Abstract:
:Schizophrenia is a multifactorial disease in both clinical and molecular terms. Thus, depicting the molecular aspects of the disease will contribute to the understanding of its biochemical mechanisms and consequently may lead to the development of new treatment strategies. The protein phosphorylation/dephosphorylation switch acts as the main mechanism for regulating cellular signaling. Moreover, approximately onethird of human proteins are phosphorylable. Thus, identifying proteins differentially phosphorylated in schizophrenia postmortem brains may improve our understanding of the molecular basis of brain function in this disease. Hence, we quantified the phosphoproteome of corpus callosum samples collected post mortem from schizophrenia patients and healthy controls. We used state-of-the-art, bottom-up shotgun mass spectrometry in a two-dimensional liquid chromatography-tandem mass spectrometry setup in the MSE mode with label-free quantification. We identified 60,634 peptides, belonging to 3283 proteins. Of these, 68 proteins were differentially phosphorylated, and 56 were differentially expressed. These proteins are mostly involved in signaling pathways, such as ephrin B and ciliary neurotrophic factor signaling. The data presented here are novel because this was the very first phosphoproteome analysis of schizophrenia brains. They support the important role of glial cells, especially astrocytes, in schizophrenia and help to further the understanding of the molecular aspects of this disease. Our findings indicate a need for further studies on cell signaling, which might shape the development of treatment strategies.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Saia-Cereda VM,Cassoli JS,Schmitt A,Falkai P,Martins-de-Souza Ddoi
10.1016/j.schres.2016.03.022subject
Has Abstractpub_date
2016-11-01 00:00:00pages
70-77issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(16)30114-1journal_volume
177pub_type
杂志文章abstract:BACKGROUND:Cognitive impairment is a core feature of schizophrenia. Some evidence suggests an association between cognition deficits and gray matter reductions. In this study, we investigated the relationship between cognitive performance and gray matter volumes in patients with treatment-naïve, first-episode schizophr...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.12.015
更新日期:2014-02-01 00:00:00
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journal_title:Schizophrenia research
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.01.022
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.05.014
更新日期:2012-08-01 00:00:00
abstract::Vulnerability-stress models suggest that training in specific stress management techniques should yield benefits to those suffering from schizophrenia and related disorders. In this paper, we describe an evaluation of the impact of adding a stress management program to other medical and psychosocial interventions for ...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2020.09.013
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.05.035
更新日期:2020-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(98)00148-0
更新日期:1999-05-25 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
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更新日期:2008-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.02.002
更新日期:2004-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0920-9964(01)00261-4
更新日期:2002-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.01.013
更新日期:2020-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.04.027
更新日期:2014-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.06.012
更新日期:2008-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.06.012
更新日期:2010-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.01.040
更新日期:2017-11-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.08.027
更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2016.09.034
更新日期:2017-01-01 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1016/j.schres.2009.08.014
更新日期:2009-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2007.04.022
更新日期:2008-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.11.004
更新日期:2015-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.01.020
更新日期:2008-04-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/s0920-9964(02)00381-x
更新日期:2002-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.03.030
更新日期:2018-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(98)00070-x
更新日期:1998-10-09 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0920-9964(00)00091-8
更新日期:2001-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.11.028
更新日期:2008-02-01 00:00:00