Abstract：
OBJECTIVE:Clozapine is associated with significant weight gain. However, it is still debatable whether the majority of weight gain occurs in the early phase of treatment or if weight gain is a persistent side effect. The inconsistent results in previous outpatient studies may be due to many confounding factors, such as variations in drug adherence, diet content, activity level and environmental factors. The objective of this study was to investigate long-term weight changes in hospitalized Chinese schizophrenic patients treated with clozapine. METHODS:Patients were admitted at the largest mental hospital in Taiwan and had routine monthly body weight monitoring during the study period. Retrospective chart reviews were conducted to obtain demographic data, age at which clozapine treatment was initiated, and weight changes after the initiation of clozapine treatment. RESULTS:The study sample consisted of 349 hospitalized schizophrenic patients, including 204 males (58.8%), with an average age at clozapine initiation of 38.6+/-9.3 and an average clozapine dosage of 318+/-9.3 mg/day. Body weight increased over time, and reached a plateau at month 42. Younger age at clozapine initiation (P=0.0038) and lower baseline body mass index (BBMI) (P<0.0001) were associated with more weight gain. The patients with BBMI<25 gained significantly more weight (10.98+/-8.48 kg) compared to patients with BBMI>or=25 (1.17+/-13.29 kg) (P=0.004). CONCLUSIONS:Similar to reports on Caucasians, clozapine-associated weight gain in Chinese patients reached a plateau at month 42. Younger patients with normal BBMI were associated with higher risk of weight gain.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Bai YM,Chen JY,Chen TT,Lin CY,Chou P,Su TP,Lin CCdoi
10.1016/j.schres.2008.10.023subject
Has Abstractpub_date
2009-03-01 00:00:00pages
122-6issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(08)00504-5journal_volume
108pub_type
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pub_type： 杂志文章
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pub_type： 传,历史文章,杂志文章
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更新日期：2018-11-01 00:00:00
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更新日期：2010-08-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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