Abstract：
BACKGROUND:Several national guidelines recommend continuous use of antipsychotic medication after a psychotic episode in order to minimize the risk of relapse. However some studies have identified a subgroup of patients who obtain remission of psychotic symptoms while not being on antipsychotic medication for a period of time. This study investigated the long-term outcome and characteristics of patients in remission of psychotic symptoms with no use of antipsychotic medication at the 10-year follow-up. METHODS:The study was a cohort study including 496 patients diagnosed with schizophrenia spectrum disorders (ICD 10: F20 and F22-29). Patients were included in the Danish OPUS Trial and followed up 10years after inclusion, where patient data was collected on socio-demographic factors, psychopathology, level of functioning and medication. FINDINGS:61% of the patients from the original cohort attended the 10-year follow up and 30% of these had remission of psychotic symptoms at the time of the 10-year follow up with no current use of antipsychotic medication. This outcome was associated with female gender, high GAF-F score, participation in the labour market and absence of substance abuse. CONCLUSION:Our results describe a subgroup of patients who obtained remission while not being on antipsychotic medication at the 10-year follow-up. The finding calls for further investigation on a more individualized approach to long-term treatment with antipsychotic medication.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Wils RS,Gotfredsen DR,Hjorthøj C,Austin SF,Albert N,Secher RG,Thorup AA,Mors O,Nordentoft Mdoi
10.1016/j.schres.2016.10.030subject
Has Abstractpub_date
2017-04-01 00:00:00pages
42-48eissn
0920-9964issn
1573-2509pii
S0920-9964(16)30474-1journal_volume
182pub_type
杂志文章abstract：BACKGROUND:To develop a pharmacokinetic-pharmacodynamic (PK-PD) model using individual-level data of Positive and Negative Syndrome Scale (PANSS) total score to characterize the antipsychotic drug effect taking into account the placebo effect and dropout rate. In addition, a clinical utility (CU) criterion that describ...
journal_title：Schizophrenia research
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更新日期：2013-05-01 00:00:00
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pub_type： 杂志文章
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abstract：:Serum prolactin (PRL) was correlated with clinical symptomatology in 17 drug-free patients suffering from non-affective psychoses. A clear-cut negative correlation was found between the Comprehensive Psychiatric Rating Scale (CPRS) items assessing hallucinations and serum PRL levels (r=-6.14, P=0.009). No correlation ...
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journal_title：Schizophrenia research
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abstract：:Antipsychotic drugs (APDs) are the standard treatment for schizophrenia. The therapeutic effect of these drugs is dependent upon the dopaminergic D2 blockade, but they also modulate other neurotransmitter pathways. The exact mechanisms underlying the clinical response to APDs are not fully understood. In this study, w...
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pub_type： 杂志文章
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abstract：:Valid criteria to identify young people who are believed to be at ultra high risk (UHR) of developing a psychotic episode were developed over the last decade. The first randomized controlled trial of treatment in a UHR cohort indicated that specific pharmacotherapy and psychotherapy delayed onset of disorder, and poss...
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pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2007.05.018
更新日期：2007-11-01 00:00:00
abstract：:Recently, apolipoprotein D (apoD), a protein that is involved in the essential polyunsaturated fatty acid (EPUFA) transport and metabolism, and neuronal growth and regeneration was reported to have increased in the postmortem brain and decreased in the serum of schizophrenia patients. We studied the plasma apoD levels...
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pub_type： 杂志文章
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更新日期：2002-11-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00043-8
更新日期：2001-05-30 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2016.10.036
更新日期：2017-04-01 00:00:00
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pub_type： 历史文章,杂志文章
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更新日期：2014-11-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00078-x
更新日期：2000-02-14 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究
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更新日期：2003-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2004.02.007
更新日期：2004-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-05-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2009-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
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更新日期：2008-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2014.02.011
更新日期：2014-04-01 00:00:00
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更新日期：2014-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2006.12.032
更新日期：2007-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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pub_type： 杂志文章,meta分析
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更新日期：2014-10-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
abstract：:The aim of the study was to assess changes in cortical thickness related to the use of n-3 polyunsaturated fatty acids (PUFA) as add-on therapy in patients with first episode schizophrenia. A double-blind randomized controlled study was conducted using a 26-week intervention composed of concentrated fish oil containin...
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pub_type： 杂志文章,随机对照试验
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更新日期：2018-05-01 00:00:00
