Abstract:
:Impaired glucose tolerance (IGT), a prediabetic state, is associated with an increased risk of cardiovascular disease. Mean platelet volume (MPV), a determinant of platelet activation, is a newly emerging risk factor for atherothrombosis. This study was designed to answer the following questions: (i) Do MPV levels change in IGT? (ii) Is there any relation between MPV levels and 2 h plasma glucose levels after 75 g oral glucose tolerance test. We selected 48 subjects with IGT, and 48 healthy subjects with normal glucose tolerance matched for age, gender, and body mass index. MPV was significantly higher in IGT group than in control group (9.06 +/- 1.5 fl vs. 8.28 +/- 0.8 fl, p = 0.002). Also, MPV was positively correlated with 2 h plasma glucose concentration in IGT group (r = 0.39, p = 0.006). In conclusion, our results suggest that subjects with IGT tend to have increased platelet activation. Increased platelet activity could contribute to increasing the risk of cardiovascular disease in IGT.
journal_name
Plateletsjournal_title
Plateletsauthors
Coban E,Kucuktag S,Basyigit Sdoi
10.1080/09537100701609019subject
Has Abstractpub_date
2007-12-01 00:00:00pages
591-4issue
8eissn
0953-7104issn
1369-1635pii
787296425journal_volume
18pub_type
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