An Interleukin-1 beta (IL1B) haplotype linked with psychosis transition is associated with IL1B gene expression and brain structure.

abstract：BACKGROUND:While structural brain imaging abnormalities have been identified in schizophrenia and related disorders, it is unclear when they arise. Some appear to predate the illness and may be genetic in origin, while others are associated with the onset of the disorder. METHODS:We examined the hippocampal volumes an...

journal_title：Schizophrenia research

authors： Wood SJ,Yücel M,Velakoulis D,Phillips LJ,Yung AR,Brewer W,McGorry PD,Pantelis C

更新日期：2005-06-15 00:00:00

abstract：:[(3)H]ketanserin binding to 5HT(2A) receptors was measured in the left planum temporale (sensory speech cortex) from schizophrenic and non-schizophrenic (control) subjects using both particulate membranes and tissue sections. There was a significant decrease in the affinity of [(3)H]ketanserin binding to particulate m...

journal_title：Schizophrenia research

authors： Pralong D,Tomaskovic-Crook E,Opeskin K,Copolov D,Dean B

更新日期：2000-07-07 00:00:00

abstract：:Childhood trauma is a risk factor for the onset of schizophrenic psychosis. Because the psychosis phenotype can be described as a continuum with varying levels of severity and persistence, childhood trauma might likewise increase the risk for psychotic experiences below the diagnostic threshold. But the impact of stre...

journal_title：Schizophrenia research

authors： Rössler W,Ajdacic-Gross V,Rodgers S,Haker H,Müller M

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia. METHOD:Based on sera taken during the third trimester, we compared the level of 25 hydroxyvitamin D3 in mothers of individuals with schizophrenia or schizoaffective disorders versus mothers of unaffected c...

journal_title：Schizophrenia research

authors： McGrath J,Eyles D,Mowry B,Yolken R,Buka S

更新日期：2003-09-01 00:00:00

abstract：:Increased sulcal widening in the prefrontal cortex of patients with schizophrenia may be associated with a poor treatment response to clozapine. To further evaluate this, we examined data from patients treated with clozapine in our center. Patients with the greatest degree of improvement (n=26) and those with no impro...

journal_title：Schizophrenia research

authors： Konicki PE,Kwon KY,Steele V,White J,Fuller M,Jurjus GJ,Jaskiw GE

更新日期：2001-03-30 00:00:00

abstract：:Left or mixed-handedness, footedness, and eye dominance are thought to indicate abnormalities in lateralization related to schizophrenia. Increased left or mixed-dominance in schizophrenia suggests possible hemispheric abnormalities associated with the disorder. A related body of research suggests that some indication...

journal_title：Schizophrenia research

authors： Schiffman J,Pestle S,Mednick S,Ekstrom M,Sorensen H,Mednick S

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Recovery is the ultimate goal of psychosis treatment. Basic self-disturbances (BSDs) are non-psychotic phenomena associated with clinical outcome, present in prodromal, psychotic and residual phases of psychotic disorders. AIM:To investigate the relationship between BSDs and recovery seven years after first...

journal_title：Schizophrenia research

authors： Svendsen IH,Øie MG,Møller P,Nelson B,Haug E,Melle I

更新日期：2019-10-01 00:00:00

abstract：:Recent trials support the hypothesis of the role of inflammation in the pathogenesis of schizophrenia. The overall therapeutic benefit of anti-inflammatory medication, in particular cyclo-oxygenase-2 (COX-2) inhibitors in schizophrenia, is still controversial. There are suggestions that therapy with COX-2 inhibitors m...

journal_title：Schizophrenia research

authors： Müller N,Krause D,Dehning S,Musil R,Schennach-Wolff R,Obermeier M,Möller HJ,Klauss V,Schwarz MJ,Riedel M

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Several resting-state neuroimaging studies in schizophrenia indicate an excessive brain activity while others report an incoherent brain activity at rest. No direct evidence for the simultaneous presence of both excessive and incoherent brain activity has been established to date. Moreover, it is unclear whe...

journal_title：Schizophrenia research

authors： Liu C,Xue Z,Palaniyappan L,Zhou L,Liu H,Qi C,Wu G,Mwansisya TE,Tao H,Chen X,Huang X,Liu Z,Pu W

更新日期：2016-03-01 00:00:00

abstract：:Neurological Examination Abnormalities (NEA) are prevalent in schizophrenia, but the significance of this is obscured by methodological problems. The Neurological Evaluation Scale (NES), the most widely used structured neurological examination in schizophrenia research, has had limited study of its inter-rater reliabi...

journal_title：Schizophrenia research

authors： Sanders RD,Forman SD,Pierri JN,Baker RW,Kelley ME,Van Kammen DP,Keshavan MS

更新日期：1998-02-09 00:00:00

abstract：:We investigated the relationship between the P300, neuropsychological test performance and symptomatology in recent-onset schizophrenic patients (n = 45) to gain insight into underlying mechanisms of abnormal P300 in schizophrenia. The P300 was recorded in two sessions with an intermission of five minutes, at the midl...

journal_title：Schizophrenia research

authors： Nieman DH,Koelman JH,Linszen DH,Bour LJ,Dingemans PM,Ongerboer de Visser BW

更新日期：2002-05-01 00:00:00

abstract：:Apolipoprotein D (apoD) is a member of the lipocalin superfamily of transporter proteins that bind small hydrophobic molecules, including arachidonic acid (AA). The ability of apoD to bind AA implicates it in pathways associated with membrane phospholipid signal transduction and metabolism. Recent findings of an incre...

journal_title：Schizophrenia research

authors： Yao JK,Thomas EA,Reddy RD,Keshavan MS

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The feasibility and preliminary efficacy of a novel cognitive behavioral treatment for decreasing psychotic symptoms and improving social functioning was evaluated in a pilot study. This represents the first treatment outcome study of CBT for psychosis with a manualized, active comparison condition. METHODS...

journal_title：Schizophrenia research

authors： Cather C,Penn D,Otto MW,Yovel I,Mueser KT,Goff DC

更新日期：2005-05-01 00:00:00

abstract：:Second-generation antipsychotics have demonstrated efficacy for patients with schizophrenia but are associated with wide-ranging side effects. Brexpiprazole, a serotonin-dopamine activity modulator, has demonstrated efficacy in adult patients with schizophrenia. This paper provides an overview of the safety and tolera...

journal_title：Schizophrenia research

authors： Kane JM,Skuban A,Hobart M,Ouyang J,Weiller E,Weiss C,Correll CU

更新日期：2016-07-01 00:00:00

abstract：:The etiologic factors underlying schizophrenia have been conceptualized as reflecting two largely genetic components - those unique to schizophrenia and those representing vulnerability to neurodevelopmental deviation in general. The Developmental Instability (DI) approach suggests that the latter can be indexed by mi...

journal_title：Schizophrenia research

authors： Euler M,Thoma RJ,Gangestad SW,Cañive JM,Yeo RA

更新日期：2009-11-01 00:00:00

abstract：:Enhancing work function is now widely considered a core element of comprehensive schizophrenia treatment. While research efforts have illuminated factors that influence how well patients perform at work, less is known about the factors influencing the subjective experience of work. It is not known how, and to what ext...

journal_title：Schizophrenia research

authors： de Jong S,Renard SB,van Donkersgoed RJ,van der Gaag M,Wunderink L,Pijnenborg GH,Lysaker PH

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Impaired insight into illness is common during early psychosis and has been associated with treatment delays and poorer long-term outcomes. The relationship between patients' insight into illness and their caregivers' knowledge about psychosis is putatively associated with treatment outcome but there is limi...

journal_title：Schizophrenia research

authors： Brent BK,Giuliano AJ,Zimmet SV,Keshavan MS,Seidman LJ

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:Frontal hypoactivation has been consistently found in schizophrenia. We hypothesized that patients' deficit is asymmetrical, i.e., centred over the left frontal locations, associated with loss of language-related asymmetry, and correlated with positive symptoms. METHOD:The amplitude of EEG gamma band (36-48...

journal_title：Schizophrenia research

authors： Spironelli C,Angrilli A

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:We recently reported that the type-2 cytokine response is increased in schizophrenia. The aim of this study was to analyse the effects of antipsychotic drugs on the serum levels of type-1 (TNF-α, IFN-γ), type-2 (IL-4, IL-10), type-17 (IL-17) and regulatory cytokines (TGF-β, IL-27 and IL-6). METHODS:Cytokine ...

journal_title：Schizophrenia research

authors： Borovcanin M,Jovanovic I,Radosavljevic G,Djukic Dejanovic S,Stefanovic V,Arsenijevic N,Lukic ML

更新日期：2013-06-01 00:00:00

abstract：:Growing recognition of the inadequacy of traditional methods of providing informed consent, especially for individuals vulnerable to impaired decisional capacity, has spurred recent interest in how to assess and improve components of consent-related decision making. In this preliminary study, we aimed to compare diffe...

journal_title：Schizophrenia research

authors： Eyler LT,Mirzakhanian H,Jeste DV

更新日期：2005-06-15 00:00:00

abstract：:To clarify the molecular mechanism of phencyclidine (PCP)-induced schizophreniform psychosis in humans and of behavioral abnormalities in experimental animals, we used differential screening of a cDNA library from the cerebral cortex of rats treated with PCP. We identified a PCP-induced cDNA clone as the gene encoding...

journal_title：Schizophrenia research

authors： Shimizu E,Shirasawa H,Kodama K,Kuroyanagi H,Shirasawa T,Sato T,Simizu B

更新日期：1997-06-20 00:00:00

abstract：:Large-scale gene expression studies in schizophrenia (SZ) have generally focused on the dorsolateral prefrontal cortex. Despite a wealth of evidence implicating multiple other brain regions in the disease, studies of other brain regions have been less frequent and have rarely been performed in the same subjects. We an...

journal_title：Schizophrenia research

authors： Katsel P,Davis KL,Gorman JM,Haroutunian V

更新日期：2005-09-15 00:00:00

abstract：:Poly(A+) mRNA was extracted from the post-mortem brain of schizophrenics (9 subjects), unipolar depressives (5 subjects) and controls (10 subjects) and used to direct the in vitro translation of radiolabelled protein in a cell-free reticulocyte-lysate system. Protein species were analysed on two-dimensional gels. Over...

journal_title：Schizophrenia research

authors： Perrett CW,Whatley SA,Ferrier IN,Marchbanks RM

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVES:Cognitive remediation therapy (CRT) has shown significant improvement in cognition in schizophrenia. However, effect sizes of CRT have been reported to be modest raising the issue how to augment the effects of CRT on neurocognition and social cognition. Our aim was to examine whether the addition of computer...

journal_title：Schizophrenia research

authors： Lindenmayer JP,Khan A,McGurk SR,Kulsa MKC,Ljuri I,Ozog V,Fregenti S,Capodilupo G,Buccellato K,Thanju A,Goldring A,Parak M,Parker B

更新日期：2018-11-01 00:00:00

abstract：:Affective impairments were examined in patients with and without deficit syndrome schizophrenia. Two Emotional Stroop tasks designed to measure automatic processing of emotional information were administered to deficit (n=15) and non-deficit syndrome (n=26) schizophrenia patients classified according to the Schedule f...

journal_title：Schizophrenia research

authors： Strauss GP,Allen DN,Duke LA,Ross SA,Schwartz J

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Negative symptoms in schizophrenia are associated with deficits in executive function and frequently prove highly resistant to neuroleptic medication. Using repetitive transcranial magnetic stimulation (rTMS) to activate the prefrontal cortex has been suggested as a treatment for negative symptoms. METHODS:...

journal_title：Schizophrenia research

authors： Mogg A,Purvis R,Eranti S,Contell F,Taylor JP,Nicholson T,Brown RG,McLoughlin DM

更新日期：2007-07-01 00:00:00

abstract：:Auditory--verbal hallucinations (AVH) are a characteristic feature of schizophrenia. Patients with AVHs have been found to differ from non-hallucinating patients in volumes of certain asymmetrical brain structures on MRI, and on certain neuropsychological measures. There is also evidence of corpus callosum (CC) abnorm...

journal_title：Schizophrenia research

authors： Rossell SL,Shapleske J,Fukuda R,Woodruff PW,Simmons A,David AS

更新日期：2001-05-30 00:00:00

abstract：OBJECTIVE:Patients with schizophrenia have a high prevalence of metabolic disorders and cardiovascular mortality. It is possible that a vulnerability to metabolic abnormalities is associated with risk for psychosis, symptoms and functionality. In this study, we evaluate demographic information, cardiometabolic indices,...

journal_title：Schizophrenia research

authors： Cadenhead KS,Minichino A,Kelsven S,Addington J,Bearden C,Cannon TD,Cornblatt BA,Mathalon D,McGlashan TH,Perkins DO,Seidman LJ,Tsuang M,Walker EF,Woods SW,Yao J,North American Prodromal Longitudinal Studies (NAPLS) consortiu

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Attentional deficits represent a core cognitive impairment in schizophrenia. The distractor condition Sustained Attention Task (dSAT) has been identified by the Cognitive Neuroscience Treatment to Improve Cognition in Schizophrenia (CNTRICS) initiative as a promising translational task for assessing schizophr...

journal_title：Schizophrenia research

authors： Demeter E,Guthrie SK,Taylor SF,Sarter M,Lustig C

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Clozapine is the drug of choice for patients with unsatisfactory response to routine antipsychotic treatment. Polypharmacy is widely used among patients having clozapine-resistant schizophrenia, although no solid evidence exists for any effective augmentation therapy for this patient population. We aimed to ...

journal_title：Schizophrenia research

authors： Tiihonen J,Wahlbeck K,Kiviniemi V

更新日期：2009-04-01 00:00:00