Comparison of long-term survival of 1986 consecutive patients with breast cancer treated at the National Cancer Institute of Milano, Italy (1971 to 1972 and 1977 to 1978).


:Long-term survival of 1986 consecutive patients with infiltrating duct carcinoma of the breast treated at the National Cancer Institute of Milano (Italy) in two periods of time (1971 to 1972 and 1977 to 1978) was comparatively evaluated to verify if the evolving concepts in the management of breast cancer had an impact on survival. The authors found that 10-year survival of our patients increased from 59.4% of the first period of time to 65% of the second (P = 0.005). Both node-negative (N-) and node-positive (N+) patients had an improvement of survival rates at 10 years of the same magnitude: 6.8% and 5.9% respectively. Taking into consideration both the maximum diameter of the primary tumor and the status of axillary nodes it was found that in (1) both N- and N+ patients with a primary tumor of no more than 2 cm in greatest diameter, the improvement of survival was not statistically significant; and (2) both N- and N+ patients with a primary greater than 2 cm in maximum diameter had a better chance of survival in the second time period.






Cascinelli N,Greco M,Morabito A,Bufalino R,Testori A,Baldini MT,Andreola S,Leo E,Galluzzo D,Rilke F




Has Abstract


1991-07-15 00:00:00














  • Phase 2 trial of two courses of cyclophosphamide and etoposide for relapsed high-risk osteosarcoma patients.

    abstract:BACKGROUND:A phase 2 trial was carried out to assess the antineoplastic activity of 2 courses of cyclophosphamide-etoposide in relapsed osteosarcoma patients. METHODS:Twenty-six relapsed osteosarcoma patients with a median age of 18.5 years (8.3-47.1) were enrolled. Seven patients were in first relapse (27%), 11 in se...


    pub_type: 杂志文章


    authors: Berger M,Grignani G,Ferrari S,Biasin E,Brach del Prever A,Aliberti S,Saglio F,Aglietta M,Fagioli F

    更新日期:2009-07-01 00:00:00

  • A Phase 1 and 2 study of Filanesib alone and in combination with low-dose dexamethasone in relapsed/refractory multiple myeloma.

    abstract:BACKGROUND:Filanesib (ARRY-520) is a highly selective inhibitor of kinesin spindle protein, which has demonstrated preclinical antimyeloma activity. METHODS:This open-label Phase 1/2 study determined the maximum tolerated dose of Filanesib administered on Days 1 and 2 of 14-Day Cycles in patients with multiple myeloma...


    pub_type: 杂志文章


    authors: Shah JJ,Kaufman JL,Zonder JA,Cohen AD,Bensinger WI,Hilder BW,Rush SA,Walker DH,Tunquist BJ,Litwiler KS,Ptaszynski M,Orlowski RZ,Lonial S

    更新日期:2017-12-01 00:00:00

  • Carcinoid tumor of the gallbladder associated with adenocarcinoma.

    abstract::A case of carcinoid tumor of the gallbladder associated with adenocarcinoma in a 56-year-old man is reported and a review of the literature is made. The tumor was a polypoid mass with a size of 5.5 X 4.0 X 2.8 cm. Histologically, the tumor showed carcinoid and adenocarcinoma with areas of mucous change. Tumor cells co...


    pub_type: 杂志文章


    authors: Wada A,Ishiguro S,Tateishi R,Ishikawa O,Matsui Y

    更新日期:1983-05-15 00:00:00

  • Factor VIII related antigen in adenomatoid tumors: implications for histogenesis.

    abstract::The current study was undertaken to reevaluate the histogenesis of adenomatoid tumor by an immunoperoxidase method of detecting factor VIII related antigen, a tissue specific marker for vascular endothelium. Three of eight adenomatoid tumors showed diffuse cytoplasmic staining of the cells lining the lumina. When thes...


    pub_type: 杂志文章


    authors: Bell DA,Flotte TJ

    更新日期:1982-09-01 00:00:00

  • Survivorship after lower gastrointestinal cancer: Patient-reported outcomes and planning for care.

    abstract:BACKGROUND:There is significant need for quality follow-up care to optimize long-term outcomes for the growing population of lower gastrointestinal (GI) cancer survivors. Patient-reported outcomes (PROs) provide valuable information regarding late and long-term effects (LLTEs). METHODS:A convenience sample from 1129 c...


    pub_type: 杂志文章


    authors: Frick MA,Vachani CC,Hampshire MK,Bach C,Arnold-Korzeniowski K,Metz JM,Hill-Kayser CE

    更新日期:2017-05-15 00:00:00

  • Cytologic examination of pancreatic juice for differential diagnosis of benign and malignant mucin-producing tumors of the pancreas.

    abstract:BACKGROUND:A new clinical type of pancreatic tumor, the mucin-producing tumor, has been recognized recently. However, it is not always easy to distinguish benign from malignant tumors preoperatively. In this study, three different methods of differentiating mucin-producing tumors of the pancreas were compared. METHODS...


    pub_type: 杂志文章


    authors: Uehara H,Nakaizumi A,Iishi H,Tatsuta M,Kitamra T,Okuda S,Ohigashi H,Ishikawa O,Takenaka A,Ishiguro S

    更新日期:1994-08-01 00:00:00

  • Risk of hypothyroidism in older breast cancer patients treated with radiation.

    abstract:BACKGROUND:Hypothyroidism is a potential complication after radiation therapy (RT) when treatment fields include the thyroid. The authors assessed risk of hypothyroidism in breast cancer patients who were receiving RT to a supraclavicular field, which typically includes a portion of thyroid. METHODS:The authors identi...


    pub_type: 杂志文章


    authors: Smith GL,Smith BD,Giordano SH,Shih YC,Woodward WA,Strom EA,Perkins GH,Tereffe W,Yu TK,Buchholz TA

    更新日期:2008-03-15 00:00:00

  • Pediatric cancer mortality and survival in the United States, 2001-2016.

    abstract:BACKGROUND:Although pediatric cancer mortality and survival have improved in the United States over the past 40 years, differences exist by age, race/ethnicity, cancer site, and economic status. To assess progress, this study examined recent mortality and survival data for individuals younger than 20 years. METHODS:Ag...


    pub_type: 杂志文章


    authors: Siegel DA,Richardson LC,Henley SJ,Wilson RJ,Dowling NF,Weir HK,Tai EW,Buchanan Lunsford N

    更新日期:2020-10-01 00:00:00

  • Small carcinoma of the pancreas. Clinical and pathologic evaluation of 17 patients.

    abstract::The clinical and pathologic characteristics of 17 small carcinomas (less than 2 cm in diameter) of the pancreas are reviewed in this article. All the tumors were located in the head of the pancreas, and the clue to the diagnosis was jaundice in ten patients and abdominal pain in seven. Carcinoembryonic antigen (CEA) a...


    pub_type: 杂志文章


    authors: Manabe T,Miyashita T,Ohshio G,Nonaka A,Suzuki T,Endo K,Takahashi M,Tobe T

    更新日期:1988-07-01 00:00:00

  • The efficacy of fiberoptic endoscopic examination and biopsy in the detection of early nasopharyngeal carcinoma.

    abstract::Fiberoptic endoscopic examination and biopsy of the nasopharynx was done in 130 patients as a prospective study. They all had elevated titers of antibodies against the viral capsid antigen of Epstein-Barr virus but no symptoms or signs of nasopharyngeal carcinoma. Each underwent a biopsy from six fixed sites in the na...


    pub_type: 杂志文章


    authors: Wei WI,Sham JS,Zong YS,Choy D,Ng MH

    更新日期:1991-06-15 00:00:00

  • A comparison of treatment outcomes for black patients and white patients with metastatic breast cancer. The Piedmont Oncology Association experience.

    abstract::Prior studies have shown that black patients with breast cancer have poorer survival times compared with white patients even when adjusted for stage. Seventy-four black patients treated on six Piedmont Oncology Association (POA) protocols were compared with 74 randomly selected white patients treated with the same pro...


    pub_type: 杂志文章


    authors: Kimmick G,Muss HB,Case LD,Stanley V

    更新日期:1991-06-01 00:00:00

  • Fostering coping and nurturing hope when discussing the future with terminally ill cancer patients and their caregivers.

    abstract:BACKGROUND:It is challenging for clinicians to foster coping and allow hope when discussing prognosis and end-of-life (EOL) issues with terminally ill cancer patients and their caregivers. To the authors' knowledge, little research evidence is currently available to guide clinical practice. METHODS:The authors conduct...


    pub_type: 杂志文章


    authors: Clayton JM,Butow PN,Arnold RM,Tattersall MH

    更新日期:2005-05-01 00:00:00

  • Epidemiology of intestinal and diffuse types of gastric carcinoma. A time-trend study in Finland with comparison between studies from high- and low-risk areas.

    abstract::The incidence of gastric cancer has declined markedly in Finland during the last 4 decades. To document the changes caused by that in the ratio of the intestinal type (IT) to the diffuse type (DT) of gastric carcinoma we compared the 367 cases diagnosed from southwestern Finland at the Department of Pathology, Turku U...


    pub_type: 杂志文章


    authors: Laurén PA,Nevalainen TJ

    更新日期:1993-05-15 00:00:00

  • C-erbB-2 oncogene protein in in situ and invasive lobular breast neoplasia.

    abstract::Lobular carcinoma in situ (LCIS) has uncertain malignant potential; biologic markers that will identify patients at risk for a poor clinical outcome have been sought actively. Amplification of the c-erbB-2 protooncogene has been correlated with poor prognosis in invasive mammary carcinoma, and immunohistochemical eval...


    pub_type: 杂志文章


    authors: Porter PL,Garcia R,Moe R,Corwin DJ,Gown AM

    更新日期:1991-07-15 00:00:00

  • Carcinoembryonic antigen (CEA) levels in benign gastrointestinal disease states.

    abstract::Elevated circulating CEA levels occur in patients with benign gastrointestinal and hepatic disorders. These are usually less than 10 ng/ml. Of clinical importance is the influence of liver disease on the interpretation of CEA. At least 50% of patients with severe benign hepatic disease have elevated CEA levels, most o...


    pub_type: 杂志文章,评审


    authors: Loewenstein MS,Zamcheck N

    更新日期:1978-09-01 00:00:00

  • Levamisole in primary breast cancer. A controlled study in conjunction with l-phenylalanine mustard.

    abstract::Between September 1976 and May 1980, 135 patients with operable breast cancer and positive axillary nodes received l-phenylalanine mustard, adjunct to surgery, 0.15 mg/kg for five days, six weekly, and were randomised prospectively to levamisole 150 mg for three days, two weekly, or a placebo. Treatment was continued ...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kay RG,Mason BH,Stephens EJ,Arthur JF,Hitchcock GC,Trindall PL,Rodgers R,Mullins P

    更新日期:1983-06-01 00:00:00

  • B-cell lymphoma in severe combined immunodeficiency not associated with the Epstein-Barr virus.

    abstract::Patients with congenital and acquired immunodeficiencies are at increased risk for the development of B-cell lymphoproliferative disorders. When the appropriate tests have been performed, the Epstein-Barr virus (EBV) nuclear antigen (EBNA) or EBV DNA has been found in tissues from these tumors. These data have provide...


    pub_type: 杂志文章


    authors: Garcia CR,Brown NA,Schreck R,Stiehm ER,Hudnall SD

    更新日期:1987-12-15 00:00:00

  • Blood vessel invasion and axillary lymph node involvement as prognostic indicators for human breast cancer.

    abstract::Blood vessel invasion and axillary lymph node involvement were examined in 175 breast cancer patients. The incidence of blood vessel invasion was 35%. The presence of blood vessel invasion was highly associated with early disease recurrence. The association of poor prognosis with blood vessel invasion was independent ...


    pub_type: 杂志文章


    authors: Weigand RA,Isenberg WM,Russo J,Brennan MJ,Rich MA

    更新日期:1982-09-01 00:00:00

  • Imaging hepatic neoplasms.

    abstract::The various radiologic methods used in the detection of hepatic lesions in the oncologic patient are discussed. The advantages and disadvantages of each imaging technique as well as a new diagnostic approach are also discussed. With the rapid technological advances made in cross-sectional imaging, the authors believe ...


    pub_type: 杂志文章


    authors: Bernardino ME,Lewis E

    更新日期:1982-12-01 00:00:00

  • Unexpected long-term survival after low-dose palliative radiotherapy for non-small cell lung cancer.

    abstract:BACKGROUND:Many experienced oncologists have encountered patients with proven non-small cell lung cancer (NCLC) who received modest doses of palliative radiotherapy (RT) and who unexpectedly survived for > 5 years; some were apparently cured. We used a very large prospective database to estimate the frequency of this p...


    pub_type: 杂志文章


    authors: Mac Manus MP,Matthews JP,Wada M,Wirth A,Worotniuk V,Ball DL

    更新日期:2006-03-01 00:00:00

  • The control of breast cancer. A World Health Organization perspective.

    abstract::The greatest decrease in breast cancer mortality is likely to derive from applying globally existing therapies at an earlier stage. A high priority of the World Health Organization (WHO) cancer control program is the outreach approach that promotes worldwide access to cancer therapies of proven values. Therefore, the ...


    pub_type: 杂志文章,评审


    authors: Koroltchouk V,Stanley K,Stjernswärd J

    更新日期:1990-06-15 00:00:00

  • Essential thrombocythemia. Clinical characteristics and course of 61 cases.

    abstract::Sixty-one patients with essential thrombocythemia (ET) were followed from 1974 through 1987 at the Medizinische Poliklinik. Fifty-one patients (84%) presented with thromboembolic complications, and eight patients (13%) with hemorrhages. In seven patients (12%), a thrombocytosis was detected accidentally. Disturbances ...


    pub_type: 杂志文章


    authors: Hehlmann R,Jahn M,Baumann B,Köpcke W

    更新日期:1988-06-15 00:00:00

  • Quality of life and mood predict posttraumatic stress disorder after hematopoietic stem cell transplantation.

    abstract:BACKGROUND:During hospitalization for hematopoietic stem cell transplantation (HCT), patients experience a steep deterioration in quality of life (QOL) and mood. To our knowledge, the impact of this deterioration on patients' QOL and posttraumatic stress disorder (PTSD) symptoms after HCT is unknown. METHODS:We conduc...


    pub_type: 杂志文章


    authors: El-Jawahri AR,Vandusen HB,Traeger LN,Fishbein JN,Keenan T,Gallagher ER,Greer JA,Pirl WF,Jackson VA,Spitzer TR,Chen YB,Temel JS

    更新日期:2016-03-01 00:00:00

  • Isolated limb reperfusion with tumor necrosis factor and melphalan in patients with extremity melanoma after failure of isolated limb perfusion with chemotherapeutics.

    abstract:BACKGROUND:This retrospective study evaluated the benefit of using tumor necrosis factor (TNF) and melphalan administered via an isolated limb perfusion (ILP) in a series of patients with metastatic melanoma who failed initial ILP with chemotherapeutics. METHODS:Seventeen patients with extremity melanoma who underwent...


    pub_type: 杂志文章


    authors: Bartlett DL,Ma G,Alexander HR,Libutti SK,Fraker DL

    更新日期:1997-12-01 00:00:00

  • Cancer in the families of children with soft tissue sarcoma.

    abstract::The cancer experience among 754 first-degree relatives (mothers, fathers, and siblings) of a population-based series of 177 children with soft tissue sarcoma is reported. The current study represents an extension of our earlier work in which the authors found an excess of breast cancer in the mothers of 143 of these c...


    pub_type: 杂志文章


    authors: Birch JM,Hartley AL,Blair V,Kelsey AM,Harris M,Teare MD,Jones PH

    更新日期:1990-11-15 00:00:00

  • Serum sialyltransferase and fucosyltransferase activities in patients with bronchial carcinoma.

    abstract::Serum sialyltransferases and fucosyltransferases measured by an affinity adsorbent technique were studied in 27 exactly defined patients with malignant pulmonary diseases. Fourteen patients with benign pulmonary diseases and 56 with benign surgical diseases were used as controls. Enzyme activities were expressed as am...


    pub_type: 杂志文章


    authors: Ronquist G,Nou E

    更新日期:1983-11-01 00:00:00

  • The role of radiotherapy in the treatment of malignant sweat gland neoplasms.

    abstract::Malignant sweat gland neoplasms are rare tumors. Historically, the principal mode of treatment has been local surgical excision. Eight published studies show that greater than 50% of patients develop either local tumor recurrence after surgery or regional lymph node metastases. Most patients have evidence of locoregio...


    pub_type: 杂志文章,评审


    authors: Harari PM,Shimm DS,Bangert JL,Cassady JR

    更新日期:1990-04-15 00:00:00

  • Intravascular angiomatosis: development and distinction from angiosarcoma.

    abstract::Histologic features similar to those present in angiosarcomas were found in organizing thrombi. Within the thrombi, freely anastomosing small channels, often lined by one or more layers of prominent, occasionally atypical, endothelial cells were noted. Papillary-like projections of organizing thrombus material lined b...


    pub_type: 杂志文章


    authors: Salyer WR,Salyer DC

    更新日期:1975-09-01 00:00:00

  • Attrition rates, reasons, and predictive factors in supportive care and palliative oncology clinical trials.

    abstract:BACKGROUND:Attrition is common among supportive care/palliative oncology clinical trials. However, to the authors' knowledge, few studies to date have documented the reasons and predictors for dropout. In the current study, the authors' objective was to determine the rate, reasons, and factors associated with attrition...


    pub_type: 杂志文章


    authors: Hui D,Glitza I,Chisholm G,Yennu S,Bruera E

    更新日期:2013-03-01 00:00:00

  • Evolution of carcinoma in the extrahepatic bile ducts.

    abstract::The histopathology of 43 cases of carcinoma in the extrahepatic bile ducts was reported. All four cases of noninfiltrating carcinoma were papillary or polypoid in gross shape. Only one of the eight cases of papillary or polypoid cancers penetrated beyond the fibromuscular layer of the bile ducts, while most cases of n...


    pub_type: 杂志文章


    authors: Kozuka S,Tsubone M,Hachisuka K

    更新日期:1984-07-01 00:00:00