Abstract:
OBJECTIVE:The onset of psychosis is thought to be preceded by neurodevelopmental changes in the brain. However, the timing of these changes has not been established. We investigated structural brain changes in a sample of young adolescents (12-18 years) at ultra high-risk for psychosis (UHR). METHODS:Structural MRI data from young UHR subjects (n=54) and typically developing, matched controls (n=54) were acquired with a 1.5 Tesla scanner and compared. RESULTS:None of the measures differed between UHR subjects and controls. CONCLUSIONS:Our results do not support the presence of gross neuroanatomical changes in young UHR subjects. This suggests that early changes are too subtle to detect with conventional imaging techniques. Therefore, changes observed in older cohorts may only onset later developmentally or occur secondary to prodromal symptoms.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Ziermans TB,Durston S,Sprong M,Nederveen H,van Haren NE,Schnack HG,Lahuis BE,Schothorst PF,van Engeland Hdoi
10.1016/j.schres.2009.04.013subject
Has Abstractpub_date
2009-07-01 00:00:00pages
1-6issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(09)00183-2journal_volume
112pub_type
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journal_title:Schizophrenia research
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更新日期:2009-04-01 00:00:00
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doi:10.1016/j.schres.2008.01.010
更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-07-01 00:00:00
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1998-09-07 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1991-03-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2001-03-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2011-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
doi:10.1016/j.schres.2019.12.016
更新日期:2020-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1016/j.schres.2015.04.035
更新日期:2015-08-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.schres.2016.06.007
更新日期:2016-10-01 00:00:00