Abstract:
:Cognitive deficits have been recognized as a core feature of schizophrenia (SZ) and are present in most patients. Verbal memory (VM), working memory (WM), and executive function (EF) are domains commonly impaired in patients with SZ. These latter domains have been related to the genetic risk of the disorder characterizing as possible endophenotypes. In order to study neurocognitive endophenotypes in a Brazilian population with elevated genetic risks to develop SZ, we measured VM (Hopkins Verbal Learning Test Revised), WM (Letter-Number Sequencing and Digit Span) and EF (Stroop Test) in 90 subjects (45 unaffected siblings of patients with SZ and 45 matched healthy controls). No differences were found in EF and WM (Letter-Number Sequencing and Digit Span). However, in VM, siblings of patients performed worse than controls on the immediate recall and delayed recall. Our results suggest that VM impairment could be considered an endophenotype of SZ.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Massuda R,Bücker J,Czepielewski LS,Narvaez JC,Pedrini M,Santos BT,Teixeira AS,Souza AL,Vasconcelos-Moreno MP,Vianna-Sulzbach M,Goi PD,Belmonte-de-Abreu P,Gama CSdoi
10.1016/j.schres.2013.08.019subject
Has Abstractpub_date
2013-11-01 00:00:00pages
580-2issue
2-3eissn
0920-9964issn
1573-2509pii
S0920-9964(13)00455-6journal_volume
150pub_type
杂志文章abstract:OBJECTIVE:To assess the prevalence and correlates of antipsychotic polypharmacy (APP) across decades and regions. METHODS:Electronic PubMed/Google Scholar search for studies reporting on APP, published from 1970 to 05/2009. Median rates and interquartile ranges (IQR) were calculated and compared using non-parametric t...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2012.03.018
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:The main goal of the present study was to analyze levels of cytokines of the interleukin family (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8 and IL-10), interferon-gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP1), tumor necrosis factor-alpha (TNF-α), and vascular endothelial and endothelial growth factors (V...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.08.027
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:The Recovery Assessment Scale (RAS) is one of the most widely used measurements of recovery in mental health research. To date, no data have been available concerning the psychometric characteristics of the RAS in homeless people with severe mental illness. The aim of this study was to provide new data regard...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.10.007
更新日期:2015-12-01 00:00:00
abstract::Verbal fluency deficits in schizophrenia are difficult to interpret because the tasks are multi-factorial and groups differ in total words generated. We manipulated retrieval and switching demands by requiring alternation between over-learned sequences in which retrieval is relatively automatic (OS) and semantic categ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2007.11.017
更新日期:2008-02-01 00:00:00
abstract::In keeping with the current clinical and research focus on early intervention and the rapid increase worldwide of programs for those experiencing a first episode of psychosis, the development of services for families has to be an integral part of any comprehensive program. Families can and do play a major role in the ...
journal_title:Schizophrenia research
pub_type: 杂志文章,评审
doi:10.1016/j.schres.2005.01.013
更新日期:2005-11-01 00:00:00
abstract:BACKGROUND:The comparative antidepressant effects of clozapine and other atypical antipsychotics for schizophrenia remain elusive, leading us to examine this question using the data from the Clinical Antipsychotic Trials of Intervention Effectiveness phase 2E. METHODS:Ninety-nine patients who discontinued treatment wi...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2014.12.024
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:This study investigates the effect of exposure to "The Troubles" (the period of civil unrest from 1968 onwards) in Northern Ireland on symptomatology in people with schizophrenia. METHOD:Eighty-two participants were assessed on a number of psychiatric rating scales and on measures of trauma, including an ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2008.02.012
更新日期:2008-07-01 00:00:00
abstract::Cannabis use is highly prevalent worldwide and it is associated with psychosis, but its effects on brain structure and cognition are still controversial. The aim of this paper is to investigate cognitive functioning and brain structure in patients with their first episode of psychosis who used Cannabis. We examined gr...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2013.04.009
更新日期:2013-07-01 00:00:00
abstract:INTRODUCTION:EEG power in the delta, theta and beta1 bands has been shown to be positively correlated with negative symptoms in first episode psychotic patients. The present study investigates this correlation in an "at risk mental state for psychosis" (ARMS) with the aim to improve prediction of transition to psychosi...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.08.031
更新日期:2010-11-01 00:00:00
abstract::We examined the fractionation of executive functioning performance in ninety patients with schizophrenia, who were tested for initiation, sustained attention, switching/flexibility, attention allocation and impulsivity/disinhibition. The participants were also given tests of general intelligence and memory. We analyse...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.08.011
更新日期:2006-01-31 00:00:00
abstract:BACKGROUND:The extent of heterogeneity in the long-term course of schizophrenia is unclear. AIMS:To examine the course of schizophrenia in a population-based cohort. METHODS:This study included all Israeli individuals born in 1970-1988, of North African or European origin (N=2290), entered in the National Psychiatric...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2010.10.026
更新日期:2011-03-01 00:00:00
abstract::A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data suggest an important non-pharmacological method for ameliorating cognitive impairm...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.schres.2012.01.042
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:The use of dopaminergic antagonist antipsychotics is associated with hyperprolactinemia, but some studies have found increased prolactin concentrations in antipsychotic-naive patients with schizophrenia and related disorders. We conducted a systematic review and meta-analysis of studies of prolactin in antips...
journal_title:Schizophrenia research
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.schres.2016.03.018
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:For adults with schizophrenia, comorbidity is common and contributes to impairment. Thus, there has been an increasing effort to identify and treat comorbid symptoms. This report extends that work by examining comorbidity in children and young adolescents with childhood-onset schizophrenia. METHODS:Eighty-t...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.07.006
更新日期:2006-12-01 00:00:00
abstract::The purpose of this study was to examine the concurrent validity of a Wechsler Adult Intelligence Scale-Revised (WAIS-R) seven subtest short form. Researchers have shown that the IQ scores estimated by this short form correlate highly with full-form IQ scores in several patient populations. We compared the full WAIS-R...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(97)00134-5
更新日期:1998-03-10 00:00:00
abstract:BACKGROUND:Family studies have suggested that schizophrenia and bipolar disorders share some susceptibility factors. Schizotypal personality disorder (SPD) may be an intermediate phenotype common both to schizophrenia and bipolar disorders. We explored the familiality of schizotypal dimensions by comparing the magnitud...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.07.009
更新日期:2005-12-15 00:00:00
abstract:BACKGROUND:A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated wit...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2017.10.042
更新日期:2018-07-01 00:00:00
abstract::Valid criteria to identify young people who are believed to be at ultra high risk (UHR) of developing a psychotic episode were developed over the last decade. The first randomized controlled trial of treatment in a UHR cohort indicated that specific pharmacotherapy and psychotherapy delayed onset of disorder, and poss...
journal_title:Schizophrenia research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.schres.2007.05.018
更新日期:2007-11-01 00:00:00
abstract::It has been reported that expression of the chromogranin A (CHGA) gene is reduced in the prefrontal cortex and cerebrospinal fluid of patients with schizophrenia. Single-marker and haplotype analyses of SNPs within the CHGA gene were performed in 633 subjects with schizophrenia and 589 healthy controls. A significant ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2005.12.854
更新日期:2006-04-01 00:00:00
abstract::Psychotic experiences are far more common in the population than psychotic disorder. They are associated with a number of adverse outcomes but there has been little research on associations with functioning and distress. We wished to investigate functioning and distress in a community sample of adolescents with psycho...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.03.020
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:Research participants must have adequate consent-related abilities to provide informed consent at the time of study enrollment. We sought to determine if research participants with schizophrenia maintain adequate consent-related abilities during a longitudinal study. If participants lose abilities during a tr...
journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.schres.2011.04.012
更新日期:2011-08-01 00:00:00
abstract::First episode psychosis (FEP) has been associated with structural brain changes, largely identified by volumetric analyses. Advances in neuroimaging processing have made it possible to measure geometric properties that may identify subtle structural changes not appreciated by a measure of volume alone. In this study w...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.07.030
更新日期:2014-10-01 00:00:00
abstract::Schizophrenia is associated with premature mortality and a high rate of sudden, unexpected deaths. Autopsy data are scant, and in studies using death certificates or root cause assessments, a majority of sudden deaths remained unexplained. In the community, post-mortem data indicate that the most common cause of sudde...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2014.03.011
更新日期:2014-05-01 00:00:00
abstract::We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, positive/negative symptoms, and neuropsychological tests of facial memory and executive functioning w...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2006.11.025
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:While insight in schizophrenia improves with treatment, significant impairments often persist. The degree of persistence is not well characterised. AIMS:We assessed patient and clinician-rated changes in insight in acutely ill, minimally treated first-episode schizophrenia spectrum disorder patients over 24...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2018.10.013
更新日期:2019-04-01 00:00:00
abstract::Evidence-based decisions on indicated prevention in early psychosis require large-scale studies on the pathways to care in high-risk subjects. EPOS (The European Prediction of Psychosis Study), a prospective multi-center, naturalistic field study in four European countries (Finland, Germany, The Netherlands and Englan...
journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2013.11.031
更新日期:2014-02-01 00:00:00
abstract::Negative symptoms can be grouped into the two dimensions of diminished expression and apathy, which have been shown to be dissociable regarding external validators, such as functional outcome. Here, we investigated whether these two dimensions differentially relate to neurocognitive impairment in schizophrenia. 47 pat...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2015.10.032
更新日期:2015-12-01 00:00:00
abstract::Impaired fiber bundle connectivity between brain regions is a key neuropathological finding in schizophrenia. Symptom dimensions in schizophrenia can be clustered into factor models. Single syndromes have been related to grey and white matter brain structure alterations. We associated all core syndromes of schizophren...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2016.11.045
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Corpus callosum (CC) size and interhemispheric communication differences have been reported between patients with schizophrenia and normal controls. Childhood-onset schizophrenia (COS) is a severe form of the disorder that is continuous with later-onset disorder. Corpus callosal area was examined for COS at i...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/s0920-9964(02)00354-7
更新日期:2003-07-01 00:00:00
abstract::The incidence of cancer was studied in a cohort of all first admitted 9156 patients in Denmark with a diagnosis of schizophrenia in the period 1970-1987. The overall incidence of cancer was reduced particularly in the males. Adjustment for the smoking habits of psychiatric patients enhanced this risk reduction. Fewer ...
journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/0920-9964(94)90028-0
更新日期:1994-06-01 00:00:00