Interactive protein network of FXIII-A1 in lipid rafts of activated and non-activated platelets.

abstract：:The aim of the study was to evaluate diurnal changes of tissue factor (TF) and tissue factor pathway inhibitor (TFPI) concentrations in relation to on-treatment platelet reactivity. The study group included 51 patients with acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention and d...

journal_title：Platelets

authors： Boinska J,Koziński M,Kasprzak M,Ziołkowska K,Dziembowska I,Ziołkowski M,Kubica J,Rość D

更新日期：2020-10-02 00:00:00

abstract：:Abstract Familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML) is an autosomal dominant disorder characterized by mild to moderate thrombocytopenia with or without its impaired function, inherited RUNX1 mutation and high incidence of myeloid malignancy, such as myelodysplastic syndrome or ...

journal_title：Platelets

authors： Toya T,Yoshimi A,Morioka T,Arai S,Ichikawa M,Usuki K,Kurokawa M

更新日期：2014-01-01 00:00:00

abstract：:The multifunctional cytokine, TWEAK (TNF-like weak inducer of apoptosis), is a member of the TNFα superfamily. TWEAK is found in a broad range of cell types and has been linked to cell growth and survival, angiogenesis and other inflammatory processes. These functions and their importance in inflammatory diseases have...

journal_title：Platelets

authors： Meyer T,Amaya M,Desai H,Robles-Carrillo L,Hatfield M,Francis JL,Amirkhosravi A

更新日期：2010-01-01 00:00:00

abstract：:The objective of this study was to investigate the use of thrombopoietin-receptor agonists (TPO-ra) in patients with refractory primary immune thrombocytopenia (ITP) as well as off-label use of TPO-ra in Danish haematology departments. Hospital medical records from 32 of the 39 patients having received TPO-ra from 200...

journal_title：Platelets

authors： Gudbrandsdottir S,Frederiksen H,Hasselbalch H

更新日期：2012-01-01 00:00:00

abstract：:The present study was designed to investigate the interaction between platelet indices, inflammatory markers and disease activity in rheumatoid arthritis (RA) subjects. The effects of anti-TNF-alpha therapy and conventional treatment on platelet indices were also compared. We studied 97 patients with RA (19 men, 78 wo...

journal_title：Platelets

authors： Yazici S,Yazici M,Erer B,Erer B,Calik Y,Ozhan H,Ataoglu S

更新日期：2010-01-01 00:00:00

abstract：:Studies have reported the polymorphism of human platelet antigen (HPA)-17w, -18w, -19w, -20w, and -21w. However, the distribution of these five antigens in Chinese Cantonese is still unknown. In this study, we designed new sequence-specific primers for HPA-19w to -21w and used published primers for HPA-17w and -18w to...

journal_title：Platelets

authors： Zhou H,Ding H,Chen Y,Li X,Ye X,Nie Y

更新日期：2015-01-01 00:00:00

abstract：:Whether the simultaneous administration of ciprofloxacin or tazobactam/piperacillin increases the risk of thrombocytosis is unknown. Broncho-pulmonary infection in a 50-year-old male with acute, hypertensive, intracerebral bleeding, necessitated therapy with cefpirome (2 g/day, 6 days), ciprofloxacin (800 mg/d, 11 day...

journal_title：Platelets

authors： Finsterer J,Kotzailias N

更新日期：2003-08-01 00:00:00

abstract：:The tetraspanins are a superfamily of membrane glycoproteins which facilitate the interaction of membrane and intracellular signalling molecules (e.g., integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signalling microdomains (sometimes referred to as the tetraspanin web...

journal_title：Platelets

authors： Moseley GW

更新日期：2005-02-01 00:00:00

abstract：:The DP receptor-dependence of inhibition of platelet aggregation (PA), degranulation, and TXA(2) synthesis, by PGD(2), in human whole blood, has not been established since selective antagonists have only recently been developed. Accordingly, the effects of PGD(2) (30 nM), were determined using the DP receptor antagoni...

journal_title：Platelets

authors： Menys VC

更新日期：1995-01-01 00:00:00

abstract：:Morning increase in the occurrence of myocardial infarction, stroke and sudden cardiac death is a well-recognized phenomenon, which is in line with a morning enhancement of platelet aggregation. We investigated whether platelet inhibition during clopidogrel and aspirin therapy varies during the day. Fifty-nine consecu...

journal_title：Platelets

authors： Kozinski M,Bielis L,Wisniewska-Szmyt J,Boinska J,Stolarek W,Marciniak A,Kubica A,Grabczewska Z,Navarese EP,Andreotti F,Siller-Matula JM,Rosc D,Kubica J

更新日期：2011-01-01 00:00:00

abstract：:The aim of this study was to determine the contribution of increased PGD(2) formation to the anti-aggregatory action of a thromboxane A(2) (TXA(2)) synthase inhibitor and TP receptor antagonist (ZD1542) against collagen-induced human platelet aggregation in citrated whole blood using the prostaglandin (PG) DP receptor...

journal_title：Platelets

authors： Menys VC

更新日期：1994-01-01 00:00:00

abstract：:Bleeding in the setting of acute coronary syndromes (ACS) has negative prognostic implications. We sought to determine the impact of different levels of on-treatment platelet reactivity (PR) to ADP on both bleeding and ischemic events in ACS patients receiving coronary stenting. PR to ADP was measured with the VerifyN...

journal_title：Platelets

authors： Huczek Z,Filipiak KJ,Kochman J,Michalak M,Roik M,Grabowski M,Opolski G

更新日期：2011-01-01 00:00:00

abstract：:The objective of this study was to obtain pilot data on which to judge the feasibility and sample size needed for a future comparative-effectiveness trial of platelet transfusions in the NICU. We conducted a limited-scope pilot trial in which neonates were randomized to receive platelet transfusions based on platelet ...

journal_title：Platelets

authors： Zisk JL,Mackley A,Clearly G,Chang E,Christensen RD,Paul DA

更新日期：2014-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS, endotoxin) is a well-known causative agent of septic shock and disseminated intravascular coagulation. The action of LPS is related to the activation of many types of cells, including blood platelets. We examined the effects of different LPSs from Proteus mirabilis (smooth form LPS S1959 and r...

journal_title：Platelets

authors： Zielinski T,Wachowicz B,Saluk-Juszczak J,Kaca W

更新日期：2002-11-01 00:00:00

abstract：:The influence of three anti-platelet drugs, cilostazol, aspirin, and tirofiban, was investigated on platelet-leukocyte interaction by flow cytometry. When platelets and leukocytes were pre-incubated with anti-platelet drugs and stimulated by thrombin or collagen, cilostazol was found to inhibit platelet adhesion to mo...

journal_title：Platelets

authors： Ito H,Miyakoda G,Mori T

更新日期：2004-08-01 00:00:00

abstract：:Oxidative damage to lipids in plasma, blood platelets and neurons in patients with schizophrenia was described. The aim of our present study was to evaluate oxidative/nitrative modifications of blood platelets proteins by measurement the level of biomarkers of oxidative stress such as carbonyl groups, thiol groups and...

journal_title：Platelets

authors： Dietrich-Muszalska A,Olas B

更新日期：2009-03-01 00:00:00

abstract：:The aim of the study was to evaluate how platelet aggregation relates to left ventricular hypertrophy, presence of transient myocardial ischemia and coronary atherosclerosis in essential hypertensive patients. For that purpose platelet aggregation, symptom-limited treadmill-test, echocardiography and coronary angiogra...

journal_title：Platelets

authors： Gabbasov Z,Parfyonova Y,Popov E,Gavrilov I,Anuchin V,Dubov P,Djakonova Y

更新日期：1998-01-01 00:00:00

abstract：:The effects of prostaglandin E(2) (PGE(2)) on platelet function are believed to be the result of opposing mechanisms that lead to both enhancement and inhibition of platelet function. Enhancement of platelet function is known to be via EP3 receptors linked to G(i) and inhibition of adenylyl cyclase. However, the recep...

journal_title：Platelets

authors： Iyú D,Glenn JR,White AE,Johnson AJ,Fox SC,Heptinstall S

更新日期：2010-01-01 00:00:00

abstract：:A 38-year-old female patient was diagnosed with anemia for 3 years. Medical examination showed slight splenomegaly (250 × 62 mm), thrombocytopenia (platelets 51 × 109/L), anemia (Hb levels 107 g/L), and β-glucocerebrosidase activity (GBA) in leukocytes was lower than normal. Microscopic findings of bone marrow smear d...

journal_title：Platelets

authors： Wan L,Wu H,Xie F,Nie Y

更新日期：2017-12-01 00:00:00

abstract：:Collagen (5 microg/ml) stimulation of washed platelets increased endogenous serotonin (5-HT) release to the medium from 13.88 1.39 to 188.67 26.37 pmol/108 platelets ( P < 0.001). Adrenaline (16 microM) also increased 5-HT release, from 11.0 1.46 to 110.6 29.9 pmol/108 platelets ( P < 0.02). Naftopidil enhanced collag...

journal_title：Platelets

authors： Alarayyed NA,Prichard BN,Betteridge DJ,Smith CC

更新日期：1997-01-01 00:00:00

abstract：:Platelet aggregation in response to ADP, adrenaline, collagen, arachidonic acid and ristocetin was measured in a large population of healthy Saudi males (n = 393) and females (n = 221) whose age ranged from 11-60 years. The number of observations ranged from 130 for one of the doses of ristocetin (1.0 g/l) to 554 for ...

journal_title：Platelets

authors： Gader AM,Bahakim HM,Malaika SS

更新日期：1990-01-01 00:00:00

abstract：:Outcomes of platelet function tests are highly dependent on the type of blood anticoagulant used. The primary objective of this study was to clinically evaluate the platelet function after dual antiplatelet therapy using two different types of anticoagulant (citrate and hirudin). We compared data obtained from multipl...

journal_title：Platelets

authors： Zhang HZ,Yu LH,Kim MH

更新日期：2013-01-01 00:00:00

abstract：:Interaction of von Willebrand factor (VWF) with circulating platelets promotes hemostasis when a blood vessel is injured. The A1 domain of VWF is responsible for the initial interaction with platelets and is well conserved among species. Knowledge of the cDNA and genomic DNA sequences for human VWF allowed us to predi...

journal_title：Platelets

authors： Chitta MS,Duhé RJ,Kermode JC

更新日期：2007-05-01 00:00:00

abstract：:Autophagy is an effective strategy for cell development by recycling cytoplasmic constituents. Genetic deletion of autophagy mediator Atg7 in hematopoietic stem cells (HSCs) can lead to failure of megakaryopoiesis and enhanced autophagy has been implicated in various hematological disorders such as immune thrombocytop...

journal_title：Platelets

authors： Wang Q,You T,Fan H,Wang Y,Chu T,Poncz M,Zhu L

更新日期：2017-01-01 00:00:00

abstract：:We prospectively investigated the prevalence of Helicobacter pylori (H. pylori) infection in a cohort of 54 adult Serbian patients with chronic idiopathic thrombocytopenic purpura (ITP), and examined the effects of its eradication on their platelet counts. H. pylori infection was diagnosed in 39/54 (72.2%) patients, u...

journal_title：Platelets

authors： Suvajdzić N,Stanković B,Artiko V,Cvejić T,Bulat V,Bakrac M,Colović M,Obradović V,Atkinson HD

更新日期：2006-06-01 00:00:00

abstract：:Metabolic syndrome (MS) is becoming globally prevalent and it is clinically important because of its association with type 2 diabetes and cardiovascular disease, and some cancers. Recently, platelet count has been linked to insulin resistance and MS in addition to being a marker of hemostasis. Also, mean platelet volu...

journal_title：Platelets

authors： Park BJ,Shim JY,Lee HR,Jung DH,Lee JH,Lee YJ

更新日期：2012-01-01 00:00:00

abstract：:Autoimmune thrombocytopenic purpura (ITP) is characterized by an abnormally low platelet count and bleeding risks. The exact triggering event remains elusive. Oxidative stress may play a role in several autoimmune diseases. A direct link between platelets in ITP and oxidative stress has not yet been addressed. The int...

journal_title：Platelets

authors： Kamhieh-Milz J,Bal G,Sterzer V,Kamhieh-Milz S,Arbach O,Salama A

更新日期：2012-01-01 00:00:00

abstract：:Microalbuminuria is the best predictor of diabetic nephropathy development in patients with type II diabetes mellitus (DM). It is also accepted as an indicator of diabetic microangiopathy. Increased activation of platelets has been suggested to be involved in the pathogenesis of vascular complications. In light of the...

journal_title：Platelets

authors： Ünübol M,Ayhan M,Güney E

更新日期：2012-01-01 00:00:00

abstract：:Platelet-surface contact is the first step in thrombus formation. Platelet spreading makes this initial contact irreversible. On the other hand plasma lipids and fibrinogen have been described to activate platelets or promote adhesion. We therefore investigated whether platelet spreading under stagnation-point flow co...

journal_title：Platelets

authors： Reininger AJ,Reininger CB,Agneskirchner J,Scherb H,Spannagl M,Wurzinger LJ

更新日期：1998-01-01 00:00:00

abstract：:Vascular diseases such as myocardial infarction and ischemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel, and prasugrel. However, some patients exhibit high platelet reactivity, especially with clopidogrel. Existing...

journal_title：Platelets

authors： Bath PM,May J,Heptinstall S

更新日期：2018-07-01 00:00:00