Abstract：
:The 24-h profiles of plasma melatonin and cortisol were evaluated in 7 drug-free male paranoid schizophrenics and in 7 healthy subjects matched to the patients for age, sex, body weight, height and season of testing. Blood samples were obtained at 20.00, 22.00, 24.00, 01.00, 02.00, 06.00, 08.00 and 12.00 h. Light was turned off from 21.00 to 07.00 h. Compared with that of the normal controls, the circadian rhythm of plasma melatonin was absent in paranoid schizophrenics (F7.84 = 7.30, p less than 0.0001; two-way ANOVA with repeated measures) whereas the 24-h profile of plasma cortisol was preserved, although at a slightly higher level (F1.12 = 26.810, p less than 0.0002). The melatonin/cortisol ratio was significantly higher in healthy subjects than in the schizophrenic patients. A functional relationship between disturbances in the melatonin rhythm especially and schizophrenia may be proposed, although the significance of this relationship remains to be elucidated.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Monteleone P,Maj M,Fusco M,Kemali D,Reiter RJdoi
10.1016/0920-9964(92)90077-isubject
Has Abstractpub_date
1992-04-01 00:00:00pages
77-84issue
1eissn
0920-9964issn
1573-2509pii
0920-9964(92)90077-Ijournal_volume
7pub_type
杂志文章abstract：:A prior study in a US state hospital suggested that schizophrenia is more closely associated with tobacco smoking when compared with other severe mental illnesses. This second study, in a neighborhood hospital, tries to (1) replicate that schizophrenia is associated with smoking and heavy smoking, and (2) rule out tha...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00192-x
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:Individuals at ultra-high risk (UHR) for psychosis have significant cognitive deficits that can impede functional recovery. Applying cognitive remediation (CR) before the onset of frank psychosis may improve the cognitive and functional prognosis of UHR individuals, however, little is known about the feasibi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.08.016
更新日期：2020-10-01 00:00:00
abstract：:Sustained attention deficits and high rates of smoking are often observed in patients with schizophrenia. This has led to the hypothesis that patients may smoke as an attempt to ameliorate cognitive deficits related to abnormal nicotinic structure and function. Continuous performance tasks (CPT) are often used to inde...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.06.012
更新日期：2013-08-01 00:00:00
abstract：:A randomised trial was conducted in order to estimate the clinical and cost-effectiveness of social recovery orientated cognitive behavioural therapy (SRCBT) for people diagnosed with psychosis, compared to case management alone (CMA). The mean incremental health and social care cost, and the mean incremental quality ...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.schres.2009.03.041
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:Recent years have witnessed growing interest in the role of the social environment in the development and outcomes of schizophrenia. We investigated whether neighborhood characteristics are associated with two important prognostic factors in early-course psychosis, age at onset of psychosis (AOP) and duration...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.12.036
更新日期：2020-04-01 00:00:00
abstract：:Primary motor abnormalities (PMA), as found in patients with schizophrenia, are quantitatively and qualitatively distinct markers of motor system abnormalities. PMA have been often referred to phenomena that are present across schizophrenia-spectrum disorders. A dysfunction of frontoparietal and subcortical networks h...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.10.007
更新日期：2018-10-01 00:00:00
abstract：:Elevated serum levels of Interleukin-3 (IL-3), a major component of the cytokines, have been observed in chronic and medicated patients with schizophrenia, but this elevation may reflect either or both medication and illness chronicity effects. Thus, we compared serum IL-3 levels in first-episode drug-naive (FEDN) to ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.05.010
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Aprosody, or flattened speech intonation, is a recognized negative symptom of schizophrenia, though it has rarely been studied from a linguistic/phonological perspective. To bring the latest advances in computational linguistics to the phenomenology of schizophrenia and related psychotic disorders, a clinica...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.10.005
更新日期：2012-12-01 00:00:00
abstract：:High nailfold plexus visibility (NPV) is a trait identifying a putative endophenotype for schizophrenia. We describe a new method of NPV assessment using computer storage of digital photomicrographs. We performed a reliability study of this method using 40 subjects. The intraclass correlation between two blinded rater...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.08.017
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:The intrusion of associations into the utterances of schizophrenic individuals typically disrupts the coherence of the patient's utterances. Recent theoretical formulations of these phenomena have emphasized the hyperactivity) of associational networks in such language disturbance (e.g., Maher, B.A. 2003 Sch...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2005.05.017
更新日期：2005-10-15 00:00:00
abstract：BACKGROUND:The normal vasodilatory response to ingestion of nicotinic acid (NA) is impaired in some patients with schizophrenia. It is unclear whether the impairment is a feature of the disorder itself or to a confounding factor such as neuroleptics, caffeine or nicotine use. METHODS:To address this question in a cont...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00082-7
更新日期：2001-07-01 00:00:00
abstract：:Biomarkers which predict response to atypical antipsychotic drugs (AAPDs) increases their benefit/risk ratio. We sought to identify common variants in genes which predict response to lurasidone, an AAPD, by associating genome-wide association study (GWAS) data and changes (Δ) in Positive And Negative Syndrome Scale (P...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.schres.2017.04.009
更新日期：2018-02-01 00:00:00
abstract：:This paper examines the psychometric properties (reliability and factor structure) and validity (relationship with various self-report measures and SPEM dysfunction) of the SSQ or Schizotypic Syndrome Questionnaire, a 108-item inventory for the measurement of 12 prodromal or schizotypic symptoms present in Van Kampen'...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.02.011
更新日期：2006-06-01 00:00:00
abstract：:Schizophrenia is a multifactorial disease in both clinical and molecular terms. Thus, depicting the molecular aspects of the disease will contribute to the understanding of its biochemical mechanisms and consequently may lead to the development of new treatment strategies. The protein phosphorylation/dephosphorylation...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.03.022
更新日期：2016-11-01 00:00:00
abstract：PURPOSE:Strategic and mnemonic abilities of person with schizophrenia (SCZ) were studied using a part-list cuing (PLC) task. In this task, presentation of retrieval cues in the form of a subset of studied words typically impairs recall of the remaining items. This impairment is thought to reflect a disruption of partic...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.03.001
更新日期：2006-07-01 00:00:00
abstract：:Around 1 in 5 children under 13 years old experience sub-clinical psychotic experiences (PEs) like hallucinations and delusions. While PEs in childhood are a significant risk factor for adult psychotic disorders, the majority of those experiencing childhood PEs do not develop a psychotic disorder. Individual differenc...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.08.022
更新日期：2020-01-01 00:00:00
abstract：:Jumping to conclusions and bias against disconfirmatory evidence are two cognitive biases common in people with psychotic-like experiences and psychosis. However, many participants show comprehension problems doing traditional tasks; new paradigms with additional applied scenarios are thus needed. A large MTurk commun...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.12.016
更新日期：2020-02-01 00:00:00
abstract：:We investigated the relationship between the P300, neuropsychological test performance and symptomatology in recent-onset schizophrenic patients (n = 45) to gain insight into underlying mechanisms of abnormal P300 in schizophrenia. The P300 was recorded in two sessions with an intermission of five minutes, at the midl...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00184-0
更新日期：2002-05-01 00:00:00
abstract：:Clozapine is the only medication indicated for treating refractory schizophrenia, due to its superior efficacy among all antipsychotic agents, but its mechanism of action is poorly understood. To date, no studies of human postmortem brain have characterized the gene expression response to clozapine. Therefore, we addr...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2016.12.017
更新日期：2017-07-01 00:00:00
abstract：:Evidence-based decisions on indicated prevention in early psychosis require large-scale studies on the pathways to care in high-risk subjects. EPOS (The European Prediction of Psychosis Study), a prospective multi-center, naturalistic field study in four European countries (Finland, Germany, The Netherlands and Englan...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2013.11.031
更新日期：2014-02-01 00:00:00
abstract：:Mismatch negativity (MMN) deficits in schizophrenia (SCZ) have been studied extensively since the early 1990s, with the vast majority of studies using simple auditory oddball task deviants that vary in a single acoustic dimension such as pitch or duration. There has been a growing interest in using more complex devian...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2017.07.009
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVE:Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia. METHOD:Based on sera taken during the third trimester, we compared the level of 25 hydroxyvitamin D3 in mothers of individuals with schizophrenia or schizoaffective disorders versus mothers of unaffected c...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00435-8
更新日期：2003-09-01 00:00:00
abstract：:Diffusion Tensor Imaging (DTI) investigations in schizophrenia have provided evidence of impairment in white matter as indicated by reduced fractional anisotropy (FA). However, the neuropathological implications of these findings remain unclear. In the current study, we conducted a voxelwise analysis of the constituen...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.12.489
更新日期：2008-04-01 00:00:00
abstract：:Although a substance use disorder (SUD) is traditionally associated with psycho-bio-social impairments, recent investigations among persons with schizophrenia (Sz) generated divergent results. Certain persons with Sz+SUD might in fact present better social and cognitive functioning than persons with Sz without SUD. Th...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析
doi：10.1016/j.schres.2007.04.022
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Previous studies have shown that individuals with schizophrenia exhibit higher levels of unhelpful metacognitive beliefs than healthy controls, but no studies have explored metacognitive beliefs in early psychosis. AIMS:We examined i) differences in levels of unhelpful metacognitive beliefs between psychosi...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2015.10.026
更新日期：2015-12-01 00:00:00
abstract：:The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CA...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2017.01.011
更新日期：2017-07-01 00:00:00
abstract：:Many children of a schizophrenic parent may inherit a portion of the genetic risk factors for schizophrenia. The frequency of DSM-IV psychopathology in children of a schizophrenic parent and the frequency and type of mental health treatment accessed by these youths is not well understood. Twenty-eight adults with schi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(00)00043-8
更新日期：2001-05-30 00:00:00
abstract：:A case-control study was conducted in Singapore, in order to examine a proposed association between schizophrenia and the HLA DQB1 gene locus. The probands were male inpatients of Chinese ethnicity with schizophrenia (ICD-10 criteria, n = 102) and the controls were adults matched for gender and ethnicity (n = 111). Po...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00023-2
更新日期：1995-12-01 00:00:00
abstract：BACKGROUND:Schizophrenia with an onset in adolescence is known to be associated with a poorer outcome and cognitive difficulties. These impairments have an impact on quality of life and represent treatment targets. Cognitive remediation therapy (CRT) attempts to improve cognitive deficits by teaching information proces...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2007.03.030
更新日期：2007-08-01 00:00:00
abstract：BACKGROUND:Self-referential processing (i.e. linking internal and external stimuli to one's own self) has received scant attention thus far in schizophrenia. This type of processing is a key component of social cognition and thought to be important for adaptive social functioning. Memory studies in healthy subjects hav...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.11.011
更新日期：2011-04-01 00:00:00
