. Although clinical trials have shown CAT to be effective across functional, clinical, and treatment adherence domains, when th...

journal_title：Schizophrenia research

authors： Kidd SA,Herman Y,Barbic S,Ganguli R,George TP,Hassan S,McKenzie K,Maples N,Velligan D

更新日期：2014-06-01 00:00:00

abstract：:Schizotypal personality disorder, a diagnosis defined partially in terms of a genetic relatedness to schizophrenia, has begun to receive extensive investigative study. While the exact etiologic relationship between schizotypal personality disorder and schizophrenia remains to be determined, three models have been cons...

journal_title：Schizophrenia research

authors： Siever LJ,Koenigsberg HW,Harvey P,Mitropoulou V,Laruelle M,Abi-Dargham A,Goodman M,Buchsbaum M

更新日期：2002-03-01 00:00:00

abstract：:Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset. It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself. It also remains unclear whether such state or trait alterat...

journal_title：Schizophrenia research

authors： Bois C,Levita L,Ripp I,Owens DCG,Johnstone EC,Whalley HC,Lawrie SM

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:The diagnosis of psychotic disorder is associated with a risk of violence. Psychotic-like experiences (PLEs) in the general population may share an etiological background with psychotic disorders. The present study has evaluated the association between PLEs and violent behavior in adolescents. METHODS:PLEs a...

journal_title：Schizophrenia research

authors： Kinoshita Y,Shimodera S,Nishida A,Kinoshita K,Watanabe N,Oshima N,Akechi T,Sasaki T,Inoue S,Furukawa TA,Okazaki Y

更新日期：2011-03-01 00:00:00

abstract：:Poly(A+) mRNA was extracted from the post-mortem brain of schizophrenics (9 subjects), unipolar depressives (5 subjects) and controls (10 subjects) and used to direct the in vitro translation of radiolabelled protein in a cell-free reticulocyte-lysate system. Protein species were analysed on two-dimensional gels. Over...

journal_title：Schizophrenia research

authors： Perrett CW,Whatley SA,Ferrier IN,Marchbanks RM

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Many social processes such as emotion recognition are severely impaired in patients with schizophrenia. While basic auditory processing seems to play a key role in identifying emotions, research in this field is limited due to the lack of proper assessment batteries. Many of the widely accepted tests utilize...

journal_title：Schizophrenia research

authors： Chaturvedi R,Kraus M,Keefe RSE

更新日期：2020-08-01 00:00:00

abstract：:Although the seasonal patterns of admissions of affective disorder have been extensively studied, less attention has been given to the seasonal admission patterns of schizophrenia. The traditional method of aggregating the data over a study period, rather than analysing by year of admission may obscure potentially rel...

journal_title：Schizophrenia research

authors： Clarke M,Moran P,Keogh F,Morris M,Kinsella A,Walsh D,Larkin C,O'Callaghan E

更新日期：1998-11-30 00:00:00

abstract：:We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, positive/negative symptoms, and neuropsychological tests of facial memory and executive functioning w...

journal_title：Schizophrenia research

authors： Nestor PG,Onitsuka T,Gurrera RJ,Niznikiewicz M,Frumin M,Shenton ME,McCarley RW

更新日期：2007-03-01 00:00:00

abstract：:Abnormality of P300 waveforms of event-related potentials (ERPs) has been suggested to represent an aspect of the pathophysiology of schizophrenia. Previous work points to the contribution of altered neural function in discrete brain regions in the left hemisphere to psychotic symptoms and cognitive deficits of schizo...

journal_title：Schizophrenia research

authors： Higuchi Y,Sumiyoshi T,Kawasaki Y,Matsui M,Arai H,Kurachi M

更新日期：2008-04-01 00:00:00

abstract：:CACNA1C gene polymorphism rs2007044 has been reported to be associated with schizophrenia, but its underlying brain mechanism is not clear. First, we conducted an exploratory functional magnetic resonance imaging (fMRI) study using an N-BACK task and a Stroop task in 194 subjects (55 schizophrenia patients and 139 hea...

journal_title：Schizophrenia research

authors： Zhang Z,Wang Y,Zhang Q,Zhao W,Chen X,Zhai J,Chen M,Du B,Deng X,Ji F,Wang C,Xiang Y,Li D,Wu H,Dong Q,Chen C,Li J

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Neuroimaging findings implicate bilateral superior temporal regions in the genesis of auditory-verbal hallucinations (AVH). This study aimed to investigate whether 1 Hz repetitive transcranial magnetic stimulation (rTMS) of the bilateral temporo-parietal region would lead to increased effectiveness in the ma...

journal_title：Schizophrenia research

authors： Vercammen A,Knegtering H,Bruggeman R,Westenbroek HM,Jenner JA,Slooff CJ,Wunderink L,Aleman A

更新日期：2009-10-01 00:00:00

abstract：:Spectral entropy (SE) is a measurement from information theory field that provides an estimation of EEG regularity and may be useful as a summary of its spectral properties. Previous studies using small samples reported a deficit of EEG entropy modulation in schizophrenia during cognitive activity. The present study i...

journal_title：Schizophrenia research

authors： Molina V,Bachiller A,Gomez-Pilar J,Lubeiro A,Hornero R,Cea-Cañas B,Valcárcel C,Haidar MK,Poza J

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:The study aimed to assess the construct validity, internal consistency and factor structure of the Specific Levels of Functioning Scale (SLOF), a multidimensional instrument assessing real life functioning. METHODS:The study was carried out in 895 Italian people with schizophrenia, all living in the communi...

journal_title：Schizophrenia research

authors： Mucci A,Rucci P,Rocca P,Bucci P,Gibertoni D,Merlotti E,Galderisi S,Maj M,Italian Network for Research on Psychoses.

更新日期：2014-10-01 00:00:00

abstract：:Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and exhibit qualities of endophenotypes, including substantial heritability, test-retest reliability, and trait-like stability. These measures also fulfill criteria for use a...

journal_title：Schizophrenia research

authors： Light GA,Swerdlow NR,Thomas ML,Calkins ME,Green MF,Greenwood TA,Gur RE,Gur RC,Lazzeroni LC,Nuechterlein KH,Pela M,Radant AD,Seidman LJ,Sharp RF,Siever LJ,Silverman JM,Sprock J,Stone WS,Sugar CA,Tsuang DW,Tsuang MT

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:This study aims to differentiate schizoaffective disorder (SAD) and bipolar-I-disorder (BD) in first-episode psychotic mania (FEPM). METHODS:All 134 patients from an epidemiological first-episode psychosis cohort (N=786) with FEPM and an 18-month follow-up final diagnosis of SAD (n=36) or BD (n=98) were asse...

journal_title：Schizophrenia research

authors： Schöttle D,Schimmelmann BG,Conus P,Cotton SM,Michel C,McGorry PD,Karow A,Naber D,Lambert M

更新日期：2012-09-01 00:00:00

abstract：:Recent transcriptomic, proteomic and metabolomics studies have highlighted an abnormal cerebral glucose and energy metabolism as one of the potential pathophysiological mechanisms of schizophrenia. This raises the possibility that a metabolically-based intervention might have therapeutic value in the management of sch...

journal_title：Schizophrenia research

authors： Kraeuter AK,van den Buuse M,Sarnyai Z

更新日期：2019-04-01 00:00:00

abstract：:Motor abnormalities (MAs) may be already evidenced long before the beginning of illness and are highly prevalent in psychosis. However, the extent to which the whole range of MAs are related to cognitive impairment in psychosis remains understudied. This study aimed to examine comparatively the relationships between t...

journal_title：Schizophrenia research

authors： Cuesta MJ,Moreno-Izco L,Ribeiro M,López-Ilundain JM,Lecumberri P,Cabada T,Lorente-Omeñaca R,Sánchez-Torres AM,Gómez MS,Peralta V

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:In recent years, schizophrenia has increasingly been recognized as a neurocognitive disorder, which has led to a growing literature on cognitive rehabilitation, and suggested several potential enhancements to cognitive function. For instance, it has been shown that executive functioning deficits as measured ...

journal_title：Schizophrenia research

authors： Ohrmann P,Kugel H,Bauer J,Siegmund A,Kölkebeck K,Suslow T,Wiedl KH,Rothermundt M,Arolt V,Pedersen A

更新日期：2008-12-01 00:00:00

abstract：:Motion-induced blindness (MIB) occurs when target stimuli are presented together with a moving distractor pattern. Most observers experience the targets disappearing and reappearing repeatedly for periods of up to several seconds. MIB can be viewed as a striking marker for the organization of cognitive functioning. In...

journal_title：Schizophrenia research

authors： Tschacher W,Schuler D,Junghan U

更新日期：2006-01-31 00:00:00

abstract：BACKGROUND:We examined cognitive deficits before and after onset of schizophrenia in a longitudinal study that: 1) covers a long time interval; 2) minimizes test unreliability by including the identical measure at both childhood and post-onset cognitive assessments; and 3) minimizes bias by utilizing a population-based...

journal_title：Schizophrenia research

authors： Kremen WS,Vinogradov S,Poole JH,Schaefer CA,Deicken RF,Factor-Litvak P,Brown AS

更新日期：2010-05-01 00:00:00

abstract：:Numerous studies have described attenuated event-related potential (ERP) component amplitudes in schizophrenia (e.g., P300, Mismatch Negativity (MMN), Error Negativity/Error-Related Negativity (Ne/ERN)). Functional magnetic resonance imaging (fMRI) studies have typically shown decreased recruitment of diverse brain ar...

journal_title：Schizophrenia research

authors： Bates AT,Kiehl KA,Laurens KR,Liddle PF

更新日期：2009-12-01 00:00:00

abstract：:Long-stay patients constitute a small proportion of all patients with schizophrenia, but in both VA and state psychiatric systems these patients account for a majority of the costs associated with treatment of the illness. VA and state patients would be expected to differ in several respects, including age at onset an...

journal_title：Schizophrenia research

authors： Harvey PD,Jacobsen H,Mancini D,Parrella M,White L,Haroutunian V,Davis KL

更新日期：2000-05-25 00:00:00

abstract：:Schizophrenia (SZ) is a mental illness characterized by psychosis, negative symptoms, and cognitive deficits. The anterior cingulate cortex (ACC), a structurally and functionally diverse region, is one of several brain regions that is abnormal in SZ. The present study compared synaptic organization and mitochondrial n...

journal_title：Schizophrenia research

authors： Roberts RC,Barksdale KA,Roche JK,Lahti AC

更新日期：2015-10-01 00:00:00

abstract：:Frontal lobe dysfunction in individuals with schizophrenia has frequently been detected using both neuroimaging and neuropsychological testing. Results from previous studies vary in the findings of regional specificity vs. generalized frontal cortical dysfunction. We sought to examine potential regional differences in...

journal_title：Schizophrenia research

authors： Ritter LM,Meador-Woodruff JH,Dalack GW

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Childhood and adolescence represent the periods during which hallucinatory experiences occur at the greatest prevalence, and also constitute a critical window of vulnerability for the pathogenesis of psychotic disorders. The longitudinal course of hallucinatory experiences during late childhood and adolescen...

journal_title：Schizophrenia research

authors： Rubio JM,Sanjuán J,Flórez-Salamanca L,Cuesta MJ

更新日期：2012-07-01 00:00:00