Abstract：
:Cholesterol metabolism is vital for brain function. Previous work in cultured cells has shown that a number of psychotropic drugs inhibit the activity of 7-dehydrocholesterol reductase (DHCR7), an enzyme that catalyzes the final steps in cholesterol biosynthesis. This leads to the accumulation of 7-dehydrocholesterol (7DHC), a molecule that gives rise to oxysterols, vitamin D, and atypical neurosteroids. We examined levels of cholesterol and the cholesterol precursors desmosterol, lanosterol, 7DHC and its isomer 8-dehydrocholesterol (8DHC), in blood samples of 123 psychiatric patients on various antipsychotic and antidepressant drugs, and 85 healthy controls, to see if the observations in cell lines hold true for patients as well. Three drugs, aripiprazole, haloperidol and trazodone increased circulating 7DHC and 8DHC levels, while five other drugs, clozapine, escitalopram/citalopram, lamotrigine, olanzapine, and risperidone, did not. Studies in rat brain verified that haloperidol dose-dependently increased 7DHC and 8DHC levels, while clozapine had no effect. We conclude that further studies should investigate the role of 7DHC and 8DHC metabolites, such as oxysterols, vitamin D, and atypical neurosteroids, in the deleterious and therapeutic effects of psychotropic drugs. Finally, we recommend that drugs that increase 7DHC levels should not be prescribed during pregnancy, as children born with DHCR7 deficiency have multiple congenital malformations.
journal_name
Schizophr Resjournal_title
Schizophrenia researchauthors
Korade Ž,Liu W,Warren EB,Armstrong K,Porter NA,Konradi Cdoi
10.1016/j.schres.2017.02.001subject
Has Abstractpub_date
2017-09-01 00:00:00pages
74-81eissn
0920-9964issn
1573-2509pii
S0920-9964(17)30072-5journal_volume
187pub_type
杂志文章abstract：OBJECTIVE:Blockade of dopamine D₂ receptors with antipsychotics above 65% is associated with optimal chance of clinical response although recent data suggest a lower threshold for the maintenance treatment of schizophrenia. The objective of this study was to prospectively examine whether such continuous high blockade w...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2015.03.025
更新日期：2015-05-01 00:00:00
abstract：:Genetic and environmental models of neuropsychiatric disease have grown exponentially over the last 20years. One measure that is often used to evaluate the translational relevance of these models to human neuropsychiatric disease is prepulse inhibition of startle (PPI), an operational measure of sensorimotor gating. D...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.10.009
更新日期：2018-08-01 00:00:00
abstract：:Disrupted-in-Schizophrenia 1 (DISC1), a strong candidate gene for schizophrenia and other mental disorders, regulates neurodevelopmental processes including neurogenesis, neuronal migration, neurite outgrowth and spine development. Glycogen synthase kinase-3 (GSK3) directly interacts with DISC1 and also plays a role i...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2011.03.032
更新日期：2011-06-01 00:00:00
abstract：:Second-generation antipsychotics have demonstrated efficacy for patients with schizophrenia but are associated with wide-ranging side effects. Brexpiprazole, a serotonin-dopamine activity modulator, has demonstrated efficacy in adult patients with schizophrenia. This paper provides an overview of the safety and tolera...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2016.04.013
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Evidence indicating that symptoms of non-clinical psychosis (NCP) occur in 6-8% of the general population suggests that psychosis may occur across a continuum. Although a number of studies have examined environmental contributors, to date there have been few investigations of biological/genetic factors in th...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2012.06.018
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:Randomized trials targeting cannabis use disorders in patients with psychosis have generally been unsuccessful. One of the largest such trials was the CapOpus trial, which had an impact on the number of monthly joints used, but not on the number of days with cannabis use or positive or negative symptoms. OB...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2013.10.014
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVE:Self-rated attenuated psychotic-like experiences (APLEs) are increasingly used to screen for ultra-high-risk (UHR) across all ages. However, self-rated psychotic-like experiences (PLEs), in particular perception-related ones, were more frequent in children and adolescents, in which they possessed less clinica...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:Executive dysfunction is a common feature of schizophrenia and bipolar disorder (BP). While deficits in social cognitive abilities, including theory of mind (ToM), have been suggested to be specific to schizophrenia, available evidence suggests that there is also a significant overlap in social cognitive perf...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.06.007
更新日期：2016-10-01 00:00:00
abstract：:Evidence from event-related-potential (ERP) studies has repeatedly shown differences in the perception and processing of auditory stimuli in children with dyslexia compared to control children. The mismatch negativity (MMN) - an ERP component reflecting passive auditory change detection ability - has been found to be ...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2017.07.010
更新日期：2018-01-01 00:00:00
abstract：:Schizophrenia constitutes a complex disease. Negative and cognitive symptoms are enduring and debilitating components of the disorder, highly associated to disability and burden. Disrupted neurotransmission circuits in dorsolateral prefrontal cortex (DLPFC) have been related to these symptoms. To identify candidates a...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2016.04.050
更新日期：2016-11-01 00:00:00
abstract：:Deficits in nonverbal vocal expression (e.g., blunted vocal affect, alogia) are a hallmark of schizophrenia and are a focus of the Research Domain Criteria initiative from the National Institute of Mental Health. Results from studies using symptom rating scales suggest that these deficits are profound; on the order of...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2014.09.013
更新日期：2014-11-01 00:00:00
abstract：:Existing literature on the neurocognitive correlates of community functioning in schizophrenia has not adequately focused on the relationships among the correlated variables. In a sample of 40 outpatients with schizophrenia and related disorders, we studied two sets of variables that we expected to be related to broad...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00229-8
更新日期：2002-07-01 00:00:00
abstract：:A review of 65 studies of individuals with schizophrenia who had never been treated with antipsychotic medications indicates significant abnormalities in brain structure and function. Neurological and neuropsychological measures show the most consistent and largest group differences between those affected and normal c...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/s0920-9964(02)00381-x
更新日期：2002-12-01 00:00:00
abstract：:Normally, when two brief, non-startling auditory stimuli are presented 500 ms apart, with long (e.g., 10 s) interpair intervals, the positive potential occurring approx. 50 ms after the first stimulus (P50) is relatively large, and the P50 to the second stimulus is smaller. In schizophrenia patients, however, the P50 ...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(97)00122-9
更新日期：1998-02-27 00:00:00
abstract：BACKGROUND:Cognitive deficits are prominent in schizophrenia and represent promising endophenotypes for genetic research. METHODS:The current study investigated the importance of two conceptually distinct genetic aggregates, one based on copy number variations (uncommon deletion burden), and one based on single nucleo...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2014.03.022
更新日期：2014-06-01 00:00:00
abstract：:The purpose of this study was to examine the concurrent validity of a Wechsler Adult Intelligence Scale-Revised (WAIS-R) seven subtest short form. Researchers have shown that the IQ scores estimated by this short form correlate highly with full-form IQ scores in several patient populations. We compared the full WAIS-R...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(97)00134-5
更新日期：1998-03-10 00:00:00
abstract：OBJECTIVE:To assess the prevalence and correlates of antipsychotic polypharmacy (APP) across decades and regions. METHODS:Electronic PubMed/Google Scholar search for studies reporting on APP, published from 1970 to 05/2009. Median rates and interquartile ranges (IQR) were calculated and compared using non-parametric t...
journal_title：Schizophrenia research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.schres.2012.03.018
更新日期：2012-06-01 00:00:00
abstract：:The use of clozapine requires monitoring the absolute neutrophil count because of the risk of agranulocytosis, but other potentially fatal adverse events associated with clozapine (specifically, myocarditis and cardiomyopathy) do not have mandatory procedures. We performed a systematic review of English-language artic...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2018.03.006
更新日期：2018-09-01 00:00:00
abstract：:Persons with schizophrenia experience deficits in social cognition-the cognitive processes involved in how people perceive and interpret information about themselves, others, and social situations. These deficits may be related to the neurocognitive impairments often experienced by persons with schizophrenia. Our prim...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(01)00405-4
更新日期：2003-02-01 00:00:00
abstract：:Younger patients with schizophrenia have most likely experienced fewer adverse consequences of the illness than older patients who may have experienced a lifetime of treatment as well as socio-economic problems as a consequence of the illness. There is limited information regarding differential efficacy of long-acting...
journal_title：Schizophrenia research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.schres.2016.09.034
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:Dysfunctional serotonin signaling has been linked to the pathogenesis of autism, obsessive compulsive disorder, mood disorders and schizophrenia. While the hypo-activity of serotonin signaling is involved in the pathogenesis of depression, anxiety and obsessive compulsive disorder; LSD, an agonist of serot...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2013.12.007
更新日期：2014-02-01 00:00:00
abstract：:Antipsychotic pharmacotherapy is the standard of care for the treatment of schizophrenia. Although pharmacotherapy effectively improves some symptoms, others can remain. Pharmacotherapy alone also tends to produce only limited improvement in social functioning and quality of life. Supportive psychosocial therapies hav...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2007.12.468
更新日期：2008-03-01 00:00:00
abstract：:Results of first-episode psychosis studies have shown that the diagnosis of schizophrenia is more stable across time than other diagnoses within the psychosis spectrum disorders. The objective of this study was to determine the diagnostic stability in a sample of first-episode patients and to determine the factors tha...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2006.04.018
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:A small but significant association between schizophrenia and violence is open to a number of explanations. Impaired empathy has been associated with schizophrenia, and with violence in the general population. Our aim was to conduct a systematic review of any research into relationships between schizophrenia...
journal_title：Schizophrenia research
pub_type： 杂志文章,评审
doi：10.1016/j.schres.2012.07.019
更新日期：2012-10-01 00:00:00
abstract：:Social dysfunction is a hallmark of schizophrenia. Social isolation may increase individuals' risk for psychotic symptom exacerbation and relapse. Monitoring and timely detection of shifts in social functioning are hampered by the limitations of traditional clinic-based assessment strategies. Ubiquitous mobile technol...
journal_title：Schizophrenia research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.schres.2019.03.014
更新日期：2019-06-01 00:00:00
abstract：:Prenatal viral infection has been associated with development of schizophrenia and autism. Our laboratory has previously shown that viral infection causes deleterious effects on brain structure and function in mouse offspring following late first trimester (E9) administration of influenza virus. We hypothesized that l...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2007.11.018
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:The Discrimination and Stigma Scale (DISC-12) was specifically developed to measure experienced and anticipated discrimination reported by people with mental health problems. However, the length of the DISC-12 may represent a disadvantage especially in country settings with limited human capacity and infrast...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2019.07.018
更新日期：2019-10-01 00:00:00
abstract：:Social skill and role functioning were assessed in matched groups of patients with DSM-III-R schizoaffective disorder, bipolar disorder, and schizophrenia. Schizophrenics were categorized as negative syndrome or non-negative on the basis of the SANS. The negative schizophrenics were significantly more impaired on almo...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/0920-9964(89)90032-7
更新日期：1989-07-01 00:00:00
abstract：:The longitudinal course of primary cognitive dysfunction seen in schizophrenia has yet to be fully clarified. Whereas some studies in chronic patients have revealed a progressive decline in cognitive abilities, those studies with first-episode patients have indicated that initial cognitive deficits might remain stable...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/j.schres.2008.05.020
更新日期：2008-09-01 00:00:00
abstract：:Although the seasonal patterns of admissions of affective disorder have been extensively studied, less attention has been given to the seasonal admission patterns of schizophrenia. The traditional method of aggregating the data over a study period, rather than analysing by year of admission may obscure potentially rel...
journal_title：Schizophrenia research
pub_type： 杂志文章
doi：10.1016/s0920-9964(98)00106-6
更新日期：1998-11-30 00:00:00
