The efficacy and safety of CYP2C19 genotype-guided antiplatelet therapy compared with conventional antiplatelet therapy in patients with acute coronary syndrome or undergoing percutaneous coronary intervention: A meta-analysis of randomized controlled tri

abstract：:Microparticles (MPs) are blebs released from cellular surfaces during activation/apoptosis. They are procoagulant, pro-inflammatory and could contribute to pathogenesis of deep venous thrombosis (DVT). This study compared the number, cellular origin and procoagulant activity of MPs on DVT patients in different clinica...

journal_title：Platelets

authors： Flores-Nascimento MC,Beltrame MP,De Paula EV,Montalvão SL,Pereira FG,Orsi FL,Lorand-Metze I,Annichino-Bizzacchi JM

更新日期：2009-09-01 00:00:00

abstract：:The influence of three anti-platelet drugs, cilostazol, aspirin, and tirofiban, was investigated on platelet-leukocyte interaction by flow cytometry. When platelets and leukocytes were pre-incubated with anti-platelet drugs and stimulated by thrombin or collagen, cilostazol was found to inhibit platelet adhesion to mo...

journal_title：Platelets

authors： Ito H,Miyakoda G,Mori T

更新日期：2004-08-01 00:00:00

abstract：:The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling cascade including MEK1 and MEK2 and ERK1 and ERK2 but their role in platel...

journal_title：Platelets

authors： Unsworth AJ,Bye AP,Kriek N,Sage T,Osborne AA,Donaghy D,Gibbins JM

更新日期：2019-01-01 00:00:00

abstract：:Intracranial hemorrhage (ICH) is a devastating complication of immune thrombocytopenia (ITP). However, information on ICH in ITP patients under the age of 60 years is limited, and no predictive tools are available in clinical practice. A total of 93 adult patients with ITP who developed ICH before 60 years of age were...

journal_title：Platelets

authors： Zhao P,Hou M,Liu Y,Liu HX,Huang RB,Yao HX,Niu T,Peng J,Jiang M,Han YQ,Hu JD,Zhou H,Zhou ZP,Qiu L,Zhang LS,Wang X,Wang HQ,Feng R,Yang LH,Ma LM,Wang SQ,Kong PY,Wang WS,Sun HP,Sun J,Zhou HB,Zhu TN,Wang

更新日期：2020-07-02 00:00:00

abstract：:We measured and compared the levels of microparticles, chemokines, cell adhesion molecules and platelet activation markers with a view to developing a better understanding of their potential contributions to the pathophysiology of progressive systemic sclerosis (PSS, scleroderma). The concentrations of all the factors...

journal_title：Platelets

authors： Nomura S,Inami N,Ozaki Y,Kagawa H,Fukuhara S

更新日期：2008-05-01 00:00:00

abstract：:We present a peculiarity of the neonatal hemostatic system that might contribute to establish a procoagulant readiness in neonatal blood by sensitizing neonatal platelets for ADP stimulation. beta2-glycoprotein-I (beta2-GP-I) is a plasma constituent capable of suppressing ADP-induced platelet aggregation. We found sig...

journal_title：Platelets

authors： Cvirn G,Gallistl S,Koestenberger M,Kutschera J,Ferstl U,Kellner J,Jurgens G,Gries A

更新日期：2007-02-01 00:00:00

abstract：:Impaired glucose tolerance (IGT), a prediabetic state, is associated with an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. This study was designed to answer the following questions: (i) Do MPV levels cha...

journal_title：Platelets

authors： Coban E,Kucuktag S,Basyigit S

更新日期：2007-12-01 00:00:00

abstract：:Avian influenza A (H7N9) is a serve zoonosis with a high mortality rate. Timely and effective diagnosis and early warning is crucial for the clinical treatment of H7N9 patients. The previous studies indicated that thrombocytopenia was associated with the prognosis of influenza cases, but the related evidence of platel...

journal_title：Platelets

authors： Chen Y,Yang Y,Cheng J,Lu J,Hu W

更新日期：2020-01-01 00:00:00

abstract：:A platelet substitute, Synthocytes, is being developed for the prevention and treatment of thrombocytopenia. Synthocytes are composed of fibrinogen adsorbed on heat stabilised albumin microcapsules of defined size. The purpose of this study was to perform experiments in vitro to investigate the capacity of Synthocytes...

journal_title：Platelets

authors： Davies AR,Judge HM,May JA,Glenn JR,Heptinstall S

更新日期：2002-06-01 00:00:00

abstract：:Platelet-rich plasma (PRP) is increasingly used in the treatment of musculoskeletal diseases. Its preservation by freezing it for the realization of multiple injections in clinical use has never been discussed. Calcaneal tendons of rats were surgically sectioned. Platelet concentration of the PRP was 2.5 x 106/µl with...

journal_title：Platelets

authors： Kaux JF,Libertiaux V,Dupont L,Colige A,Denoël V,Lecut C,Hego A,Gustin M,Duwez L,Oury C,Gothot A,Greimers L,Drion P

更新日期：2020-01-01 00:00:00

abstract：:Glycoprotein (GP) IIb-IIIa (αIIbβ3-integrin) is the central receptor of platelet aggregation. Activated GP IIb-IIIa binds fibrinogen or von Willebrand factor, which forms molecular bridges between aggregating platelets. This review summarizes data on the relationship between GP IIb-IIIa expression on the platelet surf...

journal_title：Platelets

authors： Yakushkin VV,Zyuryaev IT,Khaspekova SG,Sirotkina OV,Ruda MY,Mazurov AV

更新日期：2011-01-01 00:00:00

abstract：:In humans and other mammals, Tityus discrepans (Td) scorpion envenomation produces a variety of systemic effects including respiratory distress, a generalized inflammatory reaction, modulation of blood pressure, fibrin formation, and platelet activation. For many of these effects, the venom components and underlying m...

journal_title：Platelets

authors： Brazón J,Hughes CE,Mori J,Sevcik C,D'suze G,Watson SP

更新日期：2011-01-01 00:00:00

abstract：:We have explored both the independent and combined effects of aspirin on cultured endothelial cells and platelets, and its influence on platelet deposition onto an extracellular matrix. Blood was circulated through a flat perfusion chamber with two coverslips placed sequentially with respect to blood flow. The first c...

journal_title：Platelets

authors： Alemany M,Hernández MR,Bozzo J,Bono A,Escolar G,Ordinas A,Bastida E

更新日期：1996-01-01 00:00:00

abstract：:Platelets are anucleated cells that upon activation by agonists or during storage may develop apoptotic events. The role of peroxynitrite and its reactive intermediates in apoptotic process in blood platelets is unknown. In order to study the appearance of biomarkers of apoptosis in platelets after treatment with pero...

journal_title：Platelets

authors： Wachowicz B,Rywaniak JZ,Nowak P

更新日期：2008-12-01 00:00:00

abstract：:The objective of this study was to obtain pilot data on which to judge the feasibility and sample size needed for a future comparative-effectiveness trial of platelet transfusions in the NICU. We conducted a limited-scope pilot trial in which neonates were randomized to receive platelet transfusions based on platelet ...

journal_title：Platelets

authors： Zisk JL,Mackley A,Clearly G,Chang E,Christensen RD,Paul DA

更新日期：2014-01-01 00:00:00

abstract：:In the presence of large bone defects, delayed bone union, or nonunion and fractures, bone reconstruction may be necessary. Different strategies have been employed to enhance bone healing among which the use of autologous platelet concentrates (APCs). Due to the high content of platelets and platelet-derived bioactive...

journal_title：Platelets

authors： Marcazzan S,Taschieri S,Weinstein RL,Del Fabbro M

更新日期：2018-06-01 00:00:00

abstract：:Sheehan's syndrome (SS) is an adenopituitary insufficiency caused by hypovolemia secondary to excessive blood loss during or after childbirth. However, the mechanism of postpartum hemorrhage and ischemia is not clear. We aimed to evaluate the bleeding disorders among patients with SS, in comparison with healthy contro...

journal_title：Platelets

authors： Gokalp D,Tuzcu A,Bahceci M,Ayyildiz O,Erdemoglu M,Alpagat G

更新日期：2011-01-01 00:00:00

abstract：:Thrombocytopenia is a clinically relevant outcome in HIV. However, the epidemiology of this condition, including frequency, severity, and duration, has not been well-characterized in the era of highly active antiretroviral therapy (HAART). In this study, we describe the epidemiology of thrombocytopenia using two metho...

journal_title：Platelets

authors： Vannappagari V,Nkhoma ET,Atashili J,Laurent SS,Zhao H

更新日期：2011-01-01 00:00:00

abstract：:Patients with thrombocytopenia or platelet disorders are at risk of severe bleeding. We report the development and validation of flow cytometry assays to diagnose platelet disorders and to assess platelet function independently of platelet count. The assays were developed to measure glycoprotein levels (panel 1) and p...

journal_title：Platelets

authors： Rubak P,Nissen PH,Kristensen SD,Hvas AM

更新日期：2016-01-01 00:00:00

abstract：:Activated platelets play a substantial role in Alzheimer's disease (AD) and atherothrombosis. Mean platelet volume (MPV) is an early marker of platelet activation, which is linked to a variety of pro-thrombotic and pro-inflammatory diseases. This study is to examine the association between platelet indices and vascula...

journal_title：Platelets

authors： Liang QC,Jin D,Li Y,Wang RT

更新日期：2014-01-01 00:00:00

abstract：:Studies have reported the polymorphism of human platelet antigen (HPA)-17w, -18w, -19w, -20w, and -21w. However, the distribution of these five antigens in Chinese Cantonese is still unknown. In this study, we designed new sequence-specific primers for HPA-19w to -21w and used published primers for HPA-17w and -18w to...

journal_title：Platelets

authors： Zhou H,Ding H,Chen Y,Li X,Ye X,Nie Y

更新日期：2015-01-01 00:00:00

abstract：:In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as "platelet dust" by Peter Wolf in 1967, platelet microvesicles (PMV) are now recognized as important mediators of intercellular communication. There are example...

journal_title：Platelets

authors： Edelstein LC

更新日期：2017-05-01 00:00:00

abstract：:Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP), signaling via phospholipase (PLC)β isoforms. The platelet ILRs glycoprote...

journal_title：Platelets

authors： Fernández DI,Kuijpers MJE,Heemskerk JWM

更新日期：2020-12-26 00:00:00

abstract：:Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147), which binds to the platelet-specific collagen receptor glycoprotein (GP) VI, is expressed in a range of cell types including platelets and leukocytes, and has been implicated in neoplastic disease and atherosclerotic coronary disease. Both CD147 and GPVI...

journal_title：Platelets

authors： Pennings GJ,Yong AS,Wong C,Al-Tamimi M,Gardiner EE,Andrews RK,Kritharides L

更新日期：2014-01-01 00:00:00

abstract：:A large number of patients require antiplatelet therapy (mainly aspirin and/or clopidogrel). Recent studies suggest that the combination of these agents is useful in patients with acute coronary syndrome and after percutaneous coronary intervention with stent placement. On the other hand, bleeding complications, most ...

journal_title：Platelets

authors： Liberopoulos EN,Elisaf MS,Tselepis AD,Archimandritis A,Kiskinis D,Cokkinos D,Mikhailidis DP

更新日期：2006-02-01 00:00:00

abstract：:Bleeding in the setting of acute coronary syndromes (ACS) has negative prognostic implications. We sought to determine the impact of different levels of on-treatment platelet reactivity (PR) to ADP on both bleeding and ischemic events in ACS patients receiving coronary stenting. PR to ADP was measured with the VerifyN...

journal_title：Platelets

authors： Huczek Z,Filipiak KJ,Kochman J,Michalak M,Roik M,Grabowski M,Opolski G

更新日期：2011-01-01 00:00:00

abstract：:Prominence has been given recently to the use of platelet-rich plasma (PRP) in combination with bone graft materials for predictably obtaining periodontal regeneration through bioengineering. The purpose of this report was to present clinical, radiographic and re-entry results of a generalized aggressive periodontitis...

journal_title：Platelets

authors： Yilmaz S,Cakar G,Kuru BE,Yildirim B

更新日期：2007-11-01 00:00:00

abstract：:Prostaglandins stimulate cyclic AMP synthesis in platelets, leading to inhibition of platelet aggregation. Prostaglandin receptors have been identified but knowledge of their pharmacology is limited by the lack of antagonists. Kinetic measurements of prostaglandinregulated cyclic AMP formation provide useful informati...

journal_title：Platelets

authors： Ashby B

更新日期：1990-01-01 00:00:00

abstract：:The aim of these studies was to investigate the extent of platelet P2Y(12) receptor inhibition by the thienopyridine active metabolite of prasugrel, R-138727. Blood was taken from healthy volunteers and pre-incubated with R-138727 or cangrelor (AR-C66931MX). Platelet aggregation was assessed in platelet rich plasma (P...

journal_title：Platelets

authors： Judge HM,Buckland RJ,Sugidachi A,Jakubowski JA,Storey RF

更新日期：2008-03-01 00:00:00

abstract：:The purpose of the study was to evaluate safety, effects on platelet aggregation and pharmacokinetics of F(ab')(2) fragments of anti-glycoprotein (GP) IIb-IIIa murine monoclonal antibody FRaMon (F(ab')(2) FRaMon) upon its intravenous administration in patients undergoing high-risk coronary angioplasty. Patients were t...

journal_title：Platelets

authors： Mazurov AV,Pevzner DV,Antonova OA,Byzova TV,Khaspekova SG,Semenov AV,Vlasik TN,Samko AN,Staroverov II,Ruda MY

更新日期：2002-12-01 00:00:00