Abstract:
BACKGROUND:Despite the effectiveness of anti-psychotic pharmacotherapy, residual hallucinations and delusions do not completely resolve in some medicated patients. Additional cognitive behavioral therapy (CBT) seems to improve the management of positive symptoms. Despite promising results, the efficacy of CBT is still unclear. The present study addresses this issue taking into account a number of newly published controlled studies. METHOD:Fourteen studies including 1484 patients, published between 1990 and 2004 were identified and a meta-analysis of their results performed. RESULTS:Compared to other adjunctive measures, CBT showed significant reduction in positive symptoms and there was a higher benefit of CBT for patients suffering an acute psychotic episode versus the chronic condition (effect size of 0.57 vs. 0.27). DISCUSSION:CBT is a promising adjunctive treatment for positive symptoms in schizophrenia spectrum disorders. However, a number of potentially modifying variables have not yet been examined, such as therapeutic alliance and neuropsychological deficits.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Zimmermann G,Favrod J,Trieu VH,Pomini Vdoi
10.1016/j.schres.2005.02.018subject
Has Abstractpub_date
2005-09-01 00:00:00pages
1-9issue
1eissn
0920-9964issn
1573-2509pii
S0920-9964(05)00084-8journal_volume
77pub_type
杂志文章,meta分析abstract::Individuals with schizophrenia have difficulties in emotional information processing. A relationship between behavioral variables of emotional processing and structural amygdala alterations in schizophrenia has been proposed but not shown, yet. Morphological studies of amygdala size in schizophrenia have yielded incon...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2004.02.023
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Negative symptoms are a core feature of schizophrenia. The evolution and trajectory of primary negative symptoms were under-studied. We aimed at evaluating the prevalence and stability of primary negative symptoms, and factors associated with persistent primary negative symptoms in a first-episode sample. M...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2011.09.006
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:While poor premorbid functioning is associated with poorer outcomes in psychotic illnesses, little is known about whether it is also a risk factor for suicide attempts. OBJECTIVE:The current study examined the association of premorbid functioning and suicide attempts in a county-wide cohort of first-admissi...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.11.005
更新日期:2010-02-01 00:00:00
abstract::Prior studies of mRNA expression, protein expression, and pathway metabolite levels have implicated dysregulation of the kynurenine pathway in the etiology of schizophrenia and bipolar disorder. Here we investigate whether genes involved in kynurenine pathway regulation might interact with genes that respond to kynure...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2009.05.014
更新日期:2009-09-01 00:00:00
abstract::Studies of neurocognitive function in patients with schizophrenia use widely variable assessment techniques. Clinical trials assessing the cognitive enhancing effect of new medications have used neurocognitive assessment batteries that differed in content, length and administration procedures. The Brief Assessment of ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2003.09.011
更新日期:2004-06-01 00:00:00
abstract::Schizophrenia is a heterogeneous spectrum disorder often associated with detrimental negative symptoms. In recent years, computational approaches to psychiatry have attracted growing attention. Negative symptoms have shown some overlap with general cognitive impairments and were also linked to impaired motivational pr...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2016.10.004
更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:Diffusion tensor imaging (DTI) studies in patients with schizophrenia have shown abnormalities in the microstructure of white matter tracts. Specifically, reduced fractional anisotropy (FA) has been described across multiple white matter tracts, in studies that have mainly included patients treated with an...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.01.019
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Cognitive Remediation (CR) is an evidence based treatment targeting cognitive and functional difficulties in people with psychosis. Despite the large number of effectiveness studies, only limited evidence exists for the active ingredients of this therapy. This study begins to fill this gap by exploring the r...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2017.09.012
更新日期:2019-01-01 00:00:00
abstract::Three-channel actometry was used to study neuroleptic-induced akathisia (NIA), a common and often serious disorder in association of traditional neuroleptic therapy. The aim was to explore the diagnostic possibilities of actometry in NIA and to examine in detail the motor phenomenology of the disorder in detail. The a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00045-6
更新日期:1999-11-30 00:00:00
abstract::The incidence of cancer was studied in a cohort of all first admitted 9156 patients in Denmark with a diagnosis of schizophrenia in the period 1970-1987. The overall incidence of cancer was reduced particularly in the males. Adjustment for the smoking habits of psychiatric patients enhanced this risk reduction. Fewer ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(94)90028-0
更新日期:1994-06-01 00:00:00
abstract::The dopamine hypothesis of schizophrenia was formulated 30 years ago and postulates that the symptoms of schizophrenia are related to an increased central dopaminergic neurotransmission. The two fundamental assumptions that underlay the dopamine hypothesis of schizophrenia have received support from brain imaging stud...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(97)00121-7
更新日期:1997-12-19 00:00:00
abstract::Procedural learning (PL) is a type of rule-based learning in which performance facilitation occurs with practice on task without the need for conscious awareness. Schizophrenic patients have often (though not invariably) been found to show impaired PL. We performed functional magnetic resonance imaging (fMRI) during a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(01)00270-5
更新日期:2002-09-01 00:00:00
abstract::The functional integrity of the dorsolateral prefrontal cortex (DLPFC) is altered in schizophrenia leading to profound deficits in working memory and cognition. Growing evidence indicates that dysregulation of glutamate signaling may be a significant contributor to the pathophysiology mediating these effects; however,...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.09.022
更新日期:2007-12-01 00:00:00
abstract::Evidence validating the influence of the cytochrome P450 (CYP) 2D6 and 2C19 enzymes genetic polymorphisms in the response to antipsychotics is scarce. We examined the hypothesis that a higher prevalence of CYP2D6 and/or CYP2C19 ultra rapid metabolizers might be found among refractory schizophrenia patients. Three grou...
journal_title:Schizophrenia research
pub_type: 信件
doi:10.1016/j.schres.2015.08.002
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Self-referential processing (i.e. linking internal and external stimuli to one's own self) has received scant attention thus far in schizophrenia. This type of processing is a key component of social cognition and thought to be important for adaptive social functioning. Memory studies in healthy subjects hav...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.11.011
更新日期:2011-04-01 00:00:00
abstract::Schizoaffective patients can have neurocognitive deficits and default mode network dysfunction while being acutely ill. It remains unclear to what extent these abnormalities persist when they go into clinical remission. Memory and executive function were tested in 22 acutely ill schizoaffective patients; they also und...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.08.017
更新日期:2014-11-01 00:00:00
abstract::Negative symptoms can be grouped into the two dimensions of diminished expression and apathy, which have been shown to be dissociable regarding external validators, such as functional outcome. Here, we investigated whether these two dimensions differentially relate to neurocognitive impairment in schizophrenia. 47 pat...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.10.032
更新日期:2015-12-01 00:00:00
abstract::Individuals with schizophrenia have very high rates of cigarette smoking, and much has been discovered about the influence of nicotine on brain functioning in schizophrenia. However, less is understood about the relationship between nicotine consumption and milder phenotypes related to schizophrenia, specifically schi...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.08.024
更新日期:2007-12-01 00:00:00
abstract::Systematic linkage disequilibrium (LD) mapping of 8p12-21 in the Icelandic population identified neuregulin 1 (NRG1) as a prime candidate gene for schizophrenia. However, results of replication studies have been inconsistent, and no large sample analyses have been reported. Therefore, we designed this study with the a...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.01.010
更新日期:2008-04-01 00:00:00
abstract::The finding of pyramidal cell disarray in the hippocampus of patients with schizophrenia has been disputed by several groups. Conflicting results have been attributed to differences in the subtype of patients used, staining method, the side of the hippocampus studied and the way cellular disarray has been measured. In...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(01)00201-8
更新日期:2002-05-01 00:00:00
abstract::Persistent cannabis use among young adults with first episode psychosis (FEP), even those receiving early intervention services, has been associated with poor outcomes. In the United States (US), Coordinated Specialty Care (CSC) has been shown to be more effective at reducing symptoms, improving quality of life and in...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2020.05.035
更新日期:2020-08-01 00:00:00
abstract::This study determines that visuospatial working memory (VSWM) deficits are evident in adolescent-onset schizophrenia, while the spatial strategy and spatial span components of VSWM are spared. These findings imply that frontal-striatal-parietal neural networks are dysfunctional in adolescent-onset schizophrenia, while...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.04.025
更新日期:2006-10-01 00:00:00
abstract:PURPOSE:Studies show that deficit syndrome schizophrenia patients, characterized by primary negative symptoms and poor functional outcome, have impairment in specific neural circuits. We assessed whether these same neural circuits are directly linked to functional outcomes across schizophrenia patients. METHODS:T1- an...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.10.023
更新日期:2015-12-01 00:00:00
abstract::The distribution of schizophrenia in families supports the hypothesis of heritable risk factors in schizophrenia, but there is as yet no identification of an inherited neurobiological defect. Human embryonic brain tissue fragments, derived from first trimester abortions, can be transplanted into rat hosts, where they ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(94)90051-5
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Bullying victimisation has been suggested to contribute to paranoid ideation in general population samples and recent evidence found that individuals with an ultra high risk (UHR) for psychosis are twice as likely to have been bullied than controls. AIMS:This study sought to examine whether a history of bul...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.08.029
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:There is increased interest in the impact of new long-acting treatments on health-related quality of life (HRQoL) in patients with schizophrenia. The aim of this study was to evaluate the impact of treatment with subcutaneous injections of RBP-7000, a new sustained-release formulation of risperidone, compare...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.schres.2016.03.020
更新日期:2016-07-01 00:00:00
abstract::Recent studies of cerebral pathology in patients with schizophrenia have focused on symptomatological and electrophysiological correlates of reduced temporal lobe structure volumes. Volume deficits of the left superior temporal gyrus have been correlated with auditory hallucinations as well as to left-sided P300 ampli...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00006-7
更新日期:1999-08-17 00:00:00
abstract::The first phase of the Consortium on the Genetics of Schizophrenia (COGS-1) showed performance deficits in learning and memory on the California Verbal Learning Test, Second Edition (CVLT-II) in individuals with schizophrenia (SZ), compared to healthy comparison subjects (HCS). A question is whether the COGS-1 study, ...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2014.10.029
更新日期:2015-04-01 00:00:00
abstract::The right shift (RS) theory (Annett, M., 1972. The distribution of manual asymmetry. Br. J. Psychol. 63, 343-358; Annett, M., 1985. Left, Right, Hand and Brain: The Right Shift Theory. Lawrence Erlbaum, London) suggests that the typical pattern of human cerebral and manual asymmetries depends on a single gene (RS+) wh...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(99)00072-9
更新日期:1999-10-19 00:00:00
abstract::Affective impairments were examined in patients with and without deficit syndrome schizophrenia. Two Emotional Stroop tasks designed to measure automatic processing of emotional information were administered to deficit (n=15) and non-deficit syndrome (n=26) schizophrenia patients classified according to the Schedule f...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.01.014
更新日期:2008-07-01 00:00:00