Significance of microparticles in progressive systemic sclerosis with interstitial pneumonia.

abstract：:Binding of podoplanin to the C-type lectin-like receptor 2 (CLEC-2) promotes platelet activation and soluble CLEC-2 (sCLEC-2) is shed from activated platelets. The role of sCLEC-2 in the plasma is unknown. The expression level and plasma concentration of sCLEC-2 could be affected by variants of the corresponding gene,...

journal_title：Platelets

authors： Etemad M,Christodoulou F,Weiss C,Klüter H,Bugert P

更新日期：2020-11-29 00:00:00

abstract：:The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling cascade including MEK1 and MEK2 and ERK1 and ERK2 but their role in platel...

journal_title：Platelets

authors： Unsworth AJ,Bye AP,Kriek N,Sage T,Osborne AA,Donaghy D,Gibbins JM

更新日期：2019-01-01 00:00:00

abstract：:The Gray Platelet Syndrome (GPS) is a rare inherited, hypogranular platelet disorder characterized by virtual absence of alpha granules in bone marrow megakaryocytes and circulating plates. Usually only one member of a family is affected, but families with two or more affected individuals have been reported from Franc...

journal_title：Platelets

authors： White JG,Kumar A,Hogan MJ

更新日期：2006-12-01 00:00:00

abstract：:The spleen, in addition to its role in immunity, plays key roles in erythrocyte maintenance and platelet sequestration. Loss of the spleen via splenectomy occurs in approximately 6.4 to 7.1 per 100 000 people per year globally, commonly as a life-saving emergency procedure in trauma and a therapeutic procedure in hema...

journal_title：Platelets

authors： Luu S,Woolley IJ,Andrews RK

更新日期：2021-01-02 00:00:00

abstract：:Platelets, besides their specialised role in haemostasis and atherothrombosis, actively modulate innate and adaptive immune responses with crucial roles in immune surveillance, inflammation and host defence during infection. An important prerequisite for platelet-mediated changes of immune functions involves direct en...

journal_title：Platelets

authors： Finsterbusch M,Schrottmaier WC,Kral-Pointner JB,Salzmann M,Assinger A

更新日期：2018-11-01 00:00:00

abstract：:Thrombocytopenia is common in patients with lung diseases. Lung injury is associated with deranged platelet homeostasis. The potential mechanisms underlying this association were investigated in this study. The number and morphology of circulating megakaryocytes (MK) were investigated in vivo during cardiopulmonary by...

journal_title：Platelets

authors： Xiao da W,Yang M,Yang J,Hon KL,Fok FT

更新日期：2006-08-01 00:00:00

abstract：:Collagen (5 microg/ml) stimulation of washed platelets increased endogenous serotonin (5-HT) release to the medium from 13.88 1.39 to 188.67 26.37 pmol/108 platelets ( P < 0.001). Adrenaline (16 microM) also increased 5-HT release, from 11.0 1.46 to 110.6 29.9 pmol/108 platelets ( P < 0.02). Naftopidil enhanced collag...

journal_title：Platelets

authors： Alarayyed NA,Prichard BN,Betteridge DJ,Smith CC

更新日期：1997-01-01 00:00:00

abstract：:Microparticles (MPs) are blebs released from cellular surfaces during activation/apoptosis. They are procoagulant, pro-inflammatory and could contribute to pathogenesis of deep venous thrombosis (DVT). This study compared the number, cellular origin and procoagulant activity of MPs on DVT patients in different clinica...

journal_title：Platelets

authors： Flores-Nascimento MC,Beltrame MP,De Paula EV,Montalvão SL,Pereira FG,Orsi FL,Lorand-Metze I,Annichino-Bizzacchi JM

更新日期：2009-09-01 00:00:00

abstract：:Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose ...

journal_title：Platelets

authors： Patrignani P,Patrono C

更新日期：2018-12-01 00:00:00

abstract：:Glanzmann's thrombasthenia (GT) is characterized by increased bleeding risk. The treatment options in GT are limited. The aim of this study was to test the effect of GT blood supplementation with fibrinogen and factor XIII on thrombin generation, blood clotting, and fibrinolysis. Whole blood samples of GT patients and...

journal_title：Platelets

authors： Shenkman B,Livnat T,Misgav M,Budnik I,Einav Y,Martinowitz U

更新日期：2012-01-01 00:00:00

abstract：:A platelet substitute, Synthocytes, is being developed for the prevention and treatment of thrombocytopenia. Synthocytes are composed of fibrinogen adsorbed on heat stabilised albumin microcapsules of defined size. The purpose of this study was to perform experiments in vitro to investigate the capacity of Synthocytes...

journal_title：Platelets

authors： Davies AR,Judge HM,May JA,Glenn JR,Heptinstall S

更新日期：2002-06-01 00:00:00

abstract：:A variety of flow cytometry techniques are in use to evaluate in vivo blood platelet activation. We have in this study further developed and optimised these methods to be suitable for use in clinical studies. By preloading the Monovette EDTA vacuum blood sampling tubes with 1/8 vol 4% (w/v) paraformaldehyde (PFA), we ...

journal_title：Platelets

authors： Hagberg IA,Lyberg T

更新日期：2000-05-01 00:00:00

abstract：:FVIII is an important cofactor in the tenase coagulation factor complex, lack of FVIII causes severe bleeding, whereas high FVIII levels seem to be associated with venous and arterial thromboembolism. Resting platelets do not bind FVIII, but activated platelets bind unactivated FVIII if vWF is not present. We investig...

journal_title：Platelets

authors： Obergfell A,Sturm A,Speer CP,Walter U,Grossmann R

更新日期：2006-11-01 00:00:00

abstract：:Current guidelines favor dual anti-platelet therapy with ticagrelor 90 mg BID (T90BID) over clopidogrel 75 mg QD (C75QD) in addition to aspirin for acute coronary syndrome. However, an increased risk of ticagrelor-related adverse events prompted the evaluation of low-dose regimens. This study (NCT03381742) retrospecti...

journal_title：Platelets

authors： Shi J,He M,Wang W,Liu G,Zhang H,Sun D,Li J,Mu H,Xu M,Zhao C,Wang J,Zhang C,Cang H,Zhao S,Zhang Z,Li Y

更新日期：2021-01-02 00:00:00

abstract：:Peroxynitrite is a potent nitrating and oxidizing agent that exerts differential effects on platelets. In the present study we investigated the influence of peroxynitrite on vasodilator-stimulated phosphoprotein (VASP), a protein that plays a key role in inhibition of platelet adhesion and spreading. In platelets, VAS...

journal_title：Platelets

authors： Aburima A,Riba R,Naseem KM

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Bullous pemphigoid (BP) is an autoimmune skin disease that is characterized by the formation of blisters on normal or erythematous skin. In patients with BP, eosinophils are highly represented in the inflammatory infiltrate of the lesional skin and their levels are often increased in peripheral blood. It i...

journal_title：Platelets

authors： Rifaioglu EN,Sen BB,Ekiz Ö,Dogramaci AC

更新日期：2014-01-01 00:00:00

abstract：:Platelet-rich fibrin (PRF) is generated from the patients' own venous blood by a single centrifugation step without the additional use of anticoagulants. Based on the previously described LSCC (low-speed centrifugation concept), our group showed that modification of the centrifugation setting, that is, reducing the re...

journal_title：Platelets

authors： Kubesch A,Barbeck M,Al-Maawi S,Orlowska A,Booms PF,Sader RA,Miron RJ,Kirkpatrick CJ,Choukroun J,Ghanaati S

更新日期：2019-01-01 00:00:00

abstract：:We present here a 63-year old woman with a long history of immune thrombocytopenia. She was hospitalized for a traumatic intracranial hemorrhage with thrombocytopenia. Following inefficient treatment of four platelet transfusions, immunoglobulins, and corticosteroids, we initiated treatment with a thrombopoietin (TPO)...

journal_title：Platelets

authors： Espitia O,Ternisien C,Agard C,Boisseau P,Denis CV,Fouassier M

更新日期：2017-07-01 00:00:00

abstract：:Platelets from patients with type 2 diabetes show abnormalities in intracellular Ca(2+) homeostasis that are involved in platelet hyperaggregability and the development of thrombotic complications. Different Ca(2+) transport mechanisms have been reported to be altered in platelets from patients with type 2 diabetes, i...

journal_title：Platelets

authors： Zbidi H,Jardin I,Bartegi A,Salido GM,Rosado JA

更新日期：2011-01-01 00:00:00

abstract：:Selective activation of the platelet TXA2 receptor is sufficient to mediate concurrent aggregation, deaggregation and shape change (SC) responses without activation of known Gi-coupled receptors (Platelets 2003; 14: 89). However, Gi-coupled receptor activation strongly influences the hemostasis response in vivo. This ...

journal_title：Platelets

authors： Maayani S,Schwarz TE,Patel ND,Craddock-Royal BD,Tagliente TM

更新日期：2003-09-01 00:00:00

abstract：:To study the possibility of using thrombin generation tests in platelet-rich and platelet-poor plasma for evaluation of dual antiplatelet therapy efficacy in patients with coronary artery disease (CAD), following percutaneous coronary intervention. Venous blood was analyzed from CAD patients aged 53-75 years who had u...

journal_title：Platelets

authors： Berezovskaya G,Smirnova O,Malev E,Khromov-Borisov N,Klokova E,Karpenko M,Papayan L,Petrishchev N

更新日期：2018-03-01 00:00:00

abstract：:The aim of this study was to determine whether autologous fresh platelet concentrate (PC) significantly improves haemostasis in cardiac reoperations compared with autologous fresh whole blood (WB). Forty-eight patients who had elective cardiac reoperations with a low-dose aprotinin priming regimen were divided into tw...

journal_title：Platelets

authors： Miyashita T,Kuro M

更新日期：2001-06-01 00:00:00

abstract：:Diabetic patients are at higher risk of development of cardiovascular complications than the general population. The role of platelets in the pathogenesis of these complications is still controversial, it being difficult to ascertain whether altered platelet function is a cause or consequence of vascular complications...

journal_title：Platelets

authors： Rotondo S,Cerletti C,Gaetano G,Tascione E

更新日期：1993-01-01 00:00:00

abstract：:Due to the importance of fluid flow during thrombotic episodes, it is quite appropriate to study clotting and bleeding processes in devices that have well-defined fluid shear environments. Two common devices for applying these defined shear stresses include the cone-and-plate viscometer and parallel-plate flow chamber...

journal_title：Platelets

authors： Zhang C,Neelamegham S

更新日期：2017-07-01 00:00:00

abstract：:Activated platelets serve as a catalyst for thrombin generation and a source of vasoactive and mitogenic factors affecting vascular remodeling. Oral menopausal hormone treatments (MHT) may carry greater thrombotic risk than transdermal products. This study compared effects of oral and transdermal MHT on platelet chara...

journal_title：Platelets

authors： Miller VM,Lahr BD,Bailey KR,Heit JA,Harman SM,Jayachandran M

更新日期：2016-01-01 00:00:00

abstract：:In patients with end-stage renal disease (ESRD), hemorrhagic complications are commonly encountered due to abnormalities in primary hemostasis, in particular, platelet (PLT) dysfunction and impaired PLT-vessel wall interaction. The pathogenesis of altered PLT function is considered multifactorial. Dialysis procedures ...

journal_title：Platelets

authors： Mekawy MA,Habashy DM,Abd El-Mohsen WA

更新日期：2015-01-01 00:00:00

abstract：:Plasma lipid composition, platelet aggregation, cholesterol (Ch)/glycoprotein IIb-IIIa (GP) and phospholipid (Ph)/GP molar ratios, fatty acid composition and structural order (1, 6-diphenyl-1, 3, 5-hexatriene (DPH) fluorescence anisotropy at 35 degrees C (r(DPH,35)) of human platelet plasma membranes (HPPM) were measu...

journal_title：Platelets

authors： García-Guerra R,Mateo CR,García-Muñoz MS,Zapata MA,Plaza I,González-Rodríguez J

更新日期：1998-01-01 00:00:00

abstract：:We previously reported that thrombin-induced Ca(2+) mobilization was enhanced in aged rat platelets. Since Ca(2+) mobilization in platelets is believed to be closely associated with platelet activation, we examined Ca(2+) mobilization and the aggregatory response to ADP and thrombin in young (3 months) and aged (24 mo...

journal_title：Platelets

authors： Sugidachi A,Asai F,Oshima T,Koike H

更新日期：1995-01-01 00:00:00

abstract：:Platelets in flowing blood at high-shear stress are recruited to exposed subendothelial collagen of injured vessels by GPIb-von Willebrand factor (vWf) and integrin alpha(2)beta(1) (alpha(2)beta(1))-collagen interactions. Platelet adhesion to type I collagen depends mainly on the alpha(2)beta(1)-collagen interaction a...

journal_title：Platelets

authors： Jung SM,Sonoda M,Tsuji K,Jimi A,Nomura S,Kanaji T,Moroi M

更新日期：2010-01-01 00:00:00

abstract：:In immune thrombocytopenia (ITP), antibodies reacting with platelet membrane glycoproteins (GP) mediate premature platelet cleavage, resulting in thrombocytopenia and therefore a risk of bleeding. These antibodies may induce complement activation, thus mediating complement-induced platelet destruction. In this study, ...

journal_title：Platelets

authors： Unterberger U,Eichelberger B,Ulz A,Panzer S

更新日期：2017-06-01 00:00:00