Abstract:
:Recent trials support the hypothesis of the role of inflammation in the pathogenesis of schizophrenia. The overall therapeutic benefit of anti-inflammatory medication, in particular cyclo-oxygenase-2 (COX-2) inhibitors in schizophrenia, is still controversial. There are suggestions that therapy with COX-2 inhibitors may influence the early stages of the disease. Taking these findings into account, we conducted a double-blind, placebo-controlled, randomized trial of celecoxib augmentation to amisulpride treatment in patients with a first manifestation of schizophrenia. Forty-nine patients diagnosed with schizophrenia were randomly assigned. They were treated either with amisulpride (200-1000 mg) plus celecoxib (400 mg) or amisulpride (200-1000 mg) plus placebo. Inclusion criterion was the diagnosis of schizophrenia during the past two years according to DSM-IV. The trial lasted six weeks. At weekly intervals an assessment of the psychopathology was performed using the Positive and Negative Symptom Scale (PANSS) and the Global Clinical Impression Scale (CGI). A significantly better outcome was observed in the patient group treated with amisulpride plus celecoxib compared to the group with amisulpride plus placebo (PANSS negative: p=0.03; PANSS global; p=0.05 and PANSS total: p=0.02). In addition, ratings by the CGI scale during therapy with amisulpride and celecoxib showed a significantly better result (p< or =0.001). A significantly superior therapeutic effect could be observed in the celecoxib group compared to placebo in the treatment of early stage schizophrenia. This is the first time an improvement in patients' negative symptoms has been demonstrated with celecoxib. In future, further trials are needed to investigate the effect of COX-2 inhibitors on prodromal and negative symptoms of schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Müller N,Krause D,Dehning S,Musil R,Schennach-Wolff R,Obermeier M,Möller HJ,Klauss V,Schwarz MJ,Riedel Mdoi
10.1016/j.schres.2010.04.015subject
Has Abstractpub_date
2010-08-01 00:00:00pages
118-24issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(10)01268-5journal_volume
121pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:Individuals with both physical and mental health problems may have elevated levels of emergency department (ED) service utilization either for index conditions or for associated comorbidities. This study examines the use of ED services by Medicaid beneficiaries with comorbid diabetes and schizophrenia, a dyad...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.12.002
更新日期:2014-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2017.01.005
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journal_title:Schizophrenia research
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doi:10.1016/j.schres.2006.04.013
更新日期:2006-10-01 00:00:00
abstract::Aim Research regarding the effect of antipsychotic medications on the risk of upper respiratory infection (URI) progression to pneumonia in patients with schizophrenia is rare. This study investigated the effect of antipsychotic use on the risk of URI progression to pneumonia in patients with schizophrenia. METHODS:T...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.05.013
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pub_type: 杂志文章
doi:10.1016/j.schres.2003.07.005
更新日期:2004-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2014.09.013
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.08.028
更新日期:2011-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.06.024
更新日期:2008-10-01 00:00:00
abstract::Astrocytic markers glial fibrillary acidic protein (GFAP) and connexin 43 (CX43) are known to have altered expression in brains of subjects with psychiatric disorders including autism and major depression. The current study investigated whether GFAP and CX43 expressions are affected by several commonly used psychotrop...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.05.016
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2009-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(94)00034-6
更新日期:1995-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.08.022
更新日期:2020-01-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.04.007
更新日期:2018-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/S0920-9964(03)00049-5
更新日期:2004-07-01 00:00:00
abstract::We investigated the relationship between the P300, neuropsychological test performance and symptomatology in recent-onset schizophrenic patients (n = 45) to gain insight into underlying mechanisms of abnormal P300 in schizophrenia. The P300 was recorded in two sessions with an intermission of five minutes, at the midl...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(01)00184-0
更新日期:2002-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00045-6
更新日期:1999-11-30 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.07.025
更新日期:2006-12-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2010.10.016
更新日期:2011-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.04.027
更新日期:2009-07-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.11.030
更新日期:2008-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/s0920-9964(01)00227-4
更新日期:2002-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.07.001
更新日期:2012-09-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.06.028
更新日期:2016-10-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
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更新日期:2020-02-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.01.007
更新日期:2018-07-01 00:00:00
abstract::Schizophrenia is a complex disorder that is diagnosed mainly with clinical observation and evaluation. Recent studies suggest that many people with schizophrenia have abnormalities in the function of the N-methyl-d-aspartate receptor (NMDAR). The retina is part of the central nervous system and expresses the NMDAR, ra...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.09.005
更新日期:2020-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.03.016
更新日期:2019-07-01 00:00:00
abstract::Vulnerability-stress models suggest that training in specific stress management techniques should yield benefits to those suffering from schizophrenia and related disorders. In this paper, we describe an evaluation of the impact of adding a stress management program to other medical and psychosocial interventions for ...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0920-9964(01)00371-1
更新日期:2002-12-01 00:00:00
abstract::Many children of a schizophrenic parent may inherit a portion of the genetic risk factors for schizophrenia. The frequency of DSM-IV psychopathology in children of a schizophrenic parent and the frequency and type of mental health treatment accessed by these youths is not well understood. Twenty-eight adults with schi...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(00)00043-8
更新日期:2001-05-30 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2015.03.025
更新日期:2015-05-01 00:00:00