Abstract:
BACKGROUND:We examined cognitive deficits before and after onset of schizophrenia in a longitudinal study that: 1) covers a long time interval; 2) minimizes test unreliability by including the identical measure at both childhood and post-onset cognitive assessments; and 3) minimizes bias by utilizing a population-based sample in which participants were selected neither for signs of illness in childhood nor for being at risk for schizophrenia. METHODS:Participants in the present study, Developmental Insult and Brain Anomaly in Schizophrenia (DIBS), were ascertained from an earlier epidemiologic study conducted in Oakland, CA. The original version of the Peabody Picture Vocabulary Test (PPVT), a test of receptive vocabulary, was administered at age 5 or 9 and repeated as part of the DIBS study at an average age of 40. There were 10 DIBS cases with DSM-IV schizophrenia or schizoaffective disorder and 15 demographically similar DIBS controls with both child and adult PPVT scores. RESULTS:Cases scored significantly lower than controls in childhood (d=0.95) and adulthood (d=1.67). Residualized scores indicating the number of SDs above or below one's predicted adult score revealed a mean case-control difference of -1.51SDs, consistent with significant relative decline over time among the cases (p<0.0013). CONCLUSIONS:In this prospective study, individuals who developed adult schizophrenia manifested impaired receptive vocabulary during childhood and further relative deterioration (or lack of expected improvement) between childhood and midlife. Limitations should also be acknowledged, including the small sample size and the fact that we cannot be certain when the continued deterioration took place.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Kremen WS,Vinogradov S,Poole JH,Schaefer CA,Deicken RF,Factor-Litvak P,Brown ASdoi
10.1016/j.schres.2010.01.009subject
Has Abstractpub_date
2010-05-01 00:00:00pages
1-5issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(10)00047-2journal_volume
118pub_type
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journal_title:Schizophrenia research
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doi:10.1016/j.schres.2005.03.020
更新日期:2005-09-15 00:00:00
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doi:10.1016/s0920-9964(01)00405-4
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doi:10.1016/0920-9964(94)90014-0
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究
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更新日期:2017-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
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更新日期:2004-10-01 00:00:00
abstract::Two reaction time (RT) paradigms were used to study clozapine's effects on sustained and selective attention compared to fluphenazine and placebo in 25 chronic schizophrenic patients. Sensory dominance was studied via simple and choice RTs to lights and tones, and on double-stimulus trials in which the two stimuli wer...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-09-01 00:00:00
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更新日期:1999-08-17 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2007.08.010
更新日期:2007-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2009.08.014
更新日期:2009-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2016.10.030
更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.01.020
更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2009.06.011
更新日期:2009-09-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2017-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2007.09.026
更新日期:2008-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.04.027
更新日期:2014-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.06.001
更新日期:2018-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.10.028
更新日期:2010-05-01 00:00:00
abstract::Low birth weight and preterm birth are important predictors of infant mortality and morbidity, and may increase the risk of schizophrenia. These adverse outcomes of pregnancy could be associated, therefore, with increased risk in children genetically predisposed to schizophrenia. The aim of this review was to describe...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/s0920-9964(98)00065-6
更新日期:1998-09-07 00:00:00
abstract::Speech deficits, notably those involved in psychomotor retardation, blunted affect, alogia and poverty of content of speech, are pronounced in a wide range of serious mental illnesses (e.g., schizophrenia, unipolar depression, bipolar disorders). The present project evaluated the degree to which these deficits manifes...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.10.032
更新日期:2014-12-01 00:00:00
abstract::Increased sulcal widening in the prefrontal cortex of patients with schizophrenia may be associated with a poor treatment response to clozapine. To further evaluate this, we examined data from patients treated with clozapine in our center. Patients with the greatest degree of improvement (n=26) and those with no impro...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(00)00130-4
更新日期:2001-03-30 00:00:00
abstract:BACKGROUND:The normal vasodilatory response to ingestion of nicotinic acid (NA) is impaired in some patients with schizophrenia. It is unclear whether the impairment is a feature of the disorder itself or to a confounding factor such as neuroleptics, caffeine or nicotine use. METHODS:To address this question in a cont...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(00)00082-7
更新日期:2001-07-01 00:00:00