Abstract：
BACKGROUND:Atypical antipsychotics clozapine, olanzapine, and quetiapine have significant affinity for the muscarinic receptors in vitro, while aripiprazole, risperidone, and ziprasidone do not. Dissimilarity in binding profiles may contribute to the reported differences in the anticholinergic effects of these antipsychotics. However, it is difficult with the available data to predict the likelihood of anticholinergic effects occurring with various doses of an atypical antipsychotic. METHODS:We developed a model to assess the potential anticholinergic activity (AA) of atypical antipsychotics at therapeutic doses. A radioreceptor assay was used to measure in vitro AA at 6 clinically relevant concentrations of aripiprazole, clozapine, olanzapine, quetiapine, risperidone, and ziprasidone. Using published pharmacokinetic data, in combination with the measured in vitro AA, dose-AA curves were generated. RESULTS:Clozapine, and to a lesser extent olanzapine and quetiapine showed dose-dependent increases in AA. At therapeutic doses, the AA (in pmol/mL of atropine equivalents) was estimated to range from 27-250, 1-15, and 0-5.4 pmol/mL for clozapine, olanzapine, and quetiapine, respectively. Aripiprazole, risperidone, and ziprasidone did not demonstrate AA at any of the concentrations studied. CONCLUSIONS:Therapeutic doses of clozapine, olanzapine, and, to a lesser extent, quetiapine are associated with clinically relevant AA.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Chew ML,Mulsant BH,Pollock BG,Lehman ME,Greenspan A,Kirshner MA,Bies RR,Kapur S,Gharabawi Gdoi
10.1016/j.schres.2006.07.011subject
Has Abstractpub_date
2006-12-01 00:00:00pages
63-72issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(06)00315-Xjournal_volume
88pub_type
杂志文章abstract：:This study assessed visuospatial attention in healthy adults and medicated schizophrenic patients. Participants performed a visual orientation task in which a peripheral cue was followed. at different intervals, by a target presented either at valid or invalid locations. When the long stimulus onset asynchrony (SOA) w...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00044-4
更新日期：1999-11-09 00:00:00
abstract：:Due to the limitations of analytical techniques and the complicity of schizophrenia, nowadays it is still a challenge to diagnose and stratify schizophrenia patients accurately. Many attempts have been made to identify and validate available biomarkers for schizophrenia from CSF and/or peripheral blood in clinical stu...
journal_title：Schizophrenia research
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doi：10.1016/j.schres.2019.03.009
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:Attentional deficits represent a core cognitive impairment in schizophrenia. The distractor condition Sustained Attention Task (dSAT) has been identified by the Cognitive Neuroscience Treatment to Improve Cognition in Schizophrenia (CNTRICS) initiative as a promising translational task for assessing schizophr...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.01.003
更新日期：2013-03-01 00:00:00
abstract：:Schizophrenia has generally been viewed as having a unique preschizophrenia personality or destructive to the personality post-onset. This view is reflected in the scarcity of studies of personality in schizophrenia with the exception of schizotypal personality considered by many as an endophenotype of schizophrenia. ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2017.02.015
更新日期：2017-11-01 00:00:00
abstract：:Little is known about the impact of family history of psychosis on youth from community samples. To fill this gap, we compared youth with a first-degree relative with psychosis spectrum symptoms (i.e. family history of psychosis spectrum symptoms, FHPS) to youth without FHPS in a cross-sectional analysis of the Philad...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.12.021
更新日期：2020-02-01 00:00:00
abstract：:Schizophrenia and affective disorders are relatively common neuropsychiatric diseases with a complex genetic etiology. A multigenic inheritance with variable influence of unknown environmental factors may be involved. Family studies have demonstrated the existence of both phenotypes in the same kindreds, and in certai...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/s0920-9964(99)00108-5
更新日期：1999-09-29 00:00:00
abstract：:A total of 57 schizophrenic patients (of which 17 were first-episode, neuroleptic naive) and 76 healthy controls were screened for anti-histone IgG antibodies using an enzyme immunoassay (ELISA). All patients had significantly higher anti-histone antibody titers than controls (t = 3.1, p less than 0.003). Previously m...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(92)90073-e
更新日期：1992-04-01 00:00:00
abstract：:Social perception and mentalizing are fundamental social cognitive abilities that are related to functioning and are impaired in schizophrenia. A novel approach to examine the relationship between social cognition and community functioning is to first functionally categorize individuals with schizophrenia and then eva...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.01.029
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:The feasibility and preliminary efficacy of a novel cognitive behavioral treatment for decreasing psychotic symptoms and improving social functioning was evaluated in a pilot study. This represents the first treatment outcome study of CBT for psychosis with a manualized, active comparison condition. METHODS...
journal_title：Schizophrenia research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2005-05-01 00:00:00
abstract：:A recent family-based association study identified a putative association between variants in the dystrobrevin binding protein 1 (dysbindin) gene (DTNBP1) and schizophrenia. This study used a sample of 270 Irish pedigrees multiply affected with schizophrenia. We attempted to replicate these findings in an independent ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00527-3
更新日期：2003-04-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.05.011
更新日期：2018-02-01 00:00:00
abstract：:Social anhedonia is an important feature of schizophrenia and it is a promising indicator of schizotypy. Although social anhedonia is defined as an affective construct (less pleasure derived from social encounters), little is known about the emotional responsivity and expressivity of individuals with high levels of so...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2010.06.012
更新日期：2010-12-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2016.03.016
更新日期：2016-05-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.12.032
更新日期：2007-08-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.05.029
更新日期：2018-11-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(93)90007-6
更新日期：1993-03-01 00:00:00
abstract：OBJECTIVE:Evidence from epidemiology suggests that low maternal vitamin D may be a risk factor for schizophrenia. METHOD:Based on sera taken during the third trimester, we compared the level of 25 hydroxyvitamin D3 in mothers of individuals with schizophrenia or schizoaffective disorders versus mothers of unaffected c...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(02)00435-8
更新日期：2003-09-01 00:00:00
abstract：:Levels of the histamine metabolites, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), and metabolites of other aminergic transmitters and of norepinephrine were measured in cerebrospinal fluid of 36 inpatients with chronic schizophrenia and eight controls. The mean t-MH level from controls was...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)00034-6
更新日期：1995-01-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.10.007
更新日期：2018-10-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(99)00215-7
更新日期：2000-09-29 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.07.044
更新日期：2013-10-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.09.022
更新日期：2007-02-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(94)00060-l
更新日期：1995-07-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.10.014
更新日期：2019-04-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00393-0
更新日期：2003-02-01 00:00:00
abstract：:Studies defining the course and outcome of individuals experiencing their first episode (FE) of psychosis generally report an improvement in symptoms and functioning. Today, many FE patients are treated in specialized early psychosis programs. Little is known what happens to these individuals after discharge from thes...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.08.032
更新日期：2008-12-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00106-6
更新日期：1998-11-30 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.08.010
更新日期：2007-11-01 00:00:00
abstract：:Self-determination theory (SDT) provides a model for understanding motivation deficits in schizophrenia, and recent research has focused on problems with intrinsic motivation. However, SDT emphasizes that motivated behavior results from three different factors: intrinsic motivators (facilitated by needs for autonomy, ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.04.027
更新日期：2014-07-01 00:00:00
