Abstract:
:Studies suggest that the affective response is impaired in both schizophrenia and adolescent offspring of schizophrenia patients. Adolescent offspring of patients are developmentally vulnerable to impairments in several domains, including affective responding, yet the bases of these impairments and their relation to neuronal responses within the limbic system are poorly understood. The amygdala is the central region devoted to the processing of emotional valence and its sub-nuclei including the baso-lateral and centro-medial are organized in a relative hierarchy of affective processing. Outputs from the centro-medial nucleus converge on regions involved in the autonomous regulation of behavior, and outputs from the baso-lateral nucleus modulate the response of reward processing regions. Here using fMRI we assessed the intra-amygdala response to positive, negative, and neutral valenced faces in a group of controls (with no family history of psychosis) and offspring of schizophrenia parents (n=44 subjects in total). Subjects performed an affective continuous performance task during which they continually appraised whether the affect signaled by a face on a given trial was the same or different from the previous trial (regardless of facial identity). Relative to controls, offspring showed reduced activity in the left centro-medial nucleus to positively (but not negatively or neutral) valenced faces. These results were independent of behavioral/cognitive performance (equal across groups) suggesting that an impaired affective substrate in the intra-amygdala response may lie at the core of deficits of social behavior that have been documented in this population.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Barbour T,Murphy E,Pruitt P,Eickhoff SB,Keshavan MS,Rajan U,Zajac-Benitez C,Diwadkar VAdoi
10.1016/j.schres.2010.07.023subject
Has Abstractpub_date
2010-11-01 00:00:00pages
126-36issue
2-3eissn
0920-9964issn
1573-2509pii
S0920-9964(10)01439-8journal_volume
123pub_type
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,meta分析,评审
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journal_title:Schizophrenia research
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.schres.2016.10.030
更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2008.08.013
更新日期:2008-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2019.03.009
更新日期:2020-12-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2018.04.035
更新日期:2018-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2006.11.025
更新日期:2007-03-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.1016/j.schres.2016.04.022
更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1016/0920-9964(95)00023-2
更新日期:1995-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2015.08.027
更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2013.07.052
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2015.10.032
更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2018.10.009
更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2013-12-01 00:00:00