Abstract：
:Classifications of psychotic disorders are moving towards utilizing dimensional symptom domains as the preferred mechanism for describing psychotic symptomatology. The ICD-11 has proposed six symptom domains (Positive symptoms, Negative symptoms, Depressive symptoms, Manic symptoms, Psychomotor symptoms, and Cognitive symptoms) that would be rated in addition to providing a psychotic disorder diagnosis. This study investigated clinicians' use of dichotomous versus multi-point scales for rating these six domains. Global mental health professionals (n = 273) rated case vignettes using both a 2-point and 4-point version of a rating scale for the six domains. Clinicians were more accurate using the 2-point scale in absolute terms, but after correcting for chance guessing and disagreements, the two versions of the scale were equally accurate. Clinicians believed the 2-point scale would be easier to use, although they also indicated that the 4-point scale would provide richer clinical information. Participants were able to detect the presence of psychotic symptom domains in the vignettes with good reliability with no special training using either scale. We recommend that clinicians and researchers use the version of the scale that best matches their purpose (i.e., to maximize accuracy or enhance case description). Future work should develop the implementation characteristics of the scale to improve its potential for global application.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Keeley JW,Gaebel W,First MB,Peterson DL,Rebello T,Sharan P,Reed GMdoi
10.1016/j.schres.2018.07.006subject
Has Abstractpub_date
2018-12-01 00:00:00pages
254-259eissn
0920-9964issn
1573-2509pii
S0920-9964(18)30421-3journal_volume
202pub_type
杂志文章abstract：INTRODUCTION:There is mixed evidence about emotional processing abnormalities in schizophrenia and schizoaffective disorder, with self-reports and clinician ratings indicating significant differences between patients and controls, but studies of in-the-moment, self-reported emotional experience finding only small diffe...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2019.07.013
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Febrile seizure is a benign condition for most children, but experiments in animals and neuroimaging studies in humans suggest that some febrile seizures may damage the hippocampus, a brain area of possible importance in schizophrenia. METHODS:A population-based cohort of all children born in Denmark betwee...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2004.07.004
更新日期：2005-03-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.02.011
更新日期：2013-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 历史文章,杂志文章
doi：10.1016/j.schres.2014.09.037
更新日期：2014-11-01 00:00:00
abstract：BACKGROUND:Genetic factors are important in the aetiology of psychotic disorders, but it is unclear how far they influence aspects of illness history within psychoses. AIMS:To investigate the extent, and type of familial aggregation for a range of illness history variables in psychosis. METHODS:Two-hundred-and-twenty...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.09.002
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:In schizophrenic psychoses, the normal sexual dimorphism of the brain has been shown to be disrupted or even reversed. Little is known, however, at what time point in emerging psychosis this occurs. We have therefore examined, if these alterations are already present in the at-risk mental state (ARMS) for ps...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.03.034
更新日期：2018-09-01 00:00:00
abstract：:Comorbid substance abuse disorders have emerged as one of the greatest obstacles to the effective treatment of persons with schizophrenia. Estimates of the prevalence of such comorbidity vary, but as many as half of persons with schizophrenia may suffer from a comorbid drug or alcohol disorder. Younger age, male gende...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/s0920-9964(98)00161-3
更新日期：1999-03-01 00:00:00
abstract：INTRODUCTION:Aripiprazole has been associated with a low prevalence of metabolic side effects as compared to other second generation antipsychotic (SGA) medications mostly in patients with long standing illness. The purpose of the present study was to assess specifically the effectiveness and safety of aripiprazole as ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.036
更新日期：2016-07-01 00:00:00
abstract：:Previous studies suggest that schizophrenia-related visual perceptual abnormalities are primarily attributed to deficits of the dorsal rather than ventral visual pathway. In this study, we comparatively explored changes in dorsal and ventral networks in schizophrenia patients in both static and dynamic functional conn...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.12.005
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:The concept of dose equivalence of depot medication is important for many scientific and clinical purposes. METHODS:A systematic literature search on four second-generation antipsychotics available as long-acting injectable drugs and haloperidol was conducted. We used the minimum effective dose method which...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.07.033
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Delusions of control are among the most distinctive and characteristic symptoms of schizophrenia. Several theories have been proposed that implicate aberrant communication between spatially disparate brain regions in the etiology of this symptom. Given that white matter fasciculi represent the anatomical inf...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.08.033
更新日期：2015-01-01 00:00:00
abstract：:Long-stay patients constitute a small proportion of all patients with schizophrenia, but in both VA and state psychiatric systems these patients account for a majority of the costs associated with treatment of the illness. VA and state patients would be expected to differ in several respects, including age at onset an...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00182-6
更新日期：2000-05-25 00:00:00
abstract：:The present study determined the minimal exposure time (i.e., critical stimulus duration (CSD) necessary for feature registration and recognition by normals and chronic schizophrenics. Our interest was whether the longer exposure times required by schizophrenics than by normals could be attributed to an inability of s...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(92)90049-b
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:Advanced paternal age (APA) is associated with increased risk for schizophrenia, but its effect on treatment response has not been longitudinally studied. METHODS:Association of parental ages at the time of the child's birth with age of onset, initial symptom severity and treatment response (to placebo and ...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2013.10.001
更新日期：2013-12-01 00:00:00
abstract：:Verbal fluency deficits in schizophrenia are difficult to interpret because the tasks are multi-factorial and groups differ in total words generated. We manipulated retrieval and switching demands by requiring alternation between over-learned sequences in which retrieval is relatively automatic (OS) and semantic categ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.11.017
更新日期：2008-02-01 00:00:00
abstract：:Treatment resistant schizophrenia (TRS) is defined by poor or non-response to conventional antipsychotic agents. Functional capacity is defined as the baseline potential of a patient to function in the community, irrespective of actual achievements gained, and has never been studied in TRS. Here, we screened 182 patie...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章
doi：10.1016/j.schres.2018.06.030
更新日期：2018-12-01 00:00:00
abstract：:Deficits in emotion perception are common in people with schizophrenia and current research has focused on improving these deficits. In our previous research, we demonstrated that directing attention to salient facial features via attention shaping can improve these deficits among inpatients. In this study, we examine...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.05.011
更新日期：2011-04-01 00:00:00
abstract：:Antipsychotic drugs (APDs) are the standard treatment for schizophrenia. The therapeutic effect of these drugs is dependent upon the dopaminergic D2 blockade, but they also modulate other neurotransmitter pathways. The exact mechanisms underlying the clinical response to APDs are not fully understood. In this study, w...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.05.015
更新日期：2014-08-01 00:00:00
abstract：:Here, we used data from large genome-wide association studies to test the presence of causal relationships, conducting a Mendelian randomization analysis; and shared molecular mechanisms, calculating the genetic correlation, among schizophrenia, type 2 diabetes (T2D), and impaired glucose homeostasis. Although our Men...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.10.033
更新日期：2018-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.07.021
更新日期：2018-03-01 00:00:00
abstract：:Schizophrenia is associated with poor quality of life (QOL). Whereas the effects of neurocognitive deficits and psychopathology on QOL of schizophrenia patients have recently been elucidated, little is known about social cognitive deficits in this regard. This study investigated the influence of social cognition on QO...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2012.02.017
更新日期：2012-05-01 00:00:00
abstract：:Unemployment rates for schizophrenia are high across all age groups compared to the general population. Past studies have focused on neurocognition as a key determinant of unemployment and poor work outcome in schizophrenia. However, several recent studies suggest that clinical symptoms may be equally or more importan...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.06.001
更新日期：2018-02-01 00:00:00
abstract：:We investigated IL1B genetic variation previously associated with risk for transition to psychosis for its association with gene expression in human post-mortem dorsolateral prefrontal cortex (DLPFC) from 74 (37 schizophrenia, 37 control) individuals and brain structure in 92 (44 schizophrenia, 48 control) living indi...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.09.008
更新日期：2019-02-01 00:00:00
abstract：:Insight and hopelessness have been reported to be associated with suicidality in schizophrenia. In addition, there is evidence that diminished insight is correlated with impairment in some domains of cognitive function in schizophrenia. The purpose of this study was to clarify the relative importance for suicidality i...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00310-9
更新日期：2003-03-01 00:00:00
abstract：:Neuroanatomical abnormalities are considered to be related to the pathogenesis of schizophrenia. Reversal or reduction of normal structural cerebral asymmetries in schizophrenia is particularly striking. The current study investigated the alteration of gray matter volume and cerebral asymmetry in early stage of first-...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.05.021
更新日期：2013-08-01 00:00:00
abstract：:Pro-inflammatory cytokines have been consistently reported to be elevated in schizophrenia patients. However, it is not known whether cytokines influence the presentation of psychotic symptoms. To address this issue, we evaluated the relationship between levels of inflammatory molecules and psychopathological paramete...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.10.019
更新日期：2013-12-01 00:00:00
abstract：:Structural abnormalities in the lateral prefrontal cortex (LPFC) are well-documented in schizophrenia and recent evidence suggests that these abnormalities relate to functional outcome. Cognitive control mechanisms, reliant on the LPFC, are impaired in schizophrenia and predict functional outcome, thus impaired cognit...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.12.005
更新日期：2014-02-01 00:00:00
abstract：:The relationship between social cognition (i.e., cognition for social stimuli) and ward behavior among individuals with chronic schizophrenia was investigated. Twenty-seven inpatients completed a battery of cognitive and social-cognitive tasks and were rated by staff on various indices of ward behavior. Overall, there...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(96)00010-2
更新日期：1996-07-05 00:00:00
abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that mainly function as negative regulators of gene expression (Lai, 2002) and have been shown to be involved in schizophrenia etiology through genetic and expression studies (Burmistrova et al., 2007; Hansen et al., 2007a; Perkins et al., 2007; Beveridge et al., 2010; Kim ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.06.038
更新日期：2012-10-01 00:00:00
abstract：:Recent research on risk for psychosis has focused on youth who manifest subclinical signs that are often associated with the prodrome to psychosis. Standardized measures of prodromal symptoms have been shown to significantly enhance prediction of risk for conversion to an Axis I psychotic disorder. In the present stud...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.03.034
更新日期：2011-08-01 00:00:00
