Abstract：
:There is conflicting evidence of a relationship between changes in symptoms and cognitive functioning in schizophrenia. This study investigated longitudinal changes in psychopathology and cognitive functioning in chronic schizophrenia utilising three different dimensional models of symptomatology. Sixty-two patients diagnosed with DSM-IV schizophrenia or schizoaffective disorder were examined on two occasions over a period of 6 months for symptom improvement, measured by Positive and Negative Syndrome Scale (PANSS) [Kay et al., Schizophr. Bull. 13 (1987) 261]. Participants also completed a comprehensive battery of neuropsychological tasks designed to assess attention, verbal and non-verbal memory, psychomotor processing and executive/frontal functioning on both occasions. Twenty-five control subjects were assessed for comparison purposes. Severity of negative symptoms predicted poor neuropsychological performance on IQ, verbal fluency and memory measures at occasion one. However, using regression analyses, significant improvements in symptom ratings over time using two-, three- or five-dimensional models did not predict improvements in any aspect of cognitive functioning measured, except motor speed. The results do not suggest a causal relationship between the course of symptoms and neuropsychological functioning in chronic schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Hughes C,Kumari V,Soni W,Das M,Binneman B,Drozd S,O'Neil S,Mathew V,Sharma Tdoi
10.1016/s0920-9964(01)00393-0subject
Has Abstractpub_date
2003-02-01 00:00:00pages
137-46issue
2-3eissn
0920-9964issn
1573-2509pii
S0920996401003930journal_volume
59pub_type
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