The mean platelet volume in subjects with impaired fasting glucose.

abstract：:The present study had two goals: first, to give a detailed description of a reliable method for full kinetic analysis of serotonin transporter (5HTt) on the membrane of human platelets, and second, as a main issue, to report on physiological influences on kinetic characteristics of this transmembrane transport on a la...

journal_title：Platelets

authors： Banović M,Bordukalo-Niksić T,Balija M,Cicin-Sain L,Jernej B

更新日期：2010-01-01 00:00:00

abstract：:Plasma lipid composition, platelet aggregation, cholesterol (Ch)/glycoprotein IIb-IIIa (GP) and phospholipid (Ph)/GP molar ratios, fatty acid composition and structural order (1, 6-diphenyl-1, 3, 5-hexatriene (DPH) fluorescence anisotropy at 35 degrees C (r(DPH,35)) of human platelet plasma membranes (HPPM) were measu...

journal_title：Platelets

authors： García-Guerra R,Mateo CR,García-Muñoz MS,Zapata MA,Plaza I,González-Rodríguez J

更新日期：1998-01-01 00:00:00

abstract：:Platelets contribute to blood coagulation at sites of vascular injury and to the recruitment of leukocytes at sites of inflammation. Under pathological conditions, platelets are involved in numerous diseases and clinical complications, such as deep venous thrombosis, embolism and atherosclerosis. But so far, little is...

journal_title：Platelets

authors： Slotta JE,Braun OO,Menger MD,Thorlacius H

更新日期：2009-11-01 00:00:00

abstract：:In this study, we have examined whether the platelet Fc-receptor, FcγRII (CD32), is associated with either of the two major platelet membrane glycoproteins, the GPIb-IX complex and the GPIIb-IIIa complex. Monoclonal and polyclonal anti-GPIb-IX complex antibodies inhibited to only a moderate degree (< 40%) the binding ...

journal_title：Platelets

authors： Berndt MC,Mazurov AV,Vinogradov DV,Burns GF,Chesterman CN

更新日期：1993-01-01 00:00:00

abstract：:Platelet shape change is an extremely rapid process mediated by both the calcium-sensitive and p160ROCK pathways. The present study examines how different features of shape change studied by scanning electron microscopy clearly correlate to changes in the pattern of light absorbance measured in an aggregometer. Platel...

journal_title：Platelets

authors： Paul BZ,Kim S,Dangelmaier C,Nagaswami C,Jin J,Hartwig JH,Weisel JW,Daniel JL,Kunapuli SP

更新日期：2003-05-01 00:00:00

abstract：:Epinephrine is known as a weak, but important, agonist for platelet activation. It has been reported that the responsiveness of platelets to epinephrine was markedly impaired in 6% of Caucasians and in 16% of Japanese. The purpose of this study was to screen and characterize this abnormality in healthy Taiwanese Chine...

journal_title：Platelets

authors： Lin TM,Lin JS,Tseng JY,Wu SY,Chen TY

更新日期：2016-01-01 00:00:00

abstract：:Aspirin is traditionally taken once daily in the morning and considered to be effective throughout the 24h interval. Cardiovascular events occur most frequently in the early morning, suggesting that these hours are critical in terms of adequate platelet inhibition. This study therefore assed platelet function in the e...

journal_title：Platelets

authors： Racca C,van Diemen JJK,Fuijkschot WW,Spit K,Bonten TN,Numans ME,van der Bom JG,Smulders YM,Thijs A

更新日期：2019-01-01 00:00:00

abstract：:Standardized Ginkgo biloba extract, EGb761, has been shown to possess polyvalent properties, such as anti-oxidation, anti-apoptosis and anti-inflammation. Recently, it has also been proposed to have direct protective effects on mitochondria. The effects of EGb761 make it a potential anti-aging drug. Despite that, the ...

journal_title：Platelets

authors： Shi C,Xiao S,Liu J,Guo K,Wu F,Yew DT,Xu J

更新日期：2010-01-01 00:00:00

abstract：:The assessment of platelet spreading through light microscopy, and the subsequent quantification of parameters such as surface area and circularity, is a key assay for many platelet biologists. Here we present an analysis workflow which robustly segments individual platelets to facilitate the analysis of large numbers...

journal_title：Platelets

authors： Pike JA,Simms VA,Smith CW,Morgan NV,Khan AO,Poulter NS,Styles IB,Thomas SG

更新日期：2021-01-02 00:00:00

abstract：:Platelets in flowing blood at high-shear stress are recruited to exposed subendothelial collagen of injured vessels by GPIb-von Willebrand factor (vWf) and integrin alpha(2)beta(1) (alpha(2)beta(1))-collagen interactions. Platelet adhesion to type I collagen depends mainly on the alpha(2)beta(1)-collagen interaction a...

journal_title：Platelets

authors： Jung SM,Sonoda M,Tsuji K,Jimi A,Nomura S,Kanaji T,Moroi M

更新日期：2010-01-01 00:00:00

abstract：:Autoimmune thrombocytopenic purpura (ITP) is characterized by an abnormally low platelet count and bleeding risks. The exact triggering event remains elusive. Oxidative stress may play a role in several autoimmune diseases. A direct link between platelets in ITP and oxidative stress has not yet been addressed. The int...

journal_title：Platelets

authors： Kamhieh-Milz J,Bal G,Sterzer V,Kamhieh-Milz S,Arbach O,Salama A

更新日期：2012-01-01 00:00:00

abstract：:The phytochemical resveratrol (3,4',5-trihydroxystilbene), which is found in grapes and wine, has been reported to have a variety of anti-inflammatory, anti-platelet and anti-carcinogenic effects. The aim of the present study was to evaluate the effects of trans-resveratrol on adhesion of blood platelets to collagen, ...

journal_title：Platelets

authors： Zbikowska HM,Olas B,Wachowicz B,Krajewski T

更新日期：1999-07-01 00:00:00

abstract：:Extracellular vesicles (EV) act as a cellular communication tool by carrying lipids, proteins and micro RNA (miR) between cells, thereby playing a pivotal role in thromboembolic processes. The effect of P2Y12 inhibitors on pro-coagulatory, phosphatidylserine (PS)-expressing EV has been investigated previously, but onl...

journal_title：Platelets

authors： Haller PM,Stojkovic S,Piackova E,Andric T,Wisgrill L,Spittler A,Wojta J,Huber K,Jäger B

更新日期：2020-05-18 00:00:00

abstract：:Studies on markers for bleeding risk among thrombocytopenic cancer patients are lacking. This prospective observational cohort study investigated whether platelet parameters and a standardised bleeding questionnaire predicted bleeding or prophylactic platelet transfusions in patients with cancer and thrombocytopenia. ...

journal_title：Platelets

authors： Vinholt PJ,Alnor A,Nybo M,Hvas AM

更新日期：2016-09-01 00:00:00

abstract：:The ADP receptor P2Y12, the thromboxane A2 receptor (TXA2R) and the C-type lectin-like receptor 2 (CLEC-2) mediate platelet activation by different mechanisms. Only little is known about the expression of the receptors in human megakaryopoiesis. Our study aimed to establish a flow cytometry (FC) method for the measure...

journal_title：Platelets

authors： Gerhards C,Uhlig S,Etemad M,Christodoulou F,Bieback K,Klüter H,Bugert P

更新日期：2020-07-03 00:00:00

abstract：:A 38-year-old female patient was diagnosed with anemia for 3 years. Medical examination showed slight splenomegaly (250 × 62 mm), thrombocytopenia (platelets 51 × 109/L), anemia (Hb levels 107 g/L), and β-glucocerebrosidase activity (GBA) in leukocytes was lower than normal. Microscopic findings of bone marrow smear d...

journal_title：Platelets

authors： Wan L,Wu H,Xie F,Nie Y

更新日期：2017-12-01 00:00:00

abstract：:The Multiplate is a popular instrument that measures platelet function using whole blood. Potentially considered a point of care instrument, it is also used by hemostasis laboratories. The instrument is usually utilized to assess antiplatelet medication or as a screen of platelet function. According to the manufacture...

journal_title：Platelets

authors： Chapman K,Favaloro EJ

更新日期：2018-05-01 00:00:00

abstract：:The objective of this study was to obtain pilot data on which to judge the feasibility and sample size needed for a future comparative-effectiveness trial of platelet transfusions in the NICU. We conducted a limited-scope pilot trial in which neonates were randomized to receive platelet transfusions based on platelet ...

journal_title：Platelets

authors： Zisk JL,Mackley A,Clearly G,Chang E,Christensen RD,Paul DA

更新日期：2014-01-01 00:00:00

abstract：:It has been suggested that thromboelastography TEG) can help in limiting or directing the appropriate use of blood products during surgery. However, the contribution of platelets to the TEG profile has not been studied in detail. Blood was taken from eight healthy subjects and eight patients with peripheral arterial d...

journal_title：Platelets

authors： Bowbrick VA,Mikhailidis DP,Stansby G

更新日期：2003-06-01 00:00:00

abstract：:In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as "platelet dust" by Peter Wolf in 1967, platelet microvesicles (PMV) are now recognized as important mediators of intercellular communication. There are example...

journal_title：Platelets

authors： Edelstein LC

更新日期：2017-05-01 00:00:00

abstract：:Platelet activation has long been known to be accompanied by secretion from at least three types of compartments. These include dense granules, the major source of small molecules; α-granules, the major protein storage organelle; and lysosomes, the site of acid hydrolase storage. Despite ~60 years of research, there a...

journal_title：Platelets

authors： Yadav S,Storrie B

更新日期：2017-03-01 00:00:00

abstract：:Lipid-rafts are defined as membrane microdomains enriched in cholesterol and glycosphingolipids within platelet plasma membrane. Lipid raft-mediated clot retraction requires factor XIII and other interacting proteins. The aim of this study was to investigate the proteins that interact with factor XIII in raft and non-...

journal_title：Platelets

authors： Rabani V,Montange D,Davani S

更新日期：2016-09-01 00:00:00

abstract：:A platelet substitute, Synthocytes, is being developed for the prevention and treatment of thrombocytopenia. Synthocytes are composed of fibrinogen adsorbed on heat stabilised albumin microcapsules of defined size. The purpose of this study was to perform experiments in vitro to investigate the capacity of Synthocytes...

journal_title：Platelets

authors： Davies AR,Judge HM,May JA,Glenn JR,Heptinstall S

更新日期：2002-06-01 00:00:00

abstract：:R-lipoic acid (ALA), a powerful antioxidant valuable for the treatment of diabetes and its complications, has been reported to exhibit an antiplatelet activity in vitro. The aim of this study was to investigate the effect and mechanism of ALA on platelets in vivo. Sprague-Dawley (SD) male rats were intravenously admin...

journal_title：Platelets

authors： Liu J,Song Q,Huang Y,Sun W,Lu D,Zhou B

更新日期：2018-11-01 00:00:00

abstract：:Platelet-rich plasma (PRP) has a potential effect on tissue repair through proliferation and differentiation of tissue progenitor cells. The aim of this study was to evaluate the effect of PRP on the testis structure and function in infertile rat model by stereological method. Thirty-two male rats were divided into fo...

journal_title：Platelets

authors： Dehghani F,Sotoude N,Bordbar H,Panjeshahin MR,Karbalay-Doust S

更新日期：2019-01-01 00:00:00

abstract：:Thrombocytopenia is a clinically relevant outcome in HIV. However, the epidemiology of this condition, including frequency, severity, and duration, has not been well-characterized in the era of highly active antiretroviral therapy (HAART). In this study, we describe the epidemiology of thrombocytopenia using two metho...

journal_title：Platelets

authors： Vannappagari V,Nkhoma ET,Atashili J,Laurent SS,Zhao H

更新日期：2011-01-01 00:00:00

abstract：:Recent studies suggest that anti-platelet agents are not equally effective in all individuals. We have developed a new method to evaluate the effect of anti-platelet drugs using the cone and plate(let) analyzer (CPA) test. The method is based on the ability of activators to reduce platelet adhesion under flow conditio...

journal_title：Platelets

authors： Spectre G,Brill A,Gural A,Shenkman B,Touretsky N,Mosseri E,Savion N,Varon D

更新日期：2005-08-01 00:00:00

abstract：:Selective activation of the platelet TXA2 receptor is sufficient to mediate concurrent aggregation, deaggregation and shape change (SC) responses without activation of known Gi-coupled receptors (Platelets 2003; 14: 89). However, Gi-coupled receptor activation strongly influences the hemostasis response in vivo. This ...

journal_title：Platelets

authors： Maayani S,Schwarz TE,Patel ND,Craddock-Royal BD,Tagliente TM

更新日期：2003-09-01 00:00:00

abstract：:The aim of the present study was to investigate the role of 12-lipoxygenase (12-LOX) on platelet-induced airway smooth muscle cell (ASMC) proliferation. Co-incubation of platelets and ASMC caused platelet activation as determined by morphological changes. Simultaneously, reactive oxygen species (ROS)-generation was de...

journal_title：Platelets

authors： Svensson Holm AC,Grenegård M,Ollinger K,Lindström EG

更新日期：2014-01-01 00:00:00

abstract：:The present study was performed to explore differences in the expression of P-selectin and IL-8 production of blood cells in healthy individuals with large size platelets (MI-families) as compared to people having normal size platelets. A positive correlation between LPS-induced IL-8 production per platelet in whole b...

journal_title：Platelets

authors： Breimo ES,Østerud B

更新日期：2003-11-01 00:00:00