当前位置： SCI文献检索 > SCHIZOPHRENIA RESEARCH期刊下所有文献 > The glial phosphorylase of glycogen isoform is reduced in the dorsolateral prefrontal cortex in chronic schizophrenia.

The glial phosphorylase of glycogen isoform is reduced in the dorsolateral prefrontal cortex in chronic schizophrenia.

Abstract：

:Reduced glutamatergic activity and energy metabolism in the dorsolateral prefrontal cortex (DLPFC) have been described in schizophrenia. Glycogenolysis in astrocytes is responsible for providing neurons with lactate as a transient energy supply helping to couple glutamatergic neurotransmission and glucose utilization in the brain. This mechanism could be disrupted in schizophrenia. The aim of this study was to explore whether the protein levels of the astrocyte isoform of glycogen phosphorylase (PYGM), key enzyme of glycogenolysis, and the isoform A of Ras-related C3 botulinum toxin substrate 1 (RAC1), a kinase that regulates PYGM activity, are altered in the postmortem DLPFC of chronic schizophrenia patients (n=23) and matched controls (n=23). We also aimed to test NMDAR blockade effect on these proteins in the mouse cortex and cortical astrocytes and antipsychotic treatments in rats. Here we report a reduction in PYGM and RAC1 protein levels in the DLPFC in schizophrenia. We found that treatment with the NMDAR antagonist dizocilpine in mice as a model of psychosis increased PYGM and reduced RAC1 protein levels. The same result was observed in rat cortical astroglial-enriched cultures. 21-day haloperidol treatment increased PYGM levels in rats. These results show that PYGM and RAC1 are altered in the DLPFC in chronic schizophrenia and are controlled by NMDA signalling in the rodent cortex and cortical astrocytes suggesting an altered NMDA-dependent glycogenolysis in astrocytes in schizophrenia. Together, this study provides evidence of a NMDA-dependent transient local energy deficit in neuron-glia crosstalk in schizophrenia, contributing to energy deficits of the disorder.

journal_name

Schizophr Res

journal_title

Schizophrenia research

authors

Pinacho R,Vila E,Prades R,Tarragó T,Castro E,Ferrer I,Ramos B

doi

10.1016/j.schres.2016.04.024

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

37-43

issue

1-3

eissn

0920-9964

issn

1573-2509

pii

S0920-9964(16)30169-4

journal_volume

177

pub_type

杂志文章

相关文献

SCHIZOPHRENIA RESEARCH文献大全
  • Mental health multimorbidity and poor quality of life in patients with schizophrenia.

    abstract：OBJECTIVE:While "dual diagnosis" involving both psychiatric and substance use disorders has long been a focus of schizophrenia research, recent studies have advocated for a shift of focus to multimorbidity, addressing comorbidity from both additional psychiatric disorders and substance use disorders. We hypothesized th...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.schres.2018.04.035

    authors： Bhalla IP,Stefanovics EA,Rosenheck RA

    更新日期：2018-11-01 00:00:00

  • Psychotic experiences in the population: Association with functioning and mental distress.

    abstract：:Psychotic experiences are far more common in the population than psychotic disorder. They are associated with a number of adverse outcomes but there has been little research on associations with functioning and distress. We wished to investigate functioning and distress in a community sample of adolescents with psycho...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.03.020

    authors： Kelleher I,Wigman JT,Harley M,O'Hanlon E,Coughlan H,Rawdon C,Murphy J,Power E,Higgins NM,Cannon M

    更新日期：2015-06-01 00:00:00

  • The relationship between prepulse inhibition and general psychopathology in patients with schizophrenia treated with long-acting risperidone.

    abstract：:Patients with schizophrenia exhibit impairments in prepulse inhibition (PPI) of the startle response. Available data suggest that atypical antipsychotics may be more effective than typical antipsychotics in improving PPI deficits in schizophrenia. However, previous studies have used between-subjects rather than longit...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2009.09.035

    authors： Martinez-Gras I,Rubio G,del Manzano BA,Rodriguez-Jimenez R,Garcia-Sanchez F,Bagney A,Leza JC,Borrell J

    更新日期：2009-12-01 00:00:00

  • Confirmatory factor analysis of the WAIS-R in patients with schizophrenia.

    abstract：:Although factor scores are commonly used to interpret the Weschsler Adult Intelligence Scale--Revised (WAIS-R), the WAIS-R factor structure has not been investigated in patients with schizophrenia. We used confirmatory factor analysis (CFA) to examine five latent construct models in 169 males with schizophrenia. The W...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(98)00090-5

    authors： Allen DN,Huegel SG,Seaton BE,Goldstein G,Gurklis JA Jr,van Kammen DP

    更新日期：1998-11-09 00:00:00

  • Quantitative assessment of the frequency of normal associations in the utterances of schizophrenia patients and healthy controls.

    abstract：BACKGROUND:The intrusion of associations into the utterances of schizophrenic individuals typically disrupts the coherence of the patient's utterances. Recent theoretical formulations of these phenomena have emphasized the hyperactivity) of associational networks in such language disturbance (e.g., Maher, B.A. 2003 Sch...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2005.05.017

    authors： Maher BA,Manschreck TC,Linnet J,Candela S

    更新日期：2005-10-15 00:00:00

  • Admixture analysis of age at onset in schizophrenia.

    abstract：:In schizophrenia, clinical, familial and biological characteristics according to age at onset (AAO) suggest that AAO is a valid candidate symptom for genetic studies. However, none of the various thresholds used to define AAO subgroups in schizophrenia has been validated. We aim to define different AAO subtypes by adm...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2004.02.002

    authors： Schürhoff F,Golmard JL,Szöke A,Bellivier F,Berthier A,Méary A,Rouillon F,Leboyer M

    更新日期：2004-11-01 00:00:00

  • Schizophrenic feature recognition deficits are independent of task criterion.

    abstract：:The present study determined the minimal exposure time (i.e., critical stimulus duration (CSD) necessary for feature registration and recognition by normals and chronic schizophrenics. Our interest was whether the longer exposure times required by schizophrenics than by normals could be attributed to an inability of s...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/0920-9964(92)90049-b

    authors： Schwartz BD,Evans WJ,Sautter F,Winstead DK

    更新日期：1992-07-01 00:00:00

  • Ventral and dorsal visual pathways exhibit abnormalities of static and dynamic connectivities, respectively, in patients with schizophrenia.

    abstract：:Previous studies suggest that schizophrenia-related visual perceptual abnormalities are primarily attributed to deficits of the dorsal rather than ventral visual pathway. In this study, we comparatively explored changes in dorsal and ventral networks in schizophrenia patients in both static and dynamic functional conn...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2018.12.005

    authors： Deng Y,Liu K,Cheng D,Zhang J,Chen H,Chen B,Li Y,Wang W,Kong Y,Wen G

    更新日期：2019-04-01 00:00:00

  • Longitudinal consent-related abilities among research participants with schizophrenia: results from the CATIE study.

    abstract：OBJECTIVE:Research participants must have adequate consent-related abilities to provide informed consent at the time of study enrollment. We sought to determine if research participants with schizophrenia maintain adequate consent-related abilities during a longitudinal study. If participants lose abilities during a tr...

    journal_title：Schizophrenia research

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/j.schres.2011.04.012

    authors： Stroup TS,Appelbaum PS,Gu H,Hays S,Swartz MS,Keefe RS,Kim SY,Manschreck TC,Boshes RA,McEvoy JP,Lieberman JA

    更新日期：2011-08-01 00:00:00

  • Antipsychotic treatment reduces psychotic symptoms and markers of low-grade inflammation in first episode psychosis patients, but increases their body mass index.

    abstract：OBJECTIVE:The main goal of the present study was to analyze levels of cytokines of the interleukin family (IL-1α, IL-1β, IL-2, IL-4, IL-6, IL-8 and IL-10), interferon-gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP1), tumor necrosis factor-alpha (TNF-α), and vascular endothelial and endothelial growth factors (V...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2015.08.027

    authors： Haring L,Koido K,Vasar V,Leping V,Zilmer K,Zilmer M,Vasar E

    更新日期：2015-12-01 00:00:00

  • Childhood adversities and psychotic symptoms: The potential mediating or moderating role of neurocognition and social cognition.

    abstract：INTRODUCTION:Childhood abuse and neglect are risk factors for psychotic symptoms. Early adversities may contribute to alterations in neuro/social cognition, which in turn is associated with psychosis. This study explored the possible mediating/moderating role of neuro/social cognition between childhood abuse and neglec...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2018.11.028

    authors： Mansueto G,Schruers K,Cosci F,van Os J,GROUP Investigators.

    更新日期：2019-04-01 00:00:00

  • A longitudinal study of hippocampal volume in first episode psychosis and chronic schizophrenia.

    abstract：:Brain abnormalities have been identified in patients with schizophrenia, but what is unclear is whether these changes are progressive over the course of the disorder. In this longitudinal study, hippocampal and temporal lobe volumes were measured at two time points in 30 patients with first episode psychosis (mean fol...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(01)00175-x

    authors： Wood SJ,Velakoulis D,Smith DJ,Bond D,Stuart GW,McGorry PD,Brewer WJ,Bridle N,Eritaia J,Desmond P,Singh B,Copolov D,Pantelis C

    更新日期：2001-10-01 00:00:00

  • Do people with schizophrenia who have objective cognitive impairment identify cognitive deficits on a self report measure?

    abstract：:Individuals diagnosed with schizophrenia spectrum disorders have significant neuropsychological deficits that have been linked to poor functional outcome. As more treatments are developed and implemented for cognitive impairments, it will be important to consider whether people with schizophrenia have insight into the...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2008.07.007

    authors： Medalia A,Thysen J,Freilich B

    更新日期：2008-10-01 00:00:00

  • Brainstem alterations contribute to catatonia in schizophrenia spectrum disorders.

    abstract：:Catatonia is a severe psychomotor syndrome that frequently occurs in patients with schizophrenia spectrum disorders (SSD). Accumulating neuroimaging evidence suggests orbitofrontal, frontoparietal and cerebellar network dysfunction in catatonia. Very little is known about contributions of brainstem regions (as part of...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2020.09.025

    authors： Fritze S,Thieme CE,Kubera KM,Northoff G,Schmitgen MM,Wolf RC,Hirjak D

    更新日期：2020-10-01 00:00:00

  • Histamine metabolites in cerebrospinal fluid of patients with chronic schizophrenia: their relationships to levels of other aminergic transmitters and ratings of symptoms.

    abstract：:Levels of the histamine metabolites, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), and metabolites of other aminergic transmitters and of norepinephrine were measured in cerebrospinal fluid of 36 inpatients with chronic schizophrenia and eight controls. The mean t-MH level from controls was...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/0920-9964(94)00034-6

    authors： Prell GD,Green JP,Kaufmann CA,Khandelwal JK,Morrishow AM,Kirch DG,Linnoila M,Wyatt RJ

    更新日期：1995-01-01 00:00:00

  • Prolonged rather than hasty decision-making in schizophrenia using the box task. Must we rethink the jumping to conclusions account of paranoia?

    abstract：:Jumping to conclusions (JTC) is the best established cognitive bias in schizophrenia and is increasingly targeted in interventions aimed to improve positive symptoms. To address shortcomings of the standard measure to capture JTC, the beads task, we developed a new variant-the box task-which was subsequently validated...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2020.05.056

    authors： Moritz S,Scheunemann J,Lüdtke T,Westermann S,Pfuhl G,Balzan RP,Andreou C

    更新日期：2020-08-01 00:00:00

  • Differential proteome and phosphoproteome may impact cell signaling in the corpus callosum of schizophrenia patients.

    abstract：:Schizophrenia is a multifactorial disease in both clinical and molecular terms. Thus, depicting the molecular aspects of the disease will contribute to the understanding of its biochemical mechanisms and consequently may lead to the development of new treatment strategies. The protein phosphorylation/dephosphorylation...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2016.03.022

    authors： Saia-Cereda VM,Cassoli JS,Schmitt A,Falkai P,Martins-de-Souza D

    更新日期：2016-11-01 00:00:00

  • Remember and know judgments during recognition in chronic schizophrenia.

    abstract：:Deficits in learning and memory are among the most robust correlates of schizophrenia. It has been hypothesized that these deficits are in part due to reduced conscious recollection and increased reliance on familiarity assessment as a basis for retrieval. The Remember-Know (R-K) paradigm was administered to 35 patien...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2007.09.021

    authors： van Erp TG,Lesh TA,Knowlton BJ,Bearden CE,Hardt M,Karlsgodt KH,Shirinyan D,Rao V,Green MF,Subotnik KL,Nuechterlein K,Cannon TD

    更新日期：2008-03-01 00:00:00

  • Contradictory cognitive capacities among substance-abusing patients with schizophrenia: a meta-analysis.

    abstract：:Although a substance use disorder (SUD) is traditionally associated with psycho-bio-social impairments, recent investigations among persons with schizophrenia (Sz) generated divergent results. Certain persons with Sz+SUD might in fact present better social and cognitive functioning than persons with Sz without SUD. Th...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.schres.2007.04.022

    authors： Potvin S,Joyal CC,Pelletier J,Stip E

    更新日期：2008-03-01 00:00:00

  • Psychiatric drugs impact mitochondrial function in brain and other tissues.

    abstract：:Mitochondria have been linked to the etiology of schizophrenia (SZ). However, studies of mitochondria in SZ might be confounded by the effects of pharmacological treatment with antipsychotic drugs (APDs) and other common medications. This review summarizes findings on relevant mitochondria mechanisms underlying SZ, an...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2019.09.007

    authors： Chan ST,McCarthy MJ,Vawter MP

    更新日期：2020-03-01 00:00:00

  • Memory for temporal order in patients with schizophrenia.

    abstract：:There is some evidence that memory for temporal order is a process that may be impaired independently of other forms of memory. For example, patients with Korsakoff's syndrome have been shown to have poorer temporal-order memory than other amnesic patients, despite item memory being equivalent. Patients with schizophr...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(00)00014-1

    authors： Elvevåg B,Egan MF,Goldberg TE

    更新日期：2000-12-15 00:00:00

  • Neighborhood crime, socioeconomic status, and suspiciousness in adolescents and young adults at Clinical High Risk (CHR) for psychosis.

    abstract：INTRODUCTION:Contextual factors representing chronic stressors, such as neighborhood crime characteristics, have been repeatedly linked to compromised mental and physical health, and may contribute to the pathologizing of normative/non-clinical experiences. However, the impact of such structural factors has seldom been...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2019.11.024

    authors： Vargas T,Rakhshan Rouhakhtar PJ,Schiffman J,Zou DS,Rydland KJ,Mittal VA

    更新日期：2020-01-01 00:00:00

  • A preliminary study of interactive questioning methods to assess and improve understanding of informed consent among patients with schizophrenia.

    abstract：:Growing recognition of the inadequacy of traditional methods of providing informed consent, especially for individuals vulnerable to impaired decisional capacity, has spurred recent interest in how to assess and improve components of consent-related decision making. In this preliminary study, we aimed to compare diffe...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.schres.2004.06.009

    authors： Eyler LT,Mirzakhanian H,Jeste DV

    更新日期：2005-06-15 00:00:00

  • Elevated levels of adiponectin and other cytokines in drug naïve, first episode schizophrenia patients with normal weight.

    abstract：OBJECTIVE:The study was to examine the levels of adiponectin (APN) and other cytokines, and body metabolism in drug naïve, first episode schizophrenia patients with normal weight. METHODS:Ninety-six drug naïve, first episode schizophrenia patients with normal weight (SZ group), 60 healthy individuals with normal weigh...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2013.07.044

    authors： Song X,Fan X,Song X,Zhang J,Zhang W,Li X,Gao J,Harrington A,Ziedonis D,Lv L

    更新日期：2013-10-01 00:00:00

  • Comparison of cost, dosage and clinical preference for risperidone and olanzapine.

    abstract：BACKGROUND:Because risperidone and olanzapine have similar efficacy and tolerability in the treatment of schizophrenia, costs, physician experience, and preference become relevant considerations in making treatment decisions. The purpose of this paper is to compare daily treatment costs of risperidone and olanzapine, a...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/s0920-9964(00)00036-0

    authors： Rabinowitz J,Lichtenberg P,Kaplan Z

    更新日期：2000-12-15 00:00:00

  • On the use of the Positive and Negative Syndrome Scale in randomized clinical trials.

    abstract：:In the last 25 years, the Positive and Negative Syndrome Scale (PANSS) has been largely used to assess schizophrenia symptom intensity, but little information is available on how this scale was generally applied when evaluating the efficacy of schizophrenia therapies in randomized clinical trials. In the attempt to ad...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,评审

    doi：10.1016/j.schres.2015.04.006

    authors： Nicotra E,Casu G,Piras S,Marchese G

    更新日期：2015-07-01 00:00:00

  • Factor structure of the Brief Negative Symptom Scale.

    abstract：:The current study examined the factor structure of the Brief Negative Symptom Scale (BNSS), a next-generation negative symptom rating instrument developed in response to the NIMH-sponsored Consensus Development Conference on Negative Symptoms. Participants included 146 individuals with a DSM-IV diagnosis of schizophre...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2012.09.007

    authors： Strauss GP,Hong LE,Gold JM,Buchanan RW,McMahon RP,Keller WR,Fischer BA,Catalano LT,Culbreth AJ,Carpenter WT,Kirkpatrick B

    更新日期：2012-12-01 00:00:00

  • In vivo gamma-aminobutyric acid and glutamate levels in people with first-episode schizophrenia: A proton magnetic resonance spectroscopy study.

    abstract：BACKGROUND:Gamma-aminobutyric acid (GABA) dysfunction and its consequent imbalance are implicated in the pathophysiology of schizophrenia. Reduced GABA production would lead to a disinhibition of glutamatergic neurons and subsequently cause a disruption of the modulation between GABAergic interneurons and glutamatergic...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/j.schres.2017.07.021

    authors： Chiu PW,Lui SSY,Hung KSY,Chan RCK,Chan Q,Sham PC,Cheung EFC,Mak HKF

    更新日期：2018-03-01 00:00:00

  • Natural killer cell activity in schizophrenia and schizoaffective disorder: a pilot study.

    abstract：:Natural killer cell activity was prospectively studied in 15 patients with chronic schizophrenia and in seven patients with schizoaffective disorder, depressed type. These patients were compared to individually matched normal controls. No mean differences in natural killer cell activity between the patient groups and ...

    journal_title：Schizophrenia research

    pub_type： 杂志文章

    doi：10.1016/0920-9964(92)90028-4

    authors： McDaniel JS,Jewart RD,Eccard MB,Pollard WE,Caudle J,Stipetic M,Risby ED,Lewine R,Risch SC

    更新日期：1992-12-01 00:00:00

  • Schizophrenia and HLA: a review.

    abstract：:A number of reports of genetic association of human leucocyte antigens (HLA) and alleles with schizophrenia have recently been published. A schizophrenia locus on chromosome 6p near the HLA region has also been reported, on the basis of linkage studies. We have therefore reviewed the investigations of association of H...

    journal_title：Schizophrenia research

    pub_type： 杂志文章,评审

    doi：10.1016/s0920-9964(00)00022-0

    authors： Wright P,Nimgaonkar VL,Donaldson PT,Murray RM

    更新日期：2001-01-15 00:00:00