Abstract:
:The finding of pyramidal cell disarray in the hippocampus of patients with schizophrenia has been disputed by several groups. Conflicting results have been attributed to differences in the subtype of patients used, staining method, the side of the hippocampus studied and the way cellular disarray has been measured. In the present study, we correct for these confounds by using a well-defined population of schizophrenic patients (n = 14) and controls (n = 10) in which Golgi impregnated material was available. Measurements were performed manually according to the method of Kovelman and Scheibel (1984). Pyramidal cell disarray for the CA1/prosubicular interface indicated significant differences between patients and controls (p = 0.0183). The findings were attributed to a bias accrued to referencing measurements in schizophrenics to the distorted circumventricular surface of the temporal horn.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Casanova MF,Rothberg Bdoi
10.1016/s0920-9964(01)00201-8subject
Has Abstractpub_date
2002-05-01 00:00:00pages
19-24issue
1-2eissn
0920-9964issn
1573-2509pii
S0920996401002018journal_volume
55pub_type
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.05.007
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journal_title:Schizophrenia research
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journal_title:Schizophrenia research
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pub_type: 杂志文章
doi:10.1016/j.schres.2013.11.023
更新日期:2014-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.11.006
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.10.011
更新日期:2012-12-01 00:00:00
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journal_title:Schizophrenia research
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doi:10.1016/j.schres.2007.11.017
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.08.034
更新日期:2013-11-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.12.005
更新日期:2014-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2017.09.012
更新日期:2019-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.03.015
更新日期:2014-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2014.12.031
更新日期:2015-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.schres.2006.03.025
更新日期:2006-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2003.07.005
更新日期:2004-08-01 00:00:00
abstract::Healthy siblings of schizophrenia patients have an almost 9-fold higher risk for developing the illness than the general population. Disruption of white matter (WM) integrity as indicated by reduced fractional anisotropy (FA) derived from diffusion tensor imaging (DTI), is believed to be the key substrate of schizophr...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.07.001
更新日期:2009-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.03.016
更新日期:2019-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.09.014
更新日期:2009-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.schres.2018.06.030
更新日期:2018-12-01 00:00:00
abstract::It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.12.854
更新日期:2006-04-01 00:00:00
abstract::Schizophrenia (SZ) is associated with broad burden. The clinical manifestations of SZ are related to pathophysiological alterations similar to what is seen in normal aging. Our aim was to evaluate the differences in telomere length (TL), a biomarker of cellular aging, in subjects with SZ (n=36), unaffected siblings (S...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.04.004
更新日期:2016-07-01 00:00:00
abstract::Auditory-verbal hallucinations (AVHs) are associated with an impaired connectivity of large-scale networks. To examine the relationship between white-matter integrity and AVHs, we conducted a meta-analysis of diffusion-tensor-imaging studies that compared patients with schizophrenia and AVHs with matched healthy contr...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2014.07.014
更新日期:2014-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.08.010
更新日期:2007-11-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.11.028
更新日期:2008-02-01 00:00:00
abstract::In this study, we examined the preliminary concurrent validity of a brief version of the Prodromal Questionnaire (PQ-B), a self-report screening measure for psychosis risk syndromes. Adolescents and young adults (N=141) who presented consecutively for clinical assessment to one of two early psychosis research clinics ...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2011.03.029
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:The Heinrichs-Carpenter Quality of Life Scale (QLS) is the most extensively used real-world community functioning scale in schizophrenia research. However, the extensive time required to administer it and the inclusion of items that overlap conceptually with negative symptoms limit its use across studies. Th...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.02.013
更新日期:2014-04-01 00:00:00
abstract::The glutamatergic dysfunction hypothesis of schizophrenia implicates the genes involved in glutamatergic transmission as strong candidates for schizophrenia-susceptibility. Recent linkage and association studies have identified the glutamate receptor, ionotropic, delta 1 gene GRID1 on 10q22 as a strong candidate for s...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.03.007
更新日期:2007-07-01 00:00:00
abstract::This study documents a severe picture naming impairment in a series of 22 chronically hospitalised schizophrenics. The pattern and level of naming impairment were comparable in degree and type to that seen neurological patients with left hemisphere lesions. This deficit was further examined to determine whether it con...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00184-x
更新日期:2000-09-29 00:00:00
abstract::An absent response to the niacin skin test has been reported to occur in about 80% of schizophrenic patients, as compared to 20% of healthy individuals. Niacin provokes redness in skin caused by a capillary vasodilatation mediated by prostaglandins. The metabolism of prostaglandins is regulated by the enzyme phospholi...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00281-5
更新日期:2003-05-01 00:00:00
abstract::Deficits in emotion perception are common in people with schizophrenia and current research has focused on improving these deficits. In our previous research, we demonstrated that directing attention to salient facial features via attention shaping can improve these deficits among inpatients. In this study, we examine...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.05.011
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Depressive symptoms frequently accompany schizophrenia. Older patients constitute the fastest growing segment of the schizophrenia population. With regard to the risk factors associated with depression, it is uncertain to which extent older schizophrenia patients differ from their age peers in the community....
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.05.002
更新日期:2014-08-01 00:00:00