Platelet and mean platelet volume kinetics in adult patients with sepsis.

abstract：:A controversial discussion as to whether human platelets are capable of regulated protein synthesis has been ongoing for over half a century. A previous study has suggested that human platelets synthesize large amounts of interleukin 1beta (IL-1beta) in response to external cues and in a physiologically significant ma...

journal_title：Platelets

authors： Pillitteri D,Bassus S,Boller K,Mahnel R,Scholz T,Westrup D,Wegert W,Kirchmaier CM

更新日期：2007-03-01 00:00:00

abstract：:Selective activation of the platelet TXA2 receptor is sufficient to mediate concurrent aggregation, deaggregation and shape change (SC) responses without activation of known Gi-coupled receptors (Platelets 2003; 14: 89). However, Gi-coupled receptor activation strongly influences the hemostasis response in vivo. This ...

journal_title：Platelets

authors： Maayani S,Schwarz TE,Patel ND,Craddock-Royal BD,Tagliente TM

更新日期：2003-09-01 00:00:00

abstract：:Microparticles (MPs) are blebs released from cellular surfaces during activation/apoptosis. They are procoagulant, pro-inflammatory and could contribute to pathogenesis of deep venous thrombosis (DVT). This study compared the number, cellular origin and procoagulant activity of MPs on DVT patients in different clinica...

journal_title：Platelets

authors： Flores-Nascimento MC,Beltrame MP,De Paula EV,Montalvão SL,Pereira FG,Orsi FL,Lorand-Metze I,Annichino-Bizzacchi JM

更新日期：2009-09-01 00:00:00

abstract：:In this study, we have examined whether the platelet Fc-receptor, FcγRII (CD32), is associated with either of the two major platelet membrane glycoproteins, the GPIb-IX complex and the GPIIb-IIIa complex. Monoclonal and polyclonal anti-GPIb-IX complex antibodies inhibited to only a moderate degree (< 40%) the binding ...

journal_title：Platelets

authors： Berndt MC,Mazurov AV,Vinogradov DV,Burns GF,Chesterman CN

更新日期：1993-01-01 00:00:00

abstract：:Previous studies suggested that the adipocytokines, adiponectin and leptin, are associated with the progression and prognosis of coronary artery disease (CAD). The aim of this study was to differentially evaluate plasma levels of adiponectin and leptin in patients with CAD and their association with conventional labor...

journal_title：Platelets

authors： Bigalke B,Stellos K,Geisler T,Seizer P,Mozes V,Gawaz M

更新日期：2010-01-01 00:00:00

abstract：:Information regarding the profile of reticulated platelets (RP) in ischemic cerebrovascular disease (CVD) patients is limited. Data from two prospective, observational, case-control studies were combined to compare the %RP using whole blood flow cytometry in patients ≤ 4 weeks of TIA/stroke onset (baseline, N = 210), ...

journal_title：Platelets

authors： Lim ST,Tobin WO,Murphy S,Kinsella JA,Smith DR,Lim SY,Murphy SM,Coughlan T,Collins DR,O'Neill D,Egan B,Tierney S,McCabe D

更新日期：2020-12-21 00:00:00

abstract：:High on-treatment platelet reactivity (HTPR) is associated with poor prognosis in patients undergoing percutaneous coronary intervention (PCI). The antiplatelet effect and safety of prasugrel was compared to that of double-dose clopidogrel in patients with stable coronary artery disease or acute coronary syndrome (ACS...

journal_title：Platelets

authors： Dridi NP,Johansson PI,Clemmensen P,Stissing T,Radu MD,Qayyum A,Pedersen F,Helqvist S,Saunamäki K,Kelbæk H,Jørgensen E,Engstrøm T,Holmvang L

更新日期：2014-01-01 00:00:00

abstract：:No consensus exists regarding the optimal estimate of light transmission aggregometry (LTA) to reflect P2Y12 ADP receptor inhibition in patients receiving thienopyridine therapy. Currently, the only completely P2Y12-receptor specific method is the measurement of vasodilator stimulated phosphoprotein (VASP) phosphoryla...

journal_title：Platelets

authors： Aradi D,Magyarlaki T,Tokés-Füzesi M,Rideg O,Vorobcsuk A,Komócsi A

更新日期：2010-01-01 00:00:00

abstract：:Studies have reported the polymorphism of human platelet antigen (HPA)-17w, -18w, -19w, -20w, and -21w. However, the distribution of these five antigens in Chinese Cantonese is still unknown. In this study, we designed new sequence-specific primers for HPA-19w to -21w and used published primers for HPA-17w and -18w to...

journal_title：Platelets

authors： Zhou H,Ding H,Chen Y,Li X,Ye X,Nie Y

更新日期：2015-01-01 00:00:00

abstract：:Platelet activation has long been known to be accompanied by secretion from at least three types of compartments. These include dense granules, the major source of small molecules; α-granules, the major protein storage organelle; and lysosomes, the site of acid hydrolase storage. Despite ~60 years of research, there a...

journal_title：Platelets

authors： Yadav S,Storrie B

更新日期：2017-03-01 00:00:00

abstract：:We prospectively investigated the prevalence of Helicobacter pylori (H. pylori) infection in a cohort of 54 adult Serbian patients with chronic idiopathic thrombocytopenic purpura (ITP), and examined the effects of its eradication on their platelet counts. H. pylori infection was diagnosed in 39/54 (72.2%) patients, u...

journal_title：Platelets

authors： Suvajdzić N,Stanković B,Artiko V,Cvejić T,Bulat V,Bakrac M,Colović M,Obradović V,Atkinson HD

更新日期：2006-06-01 00:00:00

abstract：:The spleen, in addition to its role in immunity, plays key roles in erythrocyte maintenance and platelet sequestration. Loss of the spleen via splenectomy occurs in approximately 6.4 to 7.1 per 100 000 people per year globally, commonly as a life-saving emergency procedure in trauma and a therapeutic procedure in hema...

journal_title：Platelets

authors： Luu S,Woolley IJ,Andrews RK

更新日期：2021-01-02 00:00:00

abstract：:Impaired glucose tolerance (IGT), a prediabetic state, is associated with an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. This study was designed to answer the following questions: (i) Do MPV levels cha...

journal_title：Platelets

authors： Coban E,Kucuktag S,Basyigit S

更新日期：2007-12-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is increasingly used in the treatment of musculoskeletal diseases. Its preservation by freezing it for the realization of multiple injections in clinical use has never been discussed. Calcaneal tendons of rats were surgically sectioned. Platelet concentration of the PRP was 2.5 x 106/µl with...

journal_title：Platelets

authors： Kaux JF,Libertiaux V,Dupont L,Colige A,Denoël V,Lecut C,Hego A,Gustin M,Duwez L,Oury C,Gothot A,Greimers L,Drion P

更新日期：2020-01-01 00:00:00

abstract：:Cytochrome P450 (CYP) 2C19 genotype is closely associated with the metabolism and efficacy of clopidogrel, thereby having an important impact on clinical outcomes of patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI). This study aimed to evaluate the efficacy and safety ...

journal_title：Platelets

authors： Lyu SQ,Yang YM,Zhu J,Wang J,Wu S,Zhang H,Shao XH,Ren JM

更新日期：2020-11-16 00:00:00

abstract：:Extracellular vesicles (EV) act as a cellular communication tool by carrying lipids, proteins and micro RNA (miR) between cells, thereby playing a pivotal role in thromboembolic processes. The effect of P2Y12 inhibitors on pro-coagulatory, phosphatidylserine (PS)-expressing EV has been investigated previously, but onl...

journal_title：Platelets

authors： Haller PM,Stojkovic S,Piackova E,Andric T,Wisgrill L,Spittler A,Wojta J,Huber K,Jäger B

更新日期：2020-05-18 00:00:00

abstract：:Previous studies have reported that various factors affect ADP-induced platelet reactivity during clopidogrel therapy. The aim of this study was to determine whether clinical and laboratory variables for platelet reactivity during dual antiplatelet therapy (DAPT) are dependent on the assay used. We enrolled 904 patien...

journal_title：Platelets

authors： Choi SY,Kim MH

更新日期：2019-01-01 00:00:00

abstract：:Hermansky-Pudlak syndrome (HPS) is a rare form of syndromic oculocutaneous albinism caused by disorders in lysosome-related organelles. Ten genes are associated with different forms of HPS. HPS type 9 (HPS-9) is caused by biallelic variants of BLOC1S6. To date, only three patients with HPS-9 have been reported. We des...

journal_title：Platelets

authors： Michaud V,Fiore M,Coste V,Huguenin Y,Bordet JC,Plaisant C,Lasseaux E,Morice-Picard F,Arveiler B

更新日期：2020-04-03 00:00:00

abstract：:The aim of the present study was to set up and evaluate a novel method for studies of platelet adhesion and activation in blood and platelet suspensions such as platelet concentrate (PC) samples using protein-coated polystyrene beads and flow cytometry. To demonstrate its usefulness, we studied PCs during storage. PCs...

journal_title：Platelets

authors： Tynngård N,Wallstedt M,Södergren AL,Faxälv L,Ramström S

更新日期：2015-01-01 00:00:00

abstract：:We report a case of total hyperpigmentation of the skin, severe itching, muscle weakness and thrombocytosis. Laboratory investigation showed white blood cell (WBC) 8.2 x 10(6)/L, Hb 125 g/L, platelets 1221 x 10(6)/L and urinary lead after DMSA mobilization test 2684 mcg/g creatinine (normal <5). Chelation therapy with...

journal_title：Platelets

authors： Al Momen A

更新日期：2010-01-01 00:00:00

abstract：:Aspirin is traditionally taken once daily in the morning and considered to be effective throughout the 24h interval. Cardiovascular events occur most frequently in the early morning, suggesting that these hours are critical in terms of adequate platelet inhibition. This study therefore assed platelet function in the e...

journal_title：Platelets

authors： Racca C,van Diemen JJK,Fuijkschot WW,Spit K,Bonten TN,Numans ME,van der Bom JG,Smulders YM,Thijs A

更新日期：2019-01-01 00:00:00

abstract：:We present a peculiarity of the neonatal hemostatic system that might contribute to establish a procoagulant readiness in neonatal blood by sensitizing neonatal platelets for ADP stimulation. beta2-glycoprotein-I (beta2-GP-I) is a plasma constituent capable of suppressing ADP-induced platelet aggregation. We found sig...

journal_title：Platelets

authors： Cvirn G,Gallistl S,Koestenberger M,Kutschera J,Ferstl U,Kellner J,Jurgens G,Gries A

更新日期：2007-02-01 00:00:00

abstract：:Platelets, besides their specialised role in haemostasis and atherothrombosis, actively modulate innate and adaptive immune responses with crucial roles in immune surveillance, inflammation and host defence during infection. An important prerequisite for platelet-mediated changes of immune functions involves direct en...

journal_title：Platelets

authors： Finsterbusch M,Schrottmaier WC,Kral-Pointner JB,Salzmann M,Assinger A

更新日期：2018-11-01 00:00:00

abstract：:Patients with thrombocytopenia or platelet disorders are at risk of severe bleeding. We report the development and validation of flow cytometry assays to diagnose platelet disorders and to assess platelet function independently of platelet count. The assays were developed to measure glycoprotein levels (panel 1) and p...

journal_title：Platelets

authors： Rubak P,Nissen PH,Kristensen SD,Hvas AM

更新日期：2016-01-01 00:00:00

abstract：:Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis. This study aimed to utilize small-volume, whole blood platelet functional assays to assess the neon...

journal_title：Platelets

authors： Ngo ATP,Sheriff J,Rocheleau AD,Bucher M,Jones KR,Sepp AI,Malone LE,Zigomalas A,Maloyan A,Bahou WF,Bluestein D,McCarty OJT,Haley KM

更新日期：2020-01-01 00:00:00

abstract：:The aim of the present study was to investigate the role of 12-lipoxygenase (12-LOX) on platelet-induced airway smooth muscle cell (ASMC) proliferation. Co-incubation of platelets and ASMC caused platelet activation as determined by morphological changes. Simultaneously, reactive oxygen species (ROS)-generation was de...

journal_title：Platelets

authors： Svensson Holm AC,Grenegård M,Ollinger K,Lindström EG

更新日期：2014-01-01 00:00:00

abstract：:Mean platelet volume (MPV), a determinant of platelet function, is a newly emerging risk factor for atherothrombosis. Impaired fasting glucose (IFG) is probably a frequent glycemic disorder in the general population and is considered as a prediabetic state. The present study was designed to evaluate MPV in subjects wi...

journal_title：Platelets

authors： Coban E,Bostan F,Ozdogan M

更新日期：2006-02-01 00:00:00

abstract：:In human platelets and other non-excitable cell types depletion of the intracellular calcium stores promotes calcium entry across the plasma membrane. Although the mechanism of this store-mediated calcium entry remains uncertain, it has been suggested that a tyrosine phosphorylation step could be involved. In support ...

journal_title：Platelets

authors： Jenner S,Sage SO

更新日期：2000-06-01 00:00:00

abstract：:The Total Thrombus-formation Analyser System (T-TAS) is a whole blood flow chamber system for the measurement of in vitro thrombus formation under variable shear stress conditions. Our current study sought to evaluate the potential utility of the T-TAS for the measurement of thrombus formation within human and mouse w...

journal_title：Platelets

authors： Al Ghaithi R,Mori J,Nagy Z,Maclachlan A,Hardy L,Philippou H,Hethershaw E,Morgan NV,Senis YA,Harrison P

更新日期：2019-01-01 00:00:00

abstract：:This study investigated the mechanism by which treatment of the CHRF 288-11 megakaryoblastic cell line with phorbol myristate acetate caused a transient increase in adhesion. The adhesion to tissue culture plastic occurred within 4 h and could be reversed by treatment with RGDS-peptide suggesting the involvement of on...

journal_title：Platelets

authors： Conran N,Hemming FW

更新日期：1999-01-01 00:00:00