Abstract:
:Cessation of one component of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) has been associated with increased risk of ischemic events but it is uncertain whether discontinuation of aspirin is preferable to discontinuation of the oral P2Y12 inhibitor. The GLOBAL LEADERS study compared two antiplatelet strategies following PCI, cessation of aspirin at 1 month with continued ticagrelor monotherapy for 23 months versus standard DAPT for 12 months followed by aspirin monotherapy for a further 12 months. We assessed recovery of platelet reactivity after withdrawal of either aspirin or ticagrelor at 1 month and 12 months, respectively, in this study. Platelet aggregation (PA) was assessed before cessation of DAPT ('baseline') and after 2, 7, and 14 days post-cessation using Multiplate whole-blood aggregometry with collagen, thrombin-receptor-activating peptide (TRAP), adenosine diphosphate (ADP) and arachidonic acid (AA) as agonists. Following cessation of aspirin at 1 month, there was marked recovery of PA induced by AA (baseline [mean ± SD]: 11.1 ± 7.4 U vs. 14 days: 64.9 ± 19.6 U, p < .0001) and collagen (37.4 ± 22.9 U vs. 79.8 ± 13.8 U, p < .0001), whereas PA induced by ADP (18.6 ± 6.6 vs. 69.1 ± 20.5, p < .0001) and collagen (34.4 ± 18.7 U vs. 43.0 ± 21.0, p = .0018) recovered following cessation of ticagrelor at 12 months. There were no significant changes in TRAP-induced PA in either group. In conclusion, cessation of either component of DAPT leads to substantial increase in platelet reactivity with differential effects on different pathways of platelet activation when aspirin or the P2Y12 inhibitor is stopped. Further work is required to determine which patients receive net benefit from long-term continuation of DAPT.
journal_name
Plateletsjournal_title
Plateletsauthors
Hennigan BW,Good R,Adamson C,Parker WAE,Martin L,Anderson L,Campbell M,Serruys PW,Storey RF,Oldroyd KGdoi
10.1080/09537104.2020.1863937subject
Has Abstractpub_date
2020-12-26 00:00:00pages
1-6eissn
0953-7104issn
1369-1635pub_type
杂志文章相关文献
PLATELETS文献大全abstract::Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose ...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537104.2018.1492105
更新日期:2018-12-01 00:00:00
abstract::The present study was performed to explore differences in the expression of P-selectin and IL-8 production of blood cells in healthy individuals with large size platelets (MI-families) as compared to people having normal size platelets. A positive correlation between LPS-induced IL-8 production per platelet in whole b...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/02697450310001632597
更新日期:2003-11-01 00:00:00
abstract::Recently, our laboratory has reported the presence of one acidifying Cl-/HC exchange mechanism in human platelets. This paper demonstrates that this exchanger decreases its activity after inhibition of carbonic anhydrase. BCECF-loaded platelets, previously equilibrated in a bicarbonate/CO2 buffered solution, were resu...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100500163457
更新日期:2005-11-01 00:00:00
abstract::Calcium channel blockers are known to inhibit platelet aggregation in vitro and ex vivo. We studied the influence of a single oral dose of diltiazem (60 mg), nifedipine (10 mg) and verapamil (80 mg) on ADP-, collagen-, and epinephrine-induced platelet aggregation, malondialdehyde formation, serum thromboxane B(2) and ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109109005501
更新日期:1991-01-01 00:00:00
abstract::Thrombosis and bleeding are devastating adverse events in patients supported with blood-contacting medical devices (BCMDs). In this study, we delineated that high non-physiological shear stress (NPSS) caused platelet dysfunction that may contribute to both thrombosis and bleeding. Human blood was subjected to NPSS wit...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2017.1384542
更新日期:2019-01-01 00:00:00
abstract::Selected aspirin treated patients may exhibit high platelet reactivity to agonists other than arachidonic acid. This study aimed to determine whether the VerifyNow identifies generalized high platelet reactivity supported by correlations with other established methods that stimulate platelets with various agonists. St...
journal_title:Platelets
pub_type: 杂志文章,随机对照试验
doi:10.1080/09537100701206824
更新日期:2007-09-01 00:00:00
abstract::In patients with end-stage renal disease (ESRD), hemorrhagic complications are commonly encountered due to abnormalities in primary hemostasis, in particular, platelet (PLT) dysfunction and impaired PLT-vessel wall interaction. The pathogenesis of altered PLT function is considered multifactorial. Dialysis procedures ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537104.2014.931569
更新日期:2015-01-01 00:00:00
abstract::High on-treatment platelet reactivity (HTPR) is associated with poor prognosis in patients undergoing percutaneous coronary intervention (PCI). The antiplatelet effect and safety of prasugrel was compared to that of double-dose clopidogrel in patients with stable coronary artery disease or acute coronary syndrome (ACS...
journal_title:Platelets
pub_type: 杂志文章,随机对照试验
doi:10.3109/09537104.2013.845874
更新日期:2014-01-01 00:00:00
abstract::Bioactive substances found in numerous foods can be successfully and safely used to modify various cellular functions and affect the oxidative stress. Aronia melanocarpa fruits (Rosaceae) are one of the richest plant sources of phenolic substances shown to have anti-inflammatory, antitumor, antioxidative and antiplate...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537101003612821
更新日期:2010-01-01 00:00:00
abstract::Platelet shape change is an extremely rapid process mediated by both the calcium-sensitive and p160ROCK pathways. The present study examines how different features of shape change studied by scanning electron microscopy clearly correlate to changes in the pattern of light absorbance measured in an aggregometer. Platel...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/0953710031000092794
更新日期:2003-05-01 00:00:00
abstract::Thrombocytopenia is common in patients with lung diseases. Lung injury is associated with deranged platelet homeostasis. The potential mechanisms underlying this association were investigated in this study. The number and morphology of circulating megakaryocytes (MK) were investigated in vivo during cardiopulmonary by...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100600745120
更新日期:2006-08-01 00:00:00
abstract::We present a peculiarity of the neonatal hemostatic system that might contribute to establish a procoagulant readiness in neonatal blood by sensitizing neonatal platelets for ADP stimulation. beta2-glycoprotein-I (beta2-GP-I) is a plasma constituent capable of suppressing ADP-induced platelet aggregation. We found sig...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100600800529
更新日期:2007-02-01 00:00:00
abstract::Two putative substitutes for fresh endothelial cell (EC) extracellular matrix (ECM), frozen ECM and Matrigel, were studied using a parallel-plate perfusion system and platelet deposition was evaluated morphometrically. Coverslips covered with ECM were stored frozen at-30 C for 0 (fresh ECM), 1, 2, 3 or 4 weeks. The ab...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537109876500
更新日期:1998-01-01 00:00:00
abstract::Platelets are anucleated cells that upon activation by agonists or during storage may develop apoptotic events. The role of peroxynitrite and its reactive intermediates in apoptotic process in blood platelets is unknown. In order to study the appearance of biomarkers of apoptosis in platelets after treatment with pero...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100802406646
更新日期:2008-12-01 00:00:00
abstract::Platelets contribute to blood coagulation at sites of vascular injury and to the recruitment of leukocytes at sites of inflammation. Under pathological conditions, platelets are involved in numerous diseases and clinical complications, such as deep venous thrombosis, embolism and atherosclerosis. But so far, little is...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903215417
更新日期:2009-11-01 00:00:00
abstract::A variety of flow cytometry techniques are in use to evaluate in vivo blood platelet activation. We have in this study further developed and optimised these methods to be suitable for use in clinical studies. By preloading the Monovette EDTA vacuum blood sampling tubes with 1/8 vol 4% (w/v) paraformaldehyde (PFA), we ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/095371000403071
更新日期:2000-05-01 00:00:00
abstract::SUMMARY. Blood platelets exposed to hypotonic medium are known to undergo a regulatory volume decrease (RVD), mediated by increased conductive permeability of K(+) and Cl(-). It is presently shown that RVD in platelets is controlled by a lipoxygenase product, apparently by a selective regulation of K(+) permeability. ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109109005512
更新日期:1991-01-01 00:00:00
abstract::In this study, we have examined whether the platelet Fc-receptor, FcγRII (CD32), is associated with either of the two major platelet membrane glycoproteins, the GPIb-IX complex and the GPIIb-IIIa complex. Monoclonal and polyclonal anti-GPIb-IX complex antibodies inhibited to only a moderate degree (< 40%) the binding ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537109309013216
更新日期:1993-01-01 00:00:00
abstract::Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis. This study aimed to utilize small-volume, whole blood platelet functional assays to assess the neon...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2019.1573314
更新日期:2020-01-01 00:00:00
abstract::Dopamine (DA), a catecholamine neurotransmitter, is known to for its diverse roles on hematopoiesis, yet its function in thrombopoiesis remains poorly understood. This study shows that DA stimulation can directly induce platelet production from megakaryocytes (MKs) in the final stages of thrombopoiesis via a reactive ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2017.1356451
更新日期:2018-11-01 00:00:00
abstract::Aspirin is traditionally taken once daily in the morning and considered to be effective throughout the 24h interval. Cardiovascular events occur most frequently in the early morning, suggesting that these hours are critical in terms of adequate platelet inhibition. This study therefore assed platelet function in the e...
journal_title:Platelets
pub_type: 杂志文章,随机对照试验
doi:10.1080/09537104.2018.1528347
更新日期:2019-01-01 00:00:00
abstract::This manuscript reviews pathogenic variants in RASGRP2, which are the cause of a relatively new autosomal recessive and nonsyndromic inherited platelet function disorder, referred to as platelet-type bleeding disorder-18 (BDPLT18)(OMIM:615888). To date, 18 unrelated BDPLT18 pedigrees have been reported, harboring 19 d...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2019.1585528
更新日期:2019-01-01 00:00:00
abstract::Standardized Ginkgo biloba extract, EGb761, has been shown to possess polyvalent properties, such as anti-oxidation, anti-apoptosis and anti-inflammation. Recently, it has also been proposed to have direct protective effects on mitochondria. The effects of EGb761 make it a potential anti-aging drug. Despite that, the ...
journal_title:Platelets
pub_type: 杂志文章
doi:10.3109/09537100903511448
更新日期:2010-01-01 00:00:00
abstract::Autoimmune thrombocytopenic purpura (ITP) is characterized by an abnormally low platelet count and bleeding risks. The exact triggering event remains elusive. Oxidative stress may play a role in several autoimmune diseases. A direct link between platelets in ITP and oxidative stress has not yet been addressed. The int...
journal_title:Platelets
pub_type: 临床试验,杂志文章
doi:10.3109/09537104.2011.610909
更新日期:2012-01-01 00:00:00
abstract::Platelet-rich plasma (PRP) has a potential effect on tissue repair through proliferation and differentiation of tissue progenitor cells. The aim of this study was to evaluate the effect of PRP on the testis structure and function in infertile rat model by stereological method. Thirty-two male rats were divided into fo...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537104.2018.1478400
更新日期:2019-01-01 00:00:00
abstract::Recent studies have indicated that medical options without splenectomy, such as rituximab (RTX) or thrombopoietin receptor agonists (TPO-RAs), can be effective to treat persistent or chronic primary immune thrombocytopenia (ITP). However, it remains to be determined which of these strategies should be the first choice...
journal_title:Platelets
pub_type: 杂志文章,meta分析
doi:10.1080/09537104.2018.1543864
更新日期:2019-01-01 00:00:00
abstract::Photochemical treatment (PCT) of platelet concentrates, using amotosalen HCl and UVA-light, inactivates pathogens by forming adducts between amotosalen and nucleic acids. The impact of the photochemical treatment on pathogens and leukocytes has been studied extensively. Yet little is known about the effect of PCT on n...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100500129300
更新日期:2005-12-01 00:00:00
abstract::Previous investigations from our laboratory identified the ultrastructural pathology and cytochemistry of macrothrombocytes (MTC) from patients with the X-linked, G208S varient of the GATA-1 mutation.A subsequent biochemical study of the MTC cytoskeletal proteins using polyacrylamide gel electrophoresis and western bl...
journal_title:Platelets
pub_type: 杂志文章
doi:10.1080/09537100902818344
更新日期:2009-05-01 00:00:00
abstract::The tetraspanins are a superfamily of membrane glycoproteins which facilitate the interaction of membrane and intracellular signalling molecules (e.g., integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signalling microdomains (sometimes referred to as the tetraspanin web...
journal_title:Platelets
pub_type: 杂志文章,评审
doi:10.1080/09537100400004363
更新日期:2005-02-01 00:00:00
abstract::Disseminated intravascular coagulation (DIC) has a well-examined pathophysiology, yet some essential elements remain undetermined. During DIC, platelets play an important role in the development of micro thrombosis, but changes in platelet function parameters and their association with development of DIC have not been...
journal_title:Platelets
pub_type: 杂志文章,meta分析,评审
doi:10.1080/09537104.2018.1442567
更新日期:2018-05-01 00:00:00