Abstract:
:Unemployment rates for schizophrenia are high across all age groups compared to the general population. Past studies have focused on neurocognition as a key determinant of unemployment and poor work outcome in schizophrenia. However, several recent studies suggest that clinical symptoms may be equally or more important than cognitive dysfunction for understanding employment difficulties. An enhanced understanding of the domains of negative symptoms that hinder job obtainment and work outcomes in people with schizophrenia is vital for developing treatments that translate into better employment outcomes. The purpose of this study was to determine whether 112 participants with schizophrenia or schizoaffective disorder receiving supported employment services differed on experiential and expressive negative symptoms based on whether they obtained a job or remained unemployed. Further, in a subset of workers, this study examined the relationship of experiential "motivational" negative symptoms with work outcomes (weeks worked, hours worked, wages earned). Neurocognition was assessed using the MATRICS Consensus Cognitive Battery and clinical symptoms were assessed using the Scale for the Assessment of Negative Symptoms and the Brief Psychiatric Rating Scale. Experiential, but not expressive, negative symptoms were related to job obtainment, hours worked, and wages earned. However, these findings were attenuated and non-significant after controlling for age. These results suggest that experiential negative symptoms are potentially key to better understanding employment outcomes of individuals with schizophrenia receiving supported employment services, but further work is needed to untangle its significance vis-à-vis other individual, environmental, and program factors.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Llerena K,Reddy LF,Kern RSdoi
10.1016/j.schres.2017.06.001subject
Has Abstractpub_date
2018-02-01 00:00:00pages
148-153eissn
0920-9964issn
1573-2509pii
S0920-9964(17)30329-8journal_volume
192pub_type
杂志文章abstract::The glutamatergic dysfunction hypothesis of schizophrenia implicates the genes involved in glutamatergic transmission as strong candidates for schizophrenia-susceptibility. Recent linkage and association studies have identified the glutamate receptor, ionotropic, delta 1 gene GRID1 on 10q22 as a strong candidate for s...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.03.007
更新日期:2007-07-01 00:00:00
abstract::This randomized open-label study compared the incidence of metabolic side effects of aripiprazole, ziprasidone and quetiapine in a population of medication-naïve first-episode psychosis patients. A total of 202 subjects were enrolled. Body weight, body mass index, leptin, fasting lipids and fasting glycaemic parameter...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2014.07.045
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Although altered gamma-aminobutyric acid (GABA) neurotransmission has been implicated in the pathophysiology of schizophrenia, it is unclear whether the influence of GABA on working memory processes is confounded by nicotine use in this population. It is therefore crucial to evaluate working memory and its u...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.01.008
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:Frontal hypoactivation has been consistently found in schizophrenia. We hypothesized that patients' deficit is asymmetrical, i.e., centred over the left frontal locations, associated with loss of language-related asymmetry, and correlated with positive symptoms. METHOD:The amplitude of EEG gamma band (36-48...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.04.003
更新日期:2015-06-01 00:00:00
abstract::The aim of the study was to assess changes in cortical thickness related to the use of n-3 polyunsaturated fatty acids (PUFA) as add-on therapy in patients with first episode schizophrenia. A double-blind randomized controlled study was conducted using a 26-week intervention composed of concentrated fish oil containin...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2017.10.013
更新日期:2018-05-01 00:00:00
abstract::Two reaction time (RT) paradigms were used to study clozapine's effects on sustained and selective attention compared to fluphenazine and placebo in 25 chronic schizophrenic patients. Sensory dominance was studied via simple and choice RTs to lights and tones, and on double-stimulus trials in which the two stimuli wer...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0920-9964(94)90094-9
更新日期:1994-09-01 00:00:00
abstract::Numerous genetic and postmortem studies link N-methyl-d-aspartate receptor (NMDAR) dysfunction with schizophrenia, forming the basis of the popular glutamate hypothesis. Neuronal NMDAR abnormalities are consistently reported from both basic and clinical experiments, however, non-neuronal cells also contain NMDARs, and...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.10.004
更新日期:2020-11-11 00:00:00
abstract::Brain abnormalities have been identified in patients with schizophrenia, but what is unclear is whether these changes are progressive over the course of the disorder. In this longitudinal study, hippocampal and temporal lobe volumes were measured at two time points in 30 patients with first episode psychosis (mean fol...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(01)00175-x
更新日期:2001-10-01 00:00:00
abstract::Evidence-based decisions on indicated prevention in early psychosis require large-scale studies on the pathways to care in high-risk subjects. EPOS (The European Prediction of Psychosis Study), a prospective multi-center, naturalistic field study in four European countries (Finland, Germany, The Netherlands and Englan...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2013.11.031
更新日期:2014-02-01 00:00:00
abstract::Schizoaffective disorder is a common diagnosis in clinical practice but its nosological status has been subject to debate ever since it was conceptualized. Although it is key that diagnostic reliability is sufficient, schizoaffective disorder has been reported to have low interrater reliability. Evidence based on syst...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2016.07.012
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Alterations in bone mineral density (BMD) in patients with psychotic disorder may reflect the effect of treatment (disease effect observed in patients but not their siblings) or, as an intermediate marker of cumulative endogenous estrogen exposure, alterations in the neuroprotective effect of estrogen in the...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.10.031
更新日期:2013-01-01 00:00:00
abstract::Schizophrenia typically results in reduced performance on the Wisconsin Card Sorting Test (WCST). In the current study, we used a variety of approaches to examine the role of working memory (WM) in this deficit. One approach was to examine patterns of perseverative and non-perseverative errors. A second approach invol...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00353-5
更新日期:2003-10-01 00:00:00
abstract::Atypical antipsychotic drugs (AAPDs) are widely used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent rats with...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.10.034
更新日期:2015-02-01 00:00:00
abstract::Schizoaffective patients can have neurocognitive deficits and default mode network dysfunction while being acutely ill. It remains unclear to what extent these abnormalities persist when they go into clinical remission. Memory and executive function were tested in 22 acutely ill schizoaffective patients; they also und...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.08.017
更新日期:2014-11-01 00:00:00
abstract:BACKGROUND:Appropriate expression of emotions and correct perception of emotional expression in others are important social skills which may be impaired in schizophrenia and contribute to poor social adjustment. We examined the relationship between expression of emotions as measured by affective flattening and other ne...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(00)00093-1
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.10.030
更新日期:2017-04-01 00:00:00
abstract::Modified electroconvulsive therapy (MECT) has been widely applied to help treat schizophrenia patients who are treatment-resistant to pharmaceutical therapy. Although the technique is increasingly prevalent, the underlying neural mechanisms have not been well clarified. We conducted a longitudinal study to investigate...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.10.044
更新日期:2018-07-01 00:00:00
abstract::A prior study in a US state hospital suggested that schizophrenia is more closely associated with tobacco smoking when compared with other severe mental illnesses. This second study, in a neighborhood hospital, tries to (1) replicate that schizophrenia is associated with smoking and heavy smoking, and (2) rule out tha...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(01)00192-x
更新日期:2002-07-01 00:00:00
abstract::Association with schizophrenia of the Abelson Helper Integration Site 1 (AHI1) gene on chromosome 6q23 and the adjacent primate-specific gene, C6orf217, was demonstrated in an inbred, Arab Israeli family sample and replicated in an Icelandic case control sample. Further support was provided by a second replication in ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.03.041
更新日期:2010-07-01 00:00:00
abstract::A study of mortality for all patients with schizophrenia admitted to the University Hospital of North Norway during 1980-2006 was performed, with a special focus on gender differences and changes in mortality during a period of transition from hospital-based to community-based care. A total of 1111 patients with schiz...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.07.021
更新日期:2011-11-01 00:00:00
abstract::Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.04.050
更新日期:2016-11-01 00:00:00
abstract::Recent research conducted in high-income countries suggests psychotic experiences are common in the general population, but evidence from low- and middle-income countries (LMIC) remains limited. Sri Lanka is a LMIC affected by three decades of civil conflict and, in 2004, a devastating tsunami. This study aimed to inv...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.01.026
更新日期:2016-03-01 00:00:00
abstract::Prospective, double-blind, randomized trials comparing atypical antipsychotic drugs (APDs) to typical APDs, such as haloperidol, indicate that atypical APDs provide a modest benefit to cognitive function in schizophrenia. However, the validity of this inference has been contested by suggestions that the cognitive impr...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2006.08.021
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Suicide is one of the leading causes of death in young individuals. Timely and adequate identification of individuals with suicidal ideation could prevent from suicidal behavior. Psychotic experiences (PE) have been shown to increase levels of suicidal ideation (SI) in the general population. Therefore, deta...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.05.020
更新日期:2018-11-01 00:00:00
abstract::Non-compliance problems may rise to 50% among patients undergoing neuroleptic treatment. There are no direct measures available to predict compliance, if previous non-compliance is not taken into account. Attitudes towards neuroleptic treatment and insight into psychotic symptoms may vary during the course of the trea...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00204-2
更新日期:2000-10-27 00:00:00
abstract::While the "clinical high-risk state" for psychosis has demonstrated good reliability and fair predictive validity for psychotic disorders, over 50% of identified subjects do not progress to psychosis. Despite the benefits that early detection and treatment might offer, debate concerning the official inclusion of a "ps...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.03.012
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor alpha (TNFalpha), a cytokine involved in inflammatory processes, has been implicated in the pathophysiology of schizophrenia. The chromosomal location in the major histocompatibility complex (MHC) region on 6p21.1-21.3, a region with evidence for linkage, suggests a role in susceptibili...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00534-0
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:The impact of cannabis use on the brain tissue is still unclear, both in the healthy developing brain and in people with schizophrenia. The focus of this review is on white matter, the primary connective infrastructure of the brain. METHODS:We systematically reviewed diffusion tensor imaging (DTI) studies o...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2014.04.026
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Clozapine is the drug of choice for patients with unsatisfactory response to routine antipsychotic treatment. Polypharmacy is widely used among patients having clozapine-resistant schizophrenia, although no solid evidence exists for any effective augmentation therapy for this patient population. We aimed to ...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2009.01.002
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia. METHOD:Based on sera taken during the third trimester, we compared the level of 25 hydroxyvitamin D3 in mothers of individuals with schizophrenia or schizoaffective disorders versus mothers of unaffected c...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00435-8
更新日期:2003-09-01 00:00:00