The relationship between suicide and violence in schizophrenia: analysis of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) dataset.


BACKGROUND:Suicide and violence often co-occur in the general population as well as in mentally ill individuals. Few studies, however, have assessed whether these suicidal behaviors are predictive of violence risk in mental illness. AIMS:The aim of this study is to investigate whether suicidal behaviors, including suicidal ideation, threats, and attempts, are significantly associated with increased violence risk in individuals with schizophrenia. METHOD:Data for these analyses were obtained from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trial, a randomized controlled trial of antipsychotic medication in 1460 adults with schizophrenia. Univariate Cox regression analyses were used to calculate hazard ratios (HRs) for suicidal ideation, threats, and attempts. Multivariate analyses were conducted to adjust for common confounding factors, including: age, alcohol or drug misuse, major depression, antisocial personality disorder, depression, hostility, positive symptom, and poor impulse control scores. Tests of discrimination, calibration, and reclassification assessed the incremental predictive validity of suicidal behaviors for the prediction of violence risk. RESULTS:Suicidal threats and attempts were significantly associated with violence in both males and females with schizophrenia with little change following adjustment for common confounders. Only suicidal threats, however, were associated with a significant increase in incremental validity beyond age, diagnosis with a comorbid substance use disorder, and recent violent behavior. CONCLUSIONS:Suicidal threats are independently associated with violence risk in both males and females with schizophrenia, and may improve violence risk prediction.


Schizophr Res


Schizophrenia research


Witt K,Hawton K,Fazel S




Has Abstract


2014-04-01 00:00:00














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    abstract::The present study determined the minimal exposure time (i.e., critical stimulus duration (CSD) necessary for feature registration and recognition by normals and chronic schizophrenics. Our interest was whether the longer exposure times required by schizophrenics than by normals could be attributed to an inability of s...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Schwartz BD,Evans WJ,Sautter F,Winstead DK

    更新日期:1992-07-01 00:00:00

  • Elevated plasma level of apolipoprotein D in schizophrenia and its treatment and outcome.

    abstract::Recently, apolipoprotein D (apoD), a protein that is involved in the essential polyunsaturated fatty acid (EPUFA) transport and metabolism, and neuronal growth and regeneration was reported to have increased in the postmortem brain and decreased in the serum of schizophrenia patients. We studied the plasma apoD levels...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Mahadik SP,Khan MM,Evans DR,Parikh VV

    更新日期:2002-11-01 00:00:00

  • Paranoid schizophrenia and methamphetamine-induced paranoia are both characterized by a similar LINE-1 partial methylation profile, which is more pronounced in paranoid schizophrenia.

    abstract:BACKGROUND:There is evidence that schizophrenia is a neuro-immune disorder. Genes linked to intragenic LINE-1 methylation show a strong association with immune-associated disorders including psychosis. The aim of this study was to examine LINE-1 methylation patterns in paranoid schizophrenia and methamphetamine-induced...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Kalayasiri R,Kraijak K,Mutirangura A,Maes M

    更新日期:2019-06-01 00:00:00

  • Self and world experience in non-affective first episode of psychosis.

    abstract::A disturbance of "minimal self," - of the immediate sense of mine-ness inherent in experience-is hypothesized to be the core disturbance in schizophrenia. Research with the Examination of Anomalous Self Experience (EASE) has demonstrated the selective aggregation of anomalous self-experiences in the schizophrenia spec...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Madeira L,Pienkos E,Filipe T,Melo M,Queiroz G,Eira J,Costa C,Figueira ML,Sass L

    更新日期:2019-09-01 00:00:00

  • Self-reported sleep disturbances associated with procedural learning impairment in adolescents at ultra-high risk for psychosis.

    abstract::Sleep disturbance contributes to impaired procedural learning in schizophrenia, yet little is known about this relationship prior to psychosis onset. Adolescents at ultra high-risk (UHR; N=62) for psychosis completed the Pittsburgh Sleep Quality Index (PSQI) and a procedural learning task (Pursuit Rotor). Increased se...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Lunsford-Avery JR,Dean DJ,Mittal VA

    更新日期:2017-12-01 00:00:00

  • Olanzapine antipsychotic treatment of adolescent rats causes long term changes in glutamate and GABA levels in the nucleus accumbens.

    abstract::Atypical antipsychotic drugs (AAPDs) are widely used in children and adolescents to treat a variety of psychiatric disorders. However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent rats with...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Xu S,Gullapalli RP,Frost DO

    更新日期:2015-02-01 00:00:00

  • Effect of antipsychotic drugs on gene expression in the prefrontal cortex and nucleus accumbens in the spontaneously hypertensive rat (SHR).

    abstract::Antipsychotic drugs (APDs) are the standard treatment for schizophrenia. The therapeutic effect of these drugs is dependent upon the dopaminergic D2 blockade, but they also modulate other neurotransmitter pathways. The exact mechanisms underlying the clinical response to APDs are not fully understood. In this study, w...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Santoro ML,Ota VK,Stilhano RS,Silva PN,Santos CM,Diana MC,Gadelha A,Bressan RA,Melaragno MI,Han SW,Abílio VC,Belangero SI

    更新日期:2014-08-01 00:00:00

  • Goal-directed planning and action impairments in schizophrenia evaluated in a virtual environment.

    abstract::Planning and executing goal-directed behaviours are critical final steps in translating motivation into action. Amotivation is a key feature of schizophrenia, but its impact on goal-directed functioning has not been extensively studied in an objective and ecologically valid manner. To address this, we investigated goa...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Siddiqui I,Saperia S,Fervaha G,Da Silva S,Jeffay E,Zakzanis KK,Agid O,Remington G,Foussias G

    更新日期:2019-04-01 00:00:00

  • Brief executive function training for individuals with severe mental illness: Effects on EEG synchronization and executive functioning.

    abstract:BACKGROUND:Executive Functioning (EF) is an important factor for community functioning for people with severe mental illness. Cognitive remediation programs often improve EF, but do so by using multiple therapeutic techniques. Little is known regarding how individual treatment elements promote cognitive improvement. Os...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,随机对照试验


    authors: Best MW,Gale D,Tran T,Haque MK,Bowie CR

    更新日期:2019-01-01 00:00:00

  • Schizotypal dimensions in normals and schizophrenic patients: a comparison with other clinical samples.

    abstract::Schizotypy is usually referred to as a "liability" to schizophrenia, but it could also be more generally referred to as nonspecific "psychosis-proneness". This study examined the structure of schizotypy in a normal sample and in a sample of schizophrenics through the administration of the Schizotypal Personality Quest...

    journal_title:Schizophrenia research



    authors: Rossi A,Daneluzzo E

    更新日期:2002-03-01 00:00:00

  • Developing models of how cognitive improvements change functioning: mediation, moderation and moderated mediation.

    abstract:BACKGROUND:Cognitive remediation (CRT) affects functioning but the extent and type of cognitive improvements necessary are unknown. AIM:To develop and test models of how cognitive improvement transfers to work behaviour using the data from a current service. METHOD:Participants (N49) with a support worker and a paid ...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Wykes T,Reeder C,Huddy V,Taylor R,Wood H,Ghirasim N,Kontis D,Landau S

    更新日期:2012-06-01 00:00:00

  • Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings.

    abstract::Working memory (WM) deficits are a persistent, disabling and relatively treatment-resistant feature of schizophrenia that may underlie many cognitive deficits and symptoms. They are associated with prefrontal cortex dysfunction. While most neuroimaging studies of WM demonstrate "task-related hypofrontality" in schizop...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审


    authors: Manoach DS

    更新日期:2003-04-01 00:00:00

  • Effects of clozapine and olanzapine on cortical thickness in childhood-onset schizophrenia.

    abstract:BACKGROUND:Little is known about the effects of antipsychotic medications on gray matter (GM) in schizophrenia. Although clozapine remains the most effective antipsychotic medication in treatment-refractory cases, it is unknown whether it has a differential effect on GM development. METHODS:In an exploratory analysis,...

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    pub_type: 杂志文章


    authors: Mattai A,Chavez A,Greenstein D,Clasen L,Bakalar J,Stidd R,Rapoport J,Gogtay N

    更新日期:2010-01-01 00:00:00

  • Schizophrenic delusions: the detection of warning signals.

    abstract::Schizophrenic delusions are important target symptoms for treatment. This study aims to identify predictors of delusion formation. Two samples of schizophrenic patients (total n = 131) are examined prospectively every second week during a period of 6 months. In one sample (n = 60) delusion formation (n = 27; 45%) is c...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Jørgensen P

    更新日期:1998-06-22 00:00:00

  • Cortical gray matter deficit in patients with bipolar disorder.

    abstract:BACKGROUND:cortical gray matter volume deficit and ventricular enlargement are well documented in schizophrenia, but their presence in bipolar disorder is less well established. METHODS:global cortical gray matter, white matter and sulcal CSF, as well as lateral and third ventricular volume measures, were derived from...

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    pub_type: 杂志文章


    authors: Lim KO,Rosenbloom MJ,Faustman WO,Sullivan EV,Pfefferbaum A

    更新日期:1999-12-21 00:00:00

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    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Spironelli C,Angrilli A

    更新日期:2015-06-01 00:00:00

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    authors: Spalthoff R,Gaser C,Nenadić I

    更新日期:2018-12-01 00:00:00

  • Extensive linkage disequilibrium mapping at HTR2A and DRD3 for schizophrenia susceptibility genes in the Galician population.

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    authors: Domínguez E,Loza MI,Padín F,Gesteira A,Paz E,Páramo M,Brenlla J,Pumar E,Iglesias F,Cibeira A,Castro M,Caruncho H,Carracedo A,Costas J

    更新日期:2007-02-01 00:00:00

  • Longitudinal investigation of the relationship between family history of psychosis and affective disorders and Child Behavior Checklist ratings in clinical high-risk adolescents.

    abstract::This is the first study to investigate whether positive family history (FH) of psychosis and affective disorders moderates the relationship between child diagnostic status and parent-reported social and behavioral problems on the Child Behavior Checklist (CBCL) in clinical high-risk adolescents. This longitudinal inve...

    journal_title:Schizophrenia research

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    authors: Simeonova DI,Lee FJ,Walker EF

    更新日期:2015-08-01 00:00:00

  • Executive functioning during full and partial remission (positive and negative symptomatic remission) of schizophrenia.

    abstract:BACKGROUND:Despite the upsurge of research regarding cognitive impairment in schizophrenia we still lack adequate understanding of the executive functioning of patients in symptomatic remission. Moreover, the cognitive functioning of patients in partial remission has not been studied previously although they comprise a...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Braw Y,Benozio A,Levkovitz Y

    更新日期:2012-12-01 00:00:00

  • Social-cognitive brain function and connectivity during visual perspective-taking in autism and schizophrenia.

    abstract:BACKGROUND:Autism spectrum disorder (ASD) and schizophrenia are neurodevelopmental conditions that are characterized by significant social impairment. Emerging genomic and neurobiological evidence has increasingly pointed to shared pathophysiologic mechanisms in the two disorders. Overlap in social impairment may refle...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Eack SM,Wojtalik JA,Keshavan MS,Minshew NJ

    更新日期:2017-05-01 00:00:00

  • Failures of automatic and strategic processing in schizophrenia: comparisons of event-related brain potential and startle blink modification.

    abstract::Noises elicit startle blinks that are inhibited when immediately (approximately 100 ms) preceded by non-startling prepulses, perhaps reflecting automatic sensory gating. Startle blinks are facilitated when preceded by prepulses at longer lead intervals, perhaps reflecting strategic processes. Event-related brain poten...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Ford JM,Roth WT,Menon V,Pfefferbaum A

    更新日期:1999-05-25 00:00:00

  • Bullying victimisation and paranoid ideation in people at ultra high risk for psychosis.

    abstract:BACKGROUND:Bullying victimisation has been suggested to contribute to paranoid ideation in general population samples and recent evidence found that individuals with an ultra high risk (UHR) for psychosis are twice as likely to have been bullied than controls. AIMS:This study sought to examine whether a history of bul...

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    pub_type: 杂志文章


    authors: Valmaggia LR,Day FL,Kroll J,Laing J,Byrne M,Fusar-Poli P,McGuire P

    更新日期:2015-10-01 00:00:00

  • Emotion recognition in psychosis: no evidence for an association with real world social functioning.

    abstract:BACKGROUND:Patients with psychotic disorders show impairments in the recognition of emotions in other people. These impairments have been associated with poor social functioning as measured by self-report questionnaires, clinical interviews and laboratory-based tests of social skills. The ecological validity of these t...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Janssens M,Lataster T,Simons CJ,Oorschot M,Lardinois M,van Os J,Myin-Germeys I,GROUP.

    更新日期:2012-12-01 00:00:00

  • Transient and executive function working memory in schizophrenia.

    abstract::Transient working memory requires attention and temporary storage of information, whereas executive function working memory requires additional mental manipulation of that information. Working memory impairment is common in schizophrenia patients, but only some studies have found differential impairment in executive f...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Twamley EW,Palmer BW,Jeste DV,Taylor MJ,Heaton RK

    更新日期:2006-10-01 00:00:00

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    abstract::Poly(A+) mRNA was extracted from the post-mortem brain of schizophrenics (9 subjects), unipolar depressives (5 subjects) and controls (10 subjects) and used to direct the in vitro translation of radiolabelled protein in a cell-free reticulocyte-lysate system. Protein species were analysed on two-dimensional gels. Over...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Perrett CW,Whatley SA,Ferrier IN,Marchbanks RM

    更新日期:1992-03-01 00:00:00

  • N-methyl-d-aspartate-type glutamate receptor modulators and related medications for the enhancement of auditory system plasticity in schizophrenia.

    abstract::Deficits in N-methyl-d-aspartate-type (NMDAR) function contribute to cognitive deficits in schizophrenia, particularly dysfunction in neuroplasticity, defined as reduced learning during training on exercises that place implicit, increasing demands on early sensory (auditory and visual) information processing. Auditory...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审


    authors: Kantrowitz JT

    更新日期:2019-05-01 00:00:00

  • A survey of the 22q11 microdeletion in a large cohort of schizophrenia patients.

    abstract::The occurrence of a microdeletion at 22q11 has long been considered to constitute a risk factor for schizophrenia. Higher rates of 22q11 deletions have been reported in cohorts of patients with schizophrenia. In order to estimate the prevalence of the 22q11 deletion in schizophrenia patients more accurately, a screeni...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Horowitz A,Shifman S,Rivlin N,Pisanté A,Darvasi A

    更新日期:2005-03-01 00:00:00

  • Reading deficits in schizophrenia and their relationship to developmental dyslexia: A review.

    abstract::Although schizophrenia and developmental dyslexia are considered distinct disorders in terms of clinical presentation and functional outcome, they both involve disruption in the processes that support skilled reading, including language, auditory perception, visual perception, oculomotor control, and executive functio...

    journal_title:Schizophrenia research

    pub_type: 杂志文章,评审


    authors: Whitford V,O'Driscoll GA,Titone D

    更新日期:2018-03-01 00:00:00

  • Reprint of: Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood.

    abstract::Psychotic-like experiences (PLEs) are part of a continuum of psychosis. Previous longitudinal studies highlighted a relationship between peripheral inflammation during childhood and onset of PLEs in adulthood. In this study, we tested if this association is mediated by internalising and externalising symptoms experien...

    journal_title:Schizophrenia research

    pub_type: 杂志文章


    authors: Francesconi M,Minichino A,Khandaker GM,Midouhas E,Lewis G,Flouri E

    更新日期:2020-12-01 00:00:00