Abstract：
:Recently, apolipoprotein D (apoD), a protein that is involved in the essential polyunsaturated fatty acid (EPUFA) transport and metabolism, and neuronal growth and regeneration was reported to have increased in the postmortem brain and decreased in the serum of schizophrenia patients. We studied the plasma apoD levels in never-medicated schizophrenic patients at the onset of psychosis and in chronic patients with clozapine treatment. Plasma apoD levels were elevated in never-medicated patients at the first-episode of psychosis compared to normals (P = 0.047). Interestingly, the increase in apoD level was even more significant in chronic patients treated with clozapine compared to normals and first-episode patients (P = 0.008 and P = 0.03, respectively). The increased apoD level in never-medicated first-episode patients indicate that this increase probably predates the illness, since the duration of illness was < 5 days. Similarly, an even larger increase in apoD after clozapine treatment may be associated with its prophylactic effects, since the psychopathological scores were significantly reduced and the clozapine treatment has been found to increase the EPUFA membrane levels. These altered levels of apoD may help to understand the nature and possible mechanism of phospholipid membrane pathology in schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Mahadik SP,Khan MM,Evans DR,Parikh VVdoi
10.1016/s0920-9964(01)00378-4subject
Has Abstractpub_date
2002-11-01 00:00:00pages
55-62issue
1eissn
0920-9964issn
1573-2509pii
S0920996401003784journal_volume
58pub_type
杂志文章abstract：:Dopamine's proposed role in psychosis proved a starting point in our understanding of the neurobiology of relapse, fitting given the central role positive symptoms play. This link is reflected in early work examining neurotransmitter metabolite and drug (e.g. amphetamine, methylphenidate) challenge studies as a means ...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2013.10.009
更新日期：2014-02-01 00:00:00
abstract：:Cognitive impairments have been shown to predict impairments in adaptive functioning in patients with chronic schizophrenia and to be more predictive of overall outcome than positive or negative symptoms of the illness. Both adaptive and cognitive impairments are multidimensional, and it is possible that correlations ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(97)00068-6
更新日期：1997-10-30 00:00:00
abstract：BACKGROUND:Auditory verbal hallucinations (AVH) do not have uniform pathological significance. They affect patients with different brain disorders, and vary along multiple phenomenological dimensions. Evidence indicates that some of the phenomenological variables have specific neural substrates. Therefore, a comprehens...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(03)00013-6
更新日期：2003-06-01 00:00:00
abstract：BACKGROUND:Older paternal age predicts schizophrenia diagnosis in offspring. If this relationship reflects a pathogenic process, paternal age should predict the expression of subclinical schizophrenia liability (schizotypy). We hypothesized that paternal and maternal ages predict positive, negative, and disorganized fe...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.09.018
更新日期：2015-12-01 00:00:00
abstract：OBJECTIVE:Several risk factors of venous thromboembolism (VTE) and pulmonary embolism (PE) were found in patients with schizophrenia. Therefore, we hypothesize that the incidences of VTE and PE are relatively higher among schizophrenia patients in comparison with the general population. METHOD:For this population-base...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.01.012
更新日期：2015-03-01 00:00:00
abstract：:Systematic linkage disequilibrium (LD) mapping of 8p12-21 in the Icelandic population identified neuregulin 1 (NRG1) as a prime candidate gene for schizophrenia. However, results of replication studies have been inconsistent, and no large sample analyses have been reported. Therefore, we designed this study with the a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.01.010
更新日期：2008-04-01 00:00:00
abstract：:Impaired working memory (WM) function in schizophrenia has been associated with abnormal activation of the dorsolateral prefrontal cortex (DLPFC). It is, however, not clear whether abnormal activation is a sign of DLPFC pathology, or a correlate of poor performance. We address this question by examining activity in th...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(03)00127-0
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Severity of negative symptoms has been associated with poor functioning, cognitive deficits, and defeatist beliefs in schizophrenia patients. However, one area that remains understudied is persistent negative symptoms (PNS). Negative symptoms, including PNS, have been observed in those at clinical high-risk ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.04.004
更新日期：2020-04-30 00:00:00
abstract：:The number of psychiatric beds has declined considerably in many countries over the past decades. Long-term studies on the impact of these health care changes for the severely mentally ill, however, are still scarce. This epidemiological study investigates the use of inpatient psychiatric services by people with schiz...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.07.006
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVES:In the present study, we used Activation Likelihood Estimation (ALE) meta-analysis to quantitatively examine brain grey matter reduction in schizophrenia patients with persistent negative symptoms (PNS). METHOD:A total of 12 voxel-based morphometry (VBM) studies were included in ALE meta-analysis using more...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2017.04.005
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Heterogeneity in clinical outcomes may be caused by factors working at multiple levels, e.g., between groups, between subjects, or within subjects over time. A more nuanced assessment of differences in variation among schizophrenia patients and between patients and healthy comparison subjects can clarify eti...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.10.033
更新日期：2013-01-01 00:00:00
abstract：:The intracellular enzyme phospholipase A2 (PLA2) plays an essential role in the breakdown of membrane phospholipids, which regulate the physicochemical properties of the cell membrane. In the brain PLA2 has been reported to influence receptor function and signal transduction. Regarding dopaminergic neurons, data from ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)00060-l
更新日期：1995-07-01 00:00:00
abstract：:Transient working memory requires attention and temporary storage of information, whereas executive function working memory requires additional mental manipulation of that information. Working memory impairment is common in schizophrenia patients, but only some studies have found differential impairment in executive f...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.04.013
更新日期：2006-10-01 00:00:00
abstract：:Spectral entropy (SE) is a measurement from information theory field that provides an estimation of EEG regularity and may be useful as a summary of its spectral properties. Previous studies using small samples reported a deficit of EEG entropy modulation in schizophrenia during cognitive activity. The present study i...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.08.057
更新日期：2018-05-01 00:00:00
abstract：:Patients with schizophrenia and bipolar disorder (BD) shared a significant overlap in genetic susceptibility, pharmacological treatment responses, neuropsychological deficits, and epidemiological features. However, it remains unknown whether these clinical overlaps are mediated by shared or disorder-specific abnormali...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2017.01.005
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:Formal thought disorder (FTD) is a core feature of psychosis, however there are gaps in our knowledge about its prevalence and factor structure. We had two aims: first, to establish the factor structure of FTD; second, to explore the clinical utility of dimensions of FTD in order to further the understanding...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.07.049
更新日期：2015-10-01 00:00:00
abstract：:It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.12.854
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:Neuregulin-1 (NRG1) has been put forward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype. METHODS:Participants were 64 patients with DSM-IV schizophrenia or schizoaffective disorder, 97 of their non psychotic re...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.03.025
更新日期：2008-08-01 00:00:00
abstract：AIM:To compare the prevalence and trends of antipsychotic drug use during pregnancy between countries across four continents. METHODS:Individually linked health data in Denmark (2000-2012), Finland (2005-2014), Iceland (2004-2017), Norway (2005-2015), Sweden (2006-2015), Germany (2006-2015), Australia (New South Wales...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.03.048
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Atypical antipsychotics clozapine, olanzapine, and quetiapine have significant affinity for the muscarinic receptors in vitro, while aripiprazole, risperidone, and ziprasidone do not. Dissimilarity in binding profiles may contribute to the reported differences in the anticholinergic effects of these antipsyc...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.07.011
更新日期：2006-12-01 00:00:00
abstract：BACKGROUND:D-serine is an allosteric modulator of the brain N-methyl-d-aspartate (NMDA) receptor and a potential novel treatment of schizophrenia. Double-blind studies have been performed at 30 mg/kg/day (approximately 2 g/day) with encouraging results, but no formal dose escalation studies have been performed. We desc...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.schres.2010.05.012
更新日期：2010-08-01 00:00:00
abstract：:Although factor scores are commonly used to interpret the Weschsler Adult Intelligence Scale--Revised (WAIS-R), the WAIS-R factor structure has not been investigated in patients with schizophrenia. We used confirmatory factor analysis (CFA) to examine five latent construct models in 169 males with schizophrenia. The W...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00090-5
更新日期：1998-11-09 00:00:00
abstract：:Increased rates of comorbid physical illness have been commonly reported in patients with schizophrenia. However, there are fewer data on dental disease in these patients. We systematically evaluated existing data on the oral health survey of schizophrenia patients through meta-analysis. Using the available databases,...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2018.04.031
更新日期：2018-11-01 00:00:00
abstract：:Individuals with schizophrenia have difficulties in emotional information processing. A relationship between behavioral variables of emotional processing and structural amygdala alterations in schizophrenia has been proposed but not shown, yet. Morphological studies of amygdala size in schizophrenia have yielded incon...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.02.023
更新日期：2004-12-01 00:00:00
abstract：:Astrocytic markers glial fibrillary acidic protein (GFAP) and connexin 43 (CX43) are known to have altered expression in brains of subjects with psychiatric disorders including autism and major depression. The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotrop...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.05.016
更新日期：2008-09-01 00:00:00
abstract：:53 inpatients with a DSM-III diagnosis of schizophrenia were assessed in the week prior to discharge from hospital on measures of social skills performance and on severity of positive and negative symptoms. A cluster analysis based on the total positive and negative symptom scores resulted in three groups. The group w...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(89)90007-8
更新日期：1989-05-01 00:00:00
abstract：BACKGROUND:Higher cognitive dysfunction, lower perceptual disturbance and its relation to the structures that implicate such processes have been considered as key features in patients with schizophrenia. However, little is known about the relationship between perceptual processing and structural deficits in ultra-high-...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.06.014
更新日期：2012-09-01 00:00:00
abstract：:An accumulating body of literature supports the notion that psychotic-like experiences (PLEs) may occur as a continuous phenotype. However, researchers are still working to determine if these events accompany an underlying continuum of neurobiological vulnerability as well. Within this context, it is notable that spon...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.06.028
更新日期：2011-11-01 00:00:00
abstract：:The 24-h profiles of plasma melatonin and cortisol were evaluated in 7 drug-free male paranoid schizophrenics and in 7 healthy subjects matched to the patients for age, sex, body weight, height and season of testing. Blood samples were obtained at 20.00, 22.00, 24.00, 01.00, 02.00, 06.00, 08.00 and 12.00 h. Light was ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(92)90077-i
更新日期：1992-04-01 00:00:00
abstract：:Schizophrenia is associated with significant brain abnormalities, including changes in brain metabolites as measured by proton magnetic resonance spectroscopy (MRS). What remains unclear is the extent to which these changes are a consequence of the emergence of psychotic disorders or the result of treatment with antip...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.03.012
更新日期：2008-07-01 00:00:00
