Effects of autologous fresh platelet concentrate on haemostasis in cardiac reoperations.

abstract：:Blood platelets, in analogy to other circulating blood cells, can generate reactive oxygen/nitrogen species (ROS/RNS) that may behave as second messengers and may regulate platelet functions. Accumulating evidence suggest a role of ROS/RNS in platelet activation. On the other hand, an increased production of ROS/RNS c...

journal_title：Platelets

authors： Olas B,Wachowicz B

更新日期：2007-12-01 00:00:00

abstract：:Mechanisms involved in the reduction of blood platelet functions by various plant extract, including the grape seeds extract (rich in phenolic compounds, a mixture of about 95% oligomeric phenols; GSE) are still unclear. In the literature there are few papers describing studies on the effects of GSE on selected elemen...

journal_title：Platelets

authors： Olas B,Wachowicz B,Stochmal A,Oleszek W

更新日期：2012-01-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is increasingly used in the treatment of musculoskeletal diseases. Its preservation by freezing it for the realization of multiple injections in clinical use has never been discussed. Calcaneal tendons of rats were surgically sectioned. Platelet concentration of the PRP was 2.5 x 106/µl with...

journal_title：Platelets

authors： Kaux JF,Libertiaux V,Dupont L,Colige A,Denoël V,Lecut C,Hego A,Gustin M,Duwez L,Oury C,Gothot A,Greimers L,Drion P

更新日期：2020-01-01 00:00:00

abstract：:Platelet discoid shape is known to correlate with in vivo viability after transfusion. Measurement of shape change requires invasive sampling and laborious assays, which is difficult to perform in a blood transfusion center as a routine test for quality control of stored platelets. The objective of this study was to e...

journal_title：Platelets

authors： Mathai J,Resmi KR,Sulochana PV,Sathyabhama S,Baby Saritha G,Krishnan LK

更新日期：2006-09-01 00:00:00

abstract：:Platelets contribute to blood coagulation at sites of vascular injury and to the recruitment of leukocytes at sites of inflammation. Under pathological conditions, platelets are involved in numerous diseases and clinical complications, such as deep venous thrombosis, embolism and atherosclerosis. But so far, little is...

journal_title：Platelets

authors： Slotta JE,Braun OO,Menger MD,Thorlacius H

更新日期：2009-11-01 00:00:00

abstract：:Statins reduce coronary heart disease risk by altering blood lipids and other mechanisms. One of the possible other mechanisms is through an effect on thrombosis. We assessed the effect of simvastatin 80 mg daily versus placebo given in a single blind crossover fashion on platelet size in response to standard ex vivo ...

journal_title：Platelets

authors： Isley WL,Park Y,Harris WS

更新日期：2006-08-01 00:00:00

abstract：:SIRT1, a class III histone deacetylase, is critically involved in cellular response to stress and modulates cardiovascular risk factors. However, its role in thrombus formation is largely unknown. Thus, this study investigated the effect of SIRT1 on pulmonary thrombus formation, and then identified its role in the mod...

journal_title：Platelets

authors： Kim YH,Bae JU,Kim IS,Chang CL,Oh SO,Kim CD

更新日期：2016-12-01 00:00:00

abstract：:Microparticles (MPs) are blebs released from cellular surfaces during activation/apoptosis. They are procoagulant, pro-inflammatory and could contribute to pathogenesis of deep venous thrombosis (DVT). This study compared the number, cellular origin and procoagulant activity of MPs on DVT patients in different clinica...

journal_title：Platelets

authors： Flores-Nascimento MC,Beltrame MP,De Paula EV,Montalvão SL,Pereira FG,Orsi FL,Lorand-Metze I,Annichino-Bizzacchi JM

更新日期：2009-09-01 00:00:00

abstract：:Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI as well as externalized proteins P-selectin and CD40L releases soluble ectodomain fragments that are subsequently detectable in plasma. T...

journal_title：Platelets

authors： Au AE,Josefsson EC

更新日期：2017-06-01 00:00:00

abstract：:The Gray Platelet Syndrome (GPS) is a rare inherited, hypogranular platelet disorder characterized by virtual absence of alpha granules in bone marrow megakaryocytes and circulating plates. Usually only one member of a family is affected, but families with two or more affected individuals have been reported from Franc...

journal_title：Platelets

authors： White JG,Kumar A,Hogan MJ

更新日期：2006-12-01 00:00:00

abstract：:Erythropoietin (EPO) enhances formation of red blood cells and also affects thrombopoiesis and platelet function. We hypothesized that the effect of EPO may be reflected by changes in thromboxane B2 (TXB2) and endothelial cell function. Six male and six female subjects received recombinant human epoetin alpha (Erypo®)...

journal_title：Platelets

authors： Heinisch BB,Vcelar B,Kapiotis S,Blann A,Wolzt M,Siller-Matula JM,Jilma B

更新日期：2012-01-01 00:00:00

abstract：:Glanzmann's thrombasthenia (GT) is characterized by increased bleeding risk. The treatment options in GT are limited. The aim of this study was to test the effect of GT blood supplementation with fibrinogen and factor XIII on thrombin generation, blood clotting, and fibrinolysis. Whole blood samples of GT patients and...

journal_title：Platelets

authors： Shenkman B,Livnat T,Misgav M,Budnik I,Einav Y,Martinowitz U

更新日期：2012-01-01 00:00:00

abstract：:Aspirin is traditionally taken once daily in the morning and considered to be effective throughout the 24h interval. Cardiovascular events occur most frequently in the early morning, suggesting that these hours are critical in terms of adequate platelet inhibition. This study therefore assed platelet function in the e...

journal_title：Platelets

authors： Racca C,van Diemen JJK,Fuijkschot WW,Spit K,Bonten TN,Numans ME,van der Bom JG,Smulders YM,Thijs A

更新日期：2019-01-01 00:00:00

abstract：:Glycoprotein (GP) IIb-IIIa (αIIbβ3-integrin) is the central receptor of platelet aggregation. Activated GP IIb-IIIa binds fibrinogen or von Willebrand factor, which forms molecular bridges between aggregating platelets. This review summarizes data on the relationship between GP IIb-IIIa expression on the platelet surf...

journal_title：Platelets

authors： Yakushkin VV,Zyuryaev IT,Khaspekova SG,Sirotkina OV,Ruda MY,Mazurov AV

更新日期：2011-01-01 00:00:00

abstract：:A large number of patients require antiplatelet therapy (mainly aspirin and/or clopidogrel). Recent studies suggest that the combination of these agents is useful in patients with acute coronary syndrome and after percutaneous coronary intervention with stent placement. On the other hand, bleeding complications, most ...

journal_title：Platelets

authors： Liberopoulos EN,Elisaf MS,Tselepis AD,Archimandritis A,Kiskinis D,Cokkinos D,Mikhailidis DP

更新日期：2006-02-01 00:00:00

abstract：:In adults with immune thrombocytopenic purpura (ITP), steroids are usually proposed as first-line therapy, but long-term complete responses are obtained in no more than 20% of patients. For the remaining patients, splenectomy is considered the treatment of choice, with reported "cure" rates from 60-70%. However, the i...

journal_title：Platelets

authors： Vancine-Califani SM,De Paula EV,Ozelo MC,Orsi FL,Fabri DR,Annichino-Bizzacchi JM

更新日期：2008-11-01 00:00:00

abstract：:We investigated the relationship between the expression of IFN-gamma, IL-4, Foxp3 and perforin gene and the methylation status of their promoters in immune thrombocytopenic purpura (ITP) patients. Gene expression and DNA methylation were determined by quantitative PCR and bisulfite genomic sequencing, respectively. Th...

journal_title：Platelets

authors： Zhao H,Du W,Wang D,Gu D,Xue F,Ge J,Sui T,Yang R

更新日期：2010-01-01 00:00:00

abstract：:The generation of superoxide anion radicals (O2*-) and the other reactive oxygen species (ROS) was estimated by means of cytochrome c reduction and chemiluminescence, as well in resting blood platelets and in platelets stimulated by thrombin in the presence or absence of some inhibitors of pathways involved in platele...

journal_title：Platelets

authors： Wachowicz B,Olas B,Zbikowska HM,Buczyński A

更新日期：2002-05-01 00:00:00

abstract：:In a family, a moderate bleeding disorder in two patients has been specified as Glanzmann's thrombasthenia because of characteristic defects in platelet function. Analysis of platelet membrane glycoproteins revealed about a 50% decrease in the amount of GP IIb-IIIa complex (α(11b)β(3) integrin), which appeared normal ...

journal_title：Platelets

authors： Meyer M,Thieme A,Jablonka B,Just M,Ströhl C,Schellenberg I,Kirchmaier CM

更新日期：1996-01-01 00:00:00

abstract：:Autophagy is an effective strategy for cell development by recycling cytoplasmic constituents. Genetic deletion of autophagy mediator Atg7 in hematopoietic stem cells (HSCs) can lead to failure of megakaryopoiesis and enhanced autophagy has been implicated in various hematological disorders such as immune thrombocytop...

journal_title：Platelets

authors： Wang Q,You T,Fan H,Wang Y,Chu T,Poncz M,Zhu L

更新日期：2017-01-01 00:00:00

abstract：:Activated platelets play a substantial role in Alzheimer's disease (AD) and atherothrombosis. Mean platelet volume (MPV) is an early marker of platelet activation, which is linked to a variety of pro-thrombotic and pro-inflammatory diseases. This study is to examine the association between platelet indices and vascula...

journal_title：Platelets

authors： Liang QC,Jin D,Li Y,Wang RT

更新日期：2014-01-01 00:00:00

abstract：:The aim of the study was to evaluate how platelet aggregation relates to left ventricular hypertrophy, presence of transient myocardial ischemia and coronary atherosclerosis in essential hypertensive patients. For that purpose platelet aggregation, symptom-limited treadmill-test, echocardiography and coronary angiogra...

journal_title：Platelets

authors： Gabbasov Z,Parfyonova Y,Popov E,Gavrilov I,Anuchin V,Dubov P,Djakonova Y

更新日期：1998-01-01 00:00:00

abstract：:Peroxynitrite is a potent nitrating and oxidizing agent that exerts differential effects on platelets. In the present study we investigated the influence of peroxynitrite on vasodilator-stimulated phosphoprotein (VASP), a protein that plays a key role in inhibition of platelet adhesion and spreading. In platelets, VAS...

journal_title：Platelets

authors： Aburima A,Riba R,Naseem KM

更新日期：2010-01-01 00:00:00

abstract：:Phenolic compounds have different biological properties, including antioxidative activities, but they may also be prooxidants. The effect of phenolic fraction from roots of Alhagi maurorum on oxidative protein/lipid damages (determined by such parameters as levels of protein thiol groups and the concentration of thiob...

journal_title：Platelets

authors： Olas B,Hamed AI,Oleszek W,Stochmal A

更新日期：2015-01-01 00:00:00

abstract：:No consensus exists regarding the optimal estimate of light transmission aggregometry (LTA) to reflect P2Y12 ADP receptor inhibition in patients receiving thienopyridine therapy. Currently, the only completely P2Y12-receptor specific method is the measurement of vasodilator stimulated phosphoprotein (VASP) phosphoryla...

journal_title：Platelets

authors： Aradi D,Magyarlaki T,Tokés-Füzesi M,Rideg O,Vorobcsuk A,Komócsi A

更新日期：2010-01-01 00:00:00

abstract：:Photochemical treatment (PCT) of platelet concentrates, using amotosalen HCl and UVA-light, inactivates pathogens by forming adducts between amotosalen and nucleic acids. The impact of the photochemical treatment on pathogens and leukocytes has been studied extensively. Yet little is known about the effect of PCT on n...

journal_title：Platelets

authors： Bruchmüller I,Lösel R,Bugert P,Corash L,Lin L,Klüter H,Janetzko K

更新日期：2005-12-01 00:00:00

abstract：:The action of inorganic forms of selenium (Se) on blood platelet aggregation, secretion and the arachidonate pathway in vitro was studied. It was shown that sodium selenite, after 30 min preincubation, inhibited platelet aggregation induced by 0.1 U/ml of thrombin and by 10 microM ADP (about 30% inhibition of aggregat...

journal_title：Platelets

authors： Zbikowska HM,Wachowicz B,Krajewski T

更新日期：1999-01-01 00:00:00

abstract：:Oxidative damage to lipids in plasma, blood platelets and neurons in patients with schizophrenia was described. The aim of our present study was to evaluate oxidative/nitrative modifications of blood platelets proteins by measurement the level of biomarkers of oxidative stress such as carbonyl groups, thiol groups and...

journal_title：Platelets

authors： Dietrich-Muszalska A,Olas B

更新日期：2009-03-01 00:00:00

abstract：:Type 2B von Willebrand's disease (VWD) is an inherited bleeding disorder characterized by spontaneous binding of large von Willebrand factor (VWF) multimers to platelets in vivo. This phenomenon induces the clearance of both large multimers and platelets, usually resulting in thrombocytopenia with slightly increased p...

journal_title：Platelets

authors： Loffredo G,Baronciani L,Noris P,Menna F,Federici AB,Balduini CL

更新日期：2006-05-01 00:00:00

abstract：:The phytochemical resveratrol (3,4',5-trihydroxystilbene), which is found in grapes and wine, has been reported to have a variety of anti-inflammatory, anti-platelet and anti-carcinogenic effects. The aim of the present study was to evaluate the effects of trans-resveratrol on adhesion of blood platelets to collagen, ...

journal_title：Platelets

authors： Zbikowska HM,Olas B,Wachowicz B,Krajewski T

更新日期：1999-07-01 00:00:00