The role of experiential and expressive negative symptoms on job obtainment and work outcome in individuals with schizophrenia.

Abstract:

:Unemployment rates for schizophrenia are high across all age groups compared to the general population. Past studies have focused on neurocognition as a key determinant of unemployment and poor work outcome in schizophrenia. However, several recent studies suggest that clinical symptoms may be equally or more important than cognitive dysfunction for understanding employment difficulties. An enhanced understanding of the domains of negative symptoms that hinder job obtainment and work outcomes in people with schizophrenia is vital for developing treatments that translate into better employment outcomes. The purpose of this study was to determine whether 112 participants with schizophrenia or schizoaffective disorder receiving supported employment services differed on experiential and expressive negative symptoms based on whether they obtained a job or remained unemployed. Further, in a subset of workers, this study examined the relationship of experiential "motivational" negative symptoms with work outcomes (weeks worked, hours worked, wages earned). Neurocognition was assessed using the MATRICS Consensus Cognitive Battery and clinical symptoms were assessed using the Scale for the Assessment of Negative Symptoms and the Brief Psychiatric Rating Scale. Experiential, but not expressive, negative symptoms were related to job obtainment, hours worked, and wages earned. However, these findings were attenuated and non-significant after controlling for age. These results suggest that experiential negative symptoms are potentially key to better understanding employment outcomes of individuals with schizophrenia receiving supported employment services, but further work is needed to untangle its significance vis-à-vis other individual, environmental, and program factors.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Llerena K,Reddy LF,Kern RS

doi

10.1016/j.schres.2017.06.001

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

148-153

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(17)30329-8

journal_volume

192

pub_type

杂志文章
  • A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population.

    abstract::The glutamatergic dysfunction hypothesis of schizophrenia implicates the genes involved in glutamatergic transmission as strong candidates for schizophrenia-susceptibility. Recent linkage and association studies have identified the glutamate receptor, ionotropic, delta 1 gene GRID1 on 10q22 as a strong candidate for s...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2007.03.007

    authors: Guo SZ,Huang K,Shi YY,Tang W,Zhou J,Feng GY,Zhu SM,Liu HJ,Chen Y,Sun XD,He L

    更新日期:2007-07-01 00:00:00

  • Comparison of metabolic effects of aripiprazole, quetiapine and ziprasidone after 12 weeks of treatment in first treated episode of psychosis.

    abstract::This randomized open-label study compared the incidence of metabolic side effects of aripiprazole, ziprasidone and quetiapine in a population of medication-naïve first-episode psychosis patients. A total of 202 subjects were enrolled. Body weight, body mass index, leptin, fasting lipids and fasting glycaemic parameter...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.schres.2014.07.045

    authors: Pérez-Iglesias R,Ortiz-Garcia de la Foz V,Martínez García O,Amado JA,Garcia-Unzueta MT,Ayesa-Arriola R,Suarez-Pinilla P,Tabares-Seisdedos R,Crespo-Facorro B

    更新日期:2014-10-01 00:00:00

  • Deficits in GABAA receptor function and working memory in non-smokers with schizophrenia.

    abstract:BACKGROUND:Although altered gamma-aminobutyric acid (GABA) neurotransmission has been implicated in the pathophysiology of schizophrenia, it is unclear whether the influence of GABA on working memory processes is confounded by nicotine use in this population. It is therefore crucial to evaluate working memory and its u...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2016.01.008

    authors: Bridgman AC,Barr MS,Goodman MS,Chen R,Rajji TK,Daskalakis ZJ,George TP

    更新日期:2016-03-01 00:00:00

  • Language-related gamma EEG frontal reduction is associated with positive symptoms in schizophrenia patients.

    abstract:OBJECTIVES:Frontal hypoactivation has been consistently found in schizophrenia. We hypothesized that patients' deficit is asymmetrical, i.e., centred over the left frontal locations, associated with loss of language-related asymmetry, and correlated with positive symptoms. METHOD:The amplitude of EEG gamma band (36-48...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2015.04.003

    authors: Spironelli C,Angrilli A

    更新日期:2015-06-01 00:00:00

  • Omega-3 fatty acid supplementation may prevent loss of gray matter thickness in the left parieto-occipital cortex in first episode schizophrenia: A secondary outcome analysis of the OFFER randomized controlled study.

    abstract::The aim of the study was to assess changes in cortical thickness related to the use of n-3 polyunsaturated fatty acids (PUFA) as add-on therapy in patients with first episode schizophrenia. A double-blind randomized controlled study was conducted using a 26-week intervention composed of concentrated fish oil containin...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.schres.2017.10.013

    authors: Pawełczyk T,Piątkowska-Janko E,Bogorodzki P,Gębski P,Grancow-Grabka M,Trafalska E,Żurner N,Pawełczyk A

    更新日期:2018-05-01 00:00:00

  • Effects of clozapine, fluphenazine, and placebo on reaction time measures of attention and sensory dominance in schizophrenia.

    abstract::Two reaction time (RT) paradigms were used to study clozapine's effects on sustained and selective attention compared to fluphenazine and placebo in 25 chronic schizophrenic patients. Sensory dominance was studied via simple and choice RTs to lights and tones, and on double-stimulus trials in which the two stimuli wer...

    journal_title:Schizophrenia research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0920-9964(94)90094-9

    authors: Zahn TP,Pickar D,Haier RJ

    更新日期:1994-09-01 00:00:00

  • A role for endothelial NMDA receptors in the pathophysiology of schizophrenia.

    abstract::Numerous genetic and postmortem studies link N-methyl-d-aspartate receptor (NMDAR) dysfunction with schizophrenia, forming the basis of the popular glutamate hypothesis. Neuronal NMDAR abnormalities are consistently reported from both basic and clinical experiments, however, non-neuronal cells also contain NMDARs, and...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2020.10.004

    authors: Intson K,Geissah S,McCullumsmith RE,Ramsey AJ

    更新日期:2020-11-11 00:00:00

  • A longitudinal study of hippocampal volume in first episode psychosis and chronic schizophrenia.

    abstract::Brain abnormalities have been identified in patients with schizophrenia, but what is unclear is whether these changes are progressive over the course of the disorder. In this longitudinal study, hippocampal and temporal lobe volumes were measured at two time points in 30 patients with first episode psychosis (mean fol...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(01)00175-x

    authors: Wood SJ,Velakoulis D,Smith DJ,Bond D,Stuart GW,McGorry PD,Brewer WJ,Bridle N,Eritaia J,Desmond P,Singh B,Copolov D,Pantelis C

    更新日期:2001-10-01 00:00:00

  • Pathways to care in subjects at high risk for psychotic disorders - a European perspective.

    abstract::Evidence-based decisions on indicated prevention in early psychosis require large-scale studies on the pathways to care in high-risk subjects. EPOS (The European Prediction of Psychosis Study), a prospective multi-center, naturalistic field study in four European countries (Finland, Germany, The Netherlands and Englan...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.schres.2013.11.031

    authors: von Reventlow HG,Krüger-Özgürdal S,Ruhrmann S,Schultze-Lutter F,Heinz A,Patterson P,Heinimaa M,Dingemans P,French P,Birchwood M,Salokangas RK,Linszen D,Morrison A,Klosterkötter J,Juckel G

    更新日期:2014-02-01 00:00:00

  • Interrater reliability of schizoaffective disorder compared with schizophrenia, bipolar disorder, and unipolar depression - A systematic review and meta-analysis.

    abstract::Schizoaffective disorder is a common diagnosis in clinical practice but its nosological status has been subject to debate ever since it was conceptualized. Although it is key that diagnostic reliability is sufficient, schizoaffective disorder has been reported to have low interrater reliability. Evidence based on syst...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.schres.2016.07.012

    authors: Santelmann H,Franklin J,Bußhoff J,Baethge C

    更新日期:2016-10-01 00:00:00

  • Bone mineral density as a marker of cumulative endogenous estrogen exposure: relationship to background genetic risk of psychotic disorder.

    abstract:BACKGROUND:Alterations in bone mineral density (BMD) in patients with psychotic disorder may reflect the effect of treatment (disease effect observed in patients but not their siblings) or, as an intermediate marker of cumulative endogenous estrogen exposure, alterations in the neuroprotective effect of estrogen in the...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2012.10.031

    authors: van der Leeuw C,Habets P,Domen P,van Kroonenburgh M,van Os J,Marcelis M,for G.R.O.U.P.

    更新日期:2013-01-01 00:00:00

  • Wisconsin Card Sorting Test performance in schizophrenia: the role of working memory.

    abstract::Schizophrenia typically results in reduced performance on the Wisconsin Card Sorting Test (WCST). In the current study, we used a variety of approaches to examine the role of working memory (WM) in this deficit. One approach was to examine patterns of perseverative and non-perseverative errors. A second approach invol...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(02)00353-5

    authors: Hartman M,Steketee MC,Silva S,Lanning K,Andersson C

    更新日期:2003-10-01 00:00:00

  • Olanzapine antipsychotic treatment of adolescent rats causes long term changes in glutamate and GABA levels in the nucleus accumbens.

    abstract::Atypical antipsychotic drugs (AAPDs) are widely used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent rats with...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2014.10.034

    authors: Xu S,Gullapalli RP,Frost DO

    更新日期:2015-02-01 00:00:00

  • Trait or state? A longitudinal neuropsychological evaluation and fMRI study in schizoaffective disorder.

    abstract::Schizoaffective patients can have neurocognitive deficits and default mode network dysfunction while being acutely ill. It remains unclear to what extent these abnormalities persist when they go into clinical remission. Memory and executive function were tested in 22 acutely ill schizoaffective patients; they also und...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2014.08.017

    authors: Madre M,Radua J,Landin-Romero R,Alonso-Lana S,Salvador R,Panicali F,Pomarol-Clotet E,Amann BL

    更新日期:2014-11-01 00:00:00

  • Perception of facial emotions in chronic schizophrenia does not correlate with negative symptoms but correlates with cognitive and motor dysfunction.

    abstract:BACKGROUND:Appropriate expression of emotions and correct perception of emotional expression in others are important social skills which may be impaired in schizophrenia and contribute to poor social adjustment. We examined the relationship between expression of emotions as measured by affective flattening and other ne...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(00)00093-1

    authors: Silver H,Shlomo N

    更新日期:2001-12-01 00:00:00

  • Antipsychotic medication and remission of psychotic symptoms 10years after a first-episode psychosis.

    abstract:BACKGROUND:Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2016.10.030

    authors: Wils RS,Gotfredsen DR,Hjorthøj C,Austin SF,Albert N,Secher RG,Thorup AA,Mors O,Nordentoft M

    更新日期:2017-04-01 00:00:00

  • Increased resting-state global functional connectivity density of default mode network in schizophrenia subjects treated with electroconvulsive therapy.

    abstract::Modified electroconvulsive therapy (MECT) has been widely applied to help treat schizophrenia patients who are treatment-resistant to pharmaceutical therapy. Although the technique is increasingly prevalent, the underlying neural mechanisms have not been well clarified. We conducted a longitudinal study to investigate...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2017.10.044

    authors: Huang H,Jiang Y,Xia M,Tang Y,Zhang T,Cui H,Wang J,Li Y,Xu L,Curtin A,Sheng J,Jia Y,Yao D,Li C,Luo C,Wang J

    更新日期:2018-07-01 00:00:00

  • Schizophrenia and tobacco smoking: a replication study in another US psychiatric hospital.

    abstract::A prior study in a US state hospital suggested that schizophrenia is more closely associated with tobacco smoking when compared with other severe mental illnesses. This second study, in a neighborhood hospital, tries to (1) replicate that schizophrenia is associated with smoking and heavy smoking, and (2) rule out tha...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(01)00192-x

    authors: de Leon J,Tracy J,McCann E,McGrory A,Diaz FJ

    更新日期:2002-07-01 00:00:00

  • Lymphoblast and brain expression of AHI1 and the novel primate-specific gene, C6orf217, in schizophrenia and bipolar disorder.

    abstract::Association with schizophrenia of the Abelson Helper Integration Site 1 (AHI1) gene on chromosome 6q23 and the adjacent primate-specific gene, C6orf217, was demonstrated in an inbred, Arab Israeli family sample and replicated in an Icelandic case control sample. Further support was provided by a second replication in ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2010.03.041

    authors: Slonimsky A,Levy I,Kohn Y,Rigbi A,Ben-Asher E,Lancet D,Agam G,Lerer B

    更新日期:2010-07-01 00:00:00

  • Increasing mortality in schizophrenia: are women at particular risk? A follow-up of 1111 patients admitted during 1980-2006 in Northern Norway.

    abstract::A study of mortality for all patients with schizophrenia admitted to the University Hospital of North Norway during 1980-2006 was performed, with a special focus on gender differences and changes in mortality during a period of transition from hospital-based to community-based care. A total of 1111 patients with schiz...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2011.07.021

    authors: Høye A,Jacobsen BK,Hansen V

    更新日期:2011-11-01 00:00:00

  • Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia.

    abstract::Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2016.04.050

    authors: Pinacho R,Villalmanzo N,Meana JJ,Ferrer I,Berengueras A,Haro JM,Villén J,Ramos B

    更新日期:2016-11-01 00:00:00

  • Exposure to conflict and disaster: A national survey on the prevalence of psychotic experiences in Sri Lanka.

    abstract::Recent research conducted in high-income countries suggests psychotic experiences are common in the general population, but evidence from low- and middle-income countries (LMIC) remains limited. Sri Lanka is a LMIC affected by three decades of civil conflict and, in 2004, a devastating tsunami. This study aimed to inv...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2016.01.026

    authors: Keraite A,Sumathipala A,Siriwardhana C,Morgan C,Reininghaus U

    更新日期:2016-03-01 00:00:00

  • A meta-analysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects.

    abstract::Prospective, double-blind, randomized trials comparing atypical antipsychotic drugs (APDs) to typical APDs, such as haloperidol, indicate that atypical APDs provide a modest benefit to cognitive function in schizophrenia. However, the validity of this inference has been contested by suggestions that the cognitive impr...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.schres.2006.08.021

    authors: Woodward ND,Purdon SE,Meltzer HY,Zald DH

    更新日期:2007-01-01 00:00:00

  • Examining relationships between psychotic experiences and suicidal ideation in adolescents using a network approach.

    abstract:BACKGROUND:Suicide is one of the leading causes of death in young individuals. Timely and adequate identification of individuals with suicidal ideation could prevent from suicidal behavior. Psychotic experiences (PE) have been shown to increase levels of suicidal ideation (SI) in the general population. Therefore, deta...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2018.05.020

    authors: Núñez D,Fresno A,van Borkulo CD,Courtet P,Arias V,Garrido V,Wigman JTW

    更新日期:2018-11-01 00:00:00

  • Attitudes towards neuroleptic treatment: reliability and validity of the attitudes towards neuroleptic treatment (ANT) questionnaire.

    abstract::Non-compliance problems may rise to 50% among patients undergoing neuroleptic treatment. There are no direct measures available to predict compliance, if previous non-compliance is not taken into account. Attitudes towards neuroleptic treatment and insight into psychotic symptoms may vary during the course of the trea...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(99)00204-2

    authors: Kampman O,Lehtinen K,Lassila V,Leinonen E,Poutanen O,Koivisto A

    更新日期:2000-10-27 00:00:00

  • Potential stigma associated with inclusion of the psychosis risk syndrome in the DSM-V: an empirical question.

    abstract::While the "clinical high-risk state" for psychosis has demonstrated good reliability and fair predictive validity for psychotic disorders, over 50% of identified subjects do not progress to psychosis. Despite the benefits that early detection and treatment might offer, debate concerning the official inclusion of a "ps...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2010.03.012

    authors: Yang LH,Wonpat-Borja AJ,Opler MG,Corcoran CM

    更新日期:2010-07-01 00:00:00

  • Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia.

    abstract:BACKGROUND:Tumor necrosis factor alpha (TNFalpha), a cytokine involved in inflammatory processes, has been implicated in the pathophysiology of schizophrenia. The chromosomal location in the major histocompatibility complex (MHC) region on 6p21.1-21.3, a region with evidence for linkage, suggests a role in susceptibili...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(02)00534-0

    authors: Schwab SG,Mondabon S,Knapp M,Albus M,Hallmayer J,Borrmann-Hassenbach M,Trixler M,Gross M,Schulze TG,Rietschel M,Lerer B,Maier W,Wildenauer DB

    更新日期:2003-12-01 00:00:00

  • White matter changes in early phase schizophrenia and cannabis use: an update and systematic review of diffusion tensor imaging studies.

    abstract:OBJECTIVES:The impact of cannabis use on the brain tissue is still unclear, both in the healthy developing brain and in people with schizophrenia. The focus of this review is on white matter, the primary connective infrastructure of the brain. METHODS:We systematically reviewed diffusion tensor imaging (DTI) studies o...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审

    doi:10.1016/j.schres.2014.04.026

    authors: Cookey J,Bernier D,Tibbo PG

    更新日期:2014-07-01 00:00:00

  • The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and meta-analysis.

    abstract:BACKGROUND:Clozapine is the drug of choice for patients with unsatisfactory response to routine antipsychotic treatment. Polypharmacy is widely used among patients having clozapine-resistant schizophrenia, although no solid evidence exists for any effective augmentation therapy for this patient population. We aimed to ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.schres.2009.01.002

    authors: Tiihonen J,Wahlbeck K,Kiviniemi V

    更新日期:2009-04-01 00:00:00

  • Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera.

    abstract:OBJECTIVE:Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia. METHOD:Based on sera taken during the third trimester, we compared the level of 25 hydroxyvitamin D3 in mothers of individuals with schizophrenia or schizoaffective disorders versus mothers of unaffected c...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(02)00435-8

    authors: McGrath J,Eyles D,Mowry B,Yolken R,Buka S

    更新日期:2003-09-01 00:00:00