Abstract:
:Astrocytic markers glial fibrillary acidic protein (GFAP) and connexin 43 (CX43) are known to have altered expression in brains of subjects with psychiatric disorders including autism and major depression. The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotropic medications (clozapine, fluoxetine, haloperidol, lithium, olanzapine, and valproic acid). Using SDS-PAGE and western blotting technique, we observed that CX43 protein expression in prefrontal cortex was significantly increased following chronic treatment with fluoxetine and clozapine, while it was significantly decreased by haloperidol and lithium. GFAP protein expression was significantly decreased following chronic treatment with clozapine and valproic acid. These results suggest that astroglial markers GFAP and CX43 could be potential targets for therapeutic intervention.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Fatemi SH,Folsom TD,Reutiman TJ,Pandian T,Braun NN,Haug Kdoi
10.1016/j.schres.2008.05.016subject
Has Abstractpub_date
2008-09-01 00:00:00pages
127-34issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(08)00244-2journal_volume
104pub_type
杂志文章abstract:BACKGROUND:Bullying victimisation has been suggested to contribute to paranoid ideation in general population samples and recent evidence found that individuals with an ultra high risk (UHR) for psychosis are twice as likely to have been bullied than controls. AIMS:This study sought to examine whether a history of bul...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.08.029
更新日期:2015-10-01 00:00:00
abstract::Social skill and role functioning were assessed in matched groups of patients with DSM-III-R schizoaffective disorder, bipolar disorder, and schizophrenia. Schizophrenics were categorized as negative syndrome or non-negative on the basis of the SANS. The negative schizophrenics were significantly more impaired on almo...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(89)90032-7
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:The presence of a psychosis continuum is suggested by studies showing that schizophrenia and non-clinical psychotic symptoms in the general population share the same risk factors. However, to our knowledge no large-scale studies have been conducted which examine the specificity of these risk factors in the g...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.03.033
更新日期:2010-07-01 00:00:00
abstract::Studies suggest that the affective response is impaired in both schizophrenia and adolescent offspring of schizophrenia patients. Adolescent offspring of patients are developmentally vulnerable to impairments in several domains, including affective responding, yet the bases of these impairments and their relation to n...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.07.023
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Superior temporal gyrus (STG/BA22) volume is reduced in schizophrenia and to a milder degree in schizotypal personality disorder (SPD), representing a less severe disorder in the schizophrenia spectrum. SPD and Borderline personality disorder (BPD) are severe personality disorders characterized by social and...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.04.027
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Self-referential processing (i.e. linking internal and external stimuli to one's own self) has received scant attention thus far in schizophrenia. This type of processing is a key component of social cognition and thought to be important for adaptive social functioning. Memory studies in healthy subjects hav...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.11.011
更新日期:2011-04-01 00:00:00
abstract::Affective impairments were examined in patients with and without deficit syndrome schizophrenia. Two Emotional Stroop tasks designed to measure automatic processing of emotional information were administered to deficit (n=15) and non-deficit syndrome (n=26) schizophrenia patients classified according to the Schedule f...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.01.014
更新日期:2008-07-01 00:00:00
abstract::A number of reports of genetic association of human leucocyte antigens (HLA) and alleles with schizophrenia have recently been published. A schizophrenia locus on chromosome 6p near the HLA region has also been reported, on the basis of linkage studies. We have therefore reviewed the investigations of association of H...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/s0920-9964(00)00022-0
更新日期:2001-01-15 00:00:00
abstract::Schizophrenia and affective disorders are relatively common neuropsychiatric diseases with a complex genetic etiology. A multigenic inheritance with variable influence of unknown environmental factors may be involved. Family studies have demonstrated the existence of both phenotypes in the same kindreds, and in certai...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/s0920-9964(99)00108-5
更新日期:1999-09-29 00:00:00
abstract::The natural history of neurocognitive impairments in schizophrenia is unclear. We aimed to characterise this in an epidemiological first-episode cohort and relate it to long-term outcome. All but 1 of 112 first-episode psychosis cases ascertained from a geographical catchment area were traced at 10-12 years. Neurocogn...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(03)00014-8
更新日期:2003-12-15 00:00:00
abstract::Although schizophrenia and developmental dyslexia are considered distinct disorders in terms of clinical presentation and functional outcome, they both involve disruption in the processes that support skilled reading, including language, auditory perception, visual perception, oculomotor control, and executive functio...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2017.06.049
更新日期:2018-03-01 00:00:00
abstract::Studies defining the course and outcome of individuals experiencing their first episode (FE) of psychosis generally report an improvement in symptoms and functioning. Today, many FE patients are treated in specialized early psychosis programs. Little is known what happens to these individuals after discharge from thes...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.08.032
更新日期:2008-12-01 00:00:00
abstract::Executive functioning (EF) impairments are common in schizophrenia. There are two propositions regarding the causes of these impairments: (1) executive impairments are the result of the compounding effects of deficits in lower order cognitive skills (e.g. processing speed, attention) or (2) EF impairments exist in the...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.07.034
更新日期:2013-10-01 00:00:00
abstract::Recovery-oriented practices that promote client-centered care, collaboration, and functional outcome have been recommended to improve treatment engagement, especially for individuals with serious mental illness (SMI). Psychological well-being (PWB) is related to recovery and refers to experiencing purpose and meaning ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.11.032
更新日期:2017-07-01 00:00:00
abstract::The intracellular enzyme phospholipase A2 (PLA2) plays an essential role in the breakdown of membrane phospholipids, which regulate the physicochemical properties of the cell membrane. In the brain PLA2 has been reported to influence receptor function and signal transduction. Regarding dopaminergic neurons, data from ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(94)00060-l
更新日期:1995-07-01 00:00:00
abstract::Glutamate transporters facilitate the buffering, clearance and cycling of glutamate and play an important role in maintaining synaptic and extrasynaptic glutamate levels. Alterations in glutamate transporter expression may lead to abnormal glutamate neurotransmission contributing to the pathophysiology of schizophreni...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.12.019
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND:Individuals at ultra-high risk (UHR) for psychosis have significant cognitive deficits that can impede functional recovery. Applying cognitive remediation (CR) before the onset of frank psychosis may improve the cognitive and functional prognosis of UHR individuals, however, little is known about the feasibi...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.08.016
更新日期:2020-10-01 00:00:00
abstract::The MATRICS Consensus Cognitive Battery (MCCB) was developed to assess cognitive treatment effects in schizophrenia clinical trials, and is considered the FDA gold standard outcome measure for that purpose. The aim of the present study was to establish pre-treatment psychometric characteristics of the MCCB in a large ...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.schres.2017.03.040
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:The main goal of the present study was to analyze levels of cytokines of the interleukin family (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8 and IL-10), interferon-gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP1), tumor necrosis factor-alpha (TNF-α), and vascular endothelial and endothelial growth factors (V...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.08.027
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:Deficits in the mediodorsal and anterior nuclei of the thalamus may contribute to the psychopathological symptoms of schizophrenia. These thalamic nuclei have been found to be abnormal in schizophrenia and have close connections with other brain structures implicated in the disorder. We therefore examined sch...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.02.012
更新日期:2005-07-15 00:00:00
abstract::Defeatist beliefs and amotivation are prominent obstacles in vocational rehabilitation for people with serious mental illnesses (SMI). The CBT-based Indianapolis Vocational Intervention Program (IVIP) was specifically designed to reduce defeatist beliefs related to work functioning. In the current study, we examined t...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.10.036
更新日期:2017-04-01 00:00:00
abstract::A case-control study was conducted in Singapore, in order to examine a proposed association between schizophrenia and the HLA DQB1 gene locus. The probands were male inpatients of Chinese ethnicity with schizophrenia (ICD-10 criteria, n = 102) and the controls were adults matched for gender and ethnicity (n = 111). Po...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(95)00023-2
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVE:Research participants must have adequate consent-related abilities to provide informed consent at the time of study enrollment. We sought to determine if research participants with schizophrenia maintain adequate consent-related abilities during a longitudinal study. If participants lose abilities during a tr...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.schres.2011.04.012
更新日期:2011-08-01 00:00:00
abstract::Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and exhibit qualities of endophenotypes, including substantial heritability, test-retest reliability, and trait-like stability. These measures also fulfill criteria for use a...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2014.09.042
更新日期:2015-04-01 00:00:00
abstract::The present study determined the minimal exposure time (i.e., critical stimulus duration (CSD) necessary for feature registration and recognition by normals and chronic schizophrenics. Our interest was whether the longer exposure times required by schizophrenics than by normals could be attributed to an inability of s...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(92)90049-b
更新日期:1992-07-01 00:00:00
abstract::A study of mortality for all patients with schizophrenia admitted to the University Hospital of North Norway during 1980-2006 was performed, with a special focus on gender differences and changes in mortality during a period of transition from hospital-based to community-based care. A total of 1111 patients with schiz...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.07.021
更新日期:2011-11-01 00:00:00
abstract::Low birth weight and preterm birth are important predictors of infant mortality and morbidity, and may increase the risk of schizophrenia. These adverse outcomes of pregnancy could be associated, therefore, with increased risk in children genetically predisposed to schizophrenia. The aim of this review was to describe...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/s0920-9964(98)00065-6
更新日期:1998-09-07 00:00:00
abstract::Schizoaffective disorder is a common diagnosis in clinical practice but its nosological status has been subject to debate ever since it was conceptualized. Although it is key that diagnostic reliability is sufficient, schizoaffective disorder has been reported to have low interrater reliability. Evidence based on syst...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2016.07.012
更新日期:2016-10-01 00:00:00
abstract::The goal of this study was to determine if family burden experienced by the families of individuals with a recent-onset of schizophrenia is associated with whether the individual is able to work or attend school during the first year of treatment. Forty-one participants with a recent first episode of schizophrenia and...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.06.068
更新日期:2018-12-01 00:00:00
abstract::A literature review and power analysis of longitudinal studies published since 1997 investigating the trajectory of neurocognitive deficits across time in patients with schizophrenia was conducted. Ten studies were identified, evaluating a total of 834 patients with mean ages of 24.0-77.8 years at study entry. Power e...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2004.07.005
更新日期:2005-04-01 00:00:00