Abstract:
BACKGROUND:High rates of tobacco smoking and smoking cessation failure in schizophrenia may be related to prefrontal cortical dysfunction. Novel treatment options for tobacco use disorder are needed given the limited efficacy of current pharmacotherapies. Preliminary evidence suggests high-frequency repetitive transcranial magnetic stimulation (rTMS) to bilateral dorsolateral prefrontal cortex (DLPFC) may suppress tobacco craving in smokers with schizophrenia. The goal of this study was to determine effects of rTMS for tobacco craving and cognition using a short-term (3-day) human laboratory paradigm. METHODS:Bilateral active (20Hz) versus sham rTMS stimulation was administered in a counterbalanced, double-blind, cross-over design to thirteen smokers with schizophrenia and n=14 non-psychiatric smoking controls. Participants were studied at baseline (smoking satiated), after 16h of smoking abstinence, and after smoking reinstatement. Primary outcome measures included tobacco craving, withdrawal and cognition. RESULTS:Overnight abstinence produced a significant increase in tobacco craving and withdrawal, and impaired verbal memory and visuospatial working memory in both diagnostic groups; these effects were reversed with smoking reinstatement. However, active rTMS did not modify this pattern of results. Moreover, active versus sham rTMS had no significant effects on cognitive outcomes, and was not associated with significant adverse events. CONCLUSIONS:Our preliminary findings suggest that short-term rTMS administration may not be sufficient enough to modify cognition, craving, and withdrawal outcomes in smokers with schizophrenia (NCT00736710). Longer-term, controlled treatment studies examining effects of rTMS on smoking behaviors and cognition in schizophrenia are warranted.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Kozak K,Sharif-Razi M,Morozova M,Gaudette EV,Barr MS,Daskalakis ZJ,Blumberger DM,George TPdoi
10.1016/j.schres.2018.02.015subject
Has Abstractpub_date
2018-07-01 00:00:00pages
441-443eissn
0920-9964issn
1573-2509pii
S0920-9964(18)30089-6journal_volume
197pub_type
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journal_title:Schizophrenia research
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journal_title:Schizophrenia research
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doi:10.1016/j.schres.2007.08.027
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journal_title:Schizophrenia research
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journal_title:Schizophrenia research
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2012-05-01 00:00:00
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journal_title:Schizophrenia research
pub_type: 杂志文章
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更新日期:2008-07-01 00:00:00
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doi:10.1016/j.schres.2016.04.050
更新日期:2016-11-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-12-01 00:00:00
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