Abstract:
OBJECTIVE:Blockade of dopamine D₂ receptors with antipsychotics above 65% is associated with optimal chance of clinical response although recent data suggest a lower threshold for the maintenance treatment of schizophrenia. The objective of this study was to prospectively examine whether such continuous high blockade would be necessary for maintenance treatment. METHOD:In this single-blind, 52-week, randomized controlled trial, clinically stable patients with schizophrenia receiving risperidone or olanzapine were randomly assigned to the continuous D₂ blockade (i.e. an estimated trough D2 blockade of >65%) or non-continuous blockade group (i.e. an estimated peak level of >65% with an estimated trough level of <65%). Oral doses corresponding to the assigned blockade levels were estimated from random plasma drug concentrations, using the models we developed; antipsychotic doses were then adjusted accordingly. Psychopathology and side effects were assessed at baseline and one year with the Positive and Negative Syndrome Scale (PANSS), Simpson-Angus Scale (SAS), and Abnormal Involuntary Movement Scale (AIMS). RESULTS:Sixty-eight subjects (34 in each group) were enrolled. Twenty-six (76.5%) and thirty-one (91.2%) subjects completed the study in the continuous and non-continuous blockade groups, respectively, without any significant group difference. No significant differences were found on any of the assessment scales between the two groups. The degree of dosage change was small in both groups. CONCLUSION:These results offer support that the threshold for D₂ receptor blockade in the maintenance treatment can be lower than 65%. However, these preliminary findings have to be confirmed through double-blind, larger scale trials with longer follow-up periods.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Tsuboi T,Suzuki T,Bies RR,Remington G,Pollock BG,Mimura M,Uchida Hdoi
10.1016/j.schres.2015.03.025subject
Has Abstractpub_date
2015-05-01 00:00:00pages
149-54issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(15)00162-0journal_volume
164pub_type
杂志文章,随机对照试验abstract:OBJECTIVE:To examine the effect of diagnosis, mood state, and anxiety on subjective wellbeing in patients with affective and non-affective psychotic disorders treated with quetiapine IR. METHODS:2175 patients with schizophrenia-spectrum (SZ, n=1681), schizoaffective (SA, n=249), and bipolar disorder (BPD, n=245) were ...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章
doi:10.1016/j.schres.2009.03.004
更新日期:2009-05-01 00:00:00
abstract::Patients with schizophrenia demonstrate a variety of attentional impairments which have proven difficult to relate to specific neural systems. Posner et al. (1988) reported an asymmetric slowing of right visual field orienting in schizophrenia similar to that observed in patients with parietal lesions. We examined the...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(92)90013-u
更新日期:1992-09-01 00:00:00
abstract:OBJECTIVE:To examine childhood ADHD symptoms in regard to their association with a number of illness-related variables including risk factors, early neurodevelopment, premorbid functioning and clinical characteristics in patients with schizophrenia-spectrum psychoses. METHODS:One-hundred and twenty-two first-episode p...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.09.010
更新日期:2011-03-01 00:00:00
abstract::Astrocytes regulate multiple processes in the brain ranging from trophic support of developing neurons to modulation of synaptic neurotransmission and neuroinflammation in adulthood. It is, therefore, understandable that pathogenesis and pathophysiology of major psychiatric disorders involve astrocyte dysfunctions. Un...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2014.10.044
更新日期:2016-09-01 00:00:00
abstract::A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairm...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.schres.2012.01.042
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:Strategic and mnemonic abilities of person with schizophrenia (SCZ) were studied using a part-list cuing (PLC) task. In this task, presentation of retrieval cues in the form of a subset of studied words typically impairs recall of the remaining items. This impairment is thought to reflect a disruption of partic...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.03.001
更新日期:2006-07-01 00:00:00
abstract::T1 and T2 relaxation times were measured in ten brain regions on the right and left side in a sample of 27 schizophrenic patients and 37 normal controls. The schizophrenic patients showed a prolongation of T2 relaxation time, and to a lesser extent of T1 relaxation time, which was more predominantly localized in the r...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(91)90080-b
更新日期:1991-10-01 00:00:00
abstract::An accumulating body of literature supports the notion that psychotic-like experiences (PLEs) may occur as a continuous phenotype. However, researchers are still working to determine if these events accompany an underlying continuum of neurobiological vulnerability as well. Within this context, it is notable that spon...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.06.028
更新日期:2011-11-01 00:00:00
abstract::Fragile X mental retardation protein (FMRP) is an RNA binding protein with 842 target mRNAs in mammalian brain. Silencing of the fragile X mental retardation 1 (FMR1) gene leads to loss of expression of FMRP and upregulated metabotropic glutamate receptor 5 (mGluR5) signaling resulting in the multiple physical and cog...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.04.012
更新日期:2015-07-01 00:00:00
abstract:INTRODUCTION:There is mixed evidence about emotional processing abnormalities in schizophrenia and schizoaffective disorder, with self-reports and clinician ratings indicating significant differences between patients and controls, but studies of in-the-moment, self-reported emotional experience finding only small diffe...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2019.07.013
更新日期:2019-09-01 00:00:00
abstract::Early intervention strategies in psychosis would significantly benefit from the identification of reliable prognostic biomarkers. Pattern classification methods have shown the feasibility of an early diagnosis of psychosis onset both in clinical and familial high-risk populations. Here we were interested in replicatin...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.08.061
更新日期:2019-12-01 00:00:00
abstract::Childhood trauma is a risk factor for the onset of schizophrenic psychosis. Because the psychosis phenotype can be described as a continuum with varying levels of severity and persistence, childhood trauma might likewise increase the risk for psychotic experiences below the diagnostic threshold. But the impact of stre...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.02.006
更新日期:2016-04-01 00:00:00
abstract::Estrogen has been shown in animal studies to modulate both the dopamine and serotonin neurotransmitter systems - the main neurotransmitters implicated in the pathogenesis of schizophrenia. A double blind, 28 day, placebo-controlled study was conducted with three groups of women of child-bearing age (N=12 in each group...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0920-9964(00)00088-8
更新日期:2001-03-01 00:00:00
abstract::Accumulating evidence showed that interleukin-2 (IL-2) may be involved in the pathophysiology of schizophrenia. Increased IL-2 levels have been found in the serum of schizophrenia patients with mixed results. In the present study, we assessed serum IL-2 levels in a large group of 160 schizophrenia patients compared to...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.10.038
更新日期:2015-12-01 00:00:00
abstract::To clarify the molecular mechanism of phencyclidine (PCP)-induced schizophreniform psychosis in humans and of behavioral abnormalities in experimental animals, we used differential screening of a cDNA library from the cerebral cortex of rats treated with PCP. We identified a PCP-induced cDNA clone as the gene encoding...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(97)00029-7
更新日期:1997-06-20 00:00:00
abstract:BACKGROUND:Gamma-aminobutyric acid (GABA) dysfunction and its consequent imbalance are implicated in the pathophysiology of schizophrenia. Reduced GABA production would lead to a disinhibition of glutamatergic neurons and subsequently cause a disruption of the modulation between GABAergic interneurons and glutamatergic...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.07.021
更新日期:2018-03-01 00:00:00
abstract::In order to investigate a possible relationship between schizophrenic births and viral diseases, the birth month and year of all state hospital admissions for schizophrenia in Connecticut and Massachusetts from 1973-1974 were compared with the occurrence of reportable viral diseases for 1920-1955. Data was statistical...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(88)90043-6
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:Our previous lipidomics studies demonstrated elevated sulfatides, plasmalogens, and N-acylphosphatidylserines in the frontal cortex of schizophrenia subjects. These data suggest that there may be an abnormal function of glycosynapses in schizophrenia. We further examined the disease and anatomical specificit...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.05.017
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:Functional remission (FR) is an intermediate and necessary step toward recovery, but is understudied in first-episode psychosis (FEP). We aimed to examine the rate and predictors of FR in FEP patients in the context of a randomized-controlled trial (RCT) comparing a 1-year extension of early intervention (Ex...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2016.03.016
更新日期:2016-05-01 00:00:00
abstract::Despite the notion that increases in functioning should be associated with increases in life satisfaction in schizophrenia, research has often found no association between the two. Dual change models of global and domain-specific life satisfaction and functioning were examined in 145 individuals with schizophrenia rec...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.04.014
更新日期:2012-08-01 00:00:00
abstract::Apolipoprotein D (apoD) is a member of the lipocalin superfamily of transporter proteins that bind small hydrophobic molecules, including arachidonic acid (AA). The ability of apoD to bind AA implicates it in pathways associated with membrane phospholipid signal transduction and metabolism. Recent findings of an incre...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.05.007
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Childhood and adolescence represent the periods during which hallucinatory experiences occur at the greatest prevalence, and also constitute a critical window of vulnerability for the pathogenesis of psychotic disorders. The longitudinal course of hallucinatory experiences during late childhood and adolescen...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2012.03.012
更新日期:2012-07-01 00:00:00
abstract::The distribution of schizophrenia in families supports the hypothesis of heritable risk factors in schizophrenia, but there is as yet no identification of an inherited neurobiological defect. Human embryonic brain tissue fragments, derived from first trimester abortions, can be transplanted into rat hosts, where they ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(94)90051-5
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Despite the effectiveness of anti-psychotic pharmacotherapy, residual hallucinations and delusions do not completely resolve in some medicated patients. Additional cognitive behavioral therapy (CBT) seems to improve the management of positive symptoms. Despite promising results, the efficacy of CBT is still ...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析
doi:10.1016/j.schres.2005.02.018
更新日期:2005-09-01 00:00:00
abstract::Family members of first-episode psychosis (FEP) patients are regarded as key components of the patient's evaluation, recovery and treatment. This paper aimed to investigate 75 FEP caregivers' appraisal, psychological morbidity and quality of life in the initial phase of treatment in a specialized FEP outpatient progra...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2012.03.014
更新日期:2012-07-01 00:00:00
abstract::The effects of gut microbiota on the central nervous system, along its possible role in mental disorders, have received increasing attention. Here we investigated differences in fecal microbiota between 28 patients with first-episode psychosis (FEP) and 16 healthy matched controls and explored whether such differences...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.04.017
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:Reduced procreation among men with schizophrenia has been reported consistently when compared with female patients, but the cause is unknown. Reports on Caucasian individuals predominate in the published literature. Therefore, analyses were conducted concurrently among independent Indian and US samples in the...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2003.08.009
更新日期:2004-06-01 00:00:00
abstract::Stigma may undermine the well-being of young people at risk of psychosis. We therefore measured self-labeling, stigma variables and well-being at baseline and again one year later among 77 at-risk participants. An increase in self-labeling during this period predicted heightened stigma stress after one year and a decr...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.07.016
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:Examine the association between sedentary behavior and psychiatric symptoms among overweight and obese adults with schizophrenia or schizoaffective disorders (SZO/SA). DESIGN:Randomized clinical trial; Weight Assessment and Intervention in Schizophrenia Treatment (WAIST) Study: baseline data collected 2005-2...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2013.01.010
更新日期:2013-04-01 00:00:00
abstract::Studies of neurocognitive function in patients with schizophrenia use widely variable assessment techniques. Clinical trials assessing the cognitive enhancing effect of new medications have used neurocognitive assessment batteries that differed in content, length and administration procedures. The Brief Assessment of ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2003.09.011
更新日期:2004-06-01 00:00:00