Thrombin-induced interleukin 1beta synthesis in platelet suspensions: impact of contaminating leukocytes.

abstract：:The H(1)-histamine receptor antagonist Dithaden(R) inhibited in a dose-dependent manner, human platelet aggregation in vitro that was induced with stimuli in the following rank order of potency: thrombin > A23187 > adrenaline > ADP. The aggregation of platelets in plasma induced with adrenaline was inhibited by Dithia...

journal_title：Platelets

authors： Nosál' R,Jancinová V,Danihelova E

更新日期：1997-01-01 00:00:00

abstract：:Platelet aggregation in response to ADP, adrenaline, collagen, arachidonic acid and ristocetin was measured in a large population of healthy Saudi males (n = 393) and females (n = 221) whose age ranged from 11-60 years. The number of observations ranged from 130 for one of the doses of ristocetin (1.0 g/l) to 554 for ...

journal_title：Platelets

authors： Gader AM,Bahakim HM,Malaika SS

更新日期：1990-01-01 00:00:00

abstract：:Catastrophic antiphospholipid syndrome (CAPS) involves sudden multiorgan dysfunction from thrombosis due to antibodies that cause platelet activation and endothelial dysfunction. Treatment variably combines anticoagulation, corticosteroid use, therapeutic plasma exchange (TPE), and high-dose intravenous immunoglobulin...

journal_title：Platelets

authors： James TE,Martin LJ,Warkentin TE,Crowther MA

更新日期：2020-08-07 00:00:00

abstract：:Morning increase in the occurrence of myocardial infarction, stroke and sudden cardiac death is a well-recognized phenomenon, which is in line with a morning enhancement of platelet aggregation. We investigated whether platelet inhibition during clopidogrel and aspirin therapy varies during the day. Fifty-nine consecu...

journal_title：Platelets

authors： Kozinski M,Bielis L,Wisniewska-Szmyt J,Boinska J,Stolarek W,Marciniak A,Kubica A,Grabczewska Z,Navarese EP,Andreotti F,Siller-Matula JM,Rosc D,Kubica J

更新日期：2011-01-01 00:00:00

abstract：:We previously reported the effects of diet, sulphonylureas or insulin on thrombin-induced platelet aggregation, phosphoinositide metabolism and protein phosphorylation in non-insulin-dependent diabetes mellitus (NIDDM) patients. To clarify the mechanism of glyburide and insulin on platelet function, here we studied th...

journal_title：Platelets

authors： Wada H,Ishizuka T,Itaya S,Yamada K,Kajita K,Kimura M,Miura A,Shibata T,Kanoh Y,Ishizawa M,Yasuda K

更新日期：1999-01-01 00:00:00

abstract：:Disseminated intravascular coagulation (DIC) has a well-examined pathophysiology, yet some essential elements remain undetermined. During DIC, platelets play an important role in the development of micro thrombosis, but changes in platelet function parameters and their association with development of DIC have not been...

journal_title：Platelets

authors： Laursen MA,Larsen JB,Hvas AM

更新日期：2018-05-01 00:00:00

abstract：:Platelets contribute to blood coagulation at sites of vascular injury and to the recruitment of leukocytes at sites of inflammation. Under pathological conditions, platelets are involved in numerous diseases and clinical complications, such as deep venous thrombosis, embolism and atherosclerosis. But so far, little is...

journal_title：Platelets

authors： Slotta JE,Braun OO,Menger MD,Thorlacius H

更新日期：2009-11-01 00:00:00

abstract：:Platelet activation is an important process in the pathogenesis of atherothrombosis. However, the serial changes of platelet activation in atherosclerotic ischemic stroke have not been determined. In this study, we measured serially platelet expression of CD63 and P-selectin and platelet aggregability to ADP and colla...

journal_title：Platelets

authors： Cha JK,Jo WS,Shin HC,Bae HR,Ho JM,Kim JW

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:Bullous pemphigoid (BP) is an autoimmune skin disease that is characterized by the formation of blisters on normal or erythematous skin. In patients with BP, eosinophils are highly represented in the inflammatory infiltrate of the lesional skin and their levels are often increased in peripheral blood. It i...

journal_title：Platelets

authors： Rifaioglu EN,Sen BB,Ekiz Ö,Dogramaci AC

更新日期：2014-01-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disease. Since the prevalence of NAFLD in overweight/obese people is rather high, there is a general concern about the possibility that NAFLD may have an association with cardiovascular risk factors and atherosclerosis. Mean platelet volume (MPV) i...

journal_title：Platelets

authors： Shin WY,Jung DH,Shim JY,Lee HR

更新日期：2011-01-01 00:00:00

abstract：:We present a peculiarity of the neonatal hemostatic system that might contribute to establish a procoagulant readiness in neonatal blood by sensitizing neonatal platelets for ADP stimulation. beta2-glycoprotein-I (beta2-GP-I) is a plasma constituent capable of suppressing ADP-induced platelet aggregation. We found sig...

journal_title：Platelets

authors： Cvirn G,Gallistl S,Koestenberger M,Kutschera J,Ferstl U,Kellner J,Jurgens G,Gries A

更新日期：2007-02-01 00:00:00

abstract：:We have investigated interactions between human blood platelets and the vitronectin-containing fluid-phase terminal complement complex, the SC5b-9, which is a non-cytolytic variant of the membrane attack complex C%9(m). SC5b-9 affinity for the platelet membrane glycoprotein IIb/IIIa (GPIIb/IIIa) complex was demonstrat...

journal_title：Platelets

authors： Røger M,Høgåsen K,Holme PA,Halstensen TS,Mollnes TE,Hovig T

更新日期：1995-01-01 00:00:00

abstract：:It has been suggested that thromboelastography TEG) can help in limiting or directing the appropriate use of blood products during surgery. However, the contribution of platelets to the TEG profile has not been studied in detail. Blood was taken from eight healthy subjects and eight patients with peripheral arterial d...

journal_title：Platelets

authors： Bowbrick VA,Mikhailidis DP,Stansby G

更新日期：2003-06-01 00:00:00

abstract：:Measurement of platelet aggregation in platelet-rich plasma (PRP) is a fundamental tool in platelet studies, despite the fact that the technique required for this is time-consuming, may need large volumes of blood, and require particular skill and special equipment. The use of a microplate reader seems useful to perfo...

journal_title：Platelets

authors： Krause S,Scholz T,Temmler U,Lösche W

更新日期：2001-11-01 00:00:00

abstract：:Bleeding in the setting of acute coronary syndromes (ACS) has negative prognostic implications. We sought to determine the impact of different levels of on-treatment platelet reactivity (PR) to ADP on both bleeding and ischemic events in ACS patients receiving coronary stenting. PR to ADP was measured with the VerifyN...

journal_title：Platelets

authors： Huczek Z,Filipiak KJ,Kochman J,Michalak M,Roik M,Grabowski M,Opolski G

更新日期：2011-01-01 00:00:00

abstract：:On activation platelets release microRNAs and extracellular vesicles (EV) into circulation. The release of EV from platelets has been shown to be dependent on the agonist; in this study, we investigated whether the microRNA profile or EV released from platelets was also agonist specific. Washed platelets from healthy ...

journal_title：Platelets

authors： Ambrose AR,Alsahli MA,Kurmani SA,Goodall AH

更新日期：2018-07-01 00:00:00

abstract：:Epinephrine is known as a weak, but important, agonist for platelet activation. It has been reported that the responsiveness of platelets to epinephrine was markedly impaired in 6% of Caucasians and in 16% of Japanese. The purpose of this study was to screen and characterize this abnormality in healthy Taiwanese Chine...

journal_title：Platelets

authors： Lin TM,Lin JS,Tseng JY,Wu SY,Chen TY

更新日期：2016-01-01 00:00:00

abstract：:The tetraspanins are a superfamily of membrane glycoproteins which facilitate the interaction of membrane and intracellular signalling molecules (e.g., integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signalling microdomains (sometimes referred to as the tetraspanin web...

journal_title：Platelets

authors： Moseley GW

更新日期：2005-02-01 00:00:00

abstract：:Impaired glucose tolerance (IGT), a prediabetic state, is associated with an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. This study was designed to answer the following questions: (i) Do MPV levels cha...

journal_title：Platelets

authors： Coban E,Kucuktag S,Basyigit S

更新日期：2007-12-01 00:00:00

abstract：:Information regarding the profile of reticulated platelets (RP) in ischemic cerebrovascular disease (CVD) patients is limited. Data from two prospective, observational, case-control studies were combined to compare the %RP using whole blood flow cytometry in patients ≤ 4 weeks of TIA/stroke onset (baseline, N = 210), ...

journal_title：Platelets

authors： Lim ST,Tobin WO,Murphy S,Kinsella JA,Smith DR,Lim SY,Murphy SM,Coughlan T,Collins DR,O'Neill D,Egan B,Tierney S,McCabe D

更新日期：2020-12-21 00:00:00

abstract：:Fibrin glue is a promising alternative for low-output enterocutaneous fistula closure. Bacterial flora colonizing inside the fistula tract, however, may limit the glue application. Single-donor-derived, platelet-rich materials were hypothesized in this study to have antimicrobial activity against Gram-negative microor...

journal_title：Platelets

authors： Wu X,Ren J,Yuan Y,Luan J,Yao G,Li J

更新日期：2013-01-01 00:00:00

abstract：:Standardized Ginkgo biloba extract, EGb761, has been shown to possess polyvalent properties, such as anti-oxidation, anti-apoptosis and anti-inflammation. Recently, it has also been proposed to have direct protective effects on mitochondria. The effects of EGb761 make it a potential anti-aging drug. Despite that, the ...

journal_title：Platelets

authors： Shi C,Xiao S,Liu J,Guo K,Wu F,Yew DT,Xu J

更新日期：2010-01-01 00:00:00

abstract：:The aim of this study was to determine the contribution of increased PGD(2) formation to the anti-aggregatory action of a thromboxane A(2) (TXA(2)) synthase inhibitor and TP receptor antagonist (ZD1542) against collagen-induced human platelet aggregation in citrated whole blood using the prostaglandin (PG) DP receptor...

journal_title：Platelets

authors： Menys VC

更新日期：1994-01-01 00:00:00

abstract：:Outcomes of platelet function tests are highly dependent on the type of blood anticoagulant used. The primary objective of this study was to clinically evaluate the platelet function after dual antiplatelet therapy using two different types of anticoagulant (citrate and hirudin). We compared data obtained from multipl...

journal_title：Platelets

authors： Zhang HZ,Yu LH,Kim MH

更新日期：2013-01-01 00:00:00

abstract：:D-glucono-1,4-lactone, sodium D-gluconate and calcium D-glucarate are non-toxic glucose derivatives occurring naturally in fruits and vegetables. Calcium D-glucarate is promoted as an orally bioavailability dietary supplement with potential chemopreventive activity without adverse effects. Despite many commercial appl...

journal_title：Platelets

authors： Saluk-Juszczak J

更新日期：2010-01-01 00:00:00

abstract：:Platelet aggregation induced by microbubbles (simulating microbubbles developing during deep sea diving or clinical situations such as extracorporeal circulation) in platelet rich plasma was measured in 11 male volunteers before and after intake of 15 ml seal oil (Pagophilus groenlandica) per day for 2 weeks. The rela...

journal_title：Platelets

authors： Bakken AM,Hervig T,Thorsen T,Holmsen H

更新日期：1995-01-01 00:00:00

abstract：:R-lipoic acid (ALA), a powerful antioxidant valuable for the treatment of diabetes and its complications, has been reported to exhibit an antiplatelet activity in vitro. The aim of this study was to investigate the effect and mechanism of ALA on platelets in vivo. Sprague-Dawley (SD) male rats were intravenously admin...

journal_title：Platelets

authors： Liu J,Song Q,Huang Y,Sun W,Lu D,Zhou B

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes with subsequent mortality remains unclear. METHODS:The clinical and laboratory data of 383 patients with the definite outcome by March 1, 2020 i...

journal_title：Platelets

authors： Liu Y,Sun W,Guo Y,Chen L,Zhang L,Zhao S,Long D,Yu L

更新日期：2020-05-18 00:00:00

abstract：:Lipid-rafts are defined as membrane microdomains enriched in cholesterol and glycosphingolipids within platelet plasma membrane. Lipid raft-mediated clot retraction requires factor XIII and other interacting proteins. The aim of this study was to investigate the proteins that interact with factor XIII in raft and non-...

journal_title：Platelets

authors： Rabani V,Montange D,Davani S

更新日期：2016-09-01 00:00:00

abstract：:The isolation of mitochondria is gaining importance in experimental and clinical laboratory settings. The mitochondrion is known as the powerhouse of the cell as it produces the energy to power most cellular functions but is also involved in many cellular processes. Of interest, mitochondria and mitochondrial componen...

journal_title：Platelets

authors： Léger JL,Jougleux JL,Savadogo F,Pichaud N,Boudreau LH

更新日期：2020-01-01 00:00:00