Abstract：
:Long-stay patients constitute a small proportion of all patients with schizophrenia, but in both VA and state psychiatric systems these patients account for a majority of the costs associated with treatment of the illness. VA and state patients would be expected to differ in several respects, including age at onset and premorbid educational status. Little additional information is available about the differences between these samples. Seventy-four long-stay male patients at a chronic state psychiatric center were compared with 50 male veterans from long-stay psychiatric facilities on positive and negative symptoms, cognitive deficits and functional status. The two samples did not differ on positive symptom severity, but the state patients had more severe negative and cognitive symptoms as well as functional deficits. Of all of the variables measured, deficit in self care was the only variable that entered a stepwise discriminant analysis. The correlation between functional and symptomatic variables was the same in both groups, and the group differences and correlations were not influenced by differences in educational status. These data indicate that VA patients may have reduced severity of functional and cognitive impairments relative to state hospital patients, but that the relationship between the different illness variables was similar in the two groups.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Harvey PD,Jacobsen H,Mancini D,Parrella M,White L,Haroutunian V,Davis KLdoi
10.1016/s0920-9964(99)00182-6subject
Has Abstractpub_date
2000-05-25 00:00:00pages
3-9issue
1eissn
0920-9964issn
1573-2509pii
S0920-9964(99)00182-6journal_volume
43pub_type
杂志文章abstract：:Patients with schizophrenia did not take significantly more trials than normal controls to learn to use a visual warning signal to avoid a non-aversive stimulus on a simple computer-administered avoidance learning task. When the stimulus to be avoided was aversive (i.e., a loud buzzer), however, the schizophrenic grou...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00181-9
更新日期：1999-07-27 00:00:00
abstract：:A review of 65 studies of individuals with schizophrenia who had never been treated with antipsychotic medications indicates significant abnormalities in brain structure and function. Neurological and neuropsychological measures show the most consistent and largest group differences between those affected and normal c...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/s0920-9964(02)00381-x
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:Depressive symptoms frequently accompany schizophrenia. Older patients constitute the fastest growing segment of the schizophrenia population. With regard to the risk factors associated with depression, it is uncertain to which extent older schizophrenia patients differ from their age peers in the community....
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.05.002
更新日期：2014-08-01 00:00:00
abstract：:Interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha and the soluble interleukin-2 receptor were measured in the serum of 34 healthy controls and 48 patients with chronic schizophrenia using ELISA sandwich assays. No differences were found between the controls and patients. ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00089-5
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:Working memory deficits represent a core feature of schizophrenia. These deficits have been associated with dysfunctional dorsolateral prefrontal cortex (DLPFC) cortical oscillations. Theta-gamma coupling describes the modulation of gamma oscillations by theta phasic activity that has been directly associate...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.01.044
更新日期：2017-11-01 00:00:00
abstract：:We have previously reported aberrations in the striatal presynaptic dopamine function in neuroleptic-naive schizophrenic patients compared to healthy controls (Hietala, J., Syvälahti, E., Vuorio, K. et al., 1995. Lancet 346, 1130-1131). In this extended study we explore whether the altered presynaptic dopamine functio...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00113-3
更新日期：1999-01-04 00:00:00
abstract：:Frontal lobe dysfunction in individuals with schizophrenia has frequently been detected using both neuroimaging and neuropsychological testing. Results from previous studies vary in the findings of regional specificity vs. generalized frontal cortical dysfunction. We sought to examine potential regional differences in...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/S0920-9964(03)00086-0
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Heterogeneity in clinical outcomes may be caused by factors working at multiple levels, e.g., between groups, between subjects, or within subjects over time. A more nuanced assessment of differences in variation among schizophrenia patients and between patients and healthy comparison subjects can clarify eti...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.10.033
更新日期：2013-01-01 00:00:00
abstract：:Epidemiological studies often use age-of-first-admission from psychiatric case registers to estimate age-of-onset in schizophrenia. Retrospective, interview-based methods have shown that there is a delay between onset of symptoms and eventual contact with psychiatric services, and that this delay can vary both among i...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(95)00087-9
更新日期：1996-05-01 00:00:00
abstract：:This study tested the hypothesis that maternal exposure to terror attacks during pregnancy is associated with the risk of schizophrenia in the offspring. A population-based study was conducted of Israeli children born between 1975 and 1995 and that were registered in the Ministry of Interior and followed up in the Min...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.04.024
更新日期：2018-09-01 00:00:00
abstract：:Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.050
更新日期：2016-11-01 00:00:00
abstract：:Second generation antipsychotics cause derangements in glucose metabolism that are often interpreted as insulin resistance. In previous studies we have shown that this is not classical insulin resistance but the drugs were actually inducing a hyperglycaemic state associated with elevated hepatic glucose output (HGO) a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.05.003
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE(S):To characterize the longitudinal patterns of antipsychotic treatment and to investigate the relationship between antipsychotic treatment patterns and acute hospitalizations among adults with schizophrenia. We hypothesized that continuous antipsychotic treatment would be associated with fewer hospitalizatio...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.12.475
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:For adults with schizophrenia, comorbidity is common and contributes to impairment. Thus, there has been an increasing effort to identify and treat comorbid symptoms. This report extends that work by examining comorbidity in children and young adolescents with childhood-onset schizophrenia. METHODS:Eighty-t...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.07.006
更新日期：2006-12-01 00:00:00
abstract：:Research suggests that social stress exposure influences illness presentation and course among youth at clinical high-risk (CHR) for psychosis, though less is known about the extent to which self-reported perceptions of social stress relate to the severity of positive symptoms. Importantly, despite the notion that you...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.06.002
更新日期：2018-02-01 00:00:00
abstract：:Within 1 year of severe trauma to the left anterior temporal lobe and minor injury to the frontal lobes, a 35-year-old individual developed classic positive and negative symptoms of schizophrenia. His antipsychotic drug-induced parkinsonism was greater on the left side, suggesting increased left striatal dopaminergic ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00152-4
更新日期：2002-12-01 00:00:00
abstract：:Glutamate transporters facilitate the buffering, clearance and cycling of glutamate and play an important role in maintaining synaptic and extrasynaptic glutamate levels. Alterations in glutamate transporter expression may lead to abnormal glutamate neurotransmission contributing to the pathophysiology of schizophreni...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.12.019
更新日期：2013-03-01 00:00:00
abstract：:It is now well established that the utilization of standardized clinical criteria can enhance prediction of psychosis. These criteria are primarily concerned with the presence and severity of attenuated positive symptoms. Because these symptom criteria are used to derive algorithms for designating clinical high risk (...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2015.04.035
更新日期：2015-08-01 00:00:00
abstract：:The accuracy of the WAIS-R seven subtest short form (Ward, L.C., 1990. Prediction of Verbal, Performance and Full Scale IQs from seven subtests of the WAIS-R. J. Clin. Psychol. 46, 436-440) was examined for predicting IQs of 73 inpatients diagnosed with schizophrenia. Results indicated that 93% of the estimated Full S...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00016-x
更新日期：1999-08-23 00:00:00
abstract：BACKGROUND:Eye movement abnormalities have been identified in schizophrenia; however, their relevance to cognition is still unknown. In this study, we explored the general relationship between eye movements and cognitive function. METHODS:The three eye movement measures (scanpath length, horizontal position gain, and ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.12.051
更新日期：2019-07-01 00:00:00
abstract：:A motivation is a telling hallmark of negative symptomatology in schizophrenia, and it impacts nearly every facet of behavior, including inclination to attempt the difficult cognitive tasks involved in cognitive remediation therapy. Experiences of external reward, reinforcement, and hedonic anticipatory enjoyment are ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.08.001
更新日期：2010-05-01 00:00:00
abstract：:Individuals with schizophrenia have very high rates of cigarette smoking, and much has been discovered about the influence of nicotine on brain functioning in schizophrenia. However, less is understood about the relationship between nicotine consumption and milder phenotypes related to schizophrenia, specifically schi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.08.024
更新日期：2007-12-01 00:00:00
abstract：:Schizophrenia is associated with structural brain abnormalities that are likely to be present before disease onset. It remains unclear to what extent these represent general vulnerability indicators or are associated with the developing clinical state itself. It also remains unclear whether such state or trait alterat...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.12.003
更新日期：2016-06-01 00:00:00
abstract：:Persistent cannabis use among young adults with first episode psychosis (FEP), even those receiving early intervention services, has been associated with poor outcomes. In the United States (US), Coordinated Specialty Care (CSC) has been shown to be more effective at reducing symptoms, improving quality of life and in...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2020.05.035
更新日期：2020-08-01 00:00:00
abstract：:Brain abnormalities have been identified in patients with schizophrenia, but what is unclear is whether these changes are progressive over the course of the disorder. In this longitudinal study, hippocampal and temporal lobe volumes were measured at two time points in 30 patients with first episode psychosis (mean fol...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00175-x
更新日期：2001-10-01 00:00:00
abstract：:The presence of delusions is considered a key feature of psychosis, but despite the psychopathological centrality of the concept of delusion, its definition and comprehension is a matter of continuing debate. In recent years studies showing that delusions are common in the general population have accumulated and chall...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2019.10.043
更新日期：2020-02-01 00:00:00
abstract：:Motivational deficits in patients with schizophrenia adversely affect various domains of daily living. This symptom in everyday life situations manifests in a complex behavioral pattern whose root cannot be simplified to an impaired reward-motivation scheme. This study aimed to identify impairment of the salience netw...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.01.019
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:The Heinrichs-Carpenter Quality of Life Scale (QLS) is the most extensively used real-world community functioning scale in schizophrenia research. However, the extensive time required to administer it and the inclusion of items that overlap conceptually with negative symptoms limit its use across studies. Th...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.02.013
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND:Clinical guidelines recommend maintenance treatment with antipsychotic medication for one to two years following remission of symptoms after a first episode of psychosis. However, recent research has suggested that this may not be indicated. Consistent predictors of outcome would be beneficial to guide clini...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.11.010
更新日期：2018-07-01 00:00:00
abstract：:High exposure to green space and natural environments has previously been associated with lower schizophrenia rates possibly through low air pollution and improved psychological restoration. Exposure to natural environments could explain the negative urban-rural gradient of schizophrenia, but it is unclear if all natu...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.10.012
更新日期：2020-02-01 00:00:00
