Abstract：
BACKGROUND:Prospective memory (PM) deficits have been consistently found in people with schizophrenia. Although there is evidence to suggest that PM deficits may be putative markers for schizophrenia, no longitudinal study has investigated the persistence of PM deficits. AIMS:We examined whether PM deficits persist after the onset of schizophrenia, and compared the trajectories of time- and event-based PM performance 12 months after illness onset. We also examined whether the association between PM and clinical symptoms changes over time 12 months after illness onset. METHOD:We recruited 58 individuals with first-episode schizophrenia for a 12-month follow-up study. Comparison participants were 37 healthy individuals who were matched in terms of demographics and intelligence with the patient group. PM functions and clinical symptoms were measured at baseline, the sixth month, and the twelfth month, using a computerized PM task and the Positive and Negative Syndrome Scale. RESULTS:People with schizophrenia showed a gradual improvement in both time- and event-based PM 12 months after illness onset. However, compared to event-based PM, deficit in time-based PM persisted and was relatively stable. At baseline, PM functions were not associated with clinical symptoms. However, an association between time-based PM and PANSS positive and general symptoms emerged 12 months after the onset of schizophrenia. CONCLUSION:People with first-episode schizophrenia exhibit persistent time-based PM deficit. Our findings support that PM deficit, in particular, time-based deficit, may be a putative neuropsychological marker of schizophrenia.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Cheung EFC,Lui SSY,Wang Y,Yang TX,Shum DHK,Chan RCKdoi
10.1016/j.schres.2015.09.015subject
Has Abstractpub_date
2015-12-01 00:00:00pages
147-152issue
1-3eissn
0920-9964issn
1573-2509pii
S0920-9964(15)00485-5journal_volume
169pub_type
杂志文章abstract：:Stigma may undermine the well-being of young people at risk of psychosis. We therefore measured self-labeling, stigma variables and well-being at baseline and again one year later among 77 at-risk participants. An increase in self-labeling during this period predicted heightened stigma stress after one year and a decr...
journal_title：Schizophrenia research
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journal_title：Schizophrenia research
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journal_title：Schizophrenia research
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abstract：:Patients with schizophrenia exhibit impairments in prepulse inhibition (PPI) of the startle response. Available data suggest that atypical antipsychotics may be more effective than typical antipsychotics in improving PPI deficits in schizophrenia. However, previous studies have used between-subjects rather than longit...
journal_title：Schizophrenia research
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.08.025
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journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Schizophrenia research
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journal_title：Schizophrenia research
pub_type： 杂志文章,评审
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.04.013
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journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章,随机对照试验
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2009.03.024
更新日期：2009-06-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2015.07.049
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journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
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更新日期：2016-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2011-07-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2003-01-01 00:00:00
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journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2016.02.013
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pub_type： 杂志文章
doi：10.1016/s0920-9964(03)00057-4
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doi：10.1016/j.schres.2012.11.003
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1990-07-01 00:00:00
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更新日期：2007-09-01 00:00:00
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doi：10.1016/j.schres.2007.12.489
更新日期：2008-04-01 00:00:00
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pub_type： 杂志文章,多中心研究
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更新日期：2012-05-01 00:00:00
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更新日期：2012-03-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1998-09-07 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.schres.2013.12.005
更新日期：2014-02-01 00:00:00
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更新日期：2019-04-01 00:00:00
