Ca2+ leakage rate from agonist-sensitive intracellular pools is altered in platelets from patients with type 2 diabetes.

abstract：:We measured and compared the levels of microparticles, chemokines, cell adhesion molecules and platelet activation markers with a view to developing a better understanding of their potential contributions to the pathophysiology of progressive systemic sclerosis (PSS, scleroderma). The concentrations of all the factors...

journal_title：Platelets

authors： Nomura S,Inami N,Ozaki Y,Kagawa H,Fukuhara S

更新日期：2008-05-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is increasingly used in the treatment of musculoskeletal diseases. Its preservation by freezing it for the realization of multiple injections in clinical use has never been discussed. Calcaneal tendons of rats were surgically sectioned. Platelet concentration of the PRP was 2.5 x 106/µl with...

journal_title：Platelets

authors： Kaux JF,Libertiaux V,Dupont L,Colige A,Denoël V,Lecut C,Hego A,Gustin M,Duwez L,Oury C,Gothot A,Greimers L,Drion P

更新日期：2020-01-01 00:00:00

abstract：:Previous studies have reported increased platelet activation and aggregation in patients with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) treatment has been shown to decrease platelet activation. We aimed to study the effects of nasal CPAP therapy has on MPV values in patients with severe...

journal_title：Platelets

authors： Varol E,Ozturk O,Yucel H,Gonca T,Has M,Dogan A,Akkaya A

更新日期：2011-01-01 00:00:00

abstract：:The purpose of the study was to evaluate safety, effects on platelet aggregation and pharmacokinetics of F(ab')(2) fragments of anti-glycoprotein (GP) IIb-IIIa murine monoclonal antibody FRaMon (F(ab')(2) FRaMon) upon its intravenous administration in patients undergoing high-risk coronary angioplasty. Patients were t...

journal_title：Platelets

authors： Mazurov AV,Pevzner DV,Antonova OA,Byzova TV,Khaspekova SG,Semenov AV,Vlasik TN,Samko AN,Staroverov II,Ruda MY

更新日期：2002-12-01 00:00:00

abstract：:The aims of this study were to evaluate the kinetics of platelet counts and mean platelet volume (MPV) in adults with sepsis and to determine whether the responses are infection-specific. This retrospective cohort study included patients admitted to a tertiary-care teaching hospital with microbiologically proven nosoc...

journal_title：Platelets

authors： Aydemir H,Piskin N,Akduman D,Kokturk F,Aktas E

更新日期：2015-01-01 00:00:00

abstract：:Lipid-rafts are defined as membrane microdomains enriched in cholesterol and glycosphingolipids within platelet plasma membrane. Lipid raft-mediated clot retraction requires factor XIII and other interacting proteins. The aim of this study was to investigate the proteins that interact with factor XIII in raft and non-...

journal_title：Platelets

authors： Rabani V,Montange D,Davani S

更新日期：2016-09-01 00:00:00

abstract：:Plasma lipid composition, platelet aggregation, cholesterol (Ch)/glycoprotein IIb-IIIa (GP) and phospholipid (Ph)/GP molar ratios, fatty acid composition and structural order (1, 6-diphenyl-1, 3, 5-hexatriene (DPH) fluorescence anisotropy at 35 degrees C (r(DPH,35)) of human platelet plasma membranes (HPPM) were measu...

journal_title：Platelets

authors： García-Guerra R,Mateo CR,García-Muñoz MS,Zapata MA,Plaza I,González-Rodríguez J

更新日期：1998-01-01 00:00:00

abstract：:Thrombocytopenia is common in patients with lung diseases. Lung injury is associated with deranged platelet homeostasis. The potential mechanisms underlying this association were investigated in this study. The number and morphology of circulating megakaryocytes (MK) were investigated in vivo during cardiopulmonary by...

journal_title：Platelets

authors： Xiao da W,Yang M,Yang J,Hon KL,Fok FT

更新日期：2006-08-01 00:00:00

abstract：:Thrombocytopenia is classically defined as a platelet count of less than 150 000/µl. Counts from 100 000 to 150 000/µl are considered mildly depressed, 50 000 to 100 000/µl moderately depressed, and less than 50 000/µl severely depressed. Thrombocytopenia occurs in about 10% of pregnant women. Gestational thrombocytop...

journal_title：Platelets

authors： Lim CC,Patel DK,Bakhtiari A,Subrayan V

更新日期：2013-01-01 00:00:00

abstract：:One hundred and sixty-eight children aged 13 months to 12.6 years with acquired platelet dysfunction with eosinophilia (APDE) were studied. The male to female ratio was 1.15:1. All of the children were in good health and no history of any drug ingestion was detected. All of the children had widespread spontaneous brui...

journal_title：Platelets

authors： Laosombat V,Wongchanchailert M,Sattayasevana B,Kietthubthew S,Wiriyasateinkul A

更新日期：2001-02-01 00:00:00

abstract：:Erythropoietin (EPO) enhances formation of red blood cells and also affects thrombopoiesis and platelet function. We hypothesized that the effect of EPO may be reflected by changes in thromboxane B2 (TXB2) and endothelial cell function. Six male and six female subjects received recombinant human epoetin alpha (Erypo®)...

journal_title：Platelets

authors： Heinisch BB,Vcelar B,Kapiotis S,Blann A,Wolzt M,Siller-Matula JM,Jilma B

更新日期：2012-01-01 00:00:00

abstract：:Phenolic compounds have different biological properties, including antioxidative activities, but they may also be prooxidants. The effect of phenolic fraction from roots of Alhagi maurorum on oxidative protein/lipid damages (determined by such parameters as levels of protein thiol groups and the concentration of thiob...

journal_title：Platelets

authors： Olas B,Hamed AI,Oleszek W,Stochmal A

更新日期：2015-01-01 00:00:00

abstract：:This study investigated the mechanism by which treatment of the CHRF 288-11 megakaryoblastic cell line with phorbol myristate acetate caused a transient increase in adhesion. The adhesion to tissue culture plastic occurred within 4 h and could be reversed by treatment with RGDS-peptide suggesting the involvement of on...

journal_title：Platelets

authors： Conran N,Hemming FW

更新日期：1999-01-01 00:00:00

abstract：:We report a case of total hyperpigmentation of the skin, severe itching, muscle weakness and thrombocytosis. Laboratory investigation showed white blood cell (WBC) 8.2 x 10(6)/L, Hb 125 g/L, platelets 1221 x 10(6)/L and urinary lead after DMSA mobilization test 2684 mcg/g creatinine (normal <5). Chelation therapy with...

journal_title：Platelets

authors： Al Momen A

更新日期：2010-01-01 00:00:00

abstract：:In the differential diagnosis of primary and secondary thrombocytosis platelet function tests may play an important role. We examined the applicability of a platelet filter test (shear-dependent platelet aggregation) as a tool, to differentiate primary thrombocytosis (cases with myeloproliferative disorders) from seco...

journal_title：Platelets

authors： Rejtö L,Schlammadinger A,László P,Kiss A,Telek B,Boda Z

更新日期：2000-02-01 00:00:00

abstract：:Tissue factor (TF) is the most important initiator of intravascular coagulation. This article will review published evidence on the contribution of platelets to TF exposure to the circulating blood. The following mechanisms will be discussed: decryption of monocyte TF by platelets, contribution of platelets to TF expr...

journal_title：Platelets

authors： Lösche W

更新日期：2005-09-01 00:00:00

abstract：:In patients with end-stage renal disease (ESRD), hemorrhagic complications are commonly encountered due to abnormalities in primary hemostasis, in particular, platelet (PLT) dysfunction and impaired PLT-vessel wall interaction. The pathogenesis of altered PLT function is considered multifactorial. Dialysis procedures ...

journal_title：Platelets

authors： Mekawy MA,Habashy DM,Abd El-Mohsen WA

更新日期：2015-01-01 00:00:00

abstract：:Studies on markers for bleeding risk among thrombocytopenic cancer patients are lacking. This prospective observational cohort study investigated whether platelet parameters and a standardised bleeding questionnaire predicted bleeding or prophylactic platelet transfusions in patients with cancer and thrombocytopenia. ...

journal_title：Platelets

authors： Vinholt PJ,Alnor A,Nybo M,Hvas AM

更新日期：2016-09-01 00:00:00

abstract：:Platelet activation occurs in an endothelium-dependent flow-mediated dilation (FMD) impairment environment. The aim of this study was to explore the association between platelet reactivity and brachial artery FMD in individuals without established cardiovascular disease (controls) and acute myocardial infarction (AMI)...

journal_title：Platelets

authors： Shechter M,Shechter A,Hod H,Fefer P,Shenkman B,Koren-Morag N,Feinberg MS,Harats D,Ami Sela B,Savion N,Varon D,Matetzky S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes with subsequent mortality remains unclear. METHODS:The clinical and laboratory data of 383 patients with the definite outcome by March 1, 2020 i...

journal_title：Platelets

authors： Liu Y,Sun W,Guo Y,Chen L,Zhang L,Zhao S,Long D,Yu L

更新日期：2020-05-18 00:00:00

abstract：:Platelet discoid shape is known to correlate with in vivo viability after transfusion. Measurement of shape change requires invasive sampling and laborious assays, which is difficult to perform in a blood transfusion center as a routine test for quality control of stored platelets. The objective of this study was to e...

journal_title：Platelets

authors： Mathai J,Resmi KR,Sulochana PV,Sathyabhama S,Baby Saritha G,Krishnan LK

更新日期：2006-09-01 00:00:00

abstract：:Platelets, besides their specialised role in haemostasis and atherothrombosis, actively modulate innate and adaptive immune responses with crucial roles in immune surveillance, inflammation and host defence during infection. An important prerequisite for platelet-mediated changes of immune functions involves direct en...

journal_title：Platelets

authors： Finsterbusch M,Schrottmaier WC,Kral-Pointner JB,Salzmann M,Assinger A

更新日期：2018-11-01 00:00:00

abstract：:The integrin GPIIb-IIIa plays an important role in platelet activation and plug formation. Quantitative and qualitative dysfunction in this receptor causes Glanzmann's thrombasthenia (GT) and leads to a bleeding tendency. Mutations in the GPIIb or GPIIIa gene are known to be responsible for the inherited form of this ...

journal_title：Platelets

authors： Vijapurkar M,Ghosh K,Shetty S

更新日期：2009-02-01 00:00:00

abstract：:Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose ...

journal_title：Platelets

authors： Patrignani P,Patrono C

更新日期：2018-12-01 00:00:00

abstract：:Cytochrome P450 (CYP) 2C19 genotype is closely associated with the metabolism and efficacy of clopidogrel, thereby having an important impact on clinical outcomes of patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the efficacy and safety ...

journal_title：Platelets

authors： Lyu SQ,Yang YM,Zhu J,Wang J,Wu S,Zhang H,Shao XH,Ren JM

更新日期：2020-11-16 00:00:00

abstract：:Previous studies have reported that various factors affect ADP-induced platelet reactivity during clopidogrel therapy. The aim of this study was to determine whether clinical and laboratory variables for platelet reactivity during dual antiplatelet therapy (DAPT) are dependent on the assay used. We enrolled 904 patien...

journal_title：Platelets

authors： Choi SY,Kim MH

更新日期：2019-01-01 00:00:00

abstract：:The aim of the present study was to investigate and compare the anti-platelet action of extracts from three different plants: bark of Yucca schidigera, seeds of grape and berries of Aronia melanocarpa (chokeberry). Anti-platelet action of tested extracts was compared with action of well characterized antioxidative and...

journal_title：Platelets

authors： Olas B,Wachowicz B,Tomczak A,Erler J,Stochmal A,Oleszek W

更新日期：2008-02-01 00:00:00

abstract：:The distribution of some proteoglycan anionic sites and carbohydrate moieties on the diabetic platelet surface has been investigated by cytochemical methods. Human blood platelets obtained from either diabetic patients (serum glycaemia 9.6-19.2 mmol/L) or normal donors were labeled with specific stains (Ruthenium Red,...

journal_title：Platelets

authors： Lupu C,Rizescu M,Calb M

更新日期：1994-01-01 00:00:00

abstract：:On activation platelets release microRNAs and extracellular vesicles (EV) into circulation. The release of EV from platelets has been shown to be dependent on the agonist; in this study, we investigated whether the microRNA profile or EV released from platelets was also agonist specific. Washed platelets from healthy ...

journal_title：Platelets

authors： Ambrose AR,Alsahli MA,Kurmani SA,Goodall AH

更新日期：2018-07-01 00:00:00

abstract：:Platelet function disorders (PFDs) are a common cause of mild bleeding tendency. However, they cannot be recognized by standard screening studies. The gold standard test for PFD is platelet aggregation, performed by light transmission aggregometry (LTA). A newer and less validated method is the closure time (CT), perf...

journal_title：Platelets

authors： Tanous O,Steinberg Shemer O,Yacobovich J,Zoldan M,Horovitz Y,Yaniv I,Rabizadeh E,Tamary H,Nakav S,Lahav J

更新日期：2017-11-01 00:00:00