Abstract:
:The aim of this study was to determine the contribution of increased PGD(2) formation to the anti-aggregatory action of a thromboxane A(2) (TXA(2)) synthase inhibitor and TP receptor antagonist (ZD1542) against collagen-induced human platelet aggregation in citrated whole blood using the prostaglandin (PG) DP receptor antagonists AH6809 and 868C84. ZD1542 (1 μM) was markedly more effective than aspirin (1 mM) against collagen-induced aggregation (73 vs 52% inhibition respectively), and formation of both PGI(2) and PGD(2) was evident in the presence of ZD1542. Added PGD(2) (30 nM) inhibited aggregation to a similar extent as did ZD1542 (68% inhibition) and the antiaggregatory action of PGD(2) was abolished, both by AH6809 (50 μM) and by 868C84 (0.5 μM). AH6809 significantly reduced the antiaggregatory efficacy of ZD1542, but did not modify the efficacy of aspirin. In contrast, 868C84 had little effect on the antiaggregatory efficacy of ZD1542 whereas 868C84 in combination with aspirin inhibited platelet aggregation more markedly than did aspirin alone. These findings indicate that formation of PGD(2) contributes to the antiaggregatory action of ZD1542 against collagen-induced human platelet aggregation. However, results obtained with the DP receptor antagonist 868C84 were inconclusive since 868C84 has a limited inhibitory effect against collagen-induced human platelet aggregation which is independent of eicosanoid formation.
journal_name
Plateletsjournal_title
Plateletsauthors
Menys VCdoi
10.3109/09537109409005529subject
Has Abstractpub_date
1994-01-01 00:00:00pages
156-61issue
3eissn
0953-7104issn
1369-1635journal_volume
5pub_type
杂志文章相关文献
PLATELETS文献大全abstract::Calcium channel blockers are known to inhibit platelet aggregation in vitro and ex vivo. We studied the influence of a single oral dose of diltiazem (60 mg), nifedipine (10 mg) and verapamil (80 mg) on ADP-, collagen-, and epinephrine-induced platelet aggregation, malondialdehyde formation, serum thromboxane B(2) and ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109109005501
更新日期:1991-01-01 00:00:00
abstract::Glanzmann's thrombasthenia (GT) is characterized by increased bleeding risk. The treatment options in GT are limited. The aim of this study was to test the effect of GT blood supplementation with fibrinogen and factor XIII on thrombin generation, blood clotting, and fibrinolysis. Whole blood samples of GT patients and...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2011.642031
更新日期:2012-01-01 00:00:00
abstract::Thrombocytopenia is common in patients with lung diseases. Lung injury is associated with deranged platelet homeostasis. The potential mechanisms underlying this association were investigated in this study. The number and morphology of circulating megakaryocytes (MK) were investigated in vivo during cardiopulmonary by...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100600745120
更新日期:2006-08-01 00:00:00
abstract::Infection induces platelet activation and consumption, which leads to thrombocytopenia, enhances microvascular thrombosis, impairs microcirculation and eventually triggers disseminated intravascular coagulation (DIC). It is well characterized that endotoxemia results in a pro-inflammatory and pro-coagulatory state, wh...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2015.1119814
更新日期:2016-07-01 00:00:00
abstract::Platelets in flowing blood at high-shear stress are recruited to exposed subendothelial collagen of injured vessels by GPIb-von Willebrand factor (vWf) and integrin alpha(2)beta(1) (alpha(2)beta(1))-collagen interactions. Platelet adhesion to type I collagen depends mainly on the alpha(2)beta(1)-collagen interaction a...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903497549
更新日期:2010-01-01 00:00:00
abstract::Sheehan's syndrome (SS) is an adenopituitary insufficiency caused by hypovolemia secondary to excessive blood loss during or after childbirth. However, the mechanism of postpartum hemorrhage and ischemia is not clear. We aimed to evaluate the bleeding disorders among patients with SS, in comparison with healthy contro...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2010.525722
更新日期:2011-01-01 00:00:00
abstract::This phase III, randomized, placebo-controlled study conducted in three stages (6-week, randomized, placebo-controlled stage 1; 24-week, open-label stage 2; and continuous extension stage 3) assessed the long-term efficacy and safety of eltrombopag use in Chinese patients with chronic immune thrombocytopenia (ITP). Th...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1847267
更新日期:2020-11-29 00:00:00
abstract::Platelets play a key role in thrombotic vascular occlusion at the side of an atherosclerotic plaque. Malondialdehyde (MDA) derivatives are components of oxidized LDL. Recent studies suggest enhanced adhesion of platelets on oxidized LDL, but evidence of MDA-modified LDL contribution to enhanced platelet adhesion is mi...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100500261590
更新日期:2006-03-01 00:00:00
abstract::Previous studies suggested that the adipocytokines, adiponectin and leptin, are associated with the progression and prognosis of coronary artery disease (CAD). The aim of this study was to differentially evaluate plasma levels of adiponectin and leptin in patients with CAD and their association with conventional labor...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903377584
更新日期:2010-01-01 00:00:00
abstract::In aspirin-treated platelets labelled by preincubation with [(3)H]-choline, enhanced release of both [(3)H]-choline and [(3)H]-choline phosphate resulted from stimulation by collagen or thrombin. No such release accompanied stimulation by ADP, platelet-activating factor or adrenaline. Release of [(3)H]-choline phospha...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109309013192
更新日期:1993-01-01 00:00:00
abstract::In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding. These antibodies may induce complement activation, thus mediating complement-induced platelet destruction. In this study, ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2016.1235686
更新日期:2017-06-01 00:00:00
abstract::Vascular diseases such as myocardial infarction and ischemic stroke are associated with increased platelet function whilst the risk of recurrence is reduced by antiplatelet agents such as aspirin, clopidogrel, and prasugrel. However, some patients exhibit high platelet reactivity, especially with clopidogrel. Existing...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2018.1445839
更新日期:2018-07-01 00:00:00
abstract::Platelets from patients with type 2 diabetes show abnormalities in intracellular Ca(2+) homeostasis that are involved in platelet hyperaggregability and the development of thrombotic complications. Different Ca(2+) transport mechanisms have been reported to be altered in platelets from patients with type 2 diabetes, i...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2010.528813
更新日期:2011-01-01 00:00:00
abstract::Platelet discoid shape is known to correlate with in vivo viability after transfusion. Measurement of shape change requires invasive sampling and laborious assays, which is difficult to perform in a blood transfusion center as a routine test for quality control of stored platelets. The objective of this study was to e...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100600757695
更新日期:2006-09-01 00:00:00
abstract::Current guidelines favor dual anti-platelet therapy with ticagrelor 90 mg BID (T90BID) over clopidogrel 75 mg QD (C75QD) in addition to aspirin for acute coronary syndrome. However, an increased risk of ticagrelor-related adverse events prompted the evaluation of low-dose regimens. This study (NCT03381742) retrospecti...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1732328
更新日期:2021-01-02 00:00:00
abstract::Heparin and protamine are fundamental in the management of anticoagulation during cardiac surgery. Excess protamine has been associated with increased bleeding. Interaction between protamine and platelet function has been demonstrated but the mechanism remains unclear. We examined the effect of protamine on platelet f...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1719992
更新日期:2021-01-02 00:00:00
abstract::Hemorrhage is a significant pathological feature of some fever or hyperthermia-related diseases, such as dengue fever and heatstroke. Although the mechanisms of hemorrhage in these diseases are thought to be complex, whether there is an association between hemorrhage and hyperthermia or fever remains unclear. Platelet...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903443949
更新日期:2010-01-01 00:00:00
abstract::The aim of the present study was to investigate and compare the anti-platelet action of extracts from three different plants: bark of Yucca schidigera, seeds of grape and berries of Aronia melanocarpa (chokeberry). Anti-platelet action of tested extracts was compared with action of well characterized antioxidative and...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100701708506
更新日期:2008-02-01 00:00:00
abstract::The aim of this study was to determine whether autologous fresh platelet concentrate (PC) significantly improves haemostasis in cardiac reoperations compared with autologous fresh whole blood (WB). Forty-eight patients who had elective cardiac reoperations with a low-dose aprotinin priming regimen were divided into tw...
journal_title:Platelets
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/09537100120058801
更新日期:2001-06-01 00:00:00
abstract::Thrombocytopenia is classically defined as a platelet count of less than 150 000/µl. Counts from 100 000 to 150 000/µl are considered mildly depressed, 50 000 to 100 000/µl moderately depressed, and less than 50 000/µl severely depressed. Thrombocytopenia occurs in about 10% of pregnant women. Gestational thrombocytop...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2012.724484
更新日期:2013-01-01 00:00:00
abstract::Platelet-rich plasma (PRP) is increasingly used in the treatment of musculoskeletal diseases. Its preservation by freezing it for the realization of multiple injections in clinical use has never been discussed. Calcaneal tendons of rats were surgically sectioned. Platelet concentration of the PRP was 2.5 x 106/µl with...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2019.1595563
更新日期:2020-01-01 00:00:00
abstract::In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as "platelet dust" by Peter Wolf in 1967, platelet microvesicles (PMV) are now recognized as important mediators of intercellular communication. There are example...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2016.1257114
更新日期:2017-05-01 00:00:00
abstract::Autophagy is an effective strategy for cell development by recycling cytoplasmic constituents. Genetic deletion of autophagy mediator Atg7 in hematopoietic stem cells (HSCs) can lead to failure of megakaryopoiesis and enhanced autophagy has been implicated in various hematological disorders such as immune thrombocytop...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2016.1204436
更新日期:2017-01-01 00:00:00
abstract::Combined inhibition of platelet aggregation is essential to prevent recurrent ischemic episodes in patients with acute coronary syndromes and after percutaneous coronary interventions (PCIs). In combination with aspirin, the ADP receptor antagonist clopidogrel is used widespread for this purpose; however, platelet rea...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.3109/09537104.2011.610475
更新日期:2012-01-01 00:00:00
abstract::In a family, a moderate bleeding disorder in two patients has been specified as Glanzmann's thrombasthenia because of characteristic defects in platelet function. Analysis of platelet membrane glycoproteins revealed about a 50% decrease in the amount of GP IIb-IIIa complex (α(11b)β(3) integrin), which appeared normal ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109609023581
更新日期:1996-01-01 00:00:00
abstract::The Gray Platelet Syndrome (GPS) is a rare inherited, hypogranular platelet disorder characterized by virtual absence of alpha granules in bone marrow megakaryocytes and circulating plates. Usually only one member of a family is affected, but families with two or more affected individuals have been reported from Franc...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100600758636
更新日期:2006-12-01 00:00:00
abstract::We have investigated interactions between human blood platelets and the vitronectin-containing fluid-phase terminal complement complex, the SC5b-9, which is a non-cytolytic variant of the membrane attack complex C%9(m). SC5b-9 affinity for the platelet membrane glycoprotein IIb/IIIa (GPIIb/IIIa) complex was demonstrat...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109509013269
更新日期:1995-01-01 00:00:00
abstract::Two putative substitutes for fresh endothelial cell (EC) extracellular matrix (ECM), frozen ECM and Matrigel, were studied using a parallel-plate perfusion system and platelet deposition was evaluated morphometrically. Coverslips covered with ECM were stored frozen at-30 C for 0 (fresh ECM), 1, 2, 3 or 4 weeks. The ab...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537109876500
更新日期:1998-01-01 00:00:00
abstract::The spleen, in addition to its role in immunity, plays key roles in erythrocyte maintenance and platelet sequestration. Loss of the spleen via splenectomy occurs in approximately 6.4 to 7.1 per 100 000 people per year globally, commonly as a life-saving emergency procedure in trauma and a therapeutic procedure in hema...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2020.1732322
更新日期:2021-01-02 00:00:00
abstract::Impaired glucose tolerance (IGT), a prediabetic state, is associated with an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. This study was designed to answer the following questions: (i) Do MPV levels cha...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100701609019
更新日期:2007-12-01 00:00:00