Abstract:
BACKGROUND:In randomized controlled trials of antipsychotics, various cutoffs have been used to define response on continuous outcome measures. AIMS:To find a summary effect measure that remains constant across different definitions of response. METHOD:We conducted secondary analyses of individual patient data from 10 randomized controlled trials of second-generation antipsychotics for schizophrenia (n=4278) by applying a meta-analytic approach to produce odds ratios (OR), risk ratios (RR) and risk differences (RD) and their 95% confidence intervals (CI) for different definitions of response, using cutoffs of 10% through 90% reduction on the symptom severity rating scales. Constancy of these indices was examined through visual inspection, by way of I-squared statistics to quantify heterogeneity, and by way of coefficients of variation. If any of these indices were found to remain reasonably constant, we next examined the concordance between the number needed to treat (NNT) predicted from them and the observed NNT. RESULTS:OR and RR remained reasonably constant across various definitions of response, especially for those using thresholds of 10% through 70% reduction. The NNTs predicted from OR and RR agreed well with the observed NNTs, with ANOVA intraclass correlation coefficients of 0.96 (95% CI: 0.92 to 0.98) and 0.86 (0.72 to 0.93), respectively. CONCLUSIONS:The relative measures of treatment effectiveness remain reasonably constant across different scale-derived definitions of response and, in conjunction with varying control event rates, can give accurate estimates of NNTs for individuals with schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Furukawa TA,Akechi T,Wagenpfeil S,Leucht Sdoi
10.1016/j.schres.2010.10.016subject
Has Abstractpub_date
2011-03-01 00:00:00pages
212-9issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(10)01591-4journal_volume
126pub_type
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pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2015.10.026
更新日期:2015-12-01 00:00:00
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doi:10.1016/j.schres.2009.04.027
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pub_type: 传,历史文章,杂志文章
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pub_type: 杂志文章
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journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2011.09.016
更新日期:2011-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2006.04.025
更新日期:2006-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2016.10.020
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.schres.2018.01.019
更新日期:2018-07-01 00:00:00
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pub_type: 杂志文章,meta分析
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