当前位置： SCI文献检索 > SCHIZOPHRENIA RESEARCH期刊下所有文献 > The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and meta-analysis.

The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and meta-analysis.

Abstract：

BACKGROUND:Clozapine is the drug of choice for patients with unsatisfactory response to routine antipsychotic treatment. Polypharmacy is widely used among patients having clozapine-resistant schizophrenia, although no solid evidence exists for any effective augmentation therapy for this patient population. We aimed to study the efficacy of lamotrigine in the treatment of clozapine-resistant schizophrenia. METHOD:We conducted electronic searches of the Cochrane PsiTri database, the Website of metaRegister of Controlled Trials, including NIH ClinicalTrials.gov, and a clinical trial register by the manufacturer of lamotrigine (GlaxoSmithKline). All randomized placebo-controlled studies on patients receiving clozapine were included in the analysis. The primary outcome measure was a total score for symptoms of psychosis, and the secondary outcome measures were scores for positive and negative symptoms of psychosis. For continuous and binary data, standardized mean differences (SMD), and odds ratios (OR) and the number needed to treat (NNT) were calculated, respectively. RESULTS:Five trials with 10 to 24 weeks duration and total of 161 randomized clozapine patients were included in the meta-analysis. Lamotrigine was superior to placebo augmentation in both the primary outcome measure (SMD 0.57, 95%CI 0.25-0.89, p<0.001; OR 0.19, 95%CI 0.09-0.43, p<0.001; NNT 4, 95%CI 3-6) and secondary outcome measures (SMD 0.34, 95%CI 0.02-0.65 for positive symptoms, SMD 0.43, 95%CI 0.11-0.75 for negative symptoms). CONCLUSIONS:This meta-analysis suggests that lamotrigine augmentation may be an effective treatment for patients with clozapine-resistant schizophrenia. A substantial proportion of these most severely ill patients appeared to obtain clinically meaningful benefit from this combination treatment.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Tiihonen J,Wahlbeck K,Kiviniemi V

doi

10.1016/j.schres.2009.01.002

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

10-4

issue

1-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(09)00003-6

journal_volume

109

pub_type

杂志文章,meta分析,评审

相关文献

SCHIZOPHRENIA RESEARCH文献大全
  • The theory of an agnosic right shift gene in schizophrenia and autism.

    abstract：:The right shift (RS) theory (Annett, M., 1972. The distribution of manual asymmetry. Br. J. Psychol. 63, 343-358; Annett, M., 1985. Left, Right, Hand and Brain: The Right Shift Theory. Lawrence Erlbaum, London) suggests that the typical pattern of human cerebral and manual asymmetries depends on a single gene (RS+) wh...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(99)00072-9

    authors： Annett M

    更新日期：1999-10-19 00:00:00

  • Association of maternal exposure to terror attacks during pregnancy and the risk of schizophrenia in the offspring: A population-based study.

    abstract：:This study tested the hypothesis that maternal exposure to terror attacks during pregnancy is associated with the risk of schizophrenia in the offspring. A population-based study was conducted of Israeli children born between 1975 and 1995 and that were registered in the Ministry of Interior and followed up in the Min...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2018.04.024

    authors： Weinstein Y,Levav I,Gelkopf M,Roe D,Yoffe R,Pugachova I,Levine SZ

    更新日期：2018-09-01 00:00:00

  • Empathy, schizophrenia and violence: a systematic review.

    abstract：BACKGROUND:A small but significant association between schizophrenia and violence is open to a number of explanations. Impaired empathy has been associated with schizophrenia, and with violence in the general population. Our aim was to conduct a systematic review of any research into relationships between schizophrenia...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.schres.2012.07.019

    authors： Bragado-Jimenez MD,Taylor PJ

    更新日期：2012-10-01 00:00:00

  • Impaired emotional learning and reduced amygdala size in schizophrenia: a 3-month follow-up.

    abstract：:Individuals with schizophrenia have difficulties in emotional information processing. A relationship between behavioral variables of emotional processing and structural amygdala alterations in schizophrenia has been proposed but not shown, yet. Morphological studies of amygdala size in schizophrenia have yielded incon...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2004.02.023

    authors： Exner C,Boucsein K,Degner D,Irle E,Weniger G

    更新日期：2004-12-01 00:00:00

  • A two-method meta-analysis of Neuregulin 1(NRG1) association and heterogeneity in schizophrenia.

    abstract：:NRG1 is one of the most researched genes associated with schizophrenia. Although three meta-analyses in this area have been published, the results have been inconclusive and even conflicting. Family based studies can be problematical due to the difficulty of synthesizing them with case-control studies. Heterogeneity i...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2009.03.017

    authors： Gong YG,Wu CN,Xing QH,Zhao XZ,Zhu J,He L

    更新日期：2009-06-01 00:00:00

  • In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study.

    abstract：BACKGROUND:Gamma-aminobutyric acid (GABA) dysfunction and its consequent imbalance are implicated in the pathophysiology of schizophrenia. Reduced GABA production would lead to a disinhibition of glutamatergic neurons and subsequently cause a disruption of the modulation between GABAergic interneurons and glutamatergic...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2017.07.021

    authors： Chiu PW,Lui SSY,Hung KSY,Chan RCK,Chan Q,Sham PC,Cheung EFC,Mak HKF

    更新日期：2018-03-01 00:00:00

  • Stress and arousability in schizophrenia.

    abstract：:This paper examines trait arousability (TA), a temperament characteristic, in 47 stable outpatients with schizophrenia and 50 non-psychiatric controls. Self-reported levels of stress were obtained during a negative and positive memory speech task. Levels of TA, and the association of TA scores with reported stress dur...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2004.01.008

    authors： Dinzeo TJ,Cohen AS,Nienow TM,Docherty NM

    更新日期：2004-11-01 00:00:00

  • Working memory capacity in schizophrenia: a parametric fMRI study.

    abstract：:Impaired working memory (WM) function in schizophrenia has been associated with abnormal activation of the dorsolateral prefrontal cortex (DLPFC). It is, however, not clear whether abnormal activation is a sign of DLPFC pathology, or a correlate of poor performance. We address this question by examining activity in th...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/S0920-9964(03)00127-0

    authors： Jansma JM,Ramsey NF,van der Wee NJ,Kahn RS

    更新日期：2004-06-01 00:00:00

  • Patterns of premorbid functioning in individuals at clinical high risk of psychosis.

    abstract：:In schizophrenia, four typical patterns of premorbid functioning have been observed: stable-good, stable-intermediate, poor-deteriorating and deteriorating. However, it is unknown whether similar patterns exist in those who are at clinical high risk (CHR) of psychosis. The aim of this study was to examine patterns of ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.11.004

    authors： Lyngberg K,Buchy L,Liu L,Perkins D,Woods S,Addington J

    更新日期：2015-12-01 00:00:00

  • Pronounced prefronto-temporal cortical thinning in schizophrenia: Neuroanatomical correlate of suicidal behavior?

    abstract：:Schizophrenia is characterized by increased mortality for which suicidality is the decisive factor. An analysis of cortical thickness and folding to further elucidate neuroanatomical correlates of suicidality in schizophrenia has not yet been performed. We searched for relevant brain regions with such differences betw...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.08.010

    authors： Besteher B,Wagner G,Koch K,Schachtzabel C,Reichenbach JR,Schlösser R,Sauer H,Schultz CC

    更新日期：2016-10-01 00:00:00

  • Psychometric properties of the recovery measurement in homeless people with severe mental illness.

    abstract：OBJECTIVE:The Recovery Assessment Scale (RAS) is one of the most widely used measurements of recovery in mental health research. To date, no data have been available concerning the psychometric characteristics of the RAS in homeless people with severe mental illness. The aim of this study was to provide new data regard...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.10.007

    authors： Girard V,Tinland A,Mohamed EH,French Housing First Study Group.,Boyer L,Auquier P

    更新日期：2015-12-01 00:00:00

  • Associations of suicidality with cognitive ability and cognitive insight in outpatients with Schizophrenia.

    abstract：BACKGROUND:Previous literature suggests that better cognitive ability and insight are associated with greater lifetime risk of suicide attempts in schizophrenia, counter to the direction of association in the general population. However, the conjoint association between distinct cognitive domains, insight, and suicidal...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2017.06.013

    authors： Villa J,Choi J,Kangas JL,Kaufmann CN,Harvey PD,Depp CA

    更新日期：2018-02-01 00:00:00

  • Mental health multimorbidity and poor quality of life in patients with schizophrenia.

    abstract：OBJECTIVE:While "dual diagnosis" involving both psychiatric and substance use disorders has long been a focus of schizophrenia research, recent studies have advocated for a shift of focus to multimorbidity, addressing comorbidity from both additional psychiatric disorders and substance use disorders. We hypothesized th...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.schres.2018.04.035

    authors： Bhalla IP,Stefanovics EA,Rosenheck RA

    更新日期：2018-11-01 00:00:00

  • The influence of adjunctive treatment and metacognitive deficits in schizophrenia on the experience of work.

    abstract：:Enhancing work function is now widely considered a core element of comprehensive schizophrenia treatment. While research efforts have illuminated factors that influence how well patients perform at work, less is known about the factors influencing the subjective experience of work. It is not known how, and to what ext...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2014.04.017

    authors： de Jong S,Renard SB,van Donkersgoed RJ,van der Gaag M,Wunderink L,Pijnenborg GH,Lysaker PH

    更新日期：2014-08-01 00:00:00

  • Reduced intra-amygdala activity to positively valenced faces in adolescent schizophrenia offspring.

    abstract：:Studies suggest that the affective response is impaired in both schizophrenia and adolescent offspring of schizophrenia patients. Adolescent offspring of patients are developmentally vulnerable to impairments in several domains, including affective responding, yet the bases of these impairments and their relation to n...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2010.07.023

    authors： Barbour T,Murphy E,Pruitt P,Eickhoff SB,Keshavan MS,Rajan U,Zajac-Benitez C,Diwadkar VA

    更新日期：2010-11-01 00:00:00

  • Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample.

    abstract：:Systematic linkage disequilibrium (LD) mapping of 8p12-21 in the Icelandic population identified neuregulin 1 (NRG1) as a prime candidate gene for schizophrenia. However, results of replication studies have been inconsistent, and no large sample analyses have been reported. Therefore, we designed this study with the a...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2008.01.010

    authors： Ikeda M,Takahashi N,Saito S,Aleksic B,Watanabe Y,Nunokawa A,Yamanouchi Y,Kitajima T,Kinoshita Y,Kishi T,Kawashima K,Hashimoto R,Ujike H,Inada T,Someya T,Takeda M,Ozaki N,Iwata N

    更新日期：2008-04-01 00:00:00

  • Resequencing of the vesicular glutamate transporter 2 gene (VGLUT2) reveals some rare genetic variants that may increase the genetic burden in schizophrenia.

    abstract：OBJECTIVES:Vesicular glutamate transporters (VGLUT1-3) package glutamate into vesicles in the presynaptic terminal and regulate the release of glutamate. In mesencephalic dopamine neuron culture, the majority of isolated dopamine neurons express VGLUT2, but not VGLUT1 or 3, have been demonstrated. As related to the dys...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2010.05.015

    authors： Shen YC,Liao DL,Lu CL,Chen JY,Liou YJ,Chen TT,Chen CH

    更新日期：2010-08-01 00:00:00

  • Reduced fractional anisotropy and axial diffusivity in white matter in 22q11.2 deletion syndrome: a pilot study.

    abstract：:Individuals with 22q11.2 deletion syndrome (22q11.2DS) evince a 30% incidence of schizophrenia. We compared the white matter (WM) of 22q11.2DS patients without schizophrenia to a group of matched healthy controls using Tract-Based-Spatial-Statistics (TBSS). We found localized reduction of Fractional Anisotropy (FA) an...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.schres.2012.06.032

    authors： Kikinis Z,Asami T,Bouix S,Finn CT,Ballinger T,Tworog-Dube E,Kucherlapati R,Kikinis R,Shenton ME,Kubicki M

    更新日期：2012-10-01 00:00:00

  • Trajectories of the course of schizophrenia: from progressive deterioration to amelioration over three decades.

    abstract：BACKGROUND:The extent of heterogeneity in the long-term course of schizophrenia is unclear. AIMS:To examine the course of schizophrenia in a population-based cohort. METHODS:This study included all Israeli individuals born in 1970-1988, of North African or European origin (N=2290), entered in the National Psychiatric...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2010.10.026

    authors： Levine SZ,Lurie I,Kohn R,Levav I

    更新日期：2011-03-01 00:00:00

  • Family load estimates of schizophrenia and associated risk factors in a nation-wide population study of former child and adolescent patients up to forty years of age.

    abstract：OBJECTIVES:This nation-wide register-based study investigates the family load of schizophrenia (SZ) across three generations in affected families compared to control families. Furthermore the study compares the family load in case vs. control families considering the age of onset of the disorder in the cases. In additi...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2012.05.014

    authors： Helenius D,Munk-Jørgensen P,Steinhausen HC

    更新日期：2012-08-01 00:00:00

  • Th17 and MAIT cell mediated inflammation in antipsychotic free schizophrenia patients.

    abstract：:The immune hypothesis of schizophrenia has gained significant popularity in recent years in schizophrenia research. Evidence suggests that the peripheral immune system communicates with central nervous system and the effect propagates through microglial and lymphocyte crosstalk, especially during neuro-inflammation. A...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2019.08.013

    authors： Varun CN,Venkataswamy MM,Ravikumar R,Nagaraju R,Debnath M,Varambally S,Venkatasubramanian G,Ravi V

    更新日期：2019-10-01 00:00:00

  • Executive functions in adolescents with schizotypal personality disorder.

    abstract：:Adolescents meeting diagnostic criteria for schizotypal personality disorder (SPD) are presumed to be at risk for developing schizophrenia in adulthood, making them an important group for exploring the developmental trajectory of the disease. Deficits in executive functioning have been documented in schizophrenia pati...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(99)00119-x

    authors： Diforio D,Walker EF,Kestler LP

    更新日期：2000-04-07 00:00:00

  • Uncovering the role of the nucleus accumbens in schizophrenia: A postmortem analysis of tyrosine hydroxylase and vesicular glutamate transporters.

    abstract：:The nucleus accumbens (NAcc) is often implicated in schizophrenia (SZ) pathology, but with little evidence to support its role. This study examined postmortem human tissue to determine if abnormalities are present in the dopaminergic or glutamatergic systems in the NAcc in SZ. We compared the protein levels of tyrosin...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.08.041

    authors： McCollum LA,Roberts RC

    更新日期：2015-12-01 00:00:00

  • Altered volume and lateralization of language-related regions in first-episode schizophrenia.

    abstract：:Neuroanatomical abnormalities are considered to be related to the pathogenesis of schizophrenia. Reversal or reduction of normal structural cerebral asymmetries in schizophrenia is particularly striking. The current study investigated the alteration of gray matter volume and cerebral asymmetry in early stage of first-...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2013.05.021

    authors： Sheng J,Zhu Y,Lu Z,Liu N,Huang N,Zhang Z,Tan L,Li C,Yu X

    更新日期：2013-08-01 00:00:00

  • Sex versus gender differences in schizophrenia: The case for normal personality differences.

    abstract：:Schizophrenia has generally been viewed as having a unique preschizophrenia personality or destructive to the personality post-onset. This view is reflected in the scarcity of studies of personality in schizophrenia with the exception of schizotypal personality considered by many as an endophenotype of schizophrenia. ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2017.02.015

    authors： Lewine R,Martin M,Hart M

    更新日期：2017-11-01 00:00:00

  • Cultural and linguistic diversity increases the likelihood of compulsory community treatment.

    abstract：BACKGROUND:People from culturally and linguistically diverse (CALD) backgrounds are over-represented in compulsory admissions to hospital but little is known about whether this also applies to community treatment orders (CTOs). AIMS:We investigated any differences between Australian- and foreign-born patients in the l...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2017.12.005

    authors： Kisely S,Xiao J

    更新日期：2018-07-01 00:00:00

  • The components of executive functioning in a cohort of patients with chronic schizophrenia: a multiple single-case study design.

    abstract：:We examined the fractionation of executive functioning performance in ninety patients with schizophrenia, who were tested for initiation, sustained attention, switching/flexibility, attention allocation and impulsivity/disinhibition. The participants were also given tests of general intelligence and memory. We analyse...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2005.08.011

    authors： Chan RC,Chen EY,Cheung EF,Chen RY,Cheung HK

    更新日期：2006-01-31 00:00:00

  • Neurological soft signs in psychometrically identified schizotypy.

    abstract：:Patients with schizophrenia often exhibit structural brain abnormalities, as well as neurological soft signs (NSS), consistent with its conceptualization as a neurodevelopmental disorder. NSS are mild, presumably nonlocalizing, neurological impairments that are inferred from performance deficits in domains such as sen...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2009.06.018

    authors： Kaczorowski JA,Barrantes-Vidal N,Kwapil TR

    更新日期：2009-12-01 00:00:00

  • Neither protein kinase C nor adenylate cyclase are altered in the striatum from subjects with schizophrenia.

    abstract：:Dopamine (DA) D2 receptors which act by modulating second messenger pathways that include protein kinase C (PKC) and adenylate cyclase (AC) have been repeatedly shown to be increased in striatum from subjects with schizophrenia. Therefore it seemed possible that chronic up-regulation of DA-D2 receptors in the schizoph...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(96)00065-5

    authors： Opeskin K,Dean B,Pavey G,Hill C,Keks N,Copolov D

    更新日期：1996-11-15 00:00:00

  • Shape distortion of the hippocampus: a possible explanation of the pyramidal cell disarray reported in schizophrenia.

    abstract：:The finding of pyramidal cell disarray in the hippocampus of patients with schizophrenia has been disputed by several groups. Conflicting results have been attributed to differences in the subtype of patients used, staining method, the side of the hippocampus studied and the way cellular disarray has been measured. In...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(01)00201-8

    authors： Casanova MF,Rothberg B

    更新日期：2002-05-01 00:00:00