Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro.

Abstract:

:The aim of the present study was to investigate and compare the anti-platelet action of extracts from three different plants: bark of Yucca schidigera, seeds of grape and berries of Aronia melanocarpa (chokeberry). Anti-platelet action of tested extracts was compared with action of well characterized antioxidative and anti-platelet commercial monomeric polyphenol-resveratrol. The effects of extracts on platelet adhesion to collagen, collagen-induced platelet aggregation and on the production of O2-* in resting platelets and platelets stimulated by a strong platelet agonist-thrombin were studied. The in vitro experiments have shown that all three tested extracts (5-50 microg/ml) rich in polyphenols reduce platelet adhesion, aggregation and generation of O2-* in blood platelets. Comparative studies indicate that all three plant extracts were found to be more reactive in reduction of platelet processes than the solution of pure resveratrol. The tested extracts due to their anti-platelet effects may play an important role as components of human diet in prevention of cardiovascular or inflammatory diseases, where blood platelets are involved.

journal_name

Platelets

journal_title

Platelets

authors

Olas B,Wachowicz B,Tomczak A,Erler J,Stochmal A,Oleszek W

doi

10.1080/09537100701708506

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

70-7

issue

1

eissn

0953-7104

issn

1369-1635

pii

790036099

journal_volume

19

pub_type

杂志文章
  • Update on functional and genetic laboratory assays for the detection of platelet microvesicles.

    abstract::Functional and genetic assays for measuring platelet microvesicles (PMVs) are presented and discussed. Functional assays concern two groups of methods: a) homogeneous assays using the cofactor activity of phospholipids (PPLs) contained in PMVs and present in assayed plasmas, and a coagulation or a thrombin generation ...

    journal_title:Platelets

    pub_type: 杂志文章,评审

    doi:10.1080/09537104.2016.1265925

    authors: Laroche M,Dunois C,Vissac AM,Amiral J

    更新日期:2017-05-01 00:00:00

  • Platelet reactivity and nonresponse to dual antiplatelet therapy: a review.

    abstract::Clopidogrel is a second-generation thienopyridine that irreversibly inhibits the P2Y(12) adenosine diphosphate (ADP) receptor on platelets, preventing platelet aggregation. As early as 2003, researchers have observed inter-patient variability in response to clopidogrel, leading to a multitude of studies investigating ...

    journal_title:Platelets

    pub_type: 杂志文章,评审

    doi:10.3109/09537100903261379

    authors: Vila PM,Zafar MU,Badimon JJ

    更新日期:2009-12-01 00:00:00

  • Aspirin, platelet inhibition and cancer prevention.

    abstract::Several lines of evidence are consistent with the hypothesis that activated platelets contribute to colorectal tumorigenesis and metastatization through direct cell-cell interactions and the release of different lipid and protein mediators, and microvesicles. This review examines the clinical pharmacology of low-dose ...

    journal_title:Platelets

    pub_type: 杂志文章,评审

    doi:10.1080/09537104.2018.1492105

    authors: Patrignani P,Patrono C

    更新日期:2018-12-01 00:00:00

  • Thrombopoietin-receptor agonists in haematological disorders: the Danish experience.

    abstract::The objective of this study was to investigate the use of thrombopoietin-receptor agonists (TPO-ra) in patients with refractory primary immune thrombocytopenia (ITP) as well as off-label use of TPO-ra in Danish haematology departments. Hospital medical records from 32 of the 39 patients having received TPO-ra from 200...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2011.634931

    authors: Gudbrandsdottir S,Frederiksen H,Hasselbalch H

    更新日期:2012-01-01 00:00:00

  • Upper gastrointestinal haemorrhage complicating antiplatelet treatment with aspirin and/or clopidogrel: where we are now?

    abstract::A large number of patients require antiplatelet therapy (mainly aspirin and/or clopidogrel). Recent studies suggest that the combination of these agents is useful in patients with acute coronary syndrome and after percutaneous coronary intervention with stent placement. On the other hand, bleeding complications, most ...

    journal_title:Platelets

    pub_type: 杂志文章,评审

    doi:10.1080/09537100500237004

    authors: Liberopoulos EN,Elisaf MS,Tselepis AD,Archimandritis A,Kiskinis D,Cokkinos D,Mikhailidis DP

    更新日期:2006-02-01 00:00:00

  • The in vivo effect of fibrinogen and factor XIII on clot formation and fibrinolysis in Glanzmann's thrombasthenia.

    abstract::Glanzmann's thrombasthenia (GT) is characterized by increased bleeding risk. The treatment options in GT are limited. The aim of this study was to test the effect of GT blood supplementation with fibrinogen and factor XIII on thrombin generation, blood clotting, and fibrinolysis. Whole blood samples of GT patients and...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2011.642031

    authors: Shenkman B,Livnat T,Misgav M,Budnik I,Einav Y,Martinowitz U

    更新日期:2012-01-01 00:00:00

  • Effect of different anticoagulants on multiple electrode platelet aggregometry after clopidogrel and aspirin administration in patients undergoing coronary stent implantation: a comparison between citrate and hirudin.

    abstract::Outcomes of platelet function tests are highly dependent on the type of blood anticoagulant used. The primary objective of this study was to clinically evaluate the platelet function after dual antiplatelet therapy using two different types of anticoagulant (citrate and hirudin). We compared data obtained from multipl...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2012.698431

    authors: Zhang HZ,Yu LH,Kim MH

    更新日期:2013-01-01 00:00:00

  • Immature platelet fraction related parameters in the differential diagnosis of thrombocytopenia.

    abstract::The pathogenesis of thrombocytopenia can be divided into increased destruction (ID) of platelets in the peripheral blood and decreased production (DP) of platelets in the bone marrow. This study aimed to analyze the efficacy of immature platelet fraction (IPF) related parameters, including the IPF count (IPF#), IPF pe...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2019.1678118

    authors: Li J,Li Y,Ouyang J,Zhang F,Liang C,Ye Z,Chen S,Cheng J

    更新日期:2020-08-17 00:00:00

  • Human platelets contain and release TWEAK.

    abstract::The multifunctional cytokine, TWEAK (TNF-like weak inducer of apoptosis), is a member of the TNFα superfamily. TWEAK is found in a broad range of cell types and has been linked to cell growth and survival, angiogenesis and other inflammatory processes. These functions and their importance in inflammatory diseases have...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2010.512403

    authors: Meyer T,Amaya M,Desai H,Robles-Carrillo L,Hatfield M,Francis JL,Amirkhosravi A

    更新日期:2010-01-01 00:00:00

  • A deleterious effect of aspirin on the antithrombotic properties of endothelial cells is not observed with platelets previously exposed to aspirin: studies in a flow system.

    abstract::We have explored both the independent and combined effects of aspirin on cultured endothelial cells and platelets, and its influence on platelet deposition onto an extracellular matrix. Blood was circulated through a flat perfusion chamber with two coverslips placed sequentially with respect to blood flow. The first c...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537109609079506

    authors: Alemany M,Hernández MR,Bozzo J,Bono A,Escolar G,Ordinas A,Bastida E

    更新日期:1996-01-01 00:00:00

  • The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function.

    abstract::The effects of prostaglandin E(2) (PGE(2)) on platelet function are believed to be the result of opposing mechanisms that lead to both enhancement and inhibition of platelet function. Enhancement of platelet function is known to be via EP3 receptors linked to G(i) and inhibition of adenylyl cyclase. However, the recep...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537101003718065

    authors: Iyú D,Glenn JR,White AE,Johnson AJ,Fox SC,Heptinstall S

    更新日期:2010-01-01 00:00:00

  • Use of a thrombopoietin receptor agonist in von Willebrand disease type 2B (p.V1316M) with severe thrombocytopenia and intracranial hemorrhage.

    abstract::We present here a 63-year old woman with a long history of immune thrombocytopenia. She was hospitalized for a traumatic intracranial hemorrhage with thrombocytopenia. Following inefficient treatment of four platelet transfusions, immunoglobulins, and corticosteroids, we initiated treatment with a thrombopoietin (TPO)...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2016.1246717

    authors: Espitia O,Ternisien C,Agard C,Boisseau P,Denis CV,Fouassier M

    更新日期:2017-07-01 00:00:00

  • Comparison of biological activity of phenolic fraction from roots of Alhagi maurorum with properties of commercial phenolic extracts and resveratrol.

    abstract::Phenolic compounds have different biological properties, including antioxidative activities, but they may also be prooxidants. The effect of phenolic fraction from roots of Alhagi maurorum on oxidative protein/lipid damages (determined by such parameters as levels of protein thiol groups and the concentration of thiob...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2015.1031650

    authors: Olas B,Hamed AI,Oleszek W,Stochmal A

    更新日期:2015-01-01 00:00:00

  • Efficacy and safety of switching from ticagrelor to clopidogrel during the early and late phase in acute coronary syndrome patients after percutaneous coronary intervention.

    abstract::In patients with acute coronary syndrome (ACS), treatment using ticagrelor demonstrated significant ischemic benefits over clopidogrel; however, it was associated with increased bleeding complications leading to frequent de-escalation to clopidogrel. The objective of the present study was to investigate the efficacy a...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2019.1609668

    authors: Wang C,Zheng W,Shaqdan A,Wang C,Qin X,Zhao X,Wang X,Yuan L,Nie S,Liu R

    更新日期:2020-01-01 00:00:00

  • Prasugrel or double-dose clopidogrel to overcome clopidogrel low-response--the TAILOR (Thrombocytes And IndividuaLization of ORal antiplatelet therapy in percutaneous coronary intervention) randomized trial.

    abstract::High on-treatment platelet reactivity (HTPR) is associated with poor prognosis in patients undergoing percutaneous coronary intervention (PCI). The antiplatelet effect and safety of prasugrel was compared to that of double-dose clopidogrel in patients with stable coronary artery disease or acute coronary syndrome (ACS...

    journal_title:Platelets

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/09537104.2013.845874

    authors: Dridi NP,Johansson PI,Clemmensen P,Stissing T,Radu MD,Qayyum A,Pedersen F,Helqvist S,Saunamäki K,Kelbæk H,Jørgensen E,Engstrøm T,Holmvang L

    更新日期:2014-01-01 00:00:00

  • Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis.

    abstract::Autophagy is an effective strategy for cell development by recycling cytoplasmic constituents. Genetic deletion of autophagy mediator Atg7 in hematopoietic stem cells (HSCs) can lead to failure of megakaryopoiesis and enhanced autophagy has been implicated in various hematological disorders such as immune thrombocytop...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2016.1204436

    authors: Wang Q,You T,Fan H,Wang Y,Chu T,Poncz M,Zhu L

    更新日期:2017-01-01 00:00:00

  • Comparison of treatments for persistent/chronic immune thrombocytopenia: a systematic review and network meta-analysis.

    abstract::Recent studies have indicated that medical options without splenectomy, such as rituximab (RTX) or thrombopoietin receptor agonists (TPO-RAs), can be effective to treat persistent or chronic primary immune thrombocytopenia (ITP). However, it remains to be determined which of these strategies should be the first choice...

    journal_title:Platelets

    pub_type: 杂志文章,meta分析

    doi:10.1080/09537104.2018.1543864

    authors: Arai Y,Matsui H,Jo T,Kondo T,Takaori-Kondo A

    更新日期:2019-01-01 00:00:00

  • Evaluation of the Total Thrombus-Formation System (T-TAS): application to human and mouse blood analysis.

    abstract::The Total Thrombus-formation Analyser System (T-TAS) is a whole blood flow chamber system for the measurement of in vitro thrombus formation under variable shear stress conditions. Our current study sought to evaluate the potential utility of the T-TAS for the measurement of thrombus formation within human and mouse w...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2018.1535704

    authors: Al Ghaithi R,Mori J,Nagy Z,Maclachlan A,Hardy L,Philippou H,Hethershaw E,Morgan NV,Senis YA,Harrison P

    更新日期:2019-01-01 00:00:00

  • New insights into the versatile roles of platelet FlnA.

    abstract::Recent findings have identified critical roles for the actin filament-crosslinking protein filamin A (FlnA) in platelets and megakaryocytes. This short review focuses on the structure of FlnA and its interaction with the Von Willebrand Factor receptor GPIb-IX-V complex and the fibrinogen receptor, the integrin αIIbβ3 ...

    journal_title:Platelets

    pub_type: 杂志文章,评审

    doi:10.3109/09537104.2011.654004

    authors: Falet H

    更新日期:2013-01-01 00:00:00

  • Deaggregation is an integral component of the response of platelets to ADP in vitro: kinetic studies of literature and original data.

    abstract::Adenosine diphosphate (ADP) is recognized as an important mediator of platelet aggregation. Transient aggregation at low (< or =1 microM), and sustained aggregation at higher ADP concentrations are consistently observed. Dissociation of platelet aggregates has been described and may explain the reversible component of...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537100120071004

    authors: Maayani S,Tagliente TM,Schwarz T,Craddock-Royal B,Alcala C,Marrero G,Martinez R

    更新日期:2001-08-01 00:00:00

  • Altered distribution of some surface glycosaminoglycans and glycoconjugates on human blood platelets in diabetes mellitus.

    abstract::The distribution of some proteoglycan anionic sites and carbohydrate moieties on the diabetic platelet surface has been investigated by cytochemical methods. Human blood platelets obtained from either diabetic patients (serum glycaemia 9.6-19.2 mmol/L) or normal donors were labeled with specific stains (Ruthenium Red,...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537109409006047

    authors: Lupu C,Rizescu M,Calb M

    更新日期:1994-01-01 00:00:00

  • Cloning of the cDNA for murine von Willebrand factor and identification of orthologous genes reveals the extent of conservation among diverse species.

    abstract::Interaction of von Willebrand factor (VWF) with circulating platelets promotes hemostasis when a blood vessel is injured. The A1 domain of VWF is responsible for the initial interaction with platelets and is well conserved among species. Knowledge of the cDNA and genomic DNA sequences for human VWF allowed us to predi...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537100600938816

    authors: Chitta MS,Duhé RJ,Kermode JC

    更新日期:2007-05-01 00:00:00

  • Clopidogrel resistance in North Indian patients of coronary artery disease and lack of its association with platelet ADP receptors P2Y1 and P2Y12 gene polymorphisms.

    abstract::Aspirin and Clopidogrel are used in prophylaxis of patients undergoing percutaneous coronary intervention and long-term prevention of cardiovascular and cerebrovascular events. Clopidogrel resistance has been attributed to P2Y1 and P2Y12 adenosine diphosphate (ADP) receptor polymorphisms. This study enrolled 100 patie...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2012.693992

    authors: Kar R,Meena A,Yadav BK,Yadav R,Kar SS,Saxena R

    更新日期:2013-01-01 00:00:00

  • Medium on-treatment platelet reactivity to ADP is favorable in patients with acute coronary syndromes undergoing coronary stenting.

    abstract::Bleeding in the setting of acute coronary syndromes (ACS) has negative prognostic implications. We sought to determine the impact of different levels of on-treatment platelet reactivity (PR) to ADP on both bleeding and ischemic events in ACS patients receiving coronary stenting. PR to ADP was measured with the VerifyN...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2011.568075

    authors: Huczek Z,Filipiak KJ,Kochman J,Michalak M,Roik M,Grabowski M,Opolski G

    更新日期:2011-01-01 00:00:00

  • Aspirin intake in the morning is associated with suboptimal platelet inhibition, as measured by serum Thromboxane B2, during infarct-prone early-morning hours.

    abstract::Aspirin is traditionally taken once daily in the morning and considered to be effective throughout the 24h interval. Cardiovascular events occur most frequently in the early morning, suggesting that these hours are critical in terms of adequate platelet inhibition. This study therefore assed platelet function in the e...

    journal_title:Platelets

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/09537104.2018.1528347

    authors: Racca C,van Diemen JJK,Fuijkschot WW,Spit K,Bonten TN,Numans ME,van der Bom JG,Smulders YM,Thijs A

    更新日期:2019-01-01 00:00:00

  • Antimicrobial properties of single-donor-derived, platelet-leukocyte fibrin for fistula occlusion: An in vitro study.

    abstract::Fibrin glue is a promising alternative for low-output enterocutaneous fistula closure. Bacterial flora colonizing inside the fistula tract, however, may limit the glue application. Single-donor-derived, platelet-rich materials were hypothesized in this study to have antimicrobial activity against Gram-negative microor...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2012.761685

    authors: Wu X,Ren J,Yuan Y,Luan J,Yao G,Li J

    更新日期:2013-01-01 00:00:00

  • Development of a high-yield expression and purification system for platelet factor 4.

    abstract::Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characterized by IgG antibodies bound to complexes of platelet factor 4 (PF4) and heparin. The majority of diagnostic tests for HIT rely on an exogenous source of PF4 to identify anti-PF4/heparin antibodies. These include the PF4-dependent enhanced ser...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2017.1378808

    authors: Huynh A,Arnold DM,Moore JC,Smith JW,Kelton JG,Nazy I

    更新日期:2018-05-01 00:00:00

  • Comparison of conventional aggregometry with VASP for monitoring P2Y12-specific platelet inhibition.

    abstract::No consensus exists regarding the optimal estimate of light transmission aggregometry (LTA) to reflect P2Y12 ADP receptor inhibition in patients receiving thienopyridine therapy. Currently, the only completely P2Y12-receptor specific method is the measurement of vasodilator stimulated phosphoprotein (VASP) phosphoryla...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.3109/09537104.2010.494742

    authors: Aradi D,Magyarlaki T,Tokés-Füzesi M,Rideg O,Vorobcsuk A,Komócsi A

    更新日期:2010-01-01 00:00:00

  • Assessment of neonatal, cord, and adult platelet granule trafficking and secretion.

    abstract::Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis. This study aimed to utilize small-volume, whole blood platelet functional assays to assess the neon...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537104.2019.1573314

    authors: Ngo ATP,Sheriff J,Rocheleau AD,Bucher M,Jones KR,Sepp AI,Malone LE,Zigomalas A,Maloyan A,Bahou WF,Bluestein D,McCarty OJT,Haley KM

    更新日期:2020-01-01 00:00:00

  • The H(1)-histamine antagonist dithiaden inhibits human platelet function in vitro.

    abstract::The H(1)-histamine receptor antagonist Dithaden(R) inhibited in a dose-dependent manner, human platelet aggregation in vitro that was induced with stimuli in the following rank order of potency: thrombin > A23187 > adrenaline > ADP. The aggregation of platelets in plasma induced with adrenaline was inhibited by Dithia...

    journal_title:Platelets

    pub_type: 杂志文章

    doi:10.1080/09537109709169334

    authors: Nosál' R,Jancinová V,Danihelova E

    更新日期:1997-01-01 00:00:00