Original Article: Intracellular Ca(2+) Mobilization and Aggregatory Response to ADP and Thrombin in Aged Rat Platelets.

abstract：:Stripping of cytoplasm from circulating megakaryocytes (MKs) in the pulmonary capillary bed implicates the lungs as an important site for platelet production in normal physiology. The placenta has been proposed as an alternative location for intrauterine platelet production as fetal lungs are essentially non-functioni...

journal_title：Platelets

authors： Woods MJ,Landon CR,Greaves M,Trowbridge EA

更新日期：1992-01-01 00:00:00

abstract：:The frequency distributions of HPA-1 to HPA-6 and HPA-15 were evaluated in two Brazilian populations from Parana: a mixed population of predominantly Caucasians and a population of Japanese descendants. Genotyping was performed by PCR-SSP in 364 unrelated individuals. Differences in the distribution of HPA highlight d...

journal_title：Platelets

authors： Silvestre APA,Zacarias JMV,Guelsin GAS,Visentainer JEL,Sell AM

更新日期：2017-09-01 00:00:00

abstract：:The effects of prostaglandin E(2) (PGE(2)) on platelet function are believed to be the result of opposing mechanisms that lead to both enhancement and inhibition of platelet function. Enhancement of platelet function is known to be via EP3 receptors linked to G(i) and inhibition of adenylyl cyclase. However, the recep...

journal_title：Platelets

authors： Iyú D,Glenn JR,White AE,Johnson AJ,Fox SC,Heptinstall S

更新日期：2010-01-01 00:00:00

abstract：:The aim of the present study was to investigate the role of 12-lipoxygenase (12-LOX) on platelet-induced airway smooth muscle cell (ASMC) proliferation. Co-incubation of platelets and ASMC caused platelet activation as determined by morphological changes. Simultaneously, reactive oxygen species (ROS)-generation was de...

journal_title：Platelets

authors： Svensson Holm AC,Grenegård M,Ollinger K,Lindström EG

更新日期：2014-01-01 00:00:00

abstract：:In human platelets and other non-excitable cell types depletion of the intracellular calcium stores promotes calcium entry across the plasma membrane. Although the mechanism of this store-mediated calcium entry remains uncertain, it has been suggested that a tyrosine phosphorylation step could be involved. In support ...

journal_title：Platelets

authors： Jenner S,Sage SO

更新日期：2000-06-01 00:00:00

abstract：:Lipid-rafts are defined as membrane microdomains enriched in cholesterol and glycosphingolipids within platelet plasma membrane. Lipid raft-mediated clot retraction requires factor XIII and other interacting proteins. The aim of this study was to investigate the proteins that interact with factor XIII in raft and non-...

journal_title：Platelets

authors： Rabani V,Montange D,Davani S

更新日期：2016-09-01 00:00:00

abstract：:Cessation of one component of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) has been associated with increased risk of ischemic events but it is uncertain whether discontinuation of aspirin is preferable to discontinuation of the oral P2Y12 inhibitor. The GLOBAL LEADERS study comp...

journal_title：Platelets

authors： Hennigan BW,Good R,Adamson C,Parker WAE,Martin L,Anderson L,Campbell M,Serruys PW,Storey RF,Oldroyd KG

更新日期：2020-12-26 00:00:00

abstract：:Thrombocytopenia is one of the most frequent hematologic abnormalities in the neonatal period, affecting about 18-35% of all patients admitted to the Neonatal Intensive Care Unit (NICU), with sepsis being among the most common causes of severe neonatal thrombocytopenia. It is unclear whether decreased platelet product...

journal_title：Platelets

authors： Eissa DS,El-Farrash RA

更新日期：2013-01-01 00:00:00

abstract：:Binding of podoplanin to the C-type lectin-like receptor 2 (CLEC-2) promotes platelet activation and soluble CLEC-2 (sCLEC-2) is shed from activated platelets. The role of sCLEC-2 in the plasma is unknown. The expression level and plasma concentration of sCLEC-2 could be affected by variants of the corresponding gene,...

journal_title：Platelets

authors： Etemad M,Christodoulou F,Weiss C,Klüter H,Bugert P

更新日期：2020-11-29 00:00:00

abstract：:Standardized Ginkgo biloba extract, EGb761, has been shown to possess polyvalent properties, such as anti-oxidation, anti-apoptosis and anti-inflammation. Recently, it has also been proposed to have direct protective effects on mitochondria. The effects of EGb761 make it a potential anti-aging drug. Despite that, the ...

journal_title：Platelets

authors： Shi C,Xiao S,Liu J,Guo K,Wu F,Yew DT,Xu J

更新日期：2010-01-01 00:00:00

abstract：:Tissue factor (TF) is the most important initiator of intravascular coagulation. This article will review published evidence on the contribution of platelets to TF exposure to the circulating blood. The following mechanisms will be discussed: decryption of monocyte TF by platelets, contribution of platelets to TF expr...

journal_title：Platelets

authors： Lösche W

更新日期：2005-09-01 00:00:00

abstract：:The ram gene was isolated from a rat megakaryocyte cDNA library and encodes a GTP-binding protein with a Mr of 25 000. In order to clarify the presence of the ram protein (ram p25) in human platelets, we tried to purify ram p25 from the sodium cholate extract of human platelet membranes by a combination of DEAE-Sephac...

journal_title：Platelets

authors： Nagata K,Okano Y,Suzuki T,Nozawa Y

更新日期：1993-01-01 00:00:00

abstract：:Autophagy is an effective strategy for cell development by recycling cytoplasmic constituents. Genetic deletion of autophagy mediator Atg7 in hematopoietic stem cells (HSCs) can lead to failure of megakaryopoiesis and enhanced autophagy has been implicated in various hematological disorders such as immune thrombocytop...

journal_title：Platelets

authors： Wang Q,You T,Fan H,Wang Y,Chu T,Poncz M,Zhu L

更新日期：2017-01-01 00:00:00

abstract：:Heparin and protamine are fundamental in the management of anticoagulation during cardiac surgery. Excess protamine has been associated with increased bleeding. Interaction between protamine and platelet function has been demonstrated but the mechanism remains unclear. We examined the effect of protamine on platelet f...

journal_title：Platelets

authors： Törnudd M,Ramström S,Kvitting JE,Alfredsson J,Pihl R,Berg S

更新日期：2021-01-02 00:00:00

abstract：:The distribution of some proteoglycan anionic sites and carbohydrate moieties on the diabetic platelet surface has been investigated by cytochemical methods. Human blood platelets obtained from either diabetic patients (serum glycaemia 9.6-19.2 mmol/L) or normal donors were labeled with specific stains (Ruthenium Red,...

journal_title：Platelets

authors： Lupu C,Rizescu M,Calb M

更新日期：1994-01-01 00:00:00

abstract：:Recent experimental evidence demonstrates that the platelet-specific collagen receptor, glycoprotein (GP)VI is essentially all uncleaved on normal circulating platelets, but is shed from the platelet surface in a metalloproteinase-dependent manner in response to GPVI ligands (including collagen), anti-GPVI antibodies ...

journal_title：Platelets

authors： Al-Tamimi M,Mu FT,Moroi M,Gardiner EE,Berndt MC,Andrews RK

更新日期：2009-05-01 00:00:00

abstract：:It has been suggested that thromboelastography TEG) can help in limiting or directing the appropriate use of blood products during surgery. However, the contribution of platelets to the TEG profile has not been studied in detail. Blood was taken from eight healthy subjects and eight patients with peripheral arterial d...

journal_title：Platelets

authors： Bowbrick VA,Mikhailidis DP,Stansby G

更新日期：2003-06-01 00:00:00

abstract：:Aspirin is traditionally taken once daily in the morning and considered to be effective throughout the 24h interval. Cardiovascular events occur most frequently in the early morning, suggesting that these hours are critical in terms of adequate platelet inhibition. This study therefore assed platelet function in the e...

journal_title：Platelets

authors： Racca C,van Diemen JJK,Fuijkschot WW,Spit K,Bonten TN,Numans ME,van der Bom JG,Smulders YM,Thijs A

更新日期：2019-01-01 00:00:00

abstract：:In vitro models of thrombocytopenia are useful research tools. Previously published models have shortcomings altering properties of platelets and other blood components. The aim of the present study was to develop a whole blood method to induce thrombocytopenia with minimal manipulation, and to describe platelet funct...

journal_title：Platelets

authors： Tiedemann Skipper M,Rubak P,Halfdan Larsen O,Hvas AM

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes with subsequent mortality remains unclear. METHODS:The clinical and laboratory data of 383 patients with the definite outcome by March 1, 2020 i...

journal_title：Platelets

authors： Liu Y,Sun W,Guo Y,Chen L,Zhang L,Zhao S,Long D,Yu L

更新日期：2020-05-18 00:00:00

abstract：:A hypercoagulable state has, in observational studies, been associated with increased risk of thromboembolic events. The aim of this trial was to study whether dual antiplatelet therapy (DAPT) with clopidogrel in addition to aspirin could reduce the rate of graft occlusions, thromboembolic events, and death compared t...

journal_title：Platelets

authors： Rafiq S,Johansson PI,Kofoed KF,Lund JT,Olsen PS,Bentsen S,Steinbrüchel DA

更新日期：2017-12-01 00:00:00

abstract：:In patients with acute coronary syndrome (ACS), treatment using ticagrelor demonstrated significant ischemic benefits over clopidogrel; however, it was associated with increased bleeding complications leading to frequent de-escalation to clopidogrel. The objective of the present study was to investigate the efficacy a...

journal_title：Platelets

authors： Wang C,Zheng W,Shaqdan A,Wang C,Qin X,Zhao X,Wang X,Yuan L,Nie S,Liu R

更新日期：2020-01-01 00:00:00

abstract：:Recent findings have identified critical roles for the actin filament-crosslinking protein filamin A (FlnA) in platelets and megakaryocytes. This short review focuses on the structure of FlnA and its interaction with the Von Willebrand Factor receptor GPIb-IX-V complex and the fibrinogen receptor, the integrin αIIbβ3 ...

journal_title：Platelets

authors： Falet H

更新日期：2013-01-01 00:00:00

abstract：:Pre-analytical variables interact with standard coagulation parameters. How these variables affect the platelet function analysis is not completely known. How collection site and puncture method affect multiple electrode aggregometry (MEA) and platelet function analyzer (PFA-100®) was compared regarding contact activa...

journal_title：Platelets

authors： Lancé MD,Henskens YM,Nelemans P,Theunissen MH,Oerle RV,Spronk HM,Marcus MA

更新日期：2013-01-01 00:00:00

abstract：:Metabolic syndrome (MS) is becoming globally prevalent and it is clinically important because of its association with type 2 diabetes and cardiovascular disease, and some cancers. Recently, platelet count has been linked to insulin resistance and MS in addition to being a marker of hemostasis. Also, mean platelet volu...

journal_title：Platelets

authors： Park BJ,Shim JY,Lee HR,Jung DH,Lee JH,Lee YJ

更新日期：2012-01-01 00:00:00

abstract：:We report a case of total hyperpigmentation of the skin, severe itching, muscle weakness and thrombocytosis. Laboratory investigation showed white blood cell (WBC) 8.2 x 10(6)/L, Hb 125 g/L, platelets 1221 x 10(6)/L and urinary lead after DMSA mobilization test 2684 mcg/g creatinine (normal <5). Chelation therapy with...

journal_title：Platelets

authors： Al Momen A

更新日期：2010-01-01 00:00:00

abstract：:Adrenaline is a platelet activator having a resting plasma concentration of <1 nmol/l that increases to a few nmol/l during stress. However, most in vitro assays only detect effects of adrenaline in micromolar concentrations. This makes it difficult to estimate the relevance of in vitro data for the in vivo situation....

journal_title：Platelets

authors： Eriksson AC,Whiss PA

更新日期：2013-01-01 00:00:00

abstract：:Glanzmann's thrombasthenia (GT) is characterized by increased bleeding risk. The treatment options in GT are limited. The aim of this study was to test the effect of GT blood supplementation with fibrinogen and factor XIII on thrombin generation, blood clotting, and fibrinolysis. Whole blood samples of GT patients and...

journal_title：Platelets

authors： Shenkman B,Livnat T,Misgav M,Budnik I,Einav Y,Martinowitz U

更新日期：2012-01-01 00:00:00

abstract：:Platelet function disorders (PFDs) are a common cause of mild bleeding tendency. However, they cannot be recognized by standard screening studies. The gold standard test for PFD is platelet aggregation, performed by light transmission aggregometry (LTA). A newer and less validated method is the closure time (CT), perf...

journal_title：Platelets

authors： Tanous O,Steinberg Shemer O,Yacobovich J,Zoldan M,Horovitz Y,Yaniv I,Rabizadeh E,Tamary H,Nakav S,Lahav J

更新日期：2017-11-01 00:00:00

abstract：:Phenolic compounds have different biological properties, including antioxidative activities, but they may also be prooxidants. The effect of phenolic fraction from roots of Alhagi maurorum on oxidative protein/lipid damages (determined by such parameters as levels of protein thiol groups and the concentration of thiob...

journal_title：Platelets

authors： Olas B,Hamed AI,Oleszek W,Stochmal A

更新日期：2015-01-01 00:00:00