A preliminary study of interactive questioning methods to assess and improve understanding of informed consent among patients with schizophrenia.

Abstract:

:Growing recognition of the inadequacy of traditional methods of providing informed consent, especially for individuals vulnerable to impaired decisional capacity, has spurred recent interest in how to assess and improve components of consent-related decision making. In this preliminary study, we aimed to compare different methods of interactive questioning during presentation of research consent information among patients with schizophrenia. Patients were randomized to receive either standard administration (SA) of a consent form or one of two interactive questioning methods: Corrective Feedback (CF), in which the correct answer was provided following the participant's response, or Errorless Learning (EL), in which correct answers were provided just prior to the question. The MacArthur Competence Assessment Tool for Clinical Research (MacCAT-CR) was used to measure understanding, appreciation, reasoning, and expression of a choice following presentation of the consent form. There was no significant effect of condition (SA vs. EL vs. CF) on any of the components of decisional capacity. Understanding scores measured during the consent process were higher than those measured afterward, but the two scores were highly correlated. Thus, the results of this randomized study suggest that interactive questioning neither helped nor harmed understanding, appreciation, or reasoning among patients with schizophrenia. Other considerations, however, may favor use of such methods in the consenting process.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Eyler LT,Mirzakhanian H,Jeste DV

doi

10.1016/j.schres.2004.06.009

subject

Has Abstract

pub_date

2005-06-15 00:00:00

pages

193-8

issue

2-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(04)00206-3

journal_volume

75

pub_type

杂志文章,随机对照试验
  • Psychometric characteristics of the MATRICS Consensus Cognitive Battery in a large pooled cohort of stable schizophrenia patients.

    abstract::The MATRICS Consensus Cognitive Battery (MCCB) was developed to assess cognitive treatment effects in schizophrenia clinical trials, and is considered the FDA gold standard outcome measure for that purpose. The aim of the present study was to establish pre-treatment psychometric characteristics of the MCCB in a large ...

    journal_title:Schizophrenia research

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.schres.2017.03.040

    authors: Georgiades A,Davis VG,Atkins AS,Khan A,Walker TW,Loebel A,Haig G,Hilt DC,Dunayevich E,Umbricht D,Sand M,Keefe RSE

    更新日期:2017-12-01 00:00:00

  • Dual diagnosis of substance abuse in schizophrenia: prevalence and impact on outcomes.

    abstract::Comorbid substance abuse disorders have emerged as one of the greatest obstacles to the effective treatment of persons with schizophrenia. Estimates of the prevalence of such comorbidity vary, but as many as half of persons with schizophrenia may suffer from a comorbid drug or alcohol disorder. Younger age, male gende...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审

    doi:10.1016/s0920-9964(98)00161-3

    authors: Dixon L

    更新日期:1999-03-01 00:00:00

  • High-dose galantamine augmentation inferior to placebo on attention, inhibitory control and working memory performance in nonsmokers with schizophrenia.

    abstract::Dysfunction in the neuronal nicotinic acetylcholine receptor (nAChR) system has been implicated in the pathophysiology of schizophrenia, and it has been postulated that treatments that increase nAChR activity may improve symptoms of the disorder. We investigated the effects of the acetylcholinesterase inhibitor and al...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.schres.2007.12.491

    authors: Dyer MA,Freudenreich O,Culhane MA,Pachas GN,Deckersbach T,Murphy E,Goff DC,Evins AE

    更新日期:2008-07-01 00:00:00

  • Why you can't be in sync with schizophrenia patients.

    abstract::Most individuals with schizophrenia will be confronted with some form of stigma. In recent years, clinicians and family members have increasingly contested the term "schizophrenia". Many of them discuss changing this name, as a means to fight stigma. Up until now, surprisingly, most research has been conducted using s...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2019.11.054

    authors: Rainteau N,Salesse RN,Macgregor A,Macioce V,Raffard S,Capdevielle D

    更新日期:2020-02-01 00:00:00

  • The effect of zonisamide on antipsychotic-associated weight gain in patients with schizophrenia: a randomized, double-blind, placebo-controlled clinical trial.

    abstract:BACKGROUND:Many patients with schizophrenia suffer from metabolic symptoms and weight gain in which predispose them to obesity, diabetes, and cardiovascular problems. This trial examines the efficacy and safety of zonisamide on weight and body mass index in patients with schizophrenia being administered with atypical a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.schres.2013.03.021

    authors: Ghanizadeh A,Nikseresht MS,Sahraian A

    更新日期:2013-06-01 00:00:00

  • Computerized facial analysis for understanding constricted/blunted affect: initial feasibility, reliability, and validity data.

    abstract::Diminished expression is a diagnostic feature of a range of schizophrenia-spectrum disorders/conditions and is often unresponsive to treatment, is present across premorbid, first episode and various clinical states, and is considered a poor prognostic indicator. Surprisingly, little is known about diminished expressio...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2013.05.003

    authors: Cohen AS,Morrison SC,Callaway DA

    更新日期:2013-08-01 00:00:00

  • Altered gyrification in schizophrenia and its relation to other morphometric markers.

    abstract::Schizophrenia is modelled as a neurodevelopmental disease with high heritability. However, established markers like cortical thickness and grey matter volume are heavily influenced by post-onset changes and thus provide limited possibility of accessing early pathologies. Gyrification on the other side is assumed to be...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2018.07.014

    authors: Spalthoff R,Gaser C,Nenadić I

    更新日期:2018-12-01 00:00:00

  • Olfactory deficits in neuroleptic naive patients with schizophrenia.

    abstract::Because previous studies have shown deficits in olfactory identification for male patients with schizophrenia, either withdrawn from or receiving neuroleptic medication, the purpose of the current study was to determine if such deficits occurred in male patients who had never received neuroleptics. A sample of male (n...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/0920-9964(93)90022-b

    authors: Kopala LC,Clark C,Hurwitz T

    更新日期:1993-01-01 00:00:00

  • Effects of repeated electroconvulsive shocks on dopamine supersensitivity psychosis model rats.

    abstract::While the long-term administration of antipsychotics is known to cause dopamine supersensitivity psychosis (DSP), recent studies revealed that DSP helps form the foundation of treatment resistance. Electroconvulsive shock (ES) is one of the more effective treatments for treatment-resistant schizophrenia. The objective...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2020.11.062

    authors: Kimura M,Oda Y,Oishi K,Yoshino K,Kimura H,Niitsu T,Kanahara N,Shirayama Y,Hashimoto K,Iyo M

    更新日期:2021-01-08 00:00:00

  • Altered CSNK1E, FABP4 and NEFH protein levels in the dorsolateral prefrontal cortex in schizophrenia.

    abstract::Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2016.04.050

    authors: Pinacho R,Villalmanzo N,Meana JJ,Ferrer I,Berengueras A,Haro JM,Villén J,Ramos B

    更新日期:2016-11-01 00:00:00

  • A dimensional comparison between delusional disorder, schizophrenia and schizoaffective disorder.

    abstract:INTRODUCTION:Since the early description of paranoia, the nosology of delusional disorder has always been controversial. The old idea of unitary psychosis has now gained some renewed value from the dimensional continuum model of psychotic symptoms. AIMS:1. To study the psychopathological dimensions of the psychosis sp...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2015.10.039

    authors: Muñoz-Negro JE,Ibanez-Casas I,de Portugal E,Ochoa S,Dolz M,Haro JM,Ruiz-Veguilla M,de Dios Luna Del Castillo J,Cervilla JA

    更新日期:2015-12-01 00:00:00

  • Elevated IgG anti-histone antibodies in a subgroup of medicated schizophrenic patients.

    abstract::A total of 57 schizophrenic patients (of which 17 were first-episode, neuroleptic naive) and 76 healthy controls were screened for anti-histone IgG antibodies using an enzyme immunoassay (ELISA). All patients had significantly higher anti-histone antibody titers than controls (t = 3.1, p less than 0.003). Previously m...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/0920-9964(92)90073-e

    authors: Chengappa KN,Carpenter AB,Yang ZW,Brar JS,Rabin BS,Ganguli R

    更新日期:1992-04-01 00:00:00

  • Cytokines in cerebrospinal fluid of patients with schizophrenia spectrum disorders: New data and an updated meta-analysis.

    abstract::Few studies have been conducted examining cytokines in cerebrospinal fluid of patients compared to healthy volunteers. The goals of this study were: 1) to report original data detailing cytokine levels in the cerebrospinal fluid (CSF) of 10 patients with a schizophrenia spectrum disorder (SSD) diagnosis and 10 healthy...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.schres.2018.07.019

    authors: Gallego JA,Blanco EA,Husain-Krautter S,Madeline Fagen E,Moreno-Merino P,Del Ojo-Jiménez JA,Ahmed A,Rothstein TL,Lencz T,Malhotra AK

    更新日期:2018-12-01 00:00:00

  • Shape distortion of the hippocampus: a possible explanation of the pyramidal cell disarray reported in schizophrenia.

    abstract::The finding of pyramidal cell disarray in the hippocampus of patients with schizophrenia has been disputed by several groups. Conflicting results have been attributed to differences in the subtype of patients used, staining method, the side of the hippocampus studied and the way cellular disarray has been measured. In...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(01)00201-8

    authors: Casanova MF,Rothberg B

    更新日期:2002-05-01 00:00:00

  • Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis.

    abstract:BACKGROUND:A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated wit...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2017.10.042

    authors: Gjerde PB,Dieset I,Simonsen C,Hoseth EZ,Iversen T,Lagerberg TV,Lyngstad SH,Mørch RH,Skrede S,Andreassen OA,Melle I,Steen VM

    更新日期:2018-07-01 00:00:00

  • Attention Deficit/Hyperactivity Disorder and risk for non-affective psychotic disorder: The role of ADHD medication and comorbidity, and sibling comparison.

    abstract::Attention Deficit/Hyperactivity Disorder (ADHD) is the most common psychiatric disorder in childhood. It is unclear whether ADHD increases the risk of non-affective psychotic disorder (NAPD). The study included a matched cohort, drawn from all born in Sweden 1987-1991 (n = 548,852). ADHD was defined as ICD diagnosis a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2020.01.021

    authors: Björkenstam E,Pierce M,Björkenstam C,Dalman C,Kosidou K

    更新日期:2020-04-01 00:00:00

  • Prodromal interventions for schizophrenia vulnerability: the risks of being "at risk".

    abstract::Given the morbidity and difficulty of treating psychotic disorders, including schizophrenia, there has been a move toward identifying and treating adolescents and young adults who appear to be clinically at risk or "prodromal" to psychosis. The field now has greater specificity in identification, with rates of 40-50% ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2004.05.021

    authors: Corcoran C,Malaspina D,Hercher L

    更新日期:2005-03-01 00:00:00

  • The Experience of Caregiving Inventory for first-episode psychosis caregivers: validation of the Brazilian version.

    abstract::Family members of first-episode psychosis (FEP) patients are regarded as key components of the patient's evaluation, recovery and treatment. This paper aimed to investigate 75 FEP caregivers' appraisal, psychological morbidity and quality of life in the initial phase of treatment in a specialized FEP outpatient progra...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2012.03.014

    authors: Jorge Rde C,Chaves AC

    更新日期:2012-07-01 00:00:00

  • Area deprivation, urbanicity, severe mental illness and social drift - A population-based linkage study using routinely collected primary and secondary care data.

    abstract::We investigated whether associations between area deprivation, urbanicity and elevated risk of severe mental illnesses (SMIs, including schizophrenia and bipolar disorder) is accounted for by social drift or social causation. We extracted primary and secondary care electronic health records from 2004 to 2015 from a po...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2020.03.044

    authors: Lee SC,DelPozo-Banos M,Lloyd K,Jones I,Walters JTR,Owen MJ,O'Donovan M,John A

    更新日期:2020-06-01 00:00:00

  • A potential role for adjunctive omega-3 polyunsaturated fatty acids for depression and anxiety symptoms in recent onset psychosis: Results from a 16 week randomized placebo-controlled trial for participants concurrently treated with risperidone.

    abstract::Omega-3 treatment studies for multi-episode schizophrenia or clinical high risk for conversion to psychosis states have had variable, and often negative, results. To examine adjunctive omega-3 treatment for recent onset psychosis, participants aged 15-40 years with recent onset schizophrenia-spectrum (n = 46) or bipol...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.schres.2018.09.006

    authors: Robinson DG,Gallego JA,John M,Hanna LA,Zhang JP,Birnbaum ML,Greenberg J,Naraine M,Peters BD,McNamara RK,Malhotra AK,Szeszko PR

    更新日期:2019-02-01 00:00:00

  • Attention shaping as a means to improve emotion perception deficits in outpatients with schizophrenia and impaired controls.

    abstract::Deficits in emotion perception are common in people with schizophrenia and current research has focused on improving these deficits. In our previous research, we demonstrated that directing attention to salient facial features via attention shaping can improve these deficits among inpatients. In this study, we examine...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2010.05.011

    authors: Combs DR,Chapman D,Waguspack J,Basso MR,Penn DL

    更新日期:2011-04-01 00:00:00

  • Low maternal vitamin D as a risk factor for schizophrenia: a pilot study using banked sera.

    abstract:OBJECTIVE:Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia. METHOD:Based on sera taken during the third trimester, we compared the level of 25 hydroxyvitamin D3 in mothers of individuals with schizophrenia or schizoaffective disorders versus mothers of unaffected c...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(02)00435-8

    authors: McGrath J,Eyles D,Mowry B,Yolken R,Buka S

    更新日期:2003-09-01 00:00:00

  • The impact of a family history of psychosis on age-at-onset and positive and negative symptoms of schizophrenia: a meta-analysis.

    abstract::The results of research on the relation of family history (FH) of psychosis with clinical presentation in schizophrenia have been mixed. To date, there have been no comprehensive reviews that have examined this body of research. The current review quantitatively evaluates research on the relation of FH with two aspect...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.schres.2010.01.011

    authors: Esterberg ML,Trotman HD,Holtzman C,Compton MT,Walker EF

    更新日期:2010-07-01 00:00:00

  • Examining hippocampal function in schizophrenia using a virtual reality spatial navigation task.

    abstract:BACKGROUND:Structural pathology in the hippocampus is well-documented in schizophrenia, but brain functional changes have not been consistently found. We used spatial navigation in a virtual reality environment, a task that is known to produce robust hippocampal activation in healthy subjects, to examine task-related a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2016.02.033

    authors: Salgado-Pineda P,Landin-Romero R,Portillo F,Bosque C,Pomes A,Spanlang B,Franquelo JC,Teixido C,Sarró S,Salvador R,Slater M,Pomarol-Clotet E,McKenna PJ

    更新日期:2016-04-01 00:00:00

  • No evidence for association of the dysbindin gene [DTNBP1] with schizophrenia in an Irish population-based study.

    abstract::A recent family-based association study identified a putative association between variants in the dystrobrevin binding protein 1 (dysbindin) gene (DTNBP1) and schizophrenia. This study used a sample of 270 Irish pedigrees multiply affected with schizophrenia. We attempted to replicate these findings in an independent ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(02)00527-3

    authors: Morris DW,McGhee KA,Schwaiger S,Scully P,Quinn J,Meagher D,Waddington JL,Gill M,Corvin AP

    更新日期:2003-04-01 00:00:00

  • Chronic psychotropic drug treatment causes differential expression of connexin 43 and GFAP in frontal cortex of rats.

    abstract::Astrocytic markers glial fibrillary acidic protein (GFAP) and connexin 43 (CX43) are known to have altered expression in brains of subjects with psychiatric disorders including autism and major depression. The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotrop...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2008.05.016

    authors: Fatemi SH,Folsom TD,Reutiman TJ,Pandian T,Braun NN,Haug K

    更新日期:2008-09-01 00:00:00

  • Corpus callosum area and functioning in schizophrenic patients with auditory--verbal hallucinations.

    abstract::Auditory--verbal hallucinations (AVH) are a characteristic feature of schizophrenia. Patients with AVHs have been found to differ from non-hallucinating patients in volumes of certain asymmetrical brain structures on MRI, and on certain neuropsychological measures. There is also evidence of corpus callosum (CC) abnorm...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/s0920-9964(00)00070-0

    authors: Rossell SL,Shapleske J,Fukuda R,Woodruff PW,Simmons A,David AS

    更新日期:2001-05-30 00:00:00

  • Executive functioning in schizophrenia: the result of impairments in lower order cognitive skills?

    abstract::Executive functioning (EF) impairments are common in schizophrenia. There are two propositions regarding the causes of these impairments: (1) executive impairments are the result of the compounding effects of deficits in lower order cognitive skills (e.g. processing speed, attention) or (2) EF impairments exist in the...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2013.07.034

    authors: Neill E,Rossell SL

    更新日期:2013-10-01 00:00:00

  • Insight into illness in patients and caregivers during early psychosis: a pilot study.

    abstract:BACKGROUND:Impaired insight into illness is common during early psychosis and has been associated with treatment delays and poorer long-term outcomes. The relationship between patients' insight into illness and their caregivers' knowledge about psychosis is putatively associated with treatment outcome but there is limi...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2010.12.024

    authors: Brent BK,Giuliano AJ,Zimmet SV,Keshavan MS,Seidman LJ

    更新日期:2011-04-01 00:00:00

  • Using self-determination theory to understand motivation deficits in schizophrenia: the 'why' of motivated behavior.

    abstract::Self-determination theory (SDT) provides a model for understanding motivation deficits in schizophrenia, and recent research has focused on problems with intrinsic motivation. However, SDT emphasizes that motivated behavior results from three different factors: intrinsic motivators (facilitated by needs for autonomy, ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章

    doi:10.1016/j.schres.2014.04.027

    authors: Gard DE,Sanchez AH,Starr J,Cooper S,Fisher M,Rowlands A,Vinogradov S

    更新日期:2014-07-01 00:00:00