Abstract：
BACKGROUND:Working memory deficits represent a core feature of schizophrenia. These deficits have been associated with dysfunctional dorsolateral prefrontal cortex (DLPFC) cortical oscillations. Theta-gamma coupling describes the modulation of gamma oscillations by theta phasic activity that has been directly associated with the ordering of information during working memory performance. Evaluating theta-gamma coupling may provide greater insight into the neural mechanisms mediating working memory deficits in this disorder. METHODS:Thirty-eight patients diagnosed with schizophrenia or schizoaffective disorder and 38 healthy controls performed the verbal N-Back task administered at 4 levels, while EEG was recorded. Theta (4-7Hz)-gamma (30-50Hz) coupling was calculated for target and non-target correct trials for each working memory load. The relationship between theta-gamma coupling and accuracy was determined. RESULTS:Theta-gamma coupling was significantly and selectively impaired during correct responses to target letters among schizophrenia patients compared to healthy controls. A significant and positive relationship was found between theta-gamma coupling and 3-Back accuracy in controls, while this relationship was not observed in patients. CONCLUSIONS:These findings suggest that impaired theta-gamma coupling contribute to working memory dysfunction in schizophrenia. Future work is needed to evaluate the predictive utility of theta-gamma coupling as a neurophysiological marker for functional outcomes in this disorder.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Barr MS,Rajji TK,Zomorrodi R,Radhu N,George TP,Blumberger DM,Daskalakis ZJdoi
10.1016/j.schres.2017.01.044subject
Has Abstractpub_date
2017-11-01 00:00:00pages
104-110eissn
0920-9964issn
1573-2509pii
S0920-9964(17)30057-9journal_volume
189pub_type
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