Abstract：
:The extent of age-related changes in glutamate and other neurometabolites in the anterior cingulate cortex (ACC) in individuals with schizophrenia remain unclear. Magnetic resonance spectroscopy (MRS) at 7 T, which yields precise measurements of various metabolites and can distinguish glutamate from glutamine, was used to determine levels of ACC glutamate and other metabolites in 24 individuals with schizophrenia and 24 matched controls. Multiple regression analysis revealed that ACC glutamate decreased with age in patients but not controls. No changes were detected in levels of glutamine, N-acetylaspartate, N-acetylaspartylglutamic acid, myo-inositol, GABA, glutathione, total creatine, and total choline. These results suggest that age may be an important modifier of ACC glutamate in schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Brandt AS,Unschuld PG,Pradhan S,Lim IA,Churchill G,Harris AD,Hua J,Barker PB,Ross CA,van Zijl PC,Edden RA,Margolis RLdoi
10.1016/j.schres.2016.02.017subject
Has Abstractpub_date
2016-04-01 00:00:00pages
101-5issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(16)30073-1journal_volume
172pub_type
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