Abstract:
:African trypanosomes (prototype: Trypanosoma brucei) are flagellated protozoan parasites that infect a wide variety of mammals, causing nagana in cattle and sleeping sickness in humans. These organisms can cause prolonged chronic infections due to their ability to successively expose different antigenic variants of the variant surface glycoprotein (VSG). The genomic loci where the VSG genes are expressed are telomeric and contain polycistronic transcription units with several genes that are involved in adaptation of the parasite to the host. At least three of these genes, which respectively encode the two subunits of the heterodimeric receptor for transferrin and a protein conferring resistance to the human trypanolytic factor apolipoprotein L-I, share the same origin as the VSG. The high recombination potential of the telomeric VSG expression sites, coupled to their dynamic mono-allelic expression control, provides trypanosomes with a powerful capacity for adaptation to their hosts.
journal_name
Microbes Infectjournal_title
Microbes and infectionauthors
Pays Edoi
10.1016/j.micinf.2005.10.002subject
Has Abstractpub_date
2006-03-01 00:00:00pages
930-7issue
3eissn
1286-4579issn
1769-714Xpii
S1286-4579(05)00330-8journal_volume
8pub_type
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更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00
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journal_title:Microbes and infection
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更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2008.11.015
更新日期:2009-02-01 00:00:00
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journal_title:Microbes and infection
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更新日期:2006-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(99)80054-9
更新日期:1999-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2008.07.035
更新日期:2008-10-01 00:00:00
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journal_title:Microbes and infection
pub_type:
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更新日期:2018-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2006.10.006
更新日期:2007-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2008.05.001
更新日期:2008-07-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2018.10.006
更新日期:2019-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2014.03.010
更新日期:2014-07-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/s1286-4579(01)01404-6
更新日期:2001-05-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
doi:10.1016/j.micinf.2003.08.007
更新日期:2003-11-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2009.04.006
更新日期:2009-05-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2008.01.012
更新日期:2008-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.06.008
更新日期:2006-01-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2004.01.009
更新日期:2004-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2015.02.002
更新日期:2015-05-01 00:00:00
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journal_title:Microbes and infection
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doi:10.1016/j.micinf.2006.07.020
更新日期:2006-10-01 00:00:00
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journal_title:Microbes and infection
pub_type: 信件
doi:10.1016/j.micinf.2006.10.020
更新日期:2007-02-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2005.09.018
更新日期:2006-04-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2011.06.002
更新日期:2011-11-01 00:00:00
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journal_title:Microbes and infection
pub_type: 杂志文章
doi:10.1016/j.micinf.2016.08.005
更新日期:2017-01-01 00:00:00